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TR200100167T2 - Improved method for the production of clavulanic acid - Google Patents

Improved method for the production of clavulanic acid

Info

Publication number
TR200100167T2
TR200100167T2 TR2001/00167T TR200100167T TR200100167T2 TR 200100167 T2 TR200100167 T2 TR 200100167T2 TR 2001/00167 T TR2001/00167 T TR 2001/00167T TR 200100167 T TR200100167 T TR 200100167T TR 200100167 T2 TR200100167 T2 TR 200100167T2
Authority
TR
Turkey
Prior art keywords
fermentation
clavulanic acid
production
improved method
cultures
Prior art date
Application number
TR2001/00167T
Other languages
Turkish (tr)
Inventor
Maria De Almeida Nabais Ana
Manuela Regalo Da Fonseca Maria
Original Assignee
Dsm N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm N.V. filed Critical Dsm N.V.
Publication of TR200100167T2 publication Critical patent/TR200100167T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Streptomyces clavuligerus veya mutantlarinin seçilmis ve/veya kültür toplanmis türlerini kullanan aerobik suya daldirilmis kültürleri içeren fermantasyon tekniginin kullanilmasiyla klavulanik asit üretimi için bir yöntemdir. Bundan dolayi kültürleme bir veya daha fazla organik azot kompleks kaynaklarinin kültür ortami içine sürekli veya yari sürekli besleme kullanan fermantasyon yoluyla gerçeklestirilir ve böylece filtrelenmis et suyundaki protein konsantrasyonu belli sinirlar içinde fermantasyon süresince kontrol edilir. Tanimlanan kosullar klavulanik asit fermantasyonunda kayda deger gelismeler öncülük etmektedir.It is a method for the production of clavulanic acid using streptomyces clavuligerus or mutants of selected and / or fermentation technique containing cultures dipped in aerobic water using culture aggregated cultures. Therefore, culturing is carried out by fermentation using continuous or semi-continuous feed into the culture medium of one or more organic nitrogen complex sources, so that the protein concentration in the filtered broth is controlled during fermentation in certain nerves. The defined conditions lead to significant improvements in clavulanic acid fermentation.

TR2001/00167T 1998-07-20 1999-07-19 Improved method for the production of clavulanic acid TR200100167T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT10218198A PT102181A (en) 1998-07-20 1998-07-20 IMPROVED PROCESS FOR THE PRODUCTION OF CLAVULANIC ACID

Publications (1)

Publication Number Publication Date
TR200100167T2 true TR200100167T2 (en) 2001-05-21

Family

ID=20085781

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/00167T TR200100167T2 (en) 1998-07-20 1999-07-19 Improved method for the production of clavulanic acid

Country Status (8)

Country Link
EP (1) EP1098989A1 (en)
CN (1) CN1310766A (en)
AU (1) AU4808899A (en)
CA (1) CA2337074A1 (en)
MX (1) MXPA01000653A (en)
PT (1) PT102181A (en)
TR (1) TR200100167T2 (en)
WO (1) WO2000005397A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102933717A (en) * 2007-04-27 2013-02-13 科学与工业研究委员会 Process for preparation of clavulanic acid employing streptomyces clavuligerus mtcc 1142 in solid state fermentation
CN102277310B (en) * 2010-06-11 2013-04-10 中国科学院上海生命科学研究院 Vector-host system for expressing antibiotic gene clusters and application thereof
EP2589663A1 (en) 2011-11-04 2013-05-08 LEK Pharmaceuticals d.d. Process for production of clavulanic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE41110B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Esters of clavulanic acid
JPS51101994A (en) * 1975-02-07 1976-09-08 Glaxo Lab Ltd
ES2101658B1 (en) * 1995-11-23 1998-03-01 Antibioticos Sa NEW PROCEDURE FOR THE PRODUCTION OF CLAVULANIC ACID AND ITS SALTS.

Also Published As

Publication number Publication date
CA2337074A1 (en) 2000-02-03
EP1098989A1 (en) 2001-05-16
PT102181A (en) 2000-01-31
MXPA01000653A (en) 2002-04-08
AU4808899A (en) 2000-02-14
WO2000005397A1 (en) 2000-02-03
CN1310766A (en) 2001-08-29

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