TR199902727T2 - Salts of aromatic sulfonic acids. - Google Patents
Salts of aromatic sulfonic acids.Info
- Publication number
- TR199902727T2 TR199902727T2 TR1999/02727T TR9902727T TR199902727T2 TR 199902727 T2 TR199902727 T2 TR 199902727T2 TR 1999/02727 T TR1999/02727 T TR 1999/02727T TR 9902727 T TR9902727 T TR 9902727T TR 199902727 T2 TR199902727 T2 TR 199902727T2
- Authority
- TR
- Turkey
- Prior art keywords
- aromatic sulfonic
- salts
- sulfonic acids
- salt
- besylate
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- -1 aromatic sulfonic acids Chemical class 0.000 title 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Bulus, CNS-yatistirici, trans-5-kloro-2,3,3a,12b -tetrahidro-2-metil- 1H-dibenz[2,3:6,7] oksepino [4,5-c] pirolun bir tuzu ve bir tuz olusturucu maddedir, ikincisi de bir aromatik sülfonik asittir. Tarif edilen tuzun, tercihen besilat, uygun özellikleri vardir. Yani, besilat, depo enjeksiyon preparatlarinda kullanim açisindan uygun olabilecek istenilen çözünmezlik ve kristallesme özelliklerine sahiptir.Invention, CNS-sedative, trans-5-chloro-2,3,3a, 12b-tetrahydro-2-methyl-1H-dibenz [2,3: 6,7] oxepino [4,5-c] a salt of pyrrole and is a salt-forming agent, the second is an aromatic sulfonic acid. The described salt, preferably besylate, has suitable properties. That is, besylate has the desired insolubility and crystallization properties that may be suitable for use in depot injection preparations.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97201596 | 1997-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199902727T2 true TR199902727T2 (en) | 2000-07-21 |
Family
ID=8228372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/02727T TR199902727T2 (en) | 1997-05-26 | 1998-05-19 | Salts of aromatic sulfonic acids. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0984968A1 (en) |
| JP (1) | JP2001526702A (en) |
| KR (1) | KR20010012985A (en) |
| CN (1) | CN1257504A (en) |
| AU (1) | AU7767598A (en) |
| BR (1) | BR9809162A (en) |
| CA (1) | CA2290070A1 (en) |
| HU (1) | HUP0002106A3 (en) |
| NO (1) | NO995770D0 (en) |
| PL (1) | PL337027A1 (en) |
| TR (1) | TR199902727T2 (en) |
| WO (1) | WO1998054186A1 (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0213564B8 (en) | 2001-10-30 | 2021-05-25 | Novartis Ag | deposit and microparticle formulation comprising iloperidone and poly(d,l-lactide-co-glycolide) polymer, and process for preparing said microparticle |
| HRP20020440B1 (en) | 2002-05-21 | 2008-02-29 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 1-aza-dibenzoazulenes as inhibitors of tumor necrosis factor production and intermediates for the preparation thereof |
| HRP20020452A2 (en) | 2002-05-23 | 2004-02-29 | Pliva D D | 1,2-diaza-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediates for preparation thereof |
| GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
| JP2008516925A (en) * | 2004-10-15 | 2008-05-22 | ナームローゼ・フエンノートチヤツプ・オルガノン | Treatment of bipolar disorder and associated symptoms |
| KR101435296B1 (en) | 2009-06-24 | 2014-08-27 | 머크 샤프 앤 도메 비.브이. | Injectable formulations containing asenapine and method of treatment using same |
| ITMI20110734A1 (en) | 2011-05-02 | 2012-11-03 | Olon Spa | CRYSTALLINE ASENAPINE SALTS |
| EP2524919A1 (en) | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids |
| EP2524921A1 (en) | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel Crystalline Salts of Asenapine |
| EP2524920A1 (en) | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel Crystalline Asenapine Hydrochloride Salt Forms |
| KR102506333B1 (en) | 2016-12-20 | 2023-03-06 | 에르테에스 로만 테라피-시스테메 아게 | Transdermal absorption treatment system containing asenapine |
| MX382132B (en) | 2016-12-20 | 2025-03-13 | Lts Lohmann Therapie Systeme Ag | Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene |
| CN110799180A (en) | 2017-06-26 | 2020-02-14 | 罗曼治疗系统股份公司 | Transdermal therapeutic system containing asenapine and siloxane acrylic hybrid polymer |
| WO2019243432A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| PL3810100T3 (en) | 2018-06-20 | 2025-05-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7605526A (en) * | 1976-05-24 | 1977-11-28 | Akzo Nv | NEW TETRACYCLICAL DERIVATIVES. |
-
1998
- 1998-05-19 CN CN98805420A patent/CN1257504A/en active Pending
- 1998-05-19 TR TR1999/02727T patent/TR199902727T2/en unknown
- 1998-05-19 WO PCT/EP1998/003022 patent/WO1998054186A1/en not_active Ceased
- 1998-05-19 JP JP50020299A patent/JP2001526702A/en active Pending
- 1998-05-19 BR BR9809162-0A patent/BR9809162A/en not_active Application Discontinuation
- 1998-05-19 EP EP98925632A patent/EP0984968A1/en not_active Withdrawn
- 1998-05-19 HU HU0002106A patent/HUP0002106A3/en unknown
- 1998-05-19 AU AU77675/98A patent/AU7767598A/en not_active Abandoned
- 1998-05-19 CA CA002290070A patent/CA2290070A1/en not_active Abandoned
- 1998-05-19 PL PL98337027A patent/PL337027A1/en unknown
- 1998-05-19 KR KR1019997010957A patent/KR20010012985A/en not_active Withdrawn
-
1999
- 1999-11-25 NO NO995770A patent/NO995770D0/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU7767598A (en) | 1998-12-30 |
| CA2290070A1 (en) | 1998-12-03 |
| BR9809162A (en) | 2000-08-01 |
| KR20010012985A (en) | 2001-02-26 |
| PL337027A1 (en) | 2000-07-31 |
| EP0984968A1 (en) | 2000-03-15 |
| WO1998054186A1 (en) | 1998-12-03 |
| NO995770L (en) | 1999-11-25 |
| CN1257504A (en) | 2000-06-21 |
| JP2001526702A (en) | 2001-12-18 |
| HUP0002106A2 (en) | 2000-11-28 |
| HUP0002106A3 (en) | 2001-11-28 |
| NO995770D0 (en) | 1999-11-25 |
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