[go: up one dir, main page]

TR200000022T2 - 3-ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin tek halkalı gastrokinetik benzamidleri. - Google Patents

3-ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin tek halkalı gastrokinetik benzamidleri.

Info

Publication number
TR200000022T2
TR200000022T2 TR2000/00022T TR200000022T TR200000022T2 TR 200000022 T2 TR200000022 T2 TR 200000022T2 TR 2000/00022 T TR2000/00022 T TR 2000/00022T TR 200000022 T TR200000022 T TR 200000022T TR 200000022 T2 TR200000022 T2 TR 200000022T2
Authority
TR
Turkey
Prior art keywords
gastrokinetic
benzamides
aminomethyl
conjugated
ring
Prior art date
Application number
TR2000/00022T
Other languages
English (en)
Inventor
Rene Marie Andre Bosmans Jean-Paul
Anna Jozef De Cleyn Michel
Surkyn Michel
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR200000022T2 publication Critical patent/TR200000022T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/12—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Bu bulusun önerdigi bilesikler, formül (I)'e, onun stereokimyasal bir sekline ya da N-oksit sekline veyahut farmasötik açidan geçerli asit ilaveli tuzuna özgüdür.
TR2000/00022T 1997-07-11 1998-07-07 3-ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin tek halkalı gastrokinetik benzamidleri. TR200000022T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202180 1997-07-11
EP98200624 1998-02-27

Publications (1)

Publication Number Publication Date
TR200000022T2 true TR200000022T2 (tr) 2000-06-21

Family

ID=26146699

Family Applications (2)

Application Number Title Priority Date Filing Date
TR2000/00022T TR200000022T2 (tr) 1997-07-11 1998-07-07 3-ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin tek halkalı gastrokinetik benzamidleri.
TR2000/00023T TR200000023T2 (tr) 1997-07-11 1998-07-07 3- ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin iki halkalı gastrokinetik benzamidleri.

Family Applications After (1)

Application Number Title Priority Date Filing Date
TR2000/00023T TR200000023T2 (tr) 1997-07-11 1998-07-07 3- ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin iki halkalı gastrokinetik benzamidleri.

Country Status (33)

Country Link
US (10) US6452013B1 (tr)
EP (3) EP0991410B1 (tr)
JP (2) JP4530530B2 (tr)
KR (2) KR100500372B1 (tr)
CN (2) CN1195736C (tr)
AR (2) AR013361A1 (tr)
AT (2) ATE255092T1 (tr)
AU (2) AU747199B2 (tr)
BG (2) BG63709B1 (tr)
BR (2) BRPI9811688B8 (tr)
CA (2) CA2295088C (tr)
CZ (2) CZ295506B6 (tr)
DE (2) DE69820065T2 (tr)
DK (2) DK0991410T3 (tr)
EA (1) EA002619B1 (tr)
EE (1) EE04178B1 (tr)
ES (2) ES2212330T3 (tr)
HR (2) HRP20000005B1 (tr)
HU (2) HUP0004564A3 (tr)
ID (2) ID24161A (tr)
IL (2) IL133917A (tr)
MY (2) MY123199A (tr)
NO (2) NO317467B1 (tr)
NZ (2) NZ502209A (tr)
PL (2) PL190611B1 (tr)
PT (2) PT991410E (tr)
RU (1) RU2213089C2 (tr)
SI (2) SI1000028T1 (tr)
SK (2) SK284942B6 (tr)
TR (2) TR200000022T2 (tr)
TW (2) TW402591B (tr)
UA (1) UA67745C2 (tr)
WO (2) WO1999002494A1 (tr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
US20080219928A1 (en) * 2003-02-26 2008-09-11 Becker Jane A Measuring Gastrointestinal Parameters
US20040253179A1 (en) * 2003-02-26 2004-12-16 Acm Medical Technologies, Inc. Measuring gastrointestinal parameters
RU2337905C2 (ru) * 2003-04-14 2008-11-10 Уорнер-Ламберт Компани Ллс Способ получения фениламида 5-(4-фторфенил)-1-[2-((2r,4r)-4-гидрокси-6-оксотетрагидропиран-2-ил)этил]-2-изопропил-4-фенил-1h-пиррол-3-карбоновой кислоты
ATE373651T1 (de) * 2003-06-19 2007-10-15 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidinbenzamide als 5ht4- antagonisten
PL1641783T3 (pl) 2003-06-19 2012-08-31 Janssen Pharmaceutica Nv 4-(aminometylo)-piperydyno-benzamidy podstawione aminosulfonylem jako antagoniści 5HT₄
JO2478B1 (en) * 2003-06-19 2009-01-20 جانسين فارماسوتيكا ان. في. (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists
EA008514B1 (ru) * 2003-06-19 2007-06-29 Янссен Фармацевтика Н.В. Гетероциклические замещенные 4-(аминометил)пиперидин бензамиды в качестве 5-нт-антагонистов
EP1713797B1 (en) 2004-01-29 2008-03-05 Pfizer, Inc. 1-isopropyl-2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having 5-ht4 receptor agonistic activity
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
WO2005092882A1 (en) * 2004-03-01 2005-10-06 Pfizer Japan, Inc. 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US9641902B2 (en) 2007-06-26 2017-05-02 Broadband Itv, Inc. Dynamic adjustment of electronic program guide displays based on viewer preferences for minimizing navigation in VOD program selection
JP5042028B2 (ja) * 2004-11-05 2012-10-03 セラヴァンス， インコーポレーテッド キノリノン−カルボキサミド化合物
ATE441646T1 (de) * 2004-11-05 2009-09-15 Theravance Inc 5-ht4-rezeptoragonistenverbindungen
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
PL2522365T3 (pl) 2004-11-24 2017-05-31 Meda Pharmaceuticals Inc. Kompozycje zawierające azelastynę i sposoby ich zastosowania
CA2588037A1 (en) * 2004-12-22 2006-06-29 Theravance, Inc. Indazole-carboxamide compounds
US7446114B2 (en) * 2005-03-02 2008-11-04 Theravance, Inc. Quinolinone compounds as 5-HT4 receptor agonists
TWI377206B (en) * 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
GB0603550D0 (en) * 2006-02-22 2006-04-05 Glaxo Group Ltd Novel compounds
US8642772B2 (en) 2008-10-14 2014-02-04 Sk Biopharmaceuticals Co., Ltd. Piperidine compounds, pharmaceutical composition comprising the same and its use
US20110313319A1 (en) * 2008-11-07 2011-12-22 SAND COUNTY BIOTECHNOLOGY, Inc. Measuring method for the concentration of intragastric contents
US8232315B2 (en) 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
EP2496227B1 (en) 2009-11-06 2019-05-22 SK Biopharmaceuticals Co., Ltd. Methods for treating fibromyalgia syndrome
CN102762201B (zh) 2009-11-06 2013-12-18 爱思开生物制药株式会社 注意力缺陷/多动症的治疗方法
KR101180174B1 (ko) * 2010-04-23 2012-09-05 동아제약주식회사 신규한 벤즈아미드 유도체
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
JP6182989B2 (ja) 2012-06-28 2017-08-23 セントラル硝子株式会社 １，３，３，３−テトラフルオロプロペンの製造方法
WO2014083003A1 (en) 2012-11-27 2014-06-05 Shire International Gmbh Pro-cognitive compound
CN105636946B (zh) * 2013-07-25 2017-12-19 东亚St 株式会社 制备苯甲酰胺衍生物的方法、用于制备苯甲酰胺的新型中间体以及制备新型中间体的方法
JP7753254B2 (ja) * 2020-05-04 2025-10-14 武田薬品工業株式会社 内腔で作用するｎ－（ピペリジン－４－イル）ベンズアミド誘導体
EP4393470A1 (en) 2022-12-30 2024-07-03 SkyLab AG Plant-mineral composition based on aloe barbadensis extract and trimethylglycine for ph-dependent regulation of type 3 aquaporins and transepidermal water flow in deep epidermal layers
CN117623967A (zh) * 2023-11-16 2024-03-01 迪嘉药业集团股份有限公司 一种替米沙坦中间体3-甲基-4-氨基苯甲酸的制备方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1194505A (en) * 1968-05-21 1970-06-10 Science Union & Cie Piperidinol Derivatives and Process for Preparing Them
IT1046052B (it) * 1973-10-12 1980-06-30 Sigurta Farmaceutici Spa Processo per la preparazione di i aralchil 4 aminometil piperidin 4 oli
US4348763A (en) * 1980-08-07 1982-09-07 Hewlett-Packard Company Multiple stripe leaky mode laser
US4711703A (en) 1982-02-03 1987-12-08 Orbisphere Corporation Wilmington, Succursale De Collonge-Bellerive Thermal protection method for electroanalytical cell
SU1593569A3 (ru) * 1982-07-30 1990-09-15 Janssen Pharmaceutica Nv Cпocoб пoлучehия пpoизboдhыx n-(3-гидpokcи-4-пипepидиhил)бehзamидa или иx kиcлotho-aддиtиbhыx coлeй
DE3416224C2 (de) 1983-05-06 1994-05-05 Mitsubishi Chem Ind Verfahren zur Herstellung eines Kohleverflüssigungsöls
US4772630A (en) 1984-11-23 1988-09-20 Ciba-Geigy Corp. Benzamides and their salts
US4722630A (en) 1985-09-20 1988-02-02 The Garrett Corporation Ceramic-metal braze joint
GB8527052D0 (en) 1985-11-02 1985-12-04 Beecham Group Plc Compounds
US4910312A (en) 1985-11-08 1990-03-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
US4910193A (en) 1985-12-16 1990-03-20 Sandoz Ltd. Treatment of gastrointestinal disorders
US4746655A (en) * 1987-06-10 1988-05-24 A. H. Robins Company, Incorporated Fused aromatic-spiropiperidine oxazepinones(and thiones)
BE1000689A6 (fr) 1987-07-14 1989-03-14 Donnay Donnay S A Ets Raquette de tennis, de squash ou sport analogue.
US5130312A (en) 1987-07-17 1992-07-14 Janssen Pharmaceutica N.V. Substituted N-(3-hydroxy-4-piperidinyl)benzamides
NZ225152A (en) * 1987-07-17 1990-04-26 Janssen Pharmaceutica Nv Heterocyclically substituted piperidinyl benzamides as pharmaceuticals
US4906643A (en) 1987-07-17 1990-03-06 Janssen Pharmaceutica N.V. Substituted N-(3-hydroxy-4-piperidinyl)benzamides as gastrointestinal agents
JPH0719937B2 (ja) * 1987-09-24 1995-03-06 三井石油化学工業株式会社 高周波用積層板およびその製造方法
US4975439A (en) 1987-09-25 1990-12-04 Janssen Pharmaceutical N.V. Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
US5041454A (en) 1987-09-25 1991-08-20 Janssen Pharmaceutica N.V. Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
CA1317940C (en) * 1987-09-25 1993-05-18 Georges H. P. Van Daele Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides
JP2573017B2 (ja) 1988-03-08 1997-01-16 三洋電機株式会社 ディスクプレーヤ
US5053412A (en) 1990-04-10 1991-10-01 Israel Institute For Biological Research Spiro nitrogen-bridged heterocyclic compounds
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5103141A (en) 1990-03-08 1992-04-07 U.S. Philips Corporation Switching arrangement for increasing the white life of a high pressure sodium lamp
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5407938A (en) 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
TW243449B (tr) * 1991-02-15 1995-03-21 Hokuriku Pharmaceutical
NZ243993A (en) 1991-08-20 1994-10-26 Smithkline Beecham Plc Pharmaceutical compositions having 5-ht4 receptor antagonist activity and selected compounds having such activity
HUT70154A (en) 1991-09-12 1995-09-28 Smithkline Beecham Plc 5-ht4 receptor antagonists and pharmaceutical compositions containing them
IT1252567B (it) * 1991-12-20 1995-06-19 Italfarmaco Spa Derivati di 5-isochinolinsolfonammidi inibitori delle protein-chinasi
WO1993013101A1 (fr) 1991-12-27 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Compose de pyridonecarboxylate, son utilisation pharmaceutique et compose spiro
JPH07503480A (ja) 1992-02-06 1995-04-13 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ４拮抗薬としてのベンゾピラン，ベンゾチオピランおよびベンゾフラン誘導体
JPH05236345A (ja) 1992-02-21 1993-09-10 Nec Ic Microcomput Syst Ltd 画像用垂直フィルタ回路
MX9306311A (es) 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
US5705498A (en) 1992-11-05 1998-01-06 Smithkline Beecham Plc. Piperidine derivatives as 5-HT4 receptor antagonists
US6127379A (en) * 1993-02-01 2000-10-03 Smithkline Beecham P.L.C. Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists
WO1995026953A1 (en) * 1994-03-30 1995-10-12 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compound and use thereof as medicine
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
TW490465B (en) * 1994-11-24 2002-06-11 Janssen Pharmaceutica Nv Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
EP0873990A1 (en) * 1995-09-22 1998-10-28 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and medicinal use thereof
ATE250931T1 (de) * 1996-02-15 2003-10-15 Janssen Pharmaceutica Nv Verwendung von 5-ht4 antagonisten zur überwindung der gastrointestinalen beschädigung, die durch inhibitoren der serotonin-wiederaufnahme hervorgerufen werden
US6096761A (en) * 1996-02-15 2000-08-01 Janssen Pharmaceutica N.V. Esters of 3-hydroxy-piperidinemethanol derivatives
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
CN1242863A (zh) 1997-10-31 2000-01-26 大宇电子株式会社 带有由单一驱动源操纵的驱动机构的光盘换盘装置
ES2283132T3 (es) * 1998-09-10 2007-10-16 F. Hoffmann-La Roche Ag Dihidrobenzodiaxin carboxamida y derivados de cetona como antagonistas receptores de 5-ht4.

Also Published As

Publication number Publication date
KR20010014336A (ko) 2001-02-26
WO1999002156A1 (en) 1999-01-21
AR013361A1 (es) 2000-12-27
EP0991410B1 (en) 2002-10-30
NZ502208A (en) 2001-04-27
PL190310B1 (pl) 2005-11-30
TW402591B (en) 2000-08-21
US20030078427A1 (en) 2003-04-24
ES2212330T3 (es) 2004-07-16
IL133917A0 (en) 2001-04-30
HUP0002539A2 (hu) 2000-12-28
BRPI9811688B8 (pt) 2021-07-06
HRP20000005B1 (en) 2008-12-31
PL338005A1 (en) 2000-09-25
ES2187051T3 (es) 2003-05-16
MY123199A (en) 2006-05-31
WO1999002494A1 (en) 1999-01-21
IL133918A (en) 2004-06-20
AU734475B2 (en) 2001-06-14
PT1000028E (pt) 2004-04-30
SI1000028T1 (en) 2004-04-30
USRE40793E1 (en) 2009-06-23
AR016324A1 (es) 2001-07-04
EP1000028A1 (en) 2000-05-17
SK184099A3 (en) 2000-09-12
EP1206938A1 (en) 2002-05-22
DK0991410T3 (da) 2003-02-24
CA2295088A1 (en) 1999-01-21
JP2001509503A (ja) 2001-07-24
US20040058958A1 (en) 2004-03-25
EA200000110A1 (ru) 2000-08-28
SK284632B6 (sk) 2005-08-04
DK1000028T3 (da) 2004-04-05
DE69809050D1 (de) 2002-12-05
US6635643B2 (en) 2003-10-21
US20120028987A1 (en) 2012-02-02
HUP0002539A3 (en) 2002-03-28
NO317467B1 (no) 2004-11-01
HUP0004564A3 (en) 2001-08-28
EP0991410A1 (en) 2000-04-12
NO20000116L (no) 2000-03-07
US6452013B1 (en) 2002-09-17
ATE255092T1 (de) 2003-12-15
EA002619B1 (ru) 2002-06-27
BRPI9811688B1 (pt) 2011-10-18
SI0991410T1 (en) 2003-04-30
US8063070B2 (en) 2011-11-22
NO20000115D0 (no) 2000-01-10
UA67745C2 (uk) 2004-07-15
US20060142342A1 (en) 2006-06-29
NO20000115L (no) 2000-03-13
NZ502209A (en) 2001-01-26
US20020086879A1 (en) 2002-07-04
HRP20000005A2 (en) 2000-12-31
TR200000023T2 (tr) 2000-09-21
DE69820065T2 (de) 2004-08-26
EP1000028B1 (en) 2003-11-26
NO20000116D0 (no) 2000-01-10
HRP20000006B1 (en) 2009-06-30
DE69820065D1 (de) 2004-01-08
CZ458799A3 (cs) 2000-05-17
BRPI9811688A (pt) 2000-09-26
KR100885658B1 (ko) 2009-02-25
CN1262621A (zh) 2000-08-09
CN1117568C (zh) 2003-08-13
ID24481A (id) 2000-07-20
JP4530530B2 (ja) 2010-08-25
MY117803A (en) 2004-08-30
BG64230B1 (bg) 2004-06-30
KR100500372B1 (ko) 2005-07-11
US6750349B2 (en) 2004-06-15
KR20010014341A (ko) 2001-02-26
AU8857498A (en) 1999-02-08
US8318742B2 (en) 2012-11-27
PL338008A1 (en) 2000-09-25
CN1195736C (zh) 2005-04-06
CZ295506B6 (cs) 2005-08-17
AU747199B2 (en) 2002-05-09
DE69809050T2 (de) 2003-07-24
SK173499A3 (en) 2000-06-12
US7790750B2 (en) 2010-09-07
HU227424B1 (en) 2011-05-30
IL133917A (en) 2005-05-17
NO314662B1 (no) 2003-04-28
CA2295087A1 (en) 1999-01-21
SK284942B6 (sk) 2006-02-02
EE200000015A (et) 2000-10-16
JP2002508000A (ja) 2002-03-12
EE04178B1 (et) 2003-12-15
IL133918A0 (en) 2001-04-30
TW548103B (en) 2003-08-21
BG63709B1 (bg) 2002-10-31
CA2295087C (en) 2007-05-15
AU8806398A (en) 1999-02-08
CA2295088C (en) 2007-10-23
ID24161A (id) 2000-07-13
US20060142341A1 (en) 2006-06-29
HRP20000006A2 (en) 2000-12-31
BG103983A (en) 2000-09-29
HK1025093A1 (en) 2000-11-03
CZ463899A3 (cs) 2000-04-12
RU2213089C2 (ru) 2003-09-27
CN1262674A (zh) 2000-08-09
CZ297298B6 (cs) 2006-11-15
BG103984A (en) 2000-09-29
PT991410E (pt) 2003-03-31
PL190611B1 (pl) 2005-12-30
US20100210657A1 (en) 2010-08-19
BR9811687A (pt) 2000-09-26
ATE226820T1 (de) 2002-11-15
US20070037850A1 (en) 2007-02-15
HUP0004564A2 (hu) 2001-07-30
HK1025047A1 (en) 2000-11-03

Similar Documents

Publication Publication Date Title
TR200000022T2 (tr) 3-ya da 4-eşlenimli 4-(aminometil)-piperidin türevlerinin tek halkalı gastrokinetik benzamidleri.
TR199801211T2 (tr) Takikinin reseptör antagonistleri olarak 1-(1,2-çift-ikameli piperidinil ) -4-ikameli piperidin türevleri.
ATE264852T1 (de) Chinolinderivate als antibakterielle mittel
NO20051225L (no) 1,2,4- oksadiazoler som modulatorer av metabotropisk glutamat-reseptor-5
TR199800027T1 (tr) Difenilmetilen piperidin türevleri.
TR200101155T2 (tr) 4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
EE200300403A (et) N-asendatud mittearomaatne heterotsükliline ühend, seda sisaldav ravimkompositsioon ning ühendi kasutamine ravimina
ATE297203T1 (de) Antithrombotische mitteln
JO2371B1 (en) 4-phenyl-pyridine derivatives
TR200102490T2 (tr) Fenil ve piridinil türevleri
CY1106522T1 (el) Ετepοκυκλικη ενωση και αντικαρκινικο μεσο που πepιεχει την ιδια ως δραστικο συστατικο
UY26754A1 (es) Derivados de la 1, 3, 8, -triaza-spiro (4,5) decan-4-ona
DE60107449D1 (de) Substituierte aminopropoxyarylderivate als lxr agonisten
DK0850221T3 (da) Meta-guanidin-, urinstof-, thiourinstof- eller azacykliske aminobenzoesyrederivater som intergrinantagonister
TR200001645T2 (tr) Retinoyik asit taklidi anilürler.
TR200200579T2 (tr) Amino-tirazolpiridin türevleri.
TR200102489T2 (tr) 3-Fenilpiridin Türevleri ve bunların NK-1 alıcı antagonistler olarak kullanılması
ES2191260T3 (es) Derivados de la imidazolidin-4-ona utiles como agentes anticancerosos.
DE69709938D1 (de) N-benzylpiperidin- und tetrahydropyridin-derivate
TR200101962T2 (tr) Sindirim sistemi bozukluklarını tedavi etmek için 4-(aminometil)-piperidin benzamidler
NO985518L (no) Morfinanderivater og medisinsk anvendelse derav
DE69709493D1 (de) Substituierte Indazolderivate
NO20000722L (no) 2-(4-aryl eller heteroaryl-piperazin-1-ylmetyl)-1H- indolderivater
NO973652D0 (no) 5-(4-subst.-piperidinyl-1)-3-aryl-pentansyre og derivater som tachykininreseptor-antagonist
NO20001781L (no) 3-amino-3-arylpropan-1-og lignende-derivater, deres fremstilling og anvendelse