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TR200102910T2 - èeker artìklarìyla ikame edilmiç 1,4-benzotiyazepin-1,1-dioksid trevleri - Google Patents

èeker artìklarìyla ikame edilmiç 1,4-benzotiyazepin-1,1-dioksid trevleri

Info

Publication number
TR200102910T2
TR200102910T2 TR2001/02910T TR200102910T TR200102910T2 TR 200102910 T2 TR200102910 T2 TR 200102910T2 TR 2001/02910 T TR2001/02910 T TR 2001/02910T TR 200102910 T TR200102910 T TR 200102910T TR 200102910 T2 TR200102910 T2 TR 200102910T2
Authority
TR
Turkey
Prior art keywords
benzothiazepine
substituted
dioxide
revs
sugar residues
Prior art date
Application number
TR2001/02910T
Other languages
English (en)
Inventor
Frick Wendelin
Glombik Heiner
Heuer Hubert
Sch�fer Hans-Ludwig
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200102910T2 publication Critical patent/TR200102910T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Eldeki buluç, ikame edilmiç 1,4- benzotiyazepin-1,1-dioksid türevlerini ve bunlar n asit katk tuzlar n konu almaktad r. çinde R1, R2, R3 ve Z' nin, belirtilen anlamlara sahip olduGu formül (I)' in 1,4-benzotiyazepin-1,1-dioksid türevleri, ve bunlar n fizyolojik olarak tolere edilebilir tuzlar ve fizyolojik olarak fonksiyonel türevleri ve bunlar n üretimine yönelik yöntemler tan mlanmaktad r. Bu bileçikler örneGin hipolipidemik ilaçlar için uygundur.
TR2001/02910T 1999-04-09 2000-03-23 èeker artìklarìyla ikame edilmiç 1,4-benzotiyazepin-1,1-dioksid trevleri TR200102910T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19916108A DE19916108C1 (de) 1999-04-09 1999-04-09 Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung

Publications (1)

Publication Number Publication Date
TR200102910T2 true TR200102910T2 (tr) 2002-03-21

Family

ID=7904060

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02910T TR200102910T2 (tr) 1999-04-09 2000-03-23 èeker artìklarìyla ikame edilmiç 1,4-benzotiyazepin-1,1-dioksid trevleri

Country Status (32)

Country Link
US (1) US6277831B1 (tr)
EP (1) EP1169313B1 (tr)
JP (1) JP2002541248A (tr)
KR (1) KR100686905B1 (tr)
CN (1) CN1145619C (tr)
AR (1) AR023401A1 (tr)
AT (1) ATE243686T1 (tr)
AU (1) AU765199B2 (tr)
BR (1) BR0009641A (tr)
CA (1) CA2369070C (tr)
CZ (1) CZ300410B6 (tr)
DE (2) DE19916108C1 (tr)
DK (1) DK1169313T3 (tr)
EE (1) EE04613B1 (tr)
ES (1) ES2200860T3 (tr)
HK (1) HK1044537B (tr)
HR (1) HRP20010725A2 (tr)
HU (1) HUP0200644A3 (tr)
IL (2) IL145647A0 (tr)
MY (1) MY120842A (tr)
NO (1) NO319836B1 (tr)
NZ (1) NZ514656A (tr)
PL (1) PL203806B1 (tr)
PT (1) PT1169313E (tr)
RS (1) RS49850B (tr)
RU (1) RU2232155C2 (tr)
SI (1) SI1169313T1 (tr)
SK (1) SK286744B6 (tr)
TR (1) TR200102910T2 (tr)
TW (1) TWI254045B (tr)
WO (1) WO2000061568A2 (tr)
ZA (1) ZA200107989B (tr)

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TWI871392B (zh) 2019-12-04 2025-02-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
US11014898B1 (en) 2020-12-04 2021-05-25 Albireo Ab Benzothiazepine compounds and their use as bile acid modulators
TWI865673B (zh) 2019-12-04 2024-12-11 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
TWI877263B (zh) 2019-12-04 2025-03-21 瑞典商艾爾比瑞歐公司 苯并噻二氮呯化合物及其作為膽酸調節劑之用途
JP7695242B2 (ja) 2019-12-04 2025-06-18 アルビレオ・アクチボラグ ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
AR120674A1 (es) 2019-12-04 2022-03-09 Albireo Ab Compuestos de benzotiazepina y su uso como ácido biliar
TWI867107B (zh) 2019-12-04 2024-12-21 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途
JP7665620B2 (ja) 2019-12-04 2025-04-21 アルビレオ・アクチボラグ ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
CA3186857A1 (en) 2020-08-03 2022-02-10 Per-Goran Gillberg Benzothia(di)azepine compounds and their use as bile acid modulators
CA3196488A1 (en) 2020-11-12 2022-05-19 Albireo Ab Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
CA3198216A1 (en) 2020-12-04 2022-06-09 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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