TR200101755T2 - Tricyclic farnesyl protein transferase inhibitors. - Google Patents
Tricyclic farnesyl protein transferase inhibitors.Info
- Publication number
- TR200101755T2 TR200101755T2 TR2001/01755T TR200101755T TR200101755T2 TR 200101755 T2 TR200101755 T2 TR 200101755T2 TR 2001/01755 T TR2001/01755 T TR 2001/01755T TR 200101755 T TR200101755 T TR 200101755T TR 200101755 T2 TR200101755 T2 TR 200101755T2
- Authority
- TR
- Turkey
- Prior art keywords
- protein transferase
- farnesyl protein
- group
- transferase inhibitors
- compounds
- Prior art date
Links
- 239000003528 protein farnesyltransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000002883 imidazolyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical group NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000004202 carbamide Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Electroluminescent Light Sources (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Formül (1.0)bilesikleri açiklanmaktadir; burada R13 bir imidazol halkasini temsil eder;R14 bir karbamat, üre,amit veya sülfonamit grubunu temsil eder; amit gurubu ile R13 imidazol grubu arasindaki alkil zinciri ikameli oldugunda R8 H'yi temsil eder veya R8 arilalkil, heteroarilalkil veya sikloalkil gibi bir ikameyi temsil eder;ve kalan ikameler burada tanimlandigi gibidir. Ayrica R8'in H ve amit grubu ile R13 imidazol grubu arasindaki alkil zincirinin ikamesiz oldugu bilesikler açiklanmaktadir. Ayrica açiklanan bilesikleri kullanarak kanseri tedavi etmek için bir yöntem ve farnezil protein transferazi inhibe etmek için bir yöntem açiklanmaktadir.The compounds of formula (1.0) are described; wherein R13 represents an imidazole ring, R14 represents a carbamate, urea, amide or sulfonamide group; When the alkyl chain between the amide group and the R13 imidazole group is substituted, R8 represents H, or R8 represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl, and the remaining substituents are as defined herein. Also disclosed are compounds in which the alkyl chain between R8's H and amide group and R13 imidazole group is unsubstituted. Also disclosed is a method for treating cancer using the compounds described, and a method for inhibiting farnesyl protein transferase.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21639898A | 1998-12-18 | 1998-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200101755T2 true TR200101755T2 (en) | 2001-09-21 |
Family
ID=22806914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2001/01755T TR200101755T2 (en) | 1998-12-18 | 1999-12-16 | Tricyclic farnesyl protein transferase inhibitors. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1140902A1 (en) |
| JP (1) | JP2002533336A (en) |
| KR (1) | KR20010081116A (en) |
| CN (1) | CN1326850C (en) |
| AR (1) | AR021718A1 (en) |
| AU (1) | AU776558B2 (en) |
| BR (1) | BR9916314A (en) |
| CA (1) | CA2354779A1 (en) |
| CO (1) | CO5160350A1 (en) |
| CZ (1) | CZ20011950A3 (en) |
| HU (1) | HUP0202152A2 (en) |
| IL (1) | IL143408A0 (en) |
| NO (1) | NO20012961L (en) |
| NZ (1) | NZ511878A (en) |
| PE (1) | PE20001342A1 (en) |
| PL (1) | PL348293A1 (en) |
| SK (1) | SK7592001A3 (en) |
| TR (1) | TR200101755T2 (en) |
| WO (1) | WO2000037459A1 (en) |
| ZA (1) | ZA200104233B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9916314A (en) | 1998-12-18 | 2001-10-02 | Schering Corp | Tricyclic farnesyl transferase protein inhibitors |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| WO2002056884A2 (en) * | 2001-01-22 | 2002-07-25 | Schering Corporation | Treatment of malaria with farnesyl protein transferase inhibitors |
| AU2002257114A1 (en) * | 2001-04-06 | 2002-10-21 | Schering Corporation | Treatment of malaria with farsenyl protein transferase inhibitors |
| CA2590979A1 (en) | 2004-12-13 | 2006-06-22 | Schering Corporation | Novel farnesyl protein transferase inhibitors and their use to treat cancer |
| MX2007007078A (en) | 2004-12-14 | 2007-09-04 | Schering Corp | Farnesyl protein transferase inhibitors and methods for treating proliferative diseases. |
| JP2009523799A (en) * | 2006-01-19 | 2009-06-25 | シェーリング コーポレイション | Piperazine derivatives as farnesyl protein transferase inhibitors |
| US9914726B2 (en) | 2014-03-19 | 2018-03-13 | Vps-3, Inc. | 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation |
| CN106132947B (en) | 2014-03-19 | 2019-08-09 | Vps-3有限公司 | Preparation method of compound |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111235A (en) * | 1993-10-15 | 2001-03-19 | Schering Plough Corp | Pharmaceutical compositions for inhibition of g-protein function and for treatment of proliferative diseases containing tricyclic compounds some such compounds and process for preparing part of them |
| US5712280A (en) | 1995-04-07 | 1998-01-27 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibition of g-protein function and for treatment of proliferative diseases and pharmaceutical compositions comprising them |
| US5801175A (en) * | 1995-04-07 | 1998-09-01 | Schering Corporation | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| PE92098A1 (en) * | 1996-07-31 | 1998-12-31 | Schering Corp | TRICYCLIC N-CYANOIMINES USEFUL AS PROTEIN TRANSFERASE INHIBITORS FARNESILO |
| KR100640672B1 (en) | 1997-06-17 | 2006-11-02 | 파마코페이아 드럭 디스커버리, 인크. | Benzpyrido Cycloheptane Compounds Useful for Inhibiting Farnesyl Protein Transferase and Pharmaceutical Compositions Comprising the Same |
| BR9916314A (en) | 1998-12-18 | 2001-10-02 | Schering Corp | Tricyclic farnesyl transferase protein inhibitors |
-
1999
- 1999-12-16 BR BR9916314-4A patent/BR9916314A/en not_active IP Right Cessation
- 1999-12-16 CO CO99078843A patent/CO5160350A1/en unknown
- 1999-12-16 EP EP99963980A patent/EP1140902A1/en not_active Withdrawn
- 1999-12-16 CN CNB99816206XA patent/CN1326850C/en not_active Expired - Fee Related
- 1999-12-16 PL PL99348293A patent/PL348293A1/en not_active Application Discontinuation
- 1999-12-16 TR TR2001/01755T patent/TR200101755T2/en unknown
- 1999-12-16 IL IL14340899A patent/IL143408A0/en unknown
- 1999-12-16 NZ NZ511878A patent/NZ511878A/en unknown
- 1999-12-16 WO PCT/US1999/027939 patent/WO2000037459A1/en not_active Ceased
- 1999-12-16 HU HU0202152A patent/HUP0202152A2/en unknown
- 1999-12-16 KR KR1020017007632A patent/KR20010081116A/en not_active Abandoned
- 1999-12-16 JP JP2000589531A patent/JP2002533336A/en active Pending
- 1999-12-16 SK SK759-2001A patent/SK7592001A3/en unknown
- 1999-12-16 AR ARP990106461A patent/AR021718A1/en unknown
- 1999-12-16 CZ CZ20011950A patent/CZ20011950A3/en unknown
- 1999-12-16 CA CA002354779A patent/CA2354779A1/en not_active Abandoned
- 1999-12-16 AU AU20307/00A patent/AU776558B2/en not_active Ceased
- 1999-12-17 PE PE1999001295A patent/PE20001342A1/en not_active Application Discontinuation
-
2001
- 2001-05-23 ZA ZA200104233A patent/ZA200104233B/en unknown
- 2001-06-15 NO NO20012961A patent/NO20012961L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20011950A3 (en) | 2001-12-12 |
| NZ511878A (en) | 2003-10-31 |
| AR021718A1 (en) | 2002-07-31 |
| CA2354779A1 (en) | 2000-06-29 |
| WO2000037459A1 (en) | 2000-06-29 |
| IL143408A0 (en) | 2002-04-21 |
| JP2002533336A (en) | 2002-10-08 |
| CN1334811A (en) | 2002-02-06 |
| EP1140902A1 (en) | 2001-10-10 |
| CN1326850C (en) | 2007-07-18 |
| PE20001342A1 (en) | 2000-12-09 |
| PL348293A1 (en) | 2002-05-20 |
| NO20012961D0 (en) | 2001-06-15 |
| KR20010081116A (en) | 2001-08-27 |
| SK7592001A3 (en) | 2002-03-05 |
| CO5160350A1 (en) | 2002-05-30 |
| AU776558B2 (en) | 2004-09-16 |
| ZA200104233B (en) | 2002-08-22 |
| AU2030700A (en) | 2000-07-12 |
| HUP0202152A2 (en) | 2002-10-28 |
| BR9916314A (en) | 2001-10-02 |
| NO20012961L (en) | 2001-08-16 |
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