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TR200002567T2 - Glisin naklini önleyiciler. - Google Patents

Glisin naklini önleyiciler.

Info

Publication number
TR200002567T2
TR200002567T2 TR2000/02567T TR200002567T TR200002567T2 TR 200002567 T2 TR200002567 T2 TR 200002567T2 TR 2000/02567 T TR2000/02567 T TR 2000/02567T TR 200002567 T TR200002567 T TR 200002567T TR 200002567 T2 TR200002567 T2 TR 200002567T2
Authority
TR
Turkey
Prior art keywords
transport inhibitors
relates
glycine transport
glycine
diseases
Prior art date
Application number
TR2000/02567T
Other languages
English (en)
Inventor
Herman Maria Louis Luyten Walter
Eduard Janssens Frans
Edmond Josephine Kennis Ludo
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR200002567T2 publication Critical patent/TR200002567T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

Söz konusu bulus glisin naklini önleyici [4,4-bis-(4-fluoronefil)bütil]-1-(piperazinil ve piperidinil) türevlerinin, merkezi ve çevresel sinir sistemi bozukluklarinin, bilhassa psikozlar, agri, epilepsi, nörodejeneratif hastaliklar (Alzheimer hastaligi), felç, kafa travmasi, multiple sikleroz ve benzeri gibi hastaliklarin tedavisinde kullanilan ilaçlarin hazirlanmasinda kullanilmasi ile ilgilidir. Bulus ayrica yeni terkipler, bunlarin hazirlanmasi ve farmasötik biçimleri ile de ilgilidir.
TR2000/02567T 1998-03-06 1999-02-26 Glisin naklini önleyiciler. TR200002567T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98200701 1998-03-06

Publications (1)

Publication Number Publication Date
TR200002567T2 true TR200002567T2 (tr) 2000-11-21

Family

ID=8233444

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02567T TR200002567T2 (tr) 1998-03-06 1999-02-26 Glisin naklini önleyiciler.

Country Status (17)

Country Link
EP (1) EP1059922A2 (tr)
JP (1) JP2002505277A (tr)
KR (1) KR20010032968A (tr)
CN (1) CN1292698A (tr)
AU (1) AU3408999A (tr)
BG (1) BG104685A (tr)
BR (1) BR9907951A (tr)
CA (1) CA2322164A1 (tr)
EE (1) EE200000482A (tr)
HR (1) HRP20000523A2 (tr)
HU (1) HUP0101048A2 (tr)
IL (1) IL138228A0 (tr)
NO (1) NO20004431L (tr)
PL (1) PL343435A1 (tr)
SK (1) SK13082000A3 (tr)
TR (1) TR200002567T2 (tr)
WO (1) WO1999044596A2 (tr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20014573A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
UA73749C2 (en) * 1999-11-01 2005-09-15 Diarylenines
AU2001254546A1 (en) * 2000-04-20 2001-11-07 Nps Allelix Corp. Aminopiperidines
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
WO2002019967A2 (en) 2000-09-08 2002-03-14 Gliatech, Inc. Substituted hydrazine derivatives
EP1324986A1 (en) 2000-09-14 2003-07-09 Gliatech, Inc. Nitrogen-containing compounds and their use as glycine transport inhibitors
AR032653A1 (es) 2001-02-09 2003-11-19 Telik Inc Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos.
US7030150B2 (en) 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
AU2004269889B2 (en) 2003-09-09 2009-07-23 F. Hoffmann-La Roche Ag 1- (2-amino-benzol) -piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
CA2538135C (en) 2003-09-09 2015-01-27 F. Hoffmann-La Roche Ag 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses
WO2005058885A2 (en) * 2003-12-18 2005-06-30 Glaxo Group Limited Piperidine derivatives and their use as glycine transporter inhibitors
TW200630337A (en) 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
DE602005014274D1 (de) 2004-12-09 2009-06-10 Hoffmann La Roche Phenylpiperazin-methanon-derivate
MX2007006896A (es) 2004-12-15 2007-06-26 Hoffmann La Roche Fenil-metanonas bi- y triciclicas sustituidas como inhibidores del transportador 1 de glicina (glyt-1) para el tratamiento de la enfermedad de alzheimer.
PE20061156A1 (es) 2004-12-23 2006-12-16 Glaxo Group Ltd Derivados de benzamida como agentes inhibidores del transportador de glicina
GB0428233D0 (en) * 2004-12-23 2005-01-26 Glaxo Group Ltd Compounds
US7485637B2 (en) 2005-01-04 2009-02-03 Hoffmann-La Roche Inc. Benzoyl-tetrahydropiperidine derivatives
EP1836178A1 (en) * 2005-01-06 2007-09-26 F. Hoffmann-Roche AG Sulfanyl substituted phenyl methanones as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
WO2006072436A1 (en) * 2005-01-07 2006-07-13 F. Hoffmann-La Roche Ag [4-(heteroaryl) piperazin-1-yl]-(2,5-substituted -phenyl)methanone derivatives as glycine transporter 1 (glyt-1) inhibitors for the treatment of neurological and neuropsychiatric disorders
JP2008527016A (ja) * 2005-01-18 2008-07-24 エフ．ホフマン−ラ ロシュ アーゲー 神経及び神経精神病の疾患の治療のためのグリシントランスポーター１（ＧｌｙＴ−１）阻害剤としての２，５−二置換フェニルメタノン誘導体
KR100915472B1 (ko) 2005-01-26 2009-09-03 에프. 호프만-라 로슈 아게 페닐 메탄온 유도체 및 그의 글라이신 트랜스포터 1억제제로서의 용도
ATE449761T1 (de) * 2005-02-07 2009-12-15 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1
CN100341871C (zh) * 2005-06-03 2007-10-10 复旦大学 含哌啶结构的有机硫化合物，制备方法和应用
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
TW200815353A (en) 2006-04-13 2008-04-01 Euro Celtique Sa Benzenesulfonamide compounds and their use
TW200812963A (en) 2006-04-13 2008-03-16 Euro Celtique Sa Benzenesulfonamide compounds and the use thereof
AU2007315859B2 (en) 2006-11-01 2011-09-22 Purdue Pharma L.P. Phenylpropionamide compounds and the use thereof
FR2910321B1 (fr) 2006-12-21 2009-07-10 Galderma Res & Dev S N C Snc Gel creme comprenant au moins un retinoide et du peroxyde de benzole
FR2910320B1 (fr) * 2006-12-21 2009-02-13 Galderma Res & Dev S N C Snc Emulsion comprenant au moins un retinoide et du peroxyde de benzole
WO2008124118A1 (en) 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
EP2231601B1 (en) * 2007-12-12 2014-06-18 Amgen Inc. Glycine transporter-1 inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (en) * 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4219559A (en) * 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
AU1041599A (en) * 1997-11-13 1999-06-07 Jose Luis Castro Pineiro Therapeutic uses of triazolo-pyridazine derivatives

Also Published As

Publication number Publication date
KR20010032968A (ko) 2001-04-25
AU3408999A (en) 1999-09-20
WO1999044596A2 (en) 1999-09-10
EE200000482A (et) 2002-02-15
PL343435A1 (en) 2001-08-13
CA2322164A1 (en) 1999-09-10
IL138228A0 (en) 2001-10-31
EP1059922A2 (en) 2000-12-20
SK13082000A3 (sk) 2001-03-12
BG104685A (en) 2001-04-30
HRP20000523A2 (en) 2001-02-28
NO20004431D0 (no) 2000-09-05
NO20004431L (no) 2000-10-30
CN1292698A (zh) 2001-04-25
BR9907951A (pt) 2001-01-30
WO1999044596A3 (en) 2000-02-17
HUP0101048A2 (hu) 2001-10-28
JP2002505277A (ja) 2002-02-19

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