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TR199902575T2 - Stable pharmaceutical administration form for peptides, proteins and nucleic acids. - Google Patents

Stable pharmaceutical administration form for peptides, proteins and nucleic acids.

Info

Publication number
TR199902575T2
TR199902575T2 TR1999/02575T TR9902575T TR199902575T2 TR 199902575 T2 TR199902575 T2 TR 199902575T2 TR 1999/02575 T TR1999/02575 T TR 1999/02575T TR 9902575 T TR9902575 T TR 9902575T TR 199902575 T2 TR199902575 T2 TR 199902575T2
Authority
TR
Turkey
Prior art keywords
peptides
proteins
nucleic acids
acids
administration form
Prior art date
Application number
TR1999/02575T
Other languages
Turkish (tr)
Inventor
Rödel Wolfgang
Mattern Markus
Winter Gerhard
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of TR199902575T2 publication Critical patent/TR199902575T2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Bulus biomoleküllerin depolamada stabil liyofilize farmasötik preparasyonlarina iliskindir; biomoleküller proteinler, peptitler, nükleik asitler ve karbonhidratlar arasindan seçilir ve ayrica bir veya birkaç bazik D veya L-amino asit, buna ek olarak bir veya birkaç aminodikarboksilik asit, hidroksikarboksilik asit veya dikarboksilik asit veya fizyolojik olarak uyumlu tuzlarini içerir. Yardimci maddeler liyofilizatta tamamen veya kismen amorf bir formda bulunur.The invention relates to stable lyophilized pharmaceutical preparations of biomolecules in storage; biomolecules are selected from proteins, peptides, nucleic acids and carbohydrates, and also include one or more basic D or L-amino acids, plus one or more aminodicarboxylic acids, hydroxycarboxylic acids or dicarboxylic acids or physiologically compatible salts. Auxiliary substances are completely or partially in amorphous form in the lyophilisate.

TR1999/02575T 1997-04-18 1998-04-11 Stable pharmaceutical administration form for peptides, proteins and nucleic acids. TR199902575T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19716154A DE19716154A1 (en) 1997-04-18 1997-04-18 Stable pharmaceutical dosage form for peptides, proteins and nucleic acids

Publications (1)

Publication Number Publication Date
TR199902575T2 true TR199902575T2 (en) 2000-02-21

Family

ID=7826847

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02575T TR199902575T2 (en) 1997-04-18 1998-04-11 Stable pharmaceutical administration form for peptides, proteins and nucleic acids.

Country Status (10)

Country Link
EP (1) EP0975335A1 (en)
JP (1) JP2001524090A (en)
KR (1) KR20010006562A (en)
CN (1) CN1261271A (en)
AU (1) AU744777B2 (en)
BR (1) BR9809103A (en)
CA (1) CA2288649A1 (en)
DE (1) DE19716154A1 (en)
TR (1) TR199902575T2 (en)
WO (1) WO1998047490A1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7276359B1 (en) 1998-03-13 2007-10-02 Wyeth Polynucleotide composition, method of preparation, and use thereof
DK1061955T3 (en) * 1998-03-13 2005-07-04 Wyeth Corp Polynucleotide composition, method of preparation and use thereof
CN100471522C (en) * 1998-03-13 2009-03-25 惠氏 Polynucleotide composition and its preparation method and use
DE19840531C2 (en) * 1998-08-28 2003-05-15 Roboscreen Ges Fuer Molekulare Reaction spaces coated with nucleic acids, processes for their preparation and their use
ES2408784T3 (en) * 1999-05-31 2013-06-21 Mitsubishi Chemical Corporation Lyophilized HGF preparations
DE10149030A1 (en) * 2001-10-05 2003-04-10 Viscum Ag Preparation of storage-stable medicaments containing recombinant carbohydrate-binding polypeptides, especially r-viscumin, useful e.g. as cytotoxic agent, comprises cooling, freezing, spray-drying or lyophilizing solution of pH more than 6
US20070031501A1 (en) * 2003-08-05 2007-02-08 Andries Van Es Use of recombinant or synthetic gelatin-like proteins as stabiliser in lyophilized pharmaceutical compositions
DE602005016402D1 (en) * 2004-05-24 2009-10-15 Genvault Corp STABLE STORAGE OF PROTEIN AND STABLE STORAGE OF NUCLEIC ACID IN RECYCLABLE FORM
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
EP2234603A1 (en) * 2007-12-19 2010-10-06 EKR Therapeutics, Inc. Room temperature stable, lyophilized natriuretic peptide formulations
EP2334792B1 (en) 2008-09-12 2020-09-09 GenTegra LLC Matrices and media for storage and stabilization of biomolecules
JP2016109911A (en) 2014-12-08 2016-06-20 三星ディスプレイ株式會社Ｓａｍｓｕｎｇ Ｄｉｓｐｌａｙ Ｃｏ．，Ｌｔｄ． Display device, display method and program
KR102369835B1 (en) 2014-12-08 2022-03-04 삼성디스플레이 주식회사 Display apparaus and display method
JP2016109914A (en) 2014-12-08 2016-06-20 三星ディスプレイ株式會社Ｓａｍｓｕｎｇ Ｄｉｓｐｌａｙ Ｃｏ．，Ｌｔｄ． Display device, display method and program

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63115822A (en) * 1986-11-04 1988-05-20 Teijin Ltd Powdery composition for nasotracheal administration of physiological active polypeptide
DE3729863A1 (en) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh STABILIZED ERYTHROPOIETIN LYOPHILISATES
DE4126984A1 (en) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh PROCESS FOR THE MANUFACTURE OF HUMAN PROTEIN-CONTAINING, SUITABLE MEDICAMENTS FOR INFUSION OR INJECTION USE
DE4126983A1 (en) * 1991-08-15 1993-02-18 Boehringer Mannheim Gmbh METHOD FOR THE PRODUCTION OF HUMAN-PROTEIN-CONTAINING, PRESERVED MEDICAMENTS FOR INFUSION OR INJECTION USE
DE19538687A1 (en) * 1995-10-17 1997-04-24 Boehringer Mannheim Gmbh Stable pharmaceutical dosage forms containing parathyroid hormone

Also Published As

Publication number Publication date
DE19716154A1 (en) 1998-10-22
AU7758598A (en) 1998-11-13
CA2288649A1 (en) 1998-10-29
JP2001524090A (en) 2001-11-27
AU744777B2 (en) 2002-03-07
KR20010006562A (en) 2001-01-26
WO1998047490A1 (en) 1998-10-29
BR9809103A (en) 2000-08-01
EP0975335A1 (en) 2000-02-02
CN1261271A (en) 2000-07-26

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