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TR200000140T2 - Endojenik gen etkinliği ile insan proteini üretimi için insan hücre sıralarının belirlenmesi - Google Patents

Endojenik gen etkinliği ile insan proteini üretimi için insan hücre sıralarının belirlenmesi

Info

Publication number
TR200000140T2
TR200000140T2 TR2000/00140T TR200000140T TR200000140T2 TR 200000140 T2 TR200000140 T2 TR 200000140T2 TR 2000/00140 T TR2000/00140 T TR 2000/00140T TR 200000140 T TR200000140 T TR 200000140T TR 200000140 T2 TR200000140 T2 TR 200000140T2
Authority
TR
Turkey
Prior art keywords
human
determination
gene activity
cell lines
protein production
Prior art date
Application number
TR2000/00140T
Other languages
English (en)
Inventor
Brandt Michael
Franze Reinhard
Pessara Ulrich
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27238256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200000140(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US09/113,692 external-priority patent/US6548296B1/en
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR200000140T2 publication Critical patent/TR200000140T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Yöntem, endojenik gen etkinligi ile insan proteinleri hazirlanmasi için insan hücreleri seçimi ile ilgilidir. Üretilecek proteinler hem ekonomik olarak üretilmeli hem de farmakolojik terkipler üretimi için uygun olmalidirlar. Bulus ayrica bu amaç için tespit edilmis bir hücre sirasi içindeki insan proteinleri üretimi ile ilgilidir.
TR2000/00140T 1997-07-23 1998-07-22 Endojenik gen etkinliği ile insan proteini üretimi için insan hücre sıralarının belirlenmesi TR200000140T2 (tr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97112640 1997-07-23
EP97121073 1997-12-01
US09/113,692 US6548296B1 (en) 1997-07-23 1998-07-10 Methods for identifying human cell lines useful for endogenous gene activation, isolated human lines identified thereby, and uses thereof

Publications (1)

Publication Number Publication Date
TR200000140T2 true TR200000140T2 (tr) 2000-05-22

Family

ID=27238256

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00140T TR200000140T2 (tr) 1997-07-23 1998-07-22 Endojenik gen etkinliği ile insan proteini üretimi için insan hücre sıralarının belirlenmesi

Country Status (14)

Country Link
US (1) US6395484B1 (tr)
EP (1) EP1000154B1 (tr)
JP (1) JP2001511342A (tr)
CN (1) CN1150319C (tr)
AT (1) ATE354654T1 (tr)
AU (1) AU737605B2 (tr)
BR (1) BR9811542A (tr)
CA (1) CA2298412C (tr)
DE (1) DE59813913D1 (tr)
DK (1) DK1000154T3 (tr)
ES (1) ES2281133T3 (tr)
TR (1) TR200000140T2 (tr)
TW (1) TWI224140B (tr)
WO (1) WO1999005267A1 (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1000154E (pt) * 1997-07-23 2007-03-30 Roche Diagnostics Gmbh Identificação de linhas celulares humanas para a produção de proteínas humanas por activação endógena de genes
KR101032589B1 (ko) * 2002-01-17 2011-05-06 론자 바이올로직스 피엘씨 단백질을 생산 할 수 있으며 무글루타민 배지에서 성장할수 있는 글루타민-요구성 인간세포
GB0200977D0 (en) * 2002-01-17 2002-03-06 Lonza Biologics Plc Glutamine-auxotrophic human cells capable of producing proteins and capable of growing in a glutamine-free medium
GB0208041D0 (en) * 2002-04-08 2002-05-22 Lonza Biologics Plc Method of culturing animal cells
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US11311574B2 (en) 2003-08-08 2022-04-26 Sangamo Therapeutics, Inc. Methods and compositions for targeted cleavage and recombination
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
JP4849408B2 (ja) 2004-03-01 2012-01-11 財団法人北九州産業学術推進機構 タンパク質産生新規ヒト細胞株、新規ヒト細胞株の選択方法、新規ヒト細胞株の使用、それらからのタンパク質産生方法及び精製方法、及び新規ヒト細胞株を利用した薬学組成物
DE102012009849A1 (de) 2012-05-21 2013-11-21 Hartwig Schwieger Schwingungsstabilisierte Windenergieanlage-Zug-Druck-Knoten
JP6652334B2 (ja) 2014-05-31 2020-02-19 Ｊｃｒファーマ株式会社 ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
US12188042B2 (en) 2018-07-09 2025-01-07 NanoCav, LLC Electroporation devices and methods of cell transfection
US12527950B2 (en) 2018-07-09 2026-01-20 NanoCav, LLC Electroporation devices and methods of cell transfection
DE112019003498B4 (de) 2018-07-09 2025-02-06 NanoCav, LLC Mikrodurchflusselektroporationsgeräte und verfahren zur zelltransfektion

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL77081A (en) * 1984-12-04 1999-10-28 Genetics Inst Dna sequence encoding human erythropoietin process for the preparation thereof and a pharmaceutical composition of human erythropoietin
JPS62171696A (ja) 1986-01-23 1987-07-28 Sumitomo Chem Co Ltd ヒトエリスロポエチンの製造方法
US4954437A (en) 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
JP2879906B2 (ja) * 1989-09-14 1999-04-05 鐘紡株式会社 プロコラゲナーゼの製造方法
WO1991006667A1 (en) * 1989-11-06 1991-05-16 Cell Genesys, Inc. Production of proteins using homologous recombination
US5328844A (en) * 1990-05-09 1994-07-12 University Of Colorado Foundation, Inc. Culture media for mammalian cells
PT101031B (pt) * 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
TW402639B (en) * 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
US5449015A (en) * 1994-05-12 1995-09-12 Petkovic; Tony Shock-activated shut-off valve

Also Published As

Publication number Publication date
JP2001511342A (ja) 2001-08-14
WO1999005267A1 (de) 1999-02-04
ATE354654T1 (de) 2007-03-15
US6395484B1 (en) 2002-05-28
DK1000154T3 (da) 2007-06-18
CA2298412A1 (en) 1999-02-04
BR9811542A (pt) 2000-08-22
TWI224140B (en) 2004-11-21
CA2298412C (en) 2010-10-19
CN1265144A (zh) 2000-08-30
AU9067498A (en) 1999-02-16
DE59813913D1 (de) 2007-04-05
CN1150319C (zh) 2004-05-19
EP1000154A1 (de) 2000-05-17
EP1000154B1 (de) 2007-02-21
AU737605B2 (en) 2001-08-23
ES2281133T3 (es) 2007-09-16

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