[go: up one dir, main page]

TR200000907T2 - Pyrolopirolone derivatives as neutrophil elastase inhibitors. - Google Patents

Pyrolopirolone derivatives as neutrophil elastase inhibitors.

Info

Publication number
TR200000907T2
TR200000907T2 TR2000/00907T TR200000907T TR200000907T2 TR 200000907 T2 TR200000907 T2 TR 200000907T2 TR 2000/00907 T TR2000/00907 T TR 2000/00907T TR 200000907 T TR200000907 T TR 200000907T TR 200000907 T2 TR200000907 T2 TR 200000907T2
Authority
TR
Turkey
Prior art keywords
pyrolopirolone
derivatives
neutrophil elastase
elastase inhibitors
compounds
Prior art date
Application number
TR2000/00907T
Other languages
Turkish (tr)
Inventor
Duke Edward Clarke Geoffrey
Dennis Dowle Michael
Finch Harry
Andrew Harrison Lee
George Adam Inglis Graham
Redpath Johnson Martin
John Fawcett Macdonald Simon
Shah Pritom
Andrew Smith Robin
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9719183.7A external-priority patent/GB9719183D0/en
Priority claimed from GBGB9719189.4A external-priority patent/GB9719189D0/en
Priority claimed from GBGB9719290.0A external-priority patent/GB9719290D0/en
Priority claimed from GBGB9803611.4A external-priority patent/GB9803611D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of TR200000907T2 publication Critical patent/TR200000907T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Bu bulusa göre (I) formülünün bilesikleri temin edilmektedir, bu formülde, R1,R2,ve R3 tarifnamede tanimlandigi gibidir. (I) formülü bilesikleri, diger yararlarinin yaninda, solunum yolunun ihtihapli bozukluklarinin tedavisinde yararli olmaktadir.According to the present invention, compounds of formula (I) are provided wherein R1, R2, and R3 are as defined in the specification. The compounds of formula (I) are useful, among other things, in the treatment of inflammatory disorders of the respiratory tract.

TR2000/00907T 1997-09-09 1998-09-07 Pyrolopirolone derivatives as neutrophil elastase inhibitors. TR200000907T2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9719183.7A GB9719183D0 (en) 1997-09-09 1997-09-09 Compounds
GBGB9719189.4A GB9719189D0 (en) 1997-09-09 1997-09-09 New therapeutic method
GBGB9719290.0A GB9719290D0 (en) 1997-09-10 1997-09-10 Compounds
GBGB9803611.4A GB9803611D0 (en) 1998-02-21 1998-02-21 Compounds

Publications (1)

Publication Number Publication Date
TR200000907T2 true TR200000907T2 (en) 2000-11-21

Family

ID=27451698

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00907T TR200000907T2 (en) 1997-09-09 1998-09-07 Pyrolopirolone derivatives as neutrophil elastase inhibitors.

Country Status (24)

Country Link
EP (1) EP1003748A2 (en)
JP (1) JP2001515904A (en)
KR (1) KR20010023766A (en)
CN (1) CN1278820A (en)
AP (1) AP2000001761A0 (en)
AR (1) AR017072A1 (en)
AU (1) AU9741298A (en)
BR (1) BR9812062A (en)
CA (1) CA2303176A1 (en)
CO (1) CO4970719A1 (en)
EA (1) EA200000204A1 (en)
EE (1) EE200000138A (en)
HU (1) HUP0004644A3 (en)
ID (1) ID24452A (en)
IL (1) IL134791A0 (en)
IS (1) IS5391A (en)
MA (1) MA26543A1 (en)
NO (1) NO20001198L (en)
NZ (1) NZ503130A (en)
PE (1) PE107899A1 (en)
PL (1) PL339176A1 (en)
SK (1) SK3192000A3 (en)
TR (1) TR200000907T2 (en)
WO (1) WO1999012933A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905418D0 (en) * 1999-03-09 1999-05-05 Glaxo Group Ltd Process
DE602005025222D1 (en) 2004-03-31 2011-01-20 Janssen Pharmaceutica Nv Heterocyclic nonimidazole compounds as histamine H3 receptor modulators
DE102004024772A1 (en) * 2004-05-17 2005-12-22 Grünenthal GmbH Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides
TWI355380B (en) * 2004-05-27 2012-01-01 Nihon Nohyaku Co Ltd Substituted pyrazinecarboxanilide derivatives or s
JP4853759B2 (en) * 2004-05-27 2012-01-11 日本農薬株式会社 Substituted pyrazinecarboxylic acid anilide derivatives or salts thereof, intermediates thereof, agricultural and horticultural agents, and methods of use thereof
GB2418427A (en) 2004-09-02 2006-03-29 Univ Cambridge Tech Ligands for G-protein coupled receptors
MX2007005137A (en) 2004-11-23 2007-06-22 Warner Lambert Co 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia.
SI2024367T1 (en) 2006-05-04 2011-04-29 Pulmagen Therapeutics Inflammation Ltd Tetrahydropyrrolopyrimidinediones and their use as human neutrophil elastase inhibitors
US8198288B2 (en) 2006-05-04 2012-06-12 Pulmagen Therapeutics (Inflammation) Limited Tetrahydropyrrolopyrimidinediones and their use in therapy
US7662967B2 (en) 2007-08-02 2010-02-16 Cambridge Enterprise Limited Anti-inflammatory compounds and compositions
GB2452696B (en) 2007-08-02 2009-09-23 Cambridge Entpr Ltd 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
WO2009060206A1 (en) * 2007-11-07 2009-05-14 Argenta Discovery Limited 3,4,6,7-tetrahydro-1h-pyrrolo[3,4-d]pyrimidine-2,5-diones and their therapeutic use
US20110212181A1 (en) * 2010-02-26 2011-09-01 The University Of Hong Kong Compositions and methods for treating chronic respiratory inflammation
BR112022004861A2 (en) 2019-09-17 2022-06-07 Univ Duke Alvestat for use in the treatment of transplant rejection, bronchiolitis obliterans syndrome and transplant versus host disease
FI4106757T3 (en) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
US20240382472A1 (en) 2021-10-20 2024-11-21 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211783D0 (en) * 1992-06-04 1992-07-15 Ici Plc Amide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
US5994344A (en) * 1996-03-28 1999-11-30 Glaxo Wellcome Inc. Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase

Also Published As

Publication number Publication date
AU9741298A (en) 1999-03-29
AR017072A1 (en) 2001-08-22
NO20001198D0 (en) 2000-03-08
NO20001198L (en) 2000-05-08
KR20010023766A (en) 2001-03-26
EA200000204A1 (en) 2000-10-30
CO4970719A1 (en) 2000-11-07
NZ503130A (en) 2001-08-31
AP2000001761A0 (en) 2000-03-31
SK3192000A3 (en) 2001-03-12
WO1999012933A3 (en) 1999-05-27
WO1999012933A2 (en) 1999-03-18
MA26543A1 (en) 2004-12-20
PE107899A1 (en) 1999-11-17
EE200000138A (en) 2001-02-15
IL134791A0 (en) 2001-04-30
HUP0004644A3 (en) 2002-01-28
PL339176A1 (en) 2000-12-04
HUP0004644A2 (en) 2001-09-28
EP1003748A2 (en) 2000-05-31
CA2303176A1 (en) 1999-03-18
CN1278820A (en) 2001-01-03
JP2001515904A (en) 2001-09-25
ID24452A (en) 2000-07-20
IS5391A (en) 2000-02-29
BR9812062A (en) 2000-09-26

Similar Documents

Publication Publication Date Title
ATE264846T1 (en) SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR TREATING RETROVIRAL INFECTIONS
ATE375334T1 (en) UREA DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
TR199901905T2 (en) 2- (P�rin-9-yl) -tetrahidrofuran-3,4-diol t�revleri.
TR200000907T2 (en) Pyrolopirolone derivatives as neutrophil elastase inhibitors.
ES2196396T3 (en) HETEROAROMATIC COMPOUNDS OF 5 MEMBERS CONTAINING OXYGEN OR SULFUR AS INHIBITORS OF THE XA FACTOR.
TR200000059T2 (en) Pyridine derivatives
FI970246A7 (en) Dihydrobenzofurans
TR200100805T2 (en) they Tetrahidropiridoet
TR200101709T2 (en) Compounds useful in the treatment of inflammatory diseases
ATE230392T1 (en) AMIDINOPHENYL-PYRROLIDINES, -PYRROLINES AND - ISOXAZOLIDINES AND THEIR DERIVATIVES
TR200101499T1 (en) Azepinoindole derivatives, their preparation and uses.
TR200201505T2 (en) Pirazolopyrimidines as therapeutic agents
ATE277929T1 (en) IMMUNOSUPRESSIVE EFFECTS OF PTERIDINE DERIVATIVES
IT1285770B1 (en) CORTICOID COMPOUNDS
DK1042319T3 (en) dihydrobenzofuranes
ATE311389T1 (en) PRECURSOR OF IMIDAZOPYRIDINE DERIVATIVES
TR200201128T2 (en) Tetrahydrothiopyraniphalazinone derivatives as PDE4 inhibitors.
PT775118E (en) BENZIMIDAZOLE DERIVATIVES WITH DOPAMINERGIC ACTIVITY
SE9903290D0 (en) Novel compounds
ATE287403T1 (en) 6-PHENYLBENZONAPHTHYIDINE
AP2000001760A0 (en) Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
DE60105618D1 (en) DIHYDROPORPHYRINE DERIVATIVES AND THEIR USE
DK1244614T3 (en) Tryptase inhibitors
TR200001122T2 (en) Biphenyl derivatives as pharmaceuticals.
NO20042729L (en) Hexycyclic compounds