TR200002869T2 - İkame edilmiş indolealkonik asitler. - Google Patents
İkame edilmiş indolealkonik asitler.Info
- Publication number
- TR200002869T2 TR200002869T2 TR2000/02869T TR200002869T TR200002869T2 TR 200002869 T2 TR200002869 T2 TR 200002869T2 TR 2000/02869 T TR2000/02869 T TR 2000/02869T TR 200002869 T TR200002869 T TR 200002869T TR 200002869 T2 TR200002869 T2 TR 200002869T2
- Authority
- TR
- Turkey
- Prior art keywords
- acids
- substituted
- indolealconic
- compounds
- treatment
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001684 chronic effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Sekerli diyabetten kaynaklanan kronik komplikasyonlarin tedavisinde faydali ikame edilmis indolalkanoik asitler sunulmustur. Ayrica bilesikleri ihtiva eden farmasötik kompozisyonlar ve bilesiklerin kullanildigi tedavi metotlarinin yani sira bunlarin sentez metotlari da ortaya konulmustur.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8014398P | 1998-03-31 | 1998-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200002869T2 true TR200002869T2 (tr) | 2000-12-21 |
Family
ID=22155536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/02869T TR200002869T2 (tr) | 1998-03-31 | 1999-03-31 | İkame edilmiş indolealkonik asitler. |
Country Status (29)
| Country | Link |
|---|---|
| US (9) | US6214991B1 (tr) |
| EP (1) | EP1066283B1 (tr) |
| JP (2) | JP3494990B2 (tr) |
| KR (1) | KR100584650B1 (tr) |
| CN (1) | CN1205207C (tr) |
| AP (1) | AP2000001929A0 (tr) |
| AT (1) | ATE269861T1 (tr) |
| AU (1) | AU774929B2 (tr) |
| BG (1) | BG65446B1 (tr) |
| BR (1) | BR9909358A (tr) |
| CA (1) | CA2383983C (tr) |
| CZ (1) | CZ300706B6 (tr) |
| DE (1) | DE69918278T2 (tr) |
| EE (1) | EE200000573A (tr) |
| ES (1) | ES2224632T3 (tr) |
| HU (1) | HUP0101672A3 (tr) |
| ID (1) | ID27884A (tr) |
| IL (2) | IL138711A0 (tr) |
| MX (1) | MXPA02003122A (tr) |
| NO (1) | NO20004900L (tr) |
| NZ (1) | NZ507172A (tr) |
| OA (1) | OA11622A (tr) |
| PL (1) | PL201645B1 (tr) |
| SK (1) | SK7522001A3 (tr) |
| TR (1) | TR200002869T2 (tr) |
| TW (1) | TWI243163B (tr) |
| WO (1) | WO1999050268A2 (tr) |
| YU (1) | YU59600A (tr) |
| ZA (1) | ZA200005577B (tr) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6214991B1 (en) * | 1998-03-31 | 2001-04-10 | The Institute For Pharmaceutical Discovery, Inc. | Substituted indolealkanoic acids |
| TNSN99224A1 (fr) * | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| JP2003505369A (ja) * | 1999-07-15 | 2003-02-12 | エヌピーエス アレリックス コーポレーション | 偏頭痛を治療するための複素環式化合物 |
| WO2001064205A2 (en) * | 2000-03-02 | 2001-09-07 | The Institutes For Pharmaceutical Discovery, Llc | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor |
| US20020012630A1 (en) * | 2000-05-09 | 2002-01-31 | James Nolan | Methods for testing compounds useful in treating diabetic complications |
| WO2002051805A1 (de) | 2000-12-27 | 2002-07-04 | Bayer Aktiengesellschaft | Indol-derivate |
| TWI224101B (en) | 2001-06-20 | 2004-11-21 | Wyeth Corp | Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1) |
| DK1397130T3 (da) | 2001-06-20 | 2007-11-12 | Wyeth Corp | Substituerede indolsyrederivater som inhibitorer af plasminogenaktivatorinhibitor-1 (PAI-1) |
| AU2003210610B2 (en) | 2002-01-18 | 2007-11-29 | Aryx Therapeutics | 5-HT3 receptor antagonists and methods of use |
| US20060100255A1 (en) * | 2002-07-26 | 2006-05-11 | Van Zandt Michael C | Substituted indolealkanoic acids derivative and formulations containing same for use in the treatment of diabetic complications |
| CA2395871A1 (en) * | 2002-07-26 | 2004-01-26 | The Institutes For Pharmaceutical Discovery, Llc | Substituted indolealkanoic acids derivatives and formulations containing same for use in treatment of diabetic complications |
| RU2328483C2 (ru) * | 2002-08-29 | 2008-07-10 | Мерк Энд Ко., Инк. | Индолы, обладающие противодиабетической активностью |
| DE60324183D1 (en) | 2002-12-10 | 2008-11-27 | Wyeth Corp | Aryl-, aryloxy- und alkyloxysubstituierte 1h-indol-3-yl-glyoxylsäurederivateals inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| UA80453C2 (en) | 2002-12-10 | 2007-09-25 | Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1) | |
| JP2006514637A (ja) | 2002-12-10 | 2006-05-11 | ワイス | プラスミノーゲン活性化因子の阻害因子−1(pai−1)の阻害剤としての置換3−カルボニル−1h−インドール−1−イル酢酸誘導体 |
| ATE430731T1 (de) | 2002-12-10 | 2009-05-15 | Wyeth Corp | Substituierte indoloxoacetylaminoessigsäurederivate als inhibitoren des plasminogenaktivatorinhibitors-1 (pai-1) |
| DK1569899T3 (da) | 2002-12-10 | 2006-10-23 | Wyeth Corp | Substituerede 3-alkyl- og 3-arylalkyl-1H-indol-1-yl-eddikesyrederivater som inhibitorer af plasminogenaktivator-inhibitor-1 (PAI-1) |
| EP1620088A4 (en) * | 2003-04-28 | 2007-08-29 | Bayer Pharmaceuticals Corp | ACETIC INDOLE ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS |
| CN1812977A (zh) * | 2003-04-30 | 2006-08-02 | 药物研发有限责任公司 | 取代羧酸 |
| CA2534649A1 (en) * | 2003-08-01 | 2005-02-10 | Genelabs Technologies, Inc. | Bicyclic imidazol derivatives against flaviviridae |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| US7351726B2 (en) | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7411083B2 (en) | 2003-09-25 | 2008-08-12 | Wyeth | Substituted acetic acid derivatives |
| US7446201B2 (en) | 2003-09-25 | 2008-11-04 | Wyeth | Substituted heteroaryl benzofuran acids |
| US7163954B2 (en) | 2003-09-25 | 2007-01-16 | Wyeth | Substituted naphthyl benzothiophene acids |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7141592B2 (en) | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7582773B2 (en) | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| GB0324763D0 (en) * | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| JP2008518926A (ja) * | 2004-10-28 | 2008-06-05 | ジ インスティチューツ フォー ファーマシューティカル ディスカバリー、エルエルシー | 置換フェニルアルカン酸 |
| JP2008526980A (ja) * | 2005-01-14 | 2008-07-24 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染症を治療するためのインドール誘導体 |
| GB0505048D0 (en) * | 2005-03-11 | 2005-04-20 | Oxagen Ltd | Compounds with PGD antagonist activity |
| US20080051384A1 (en) * | 2006-07-14 | 2008-02-28 | Genelabs Technologies, Inc. | Antiviral agents |
| EP2046740B1 (en) | 2006-07-22 | 2012-05-23 | Oxagen Limited | Compounds having crth2 antagonist activity |
| ES2442717T3 (es) | 2008-01-18 | 2014-02-13 | Atopix Therapeutics Limited | Compuestos que tienen actividad antagonista de CRTH2 |
| US7750027B2 (en) * | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| WO2009093029A1 (en) * | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| WO2009093026A1 (en) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| GB2457040A (en) * | 2008-01-30 | 2009-08-05 | Oxagen Ltd | 1-Acetic acid indole derivatives with PGD2 activity |
| WO2010127099A2 (en) | 2009-04-29 | 2010-11-04 | Amarin Corporation Plc | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| PL3597650T3 (pl) * | 2010-07-16 | 2023-02-06 | The Trustees Of Columbia University In The City Of New York | Inhibitory reduktazy aldozy i ich zastosowania |
| US8916563B2 (en) | 2010-07-16 | 2014-12-23 | The Trustees Of Columbia University In The City Of New York | Aldose reductase inhibitors and uses thereof |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| DK3757107T3 (da) | 2016-06-21 | 2023-11-27 | Univ Columbia | 4-oxo-3,4-dihydrothieno[3,4-d]pyridazinforbindelser som aldosereduktasehæmmere og metoder til anvendelse deraf |
| PT3658142T (pt) | 2017-07-28 | 2024-06-27 | Applied Therapeutics Inc | Composições e métodos para tratar galactosemia |
| WO2019191410A1 (en) * | 2018-03-29 | 2019-10-03 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Inhibitors for the β-catenin / t-cell factor protein–protein interaction |
| CN113840825A (zh) | 2019-04-01 | 2021-12-24 | 应用治疗公司 | 醛糖还原酶抑制剂 |
| CA3136100A1 (en) | 2019-05-07 | 2020-11-12 | Stephan L. ZUCHNER | Treatment and detection of inherited neuropathies and associated disorders |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3557142A (en) | 1968-02-20 | 1971-01-19 | Sterling Drug Inc | 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters |
| IE47592B1 (en) | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| DK151884C (da) * | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
| JPS55167282A (en) | 1979-06-12 | 1980-12-26 | Fujisawa Pharmaceut Co Ltd | Piperazine derivative or its salt and its preparation |
| US4283539A (en) | 1979-12-18 | 1981-08-11 | Pfizer Inc. | Isoquinoline acetic acids |
| US4363912A (en) * | 1980-12-15 | 1982-12-14 | Pfizer Inc. | Indole thromboxane synthetase inhibitors |
| US4442118A (en) | 1981-07-23 | 1984-04-10 | Ayerst, Mckenna & Harrison, Inc. | Aldose reductase inhibition by 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid |
| GB8607294D0 (en) | 1985-04-17 | 1986-04-30 | Ici America Inc | Heterocyclic amide derivatives |
| EP0222576B1 (en) * | 1985-11-07 | 1992-03-18 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| US4939140A (en) | 1985-11-07 | 1990-07-03 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| US4960785A (en) * | 1988-12-16 | 1990-10-02 | Pfizer Inc. | Indolinone derivatives |
| WO1993012786A1 (en) * | 1986-07-10 | 1993-07-08 | Howard Harry R Jr | Indolinone derivatives |
| US4868301A (en) * | 1987-06-09 | 1989-09-19 | Pfizer Inc. | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains |
| US5064852A (en) * | 1988-12-16 | 1991-11-12 | Pfizer Inc. | Indolinone derivatives |
| KR920700210A (ko) | 1989-03-31 | 1992-02-19 | 기따미 가즈히꼬 | 신규 이미다졸 유도체, 그의 제법 및 그의 의약용도 |
| US4996204A (en) * | 1989-05-11 | 1991-02-26 | Pfizer Inc. | Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors |
| FR2647676A1 (fr) * | 1989-06-05 | 1990-12-07 | Union Pharma Scient Appl | Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase |
| GB8916774D0 (en) * | 1989-07-21 | 1989-09-06 | Bayer Ag | New indole derivatives,a process for their preparation and their use in medicaments |
| US5304557A (en) | 1989-12-15 | 1994-04-19 | Pfizer Inc. | Substituted oxoophthalazinyl acetic acids and analogs thereof |
| GB9011335D0 (en) | 1990-05-21 | 1990-07-11 | Fujisawa Pharmaceutical Co | Indolebutyric acid derivatives and process for preparation thereof |
| US5312829A (en) * | 1990-05-21 | 1994-05-17 | Fujisawa Pharmaceutical Co., Ltd. | Indole derivatives |
| US5236945A (en) * | 1990-06-11 | 1993-08-17 | Pfizer Inc. | 1H-indazole-3-acetic acids as aldose reductase inhibitors |
| US5116753A (en) | 1991-07-30 | 1992-05-26 | The Salk Institute For Biological Studies | Maintenance of pancreatic islets |
| JPH0641071A (ja) * | 1991-09-06 | 1994-02-15 | Taisho Pharmaceut Co Ltd | インドール酢酸エステル誘導体 |
| GB9122590D0 (en) | 1991-10-24 | 1991-12-04 | Lilly Industries Ltd | Pharmaceutical compounds |
| US5391551A (en) | 1993-05-10 | 1995-02-21 | Pfizer Inc. | Method of lowering blood lipid levels |
| GB9317764D0 (en) * | 1993-08-26 | 1993-10-13 | Pfizer Ltd | Therapeutic compound |
| GB9409583D0 (en) | 1994-05-13 | 1994-07-06 | Pfizer Ltd | Indoles |
| US5641800A (en) * | 1994-07-21 | 1997-06-24 | Eli Lilly And Company | 1H-indole-1-functional sPLA2 inhibitors |
| TW401301B (en) | 1994-10-07 | 2000-08-11 | Takeda Chemical Industries Ltd | Antihypertriglyceridemic composition |
| US5700819A (en) * | 1994-11-29 | 1997-12-23 | Grelan Pharmaceutical Co., Ltd. | 2-substituted benzothiazole derivatives and prophylactic and therapeutic agents for the treatment of diabetic complications |
| IL117208A0 (en) * | 1995-02-23 | 1996-06-18 | Nissan Chemical Ind Ltd | Indole type thiazolidines |
| WO1996029075A1 (en) * | 1995-03-20 | 1996-09-26 | Eli Lilly And Company | 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists |
| JPH09165371A (ja) | 1995-10-09 | 1997-06-24 | Sankyo Co Ltd | 複素環化合物を含有する医薬 |
| DE19636150A1 (de) * | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
| US6214991B1 (en) | 1998-03-31 | 2001-04-10 | The Institute For Pharmaceutical Discovery, Inc. | Substituted indolealkanoic acids |
| TNSN99224A1 (fr) * | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique |
| WO2001064205A2 (en) * | 2000-03-02 | 2001-09-07 | The Institutes For Pharmaceutical Discovery, Llc | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor |
-
1999
- 1999-03-31 US US09/282,280 patent/US6214991B1/en not_active Expired - Fee Related
- 1999-03-31 KR KR1020007010884A patent/KR100584650B1/ko not_active Expired - Fee Related
- 1999-03-31 ES ES99916239T patent/ES2224632T3/es not_active Expired - Lifetime
- 1999-03-31 OA OA1200000269A patent/OA11622A/en unknown
- 1999-03-31 JP JP2000541171A patent/JP3494990B2/ja not_active Expired - Fee Related
- 1999-03-31 MX MXPA02003122A patent/MXPA02003122A/es active IP Right Grant
- 1999-03-31 IL IL13871199A patent/IL138711A0/xx active IP Right Grant
- 1999-03-31 ID IDW20002212A patent/ID27884A/id unknown
- 1999-03-31 CA CA002383983A patent/CA2383983C/en not_active Expired - Fee Related
- 1999-03-31 TR TR2000/02869T patent/TR200002869T2/tr unknown
- 1999-03-31 DE DE69918278T patent/DE69918278T2/de not_active Expired - Lifetime
- 1999-03-31 SK SK752-2001A patent/SK7522001A3/sk not_active Application Discontinuation
- 1999-03-31 WO PCT/US1999/007116 patent/WO1999050268A2/en not_active Ceased
- 1999-03-31 CZ CZ20003607A patent/CZ300706B6/cs not_active IP Right Cessation
- 1999-03-31 HU HU0101672A patent/HUP0101672A3/hu unknown
- 1999-03-31 CN CNB998047732A patent/CN1205207C/zh not_active Expired - Fee Related
- 1999-03-31 AU AU34595/99A patent/AU774929B2/en not_active Ceased
- 1999-03-31 AP APAP/P/2000/001929A patent/AP2000001929A0/en unknown
- 1999-03-31 YU YU59600A patent/YU59600A/sh unknown
- 1999-03-31 EE EEP200000573A patent/EE200000573A/xx unknown
- 1999-03-31 EP EP99916239A patent/EP1066283B1/en not_active Expired - Lifetime
- 1999-03-31 AT AT99916239T patent/ATE269861T1/de not_active IP Right Cessation
- 1999-03-31 BR BR9909358-8A patent/BR9909358A/pt not_active Application Discontinuation
- 1999-06-02 TW TW088109147A patent/TWI243163B/zh not_active IP Right Cessation
-
2000
- 2000-09-26 IL IL138711A patent/IL138711A/en not_active IP Right Cessation
- 2000-09-29 NO NO20004900A patent/NO20004900L/no not_active Application Discontinuation
- 2000-09-29 BG BG104819A patent/BG65446B1/bg unknown
- 2000-10-11 ZA ZA200005577A patent/ZA200005577B/en unknown
-
2001
- 2001-03-27 US US09/818,808 patent/US6426344B2/en not_active Expired - Fee Related
-
2002
- 2002-03-01 NZ NZ507172A patent/NZ507172A/en unknown
- 2002-03-01 PL PL348244A patent/PL201645B1/pl not_active IP Right Cessation
- 2002-06-28 US US10/185,863 patent/US6730794B2/en not_active Expired - Fee Related
- 2002-10-02 JP JP2002290240A patent/JP2003155274A/ja active Pending
-
2004
- 2004-04-27 US US10/832,724 patent/US7105514B2/en not_active Expired - Fee Related
-
2006
- 2006-09-12 US US11/531,151 patent/US7304079B2/en not_active Expired - Fee Related
-
2007
- 2007-12-04 US US11/999,524 patent/US7659269B2/en not_active Expired - Fee Related
-
2010
- 2010-02-08 US US12/701,967 patent/US8163932B2/en not_active Expired - Fee Related
- 2010-08-30 US US12/871,293 patent/US20100324039A1/en not_active Abandoned
-
2012
- 2012-06-27 US US13/534,875 patent/US20120270912A1/en not_active Abandoned
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