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TR199902455T2 - 5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitors - Google Patents

5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitors

Info

Publication number
TR199902455T2
TR199902455T2 TR1999/02455T TR9902455T TR199902455T2 TR 199902455 T2 TR199902455 T2 TR 199902455T2 TR 1999/02455 T TR1999/02455 T TR 1999/02455T TR 9902455 T TR9902455 T TR 9902455T TR 199902455 T2 TR199902455 T2 TR 199902455T2
Authority
TR
Turkey
Prior art keywords
adenosine kinase
compound
disebictie
aminopyrido
kinase inhibitors
Prior art date
Application number
TR1999/02455T
Other languages
Turkish (tr)
Inventor
S.Bhagwat Shripad
Lee Chih-Hung
D. Cowart Marlon
Mckie Jeffrey
Laure Grillot Anne
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of TR199902455T2 publication Critical patent/TR199902455T2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Formül (I) e sahip bir bilesik tatbik ederek adenosin kinazi inhibe etmek içiin bir yöntem; burada R1,R2,R3 ve R4 tarifnamede tarif edildigi gibidir ve kesikli çizgi---ihtiyari bir çift bag bulundugunu belirtir; bu bilesigi içeren farmasötik terkip, ve tedaviye ihtiyaci olan bir memeliye bu bilesigin terapötik etkili bir miktarini vermek suretiyle, beyin iskemisi, epilepsi, agri duyarliligi, enflamasyon ve sepsisi tedavi etmek için bir yöntem; söz konusu bilesikleri hazirlamak için bir yöntem ve yukaridaki formüle sahip ve R1,R2,R3,ve R4 ün ayri ayri tanimlandigi bilesikler saglanmistir.A method for inhibiting adenosine kinase by applying a compound of formula (I); wherein R1, R2, R3 and R4 are as described in the specification, and the dotted line indicates that there is an optional double bond; pharmaceutical composition containing this compound, and a method of treating brain ischemia, epilepsy, pain sensitivity, inflammation and sepsis, by giving a mammal in need of treatment a therapeutically effective amount of this compound; A method for preparing said compounds and the formula above are provided, and compounds in which R1, R2, R3, and R4 are defined separately.

TR1999/02455T 1997-04-16 1998-04-14 5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitors TR199902455T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83821697A 1997-04-16 1997-04-16

Publications (1)

Publication Number Publication Date
TR199902455T2 true TR199902455T2 (en) 2000-01-21

Family

ID=25276561

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/02455T TR199902455T2 (en) 1997-04-16 1998-04-14 5,7-Disebictie 4-Aminopyrido (2,3-D) Pyrimidine compounds and their use as adenosine kinase inhibitors

Country Status (18)

Country Link
EP (1) EP0989986A1 (en)
JP (1) JP2001520655A (en)
KR (1) KR20010006509A (en)
CN (1) CN1252070A (en)
AR (1) AR012436A1 (en)
AU (1) AU7108398A (en)
BG (1) BG103842A (en)
BR (1) BR9809055A (en)
CA (1) CA2286909A1 (en)
CO (1) CO4940446A1 (en)
HU (1) HUP0001434A3 (en)
IL (1) IL131618A0 (en)
NO (1) NO995036D0 (en)
PL (1) PL336304A1 (en)
SK (1) SK141799A3 (en)
TR (1) TR199902455T2 (en)
WO (1) WO1998046605A1 (en)
ZA (1) ZA983177B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023444A1 (en) * 1998-10-21 2000-04-27 Abbott Laboratories 5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
CN100376571C (en) 2001-02-12 2008-03-26 霍夫曼-拉罗奇有限公司 6-substituted pyridopyrimidines
EP1471910A2 (en) 2002-01-17 2004-11-03 Neurogen Corporation Substituted quinazolin-4-ylamine analogues as modulators of capsaicin receptors
DE10335183A1 (en) * 2003-07-30 2005-02-24 Bayer Cropscience Ag Fungicidal drug combinations
CN101243081A (en) * 2005-07-21 2008-08-13 霍夫曼-拉罗奇有限公司 Pyrido[2,3-d]pyrimidine-2,4-diamine compounds as PTP1B inhibitors
US7910595B2 (en) * 2005-12-21 2011-03-22 Abbott Laboratories Anti-viral compounds
WO2007081517A2 (en) 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
EP2094276A4 (en) 2006-12-20 2011-01-05 Abbott Lab Anti-viral compounds
AU2008293542B9 (en) 2007-08-27 2014-08-07 Dart Neuroscience (Cayman) Ltd. Therapeutic isoxazole compounds
MY150507A (en) 2007-08-31 2014-01-30 Eisai R&D Man Co Ltd Polycyclic compound
DE102007061764A1 (en) * 2007-12-20 2009-06-25 Bayer Healthcare Ag Anellated cyanopyridines and their use
US8754100B2 (en) * 2009-02-26 2014-06-17 Eisai R&D Management Co., Ltd. Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors
CA2886117C (en) 2012-10-05 2022-05-31 Merck Sharp & Dohme Corp. Indoline compounds and their use as aldosterone synthase inhibitors
KR102375929B1 (en) 2016-03-31 2022-03-16 온크터널 테라퓨틱스, 인코포레이티드. Indoline analogs and uses thereof
CN110256420B (en) * 2019-05-07 2020-04-28 江西中医药大学 Tetrahydropyridopyrimidine derivatives and preparation methods and uses thereof
CN110283171A (en) * 2019-07-17 2019-09-27 鼎泰(南京)临床医学研究有限公司 Compound of the one kind containing Pyridopyrimidine -4- amine structure, pharmaceutical composition and its application

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324731A (en) * 1989-02-14 1994-06-28 Amira, Inc. Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US6143749A (en) * 1995-06-07 2000-11-07 Abbott Laboratories Heterocyclic substituted cyclopentane compounds

Also Published As

Publication number Publication date
CO4940446A1 (en) 2000-07-24
SK141799A3 (en) 2000-08-14
IL131618A0 (en) 2001-01-28
CA2286909A1 (en) 1998-10-22
NO995036L (en) 1999-10-15
CN1252070A (en) 2000-05-03
ZA983177B (en) 1999-01-22
AR012436A1 (en) 2000-10-18
AU7108398A (en) 1998-11-11
NO995036D0 (en) 1999-10-15
KR20010006509A (en) 2001-01-26
HUP0001434A2 (en) 2000-10-28
JP2001520655A (en) 2001-10-30
HUP0001434A3 (en) 2001-01-29
PL336304A1 (en) 2000-06-19
EP0989986A1 (en) 2000-04-05
BG103842A (en) 2000-06-30
BR9809055A (en) 2000-08-08
WO1998046605A1 (en) 1998-10-22

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