TR200002757T2 - Indol derivatives with an anti-virus activity - Google Patents
Indol derivatives with an anti-virus activityInfo
- Publication number
- TR200002757T2 TR200002757T2 TR2000/02757T TR200002757T TR200002757T2 TR 200002757 T2 TR200002757 T2 TR 200002757T2 TR 2000/02757 T TR2000/02757 T TR 2000/02757T TR 200002757 T TR200002757 T TR 200002757T TR 200002757 T2 TR200002757 T2 TR 200002757T2
- Authority
- TR
- Turkey
- Prior art keywords
- optionally substituted
- hydrogen
- lower alkyl
- virus activity
- compound
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 230000002155 anti-virotic effect Effects 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010061833 Integrases Proteins 0.000 abstract 1
- 230000036436 anti-hiv Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 150000002148 esters Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
R1'in hidrojen, alt alkyl, veya tercihe göre ikameli arylsulfonyl, veya benzeri, R2'nin hidrojen, alt alkyl, veya tercihe göre ikameli aralkyl, veya benzeri, Herbir R3,R4,R5, ve R6'nin ayri ayri hidrojen, halojen, trihalojenatli alt alkyl, veya benzeri, X'in hydroxy veya tercihe göre ikameli amino; Y'nin COOR (R, hidrojen veya bir ester kalintisi), tercihe göre ikameli aryl, veya tercihe göre ikameli heteroaryl, oldugu bir formül (I): bilesiminin integraz inhibisyon aktivitesi olup, bir anti-HIV ilaç olarak kullanilabilir.R1 is hydrogen, lower alkyl, or optionally substituted arylsulfonyl, or the like, R2 is hydrogen, lower alkyl, or optionally substituted aralkyl, or the like, Each R3, R4, R5, and R6 are separately hydrogen, halogen trihalogenated lower alkyl, or the like, X is hydroxy or optionally substituted amino; A compound of formula (I) wherein Y is COOR (R, hydrogen or an ester residue), optionally substituted aryl, or optionally substituted heteroaryl, is the integrase inhibition activity of the compound, which can be used as an anti-HIV drug.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP82031998 | 1998-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200002757T2 true TR200002757T2 (en) | 2000-12-21 |
Family
ID=18528443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/02757T TR200002757T2 (en) | 1998-03-26 | 1999-03-26 | Indol derivatives with an anti-virus activity |
Country Status (1)
| Country | Link |
|---|---|
| TR (1) | TR200002757T2 (en) |
-
1999
- 1999-03-26 TR TR2000/02757T patent/TR200002757T2/en unknown
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