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TR200101163T2 - Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları - Google Patents

Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları

Info

Publication number
TR200101163T2
TR200101163T2 TR2001/01163T TR200101163T TR200101163T2 TR 200101163 T2 TR200101163 T2 TR 200101163T2 TR 2001/01163 T TR2001/01163 T TR 2001/01163T TR 200101163 T TR200101163 T TR 200101163T TR 200101163 T2 TR200101163 T2 TR 200101163T2
Authority
TR
Turkey
Prior art keywords
alkenoylguanidines
substituted phenyl
production methods
water substituted
production
Prior art date
Application number
TR2001/01163T
Other languages
English (en)
Inventor
Weichert Andreas
Enhsen Alfons
Falk Eugen
Jansen Hans-Willi
Kramer Werner
Schwark Jan-Robert
Jochen Lang Hans
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of TR200101163T2 publication Critical patent/TR200101163T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Ikame edilen fenil-alkenoilguanidinler, bunlarin üretilmesine iliskin yöntem, bunlarin ilaç ya da diagnostika olarak kullanimi ve ayrica onlari içeren ilaç. Isbu bulus, ikame edilen fenil-alkenoilguanidinlerle ve bunlarin eczacilikta uyumlu tuzlari ve fizyolojik bakimdan fonksiyonel türevleri ile ilgilidir. Artiklarinin yukarida belirtilen anlamlari içerdigi, Formül 1'in bilesikleri, ayrica bunlarin fizyolojik bakimdan uyumlu tuzlari, fizyolojik bakimdan fonksiyonel türevleri ve bunlarin üretilmesine iliskin yöntemler tarif edilmektedir. Bilesikler, örnegin profilaksi ya da safra taslarina karsi tedavide ilaç olarak kullanima uygundur.
TR2001/01163T 1998-10-28 1999-10-15 Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları TR200101163T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19849722A DE19849722A1 (de) 1998-10-28 1998-10-28 Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
TR200101163T2 true TR200101163T2 (tr) 2001-08-21

Family

ID=7885948

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01163T TR200101163T2 (tr) 1998-10-28 1999-10-15 Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları

Country Status (22)

Country Link
US (1) US6166002A (tr)
EP (1) EP1124841B1 (tr)
JP (1) JP4616479B2 (tr)
KR (1) KR20010085973A (tr)
CN (1) CN1325403A (tr)
AT (1) ATE236191T1 (tr)
AU (1) AU757365B2 (tr)
BR (1) BR9914929A (tr)
CA (1) CA2349523A1 (tr)
CZ (1) CZ20011429A3 (tr)
DE (2) DE19849722A1 (tr)
DK (1) DK1124841T3 (tr)
ES (1) ES2191466T3 (tr)
HK (1) HK1041271A1 (tr)
HU (1) HUP0103751A3 (tr)
ID (1) ID29025A (tr)
PL (1) PL348108A1 (tr)
PT (1) PT1124841E (tr)
RU (1) RU2232769C2 (tr)
TR (1) TR200101163T2 (tr)
WO (1) WO2000024761A1 (tr)
ZA (1) ZA200103106B (tr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19941764A1 (de) 1999-09-02 2001-03-15 Aventis Pharma Gmbh Substituierte Acylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika sowie sie enthaltende Medikamente
WO2004112687A2 (en) * 2003-06-26 2004-12-29 Biotron Limited Antiviral acylguanidine compounds and methods
DE10338554A1 (de) * 2003-08-22 2005-03-31 Aventis Pharma Deutschland Gmbh Pentafluorosulfanylphenyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US20050171215A1 (en) * 2004-01-30 2005-08-04 Ethicon, Inc. Germicidal compositions containing halogenated phthalaldehyes, and methods of using such compositions for disinfection or sterilization
US6891069B1 (en) 2004-01-30 2005-05-10 Ethicon, Inc. Synthesis of 4-substituted phthalaldehyde
US7476767B2 (en) 2004-01-30 2009-01-13 Ethicon, Inc. Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
US7390837B2 (en) 2004-01-30 2008-06-24 Ethicon, Inc. Germicidal compositions containing phenylmalonaldehyde-type compounds, or mixtures of phenylmalonaldehyde-type compounds and phthalaldehydes, and methods of using such compositions for disinfection or sterilization
US7291649B2 (en) 2005-06-29 2007-11-06 Ethicon, Inc. Forming germicidal aromatic dialdehydes with acetals
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
HRP20180289T1 (hr) 2008-12-31 2018-03-23 Ardelyx, Inc. Spojevi i postupci za inhibiciju antiporta posredovanu s pomoću nhe pri liječenju poremećaja povezanih sa zadržavanjem tekućine ili prevelikom količinom soli i poremećajima gastrointestinalnog trakta
PL2983667T3 (pl) 2013-04-12 2019-10-31 Ardelyx Inc Związki wiążące nhe3 oraz sposoby inhibicji transportu fosforanów
WO2018129557A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Inhibitors of nhe-mediated antiport
JP7292207B2 (ja) 2017-01-09 2023-06-16 アルデリックス， インコーポレイテッド 消化管障害を処置するために有用な化合物
WO2020041673A1 (en) 2018-08-23 2020-02-27 President And Fellows Of Harvard College Compositions and methods related to cholic acid-7-sulfate as a treatment for diabetes
US12419897B2 (en) 2018-12-04 2025-09-23 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof
CN114340631A (zh) 2019-05-21 2022-04-12 阿德利克斯股份有限公司 用于降低患者的血清磷酸盐的组合

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW289021B (tr) * 1993-05-08 1996-10-21 Hoechst Ag
US5792635A (en) * 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
JPH0959162A (ja) * 1995-08-28 1997-03-04 Makoto Takahashi 胆石溶解剤
DE19633966A1 (de) * 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
BR9914929A (pt) 2001-07-10
US6166002A (en) 2000-12-26
WO2000024761A1 (de) 2000-05-04
AU757365B2 (en) 2003-02-20
CZ20011429A3 (cs) 2001-08-15
EP1124841A1 (de) 2001-08-22
EP1124841B1 (de) 2003-04-02
RU2232769C2 (ru) 2004-07-20
ID29025A (id) 2001-07-26
ZA200103106B (en) 2002-08-28
HK1041271A1 (zh) 2002-07-05
CN1325403A (zh) 2001-12-05
DE59904875D1 (de) 2003-05-08
KR20010085973A (ko) 2001-09-07
PL348108A1 (en) 2002-05-06
CA2349523A1 (en) 2000-05-04
DE19849722A1 (de) 2000-05-04
HUP0103751A3 (en) 2002-12-28
JP4616479B2 (ja) 2011-01-19
ES2191466T3 (es) 2003-09-01
PT1124841E (pt) 2003-08-29
HUP0103751A2 (hu) 2002-04-29
ATE236191T1 (de) 2003-04-15
DK1124841T3 (da) 2003-07-28
JP2002528460A (ja) 2002-09-03
AU6203299A (en) 2000-05-15

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