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TR200000942T2 - 8-Azabisayklo(3.2.1) oktan-3-metanamin türevleri, hazırlanmaları ve terapötik uygulamaları. - Google Patents

8-Azabisayklo(3.2.1) oktan-3-metanamin türevleri, hazırlanmaları ve terapötik uygulamaları.

Info

Publication number
TR200000942T2
TR200000942T2 TR2000/00942T TR200000942T TR200000942T2 TR 200000942 T2 TR200000942 T2 TR 200000942T2 TR 2000/00942 T TR2000/00942 T TR 2000/00942T TR 200000942 T TR200000942 T TR 200000942T TR 200000942 T2 TR200000942 T2 TR 200000942T2
Authority
TR
Turkey
Prior art keywords
group
azabisayklo
octane
preparation
therapeutic applications
Prior art date
Application number
TR2000/00942T
Other languages
English (en)
Inventor
Marabout Benoit
Sevrin Mireille
George Pascal
Merly Jean-Pierre
De Peretti Daniele
Roy Jocelyne
Machnik David
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9712583A external-priority patent/FR2769629B1/fr
Priority claimed from FR9712580A external-priority patent/FR2769628B1/fr
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of TR200000942T2 publication Critical patent/TR200000942T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Genel formül (I)'deki bilesikler olup söz konusu formül içerisindeki U; genel formül (A) veya (B)'deki bir grubu simgelemekte olup, söz konusu formüllerdeki, V; bir hidrojen veya halojen atomunu, bir (C1-C3) alkil grubunu veya bir veya iki tane (C1-C3) alkoksi grubunu simgelemekte,W ve X'in her biri;sirasiyla,ya iki oksijen atomunu ya da bir oksijen atomu ve bir CH2 grubunu, veya bir CH2 grubu ve bir oksijen atomunu veya bir oksijen atomu ve bir CO grubunu simgelemekte, n; o veya 1'i simgelemektedir; U'nun genel formül (A)'daki bir grubu simgelemesi durumunda, R; bir propil grubunu simgelemekte, ya da U'nun genel formül (B)'deki bir grubu simgelemesi durumunda, R; bir hidrojen atomu veya bir (C1-C3) alkil grubunu simgelemekte, Y;hidrojen, halojen, (C1-C3)alkil ve (C1-C3)alkoksi'den seçilen bir veya daha fazla atom veya grubu simgelemekte, Z; iki hidrojen atomunu veya bir oksijen atomunu simgelemektedir.
TR2000/00942T 1997-10-09 1998-10-07 8-Azabisayklo(3.2.1) oktan-3-metanamin türevleri, hazırlanmaları ve terapötik uygulamaları. TR200000942T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9712583A FR2769629B1 (fr) 1997-10-09 1997-10-09 Derives de 8-azabicyclo[3.2.1]octane-3-methanamine, leur preparation et leur application en therapeutique
FR9712580A FR2769628B1 (fr) 1997-10-09 1997-10-09 Derives de n-(2,3-dihydro-1h-inden-2-yl)-n-propyl-8- azabicyclo[3.2.1.]octane-3-methanamine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
TR200000942T2 true TR200000942T2 (tr) 2000-09-21

Family

ID=26233854

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00942T TR200000942T2 (tr) 1997-10-09 1998-10-07 8-Azabisayklo(3.2.1) oktan-3-metanamin türevleri, hazırlanmaları ve terapötik uygulamaları.

Country Status (30)

Country Link
US (1) US6221879B1 (tr)
EP (1) EP1021442B1 (tr)
JP (1) JP4505135B2 (tr)
KR (1) KR20010015717A (tr)
CN (1) CN1140526C (tr)
AR (1) AR017300A1 (tr)
AT (1) ATE212631T1 (tr)
AU (1) AU746935B2 (tr)
BG (1) BG64859B1 (tr)
BR (1) BR9812752A (tr)
CA (1) CA2305468C (tr)
CO (1) CO5011097A1 (tr)
CZ (1) CZ290679B6 (tr)
DE (1) DE69803689T2 (tr)
DK (1) DK1021442T3 (tr)
EE (1) EE04347B1 (tr)
ES (1) ES2171306T3 (tr)
HU (1) HUP0102086A3 (tr)
IL (2) IL135520A0 (tr)
NO (1) NO325170B1 (tr)
NZ (1) NZ503829A (tr)
PL (1) PL186998B1 (tr)
PT (1) PT1021442E (tr)
RU (1) RU2203281C2 (tr)
SI (1) SI1021442T1 (tr)
SK (1) SK283080B6 (tr)
TR (1) TR200000942T2 (tr)
TW (1) TW444014B (tr)
UA (1) UA58476C2 (tr)
WO (1) WO1999019325A1 (tr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689806B1 (en) 1999-03-24 2004-02-10 Sugen, Inc. Indolinone compounds as kinase inhibitors
US6878733B1 (en) 1999-11-24 2005-04-12 Sugen, Inc. Formulations for pharmaceutical agents ionizable as free acids or free bases
CO5280092A1 (es) 2000-02-15 2003-05-30 Sugen Inc Indolinas susutituidas con pirroles inhibidoras de proteinquinasas
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
JP4754570B2 (ja) * 2004-10-14 2011-08-24 アボット ゲーエムベーハー ウント カンパニー カーゲー ドーパミンｄ３受容体の調節に応答する障害の治療に好適なアザビシクロヘプチル化合物
PA8663501A1 (es) 2005-02-17 2006-11-09 Wyeth Wyeth Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
CA2792539C (en) 2010-03-11 2017-04-18 Megumi Maruyama N-acyl cyclic amine derivative or pharmaceutically acceptable salt thereof
WO2016092547A1 (en) 2014-12-09 2016-06-16 Ezekiel Golan Alcoholic beverage substitutes
CN107406369B (zh) 2014-12-09 2021-01-15 以西结·戈兰 放纵行为调节剂
KR102128782B1 (ko) 2018-09-20 2020-07-01 한양대학교 에리카산학협력단 트로페인(Tropane) 알칼로이드 화합물 및 순차적 산화반응을 이용한 이의 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5592384A (en) * 1978-12-30 1980-07-12 Beecham Group Ltd Compound having pharmacological activity
IL59004A0 (en) 1978-12-30 1980-03-31 Beecham Group Ltd Substituted benzamides their preparation and pharmaceutical compositions containing them
US4350691A (en) * 1979-12-20 1982-09-21 Beecham Group Limited Certain azabicyclocarboxamides and compositions containing same
US4910302A (en) 1988-12-19 1990-03-20 American Home Products Corporation Psychotropic polycyclic imides
FR2659323B1 (fr) 1990-03-07 1992-06-12 Synthelabo Derives de 4-(aminomethyl) piperidine, leur preparation et leur application en therapeutique.
FI111367B (fi) * 1991-02-04 2003-07-15 Aventis Pharma Inc Menetelmä terapeuttisesti käyttökelpoisten N-(aryylioksialkyyli)heteroaryyli-8-atsabisyklo[3.2.1]oktaanijohdannaisten valmistamiseksi ja menetelmässä käytetyt välituotteet
FR2681320B1 (fr) * 1991-09-12 1994-01-14 Synthelabo Derives de n-(4,7dimethoxyindan-2-yl)-1-(phenylcarbonyl)-n-propyl-piperidine-4-methanamine, leur preparation et leur application en therapeutique.
FR2681325B1 (fr) 1991-09-16 1993-12-17 Fabre Medicament Pierre Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
FR2702211B1 (fr) * 1993-03-04 1995-06-02 Pf Medicament Nouveaux dérivés de la phénoxy-2 éthylamine, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
KR20010015717A (ko) 2001-02-26
AU9446898A (en) 1999-05-03
UA58476C2 (uk) 2003-08-15
US6221879B1 (en) 2001-04-24
CN1281455A (zh) 2001-01-24
BG64859B1 (bg) 2006-07-31
HUP0102086A3 (en) 2002-09-30
EE200000207A (et) 2001-04-16
RU2203281C2 (ru) 2003-04-27
EP1021442A1 (fr) 2000-07-26
CO5011097A1 (es) 2001-02-28
DK1021442T3 (da) 2002-05-13
BG104309A (en) 2001-05-31
PL339764A1 (en) 2001-01-02
WO1999019325A1 (fr) 1999-04-22
SK5042000A3 (en) 2001-03-12
SK283080B6 (sk) 2003-02-04
SI1021442T1 (en) 2002-08-31
PL186998B1 (pl) 2004-04-30
IL135520A (en) 2007-07-24
NO325170B1 (no) 2008-02-11
DE69803689D1 (de) 2002-03-14
NO20001810L (no) 2000-06-09
HK1029108A1 (en) 2001-03-23
NZ503829A (en) 2002-03-28
CA2305468C (en) 2007-09-25
BR9812752A (pt) 2000-08-29
AU746935B2 (en) 2002-05-09
EE04347B1 (et) 2004-08-16
DE69803689T2 (de) 2002-10-10
ATE212631T1 (de) 2002-02-15
PT1021442E (pt) 2002-06-28
ES2171306T3 (es) 2002-09-01
JP4505135B2 (ja) 2010-07-21
JP2001519431A (ja) 2001-10-23
IL135520A0 (en) 2001-05-20
TW444014B (en) 2001-07-01
CN1140526C (zh) 2004-03-03
NO20001810D0 (no) 2000-04-07
CA2305468A1 (en) 1999-04-22
AR017300A1 (es) 2001-09-05
EP1021442B1 (fr) 2002-01-30
HUP0102086A2 (hu) 2001-12-28
CZ20001278A3 (cs) 2000-07-12
CZ290679B6 (cs) 2002-09-11

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