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TR200002271T2 - Fc alıcılarının üç boyutlu yapıları ve modelleri ve bunların kullanımı - Google Patents

Fc alıcılarının üç boyutlu yapıları ve modelleri ve bunların kullanımı

Info

Publication number
TR200002271T2
TR200002271T2 TR2000/02271T TR200002271T TR200002271T2 TR 200002271 T2 TR200002271 T2 TR 200002271T2 TR 2000/02271 T TR2000/02271 T TR 2000/02271T TR 200002271 T TR200002271 T TR 200002271T TR 200002271 T2 TR200002271 T2 TR 200002271T2
Authority
TR
Turkey
Prior art keywords
models
fcgammariia
crystals
protein
dimensional coordinates
Prior art date
Application number
TR2000/02271T
Other languages
English (en)
Inventor
Mark Hogarth P.
S. Powell Maree
F.C. Mckenzie Ian
F. Maxwell Kelly
P.J. Garrett Thomas
Epa Vidana
B. Baell Jonathan
R. Matthews Barry
D. Mccarthy Thomas
A. Pietersz Geoffrey
Original Assignee
Ilexus Pty Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ilexus Pty Limited filed Critical Ilexus Pty Limited
Publication of TR200002271T2 publication Critical patent/TR200002271T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processing Or Creating Images (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Kristaller, kristal yapili FcgammaRIIa proteini, FcgammaRIIa proteininin üç boyutlu koordinatlari, ve FcgammaRIIa yapisindan türetilmis yapi ve modeller sunulmustur. Ayrica FcepsilonRI proteininin kristalleri ve FcgammaRIIa yapisinda türetilmis FcepsilonRI protein monomerleri ve dimerlerine ait üç boyutlu koordinatlar da ortaya konulmustur. Ayrica FcgammaRIIIb proteinlerinin üç boyutlu koordinatlari ve FcgammaRIIa yapisindan türetilmis FcgammaRIIIb modelleri de gösterilmistir. Mevcut bulus, bu kristallerin, kristal yapilarinin ve modellerin üretilmesine yönelik metotlari da kapsar. Yapi bazinda ilaç tasarimi ve terapötik kompozisyonlar dahil olmak üzere bu gibi kristallerin, kristal yapilarinin ve modellerin kullanimlari da sunulmustur.
TR2000/02271T 1998-02-06 1999-02-04 Fc alıcılarının üç boyutlu yapıları ve modelleri ve bunların kullanımı TR200002271T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7397298P 1998-02-06 1998-02-06
US9999498P 1998-09-11 1998-09-11

Publications (1)

Publication Number Publication Date
TR200002271T2 true TR200002271T2 (tr) 2000-11-21

Family

ID=26755120

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/02271T TR200002271T2 (tr) 1998-02-06 1999-02-04 Fc alıcılarının üç boyutlu yapıları ve modelleri ve bunların kullanımı

Country Status (16)

Country Link
US (2) US6675105B2 (tr)
EP (1) EP1053255A4 (tr)
JP (1) JP2004510681A (tr)
KR (1) KR20010024899A (tr)
CN (1) CN1291198A (tr)
AP (1) AP2000001876A0 (tr)
AU (1) AU759378B2 (tr)
BR (1) BR9907964A (tr)
CA (1) CA2316860A1 (tr)
EA (1) EA200000746A1 (tr)
IL (1) IL137583A0 (tr)
NO (1) NO20003964L (tr)
NZ (1) NZ505914A (tr)
PL (1) PL342297A1 (tr)
TR (1) TR200002271T2 (tr)
WO (1) WO1999040117A1 (tr)

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DE10157290A1 (de) * 2001-11-22 2003-06-05 Max Planck Gesellschaft Pharmazeutische Zusammensetzung enthaltend sFcRgamma IIb oder sFcRgamma III
CA2480202A1 (en) * 2002-04-10 2003-10-23 Transtech Pharma, Inc. System and method for data analysis, manipulation, and visualization
AU2002953533A0 (en) 2002-12-24 2003-01-16 Arthron Limited Fc receptor modulating compounds and compositions
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WO2006133486A1 (en) * 2005-06-14 2006-12-21 The Macfarlane Burnet Institute For Medical Research And Public Health Limited CRYSTAL STRUCTURES AND MODELS FOR Fc RECEPTOR:Fc COMPLEXES AND USES THEREOF
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WO2013187495A1 (ja) 2012-06-14 2013-12-19 中外製薬株式会社 改変されたFc領域を含む抗原結合分子
BR112015001955A2 (pt) 2012-08-24 2017-11-07 Chugai Pharmaceutical Co Ltd variante de região fc específica de fcgamariib
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KR101987279B1 (ko) * 2017-10-12 2019-06-10 국민대학교 산학협력단 Fc 감마 수용체 변이체 MG2A45.1
KR101986252B1 (ko) * 2017-09-15 2019-06-05 국민대학교 산학협력단 Fc 감마 수용체 변이체 MG2A28
KR101987268B1 (ko) * 2017-10-12 2019-06-10 국민대학교 산학협력단 Fc 감마 수용체 변이체 MG2A45
AU2018332475B2 (en) * 2017-09-15 2020-12-17 Kookmin University Industry Academy Cooperation Foundation Fc-gamma receptor mutants
KR101987272B1 (ko) * 2017-09-15 2019-06-10 국민대학교 산학협력단 Fc 감마 수용체 변이체 MG2A28.1
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Also Published As

Publication number Publication date
CN1291198A (zh) 2001-04-11
JP2004510681A (ja) 2004-04-08
NO20003964L (no) 2000-10-04
US6675105B2 (en) 2004-01-06
EP1053255A4 (en) 2003-01-02
AP2000001876A0 (en) 2000-09-30
NZ505914A (en) 2004-03-26
WO1999040117A1 (en) 1999-08-12
BR9907964A (pt) 2000-10-17
CA2316860A1 (en) 1999-08-12
KR20010024899A (ko) 2001-03-26
IL137583A0 (en) 2001-07-24
US20020107359A1 (en) 2002-08-08
AU2438299A (en) 1999-08-23
EP1053255A1 (en) 2000-11-22
NO20003964D0 (no) 2000-08-04
PL342297A1 (en) 2001-06-04
AU759378B2 (en) 2003-04-10
EA200000746A1 (ru) 2001-04-23
US20040054480A1 (en) 2004-03-18

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