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TR200003624T2 - Yeni poli(ADP-RİBOZ) polimeraz-genleri - Google Patents

Yeni poli(ADP-RİBOZ) polimeraz-genleri

Info

Publication number
TR200003624T2
TR200003624T2 TR2000/03624T TR200003624T TR200003624T2 TR 200003624 T2 TR200003624 T2 TR 200003624T2 TR 2000/03624 T TR2000/03624 T TR 2000/03624T TR 200003624 T TR200003624 T TR 200003624T TR 200003624 T2 TR200003624 T2 TR 200003624T2
Authority
TR
Turkey
Prior art keywords
scope
adp
methods
effectors
new
Prior art date
Application number
TR2000/03624T
Other languages
English (en)
Inventor
Kock Michael
H�Ger Thomas
Kr�Ger Burkhard
Otterbach Bernd
Lubisch Wilfried
Lemaire Hans-Georg
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR200003624T2 publication Critical patent/TR200003624T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/0203—NAD+ ADP-ribosyltransferase (2.4.2.30), i.e. tankyrase or poly(ADP-ribose) polymerase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91091—Glycosyltransferases (2.4)
    • G01N2333/91142—Pentosyltransferases (2.4.2)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Bulus,a) fonksiyonnel bir NAD+ baglanma domenine, b) genel formül CX2CXmHX2C'in çinko-parmagi sekans motifine sahip olmayan, m'nin 28 ila 30 arasindaki bir tam sayi deger için yazili oldugu ve x artiklarinin bagimsiz olarak herhangi bir amino asidi için yazili oldugu bir amino asidini içermesi olan, bir poli(ADP-riboz)-polimeraz (PARP)-homologunu; ve bunun islevsel esdegerlilikleri; bunlari kodlayan nükleik asitleri; yeni proteinlere yönelik spesifitesi olan antikorlari; bulus kapsamindaki ürünleri içeren farmasötik ve genetik tedavisi maddelerini; bulus kapsamindaki protein ve nükleik asitlerin analitik belirlemesi yöntemlerini; bulus kapsamindaki proteinlerin efektör ve baglanma eslerinin belirlenmesi yöntemlerini; yeni PARP-efektörlerini; bu efektörlerin etkinliginin belirlenmesine yönelik yöntemleri kapsamaktadir.
TR2000/03624T 1998-06-05 1999-06-04 Yeni poli(ADP-RİBOZ) polimeraz-genleri TR200003624T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19825213 1998-06-05
DE19908837 1999-03-01

Publications (1)

Publication Number Publication Date
TR200003624T2 true TR200003624T2 (tr) 2001-06-21

Family

ID=26046644

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03624T TR200003624T2 (tr) 1998-06-05 1999-06-04 Yeni poli(ADP-RİBOZ) polimeraz-genleri

Country Status (24)

Country Link
US (3) US7754459B1 (tr)
EP (1) EP1082416B1 (tr)
JP (1) JP2002517231A (tr)
KR (1) KR20010052582A (tr)
CN (1) CN1304446A (tr)
AR (1) AR020326A1 (tr)
AT (1) ATE358175T1 (tr)
AU (1) AU4605999A (tr)
BG (1) BG105018A (tr)
BR (1) BR9910967A (tr)
CA (1) CA2330206C (tr)
CO (1) CO5070700A1 (tr)
DE (1) DE59914280D1 (tr)
ES (1) ES2285842T3 (tr)
HK (1) HK1038591A1 (tr)
HR (1) HRP20010013A2 (tr)
HU (1) HUP0103190A2 (tr)
ID (1) ID27819A (tr)
IL (1) IL139750A0 (tr)
NO (1) NO20006153L (tr)
PL (1) PL345334A1 (tr)
SK (1) SK17892000A3 (tr)
TR (1) TR200003624T2 (tr)
WO (1) WO1999064572A2 (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19921567A1 (de) 1999-05-11 2000-11-16 Basf Ag Verwendung von Phthalazine-Derivaten
EP1192258A2 (en) 1999-06-16 2002-04-03 Icos Corporation Human poly(adp-ribose) polymerase 2 materials and methods
DE50112961D1 (de) 2000-02-01 2007-10-18 Abbott Gmbh & Co Kg Heterozyklische verbindungen und deren anwendung als parp-inhibitoren
CA2615374A1 (en) 2005-07-18 2007-01-25 Ernest Kun Kun Treatment of cancer
US7994222B2 (en) 2006-09-05 2011-08-09 Bipar Sciences, Inc. Monitoring of the inhibition of fatty acid synthesis by iodo-nitrobenzamide compounds
US8143447B2 (en) 2006-09-05 2012-03-27 Bipar Sciences, Inc. Treatment of cancer
AU2008321128A1 (en) 2007-11-12 2009-05-22 Bipar Sciences, Inc. Treatment of breast cancer with a PARP inhibitor alone or in combination with anti-tumor agents
GB201102865D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
EP2675287B1 (en) 2011-02-18 2016-08-03 DuPont Nutrition Biosciences ApS Feed additive composition
GB201102857D0 (en) 2011-02-18 2011-04-06 Danisco Feed additive composition
GB201213801D0 (en) 2012-08-03 2012-09-12 Dupont Nutrition Biosci Aps Feed additive composition
ES2812599T3 (es) 2012-08-29 2021-03-17 Sangamo Therapeutics Inc Procedimientos y composiciones para el tratamiento de una afección genética

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5162508A (en) * 1987-12-18 1992-11-10 Compagnie Oris Industrie Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers
US5272057A (en) * 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
FR2707011A1 (en) 1993-06-25 1994-12-30 Pasteur Sanofi Diagnostics Immunological process for the detection and assay of antibodies directed against poly(ADP-ribose) polymerase, application to diagnosis, kit for its implementation
DE4444949C1 (de) 1994-12-16 1996-11-21 Deutsches Krebsforsch Vektoren und Viren zur Gentherapie

Also Published As

Publication number Publication date
EP1082416A2 (de) 2001-03-14
WO1999064572A2 (de) 1999-12-16
CN1304446A (zh) 2001-07-18
HRP20010013A2 (en) 2001-12-31
EP1082416B1 (de) 2007-03-28
BR9910967A (pt) 2001-02-13
PL345334A1 (en) 2001-12-17
NO20006153D0 (no) 2000-12-04
IL139750A0 (en) 2002-02-10
US20160010067A1 (en) 2016-01-14
US20110107444A1 (en) 2011-05-05
ATE358175T1 (de) 2007-04-15
SK17892000A3 (sk) 2001-09-11
BG105018A (en) 2001-12-31
US7754459B1 (en) 2010-07-13
AR020326A1 (es) 2002-05-08
NO20006153L (no) 2001-02-02
ID27819A (id) 2001-04-26
US9051553B2 (en) 2015-06-09
AU4605999A (en) 1999-12-30
KR20010052582A (ko) 2001-06-25
HK1038591A1 (zh) 2002-03-22
CA2330206C (en) 2010-04-13
DE59914280D1 (en) 2007-05-10
WO1999064572A3 (de) 2000-06-08
CO5070700A1 (es) 2001-08-28
CA2330206A1 (en) 1999-12-16
HUP0103190A2 (hu) 2001-12-28
JP2002517231A (ja) 2002-06-18
ES2285842T3 (es) 2007-11-16

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