TR199902315T2 - Its use as a quinoline-2-carboxylic acid and excitatory amino acid antagonist. - Google Patents
Its use as a quinoline-2-carboxylic acid and excitatory amino acid antagonist.Info
- Publication number
- TR199902315T2 TR199902315T2 TR1999/02315T TR9902315T TR199902315T2 TR 199902315 T2 TR199902315 T2 TR 199902315T2 TR 1999/02315 T TR1999/02315 T TR 1999/02315T TR 9902315 T TR9902315 T TR 9902315T TR 199902315 T2 TR199902315 T2 TR 199902315T2
- Authority
- TR
- Turkey
- Prior art keywords
- quinoline
- carboxylic acid
- antagonist
- excitatory amino
- amino acid
- Prior art date
Links
- 239000003194 amino acid receptor blocking agent Substances 0.000 title 1
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1
- LNYJXORXZWTJDA-UHFFFAOYSA-N 4-[2-(4-acetamidoanilino)-2-oxoethylidene]-5,7-dichloro-2,3-dihydro-1h-quinoline-2-carboxylic acid Chemical compound C1=CC(NC(=O)C)=CC=C1NC(=O)C=C1C2=C(Cl)C=C(Cl)C=C2NC(C(O)=O)C1 LNYJXORXZWTJDA-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Uyarici amino asitlerin antagonisti olan E 4-(4-asetilamino-fenilkarbamoilmetilen)-5,7- dikloro-1,2,3,4-tetrahidro kuinolin 2-karboksilik asitin (+) enantiomeri ve tuzu, bunlari hazirlamak için islemler, bunlari içeren farmasötik bilesimleri ve tipta kullanimlari.The antagonist of stimulating amino acids E 4- (4-acetylamino-phenylcarbamoylmethylene) -5,7- dichloro-1,2,3,4-tetrahydro quinoline 2-carboxylic acid (+) enantiomer and salt, processes to prepare them, containing them pharmaceutical compositions and their use in type.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9706294.7A GB9706294D0 (en) | 1997-03-26 | 1997-03-26 | Heterocyclic compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199902315T2 true TR199902315T2 (en) | 2000-05-22 |
Family
ID=10809909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1999/02315T TR199902315T2 (en) | 1997-03-26 | 1998-03-24 | Its use as a quinoline-2-carboxylic acid and excitatory amino acid antagonist. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0971896A1 (en) |
| JP (1) | JP2001518901A (en) |
| KR (1) | KR20010005567A (en) |
| CN (1) | CN1257482A (en) |
| AP (1) | AP9901659A0 (en) |
| AU (1) | AU731394B2 (en) |
| BR (1) | BR9808424A (en) |
| CA (1) | CA2284710A1 (en) |
| EA (1) | EA199900755A1 (en) |
| GB (1) | GB9706294D0 (en) |
| HU (1) | HUP0001661A3 (en) |
| ID (1) | ID24306A (en) |
| IL (1) | IL131919A0 (en) |
| IS (1) | IS5186A (en) |
| NO (1) | NO994679L (en) |
| NZ (1) | NZ337793A (en) |
| PL (1) | PL335865A1 (en) |
| TR (1) | TR199902315T2 (en) |
| WO (1) | WO1998042673A1 (en) |
| YU (1) | YU47699A (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9917822D0 (en) * | 1999-07-29 | 1999-09-29 | Imperial College | Nmda antagonist |
| DE10132725A1 (en) | 2001-07-05 | 2006-08-03 | Grünenthal GmbH | Substituted γ-lactone compounds |
| DE10137487A1 (en) * | 2001-08-03 | 2003-03-27 | Gruenenthal Gmbh | Substituted 5,6,6a, 11b-tetrahydro-7-oxa-6-aza-benzo [c] fluorene-6-carboxylic acid derivatives |
| DE10306202A1 (en) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist |
| JP4360891B2 (en) | 2003-12-09 | 2009-11-11 | アルパイン株式会社 | Electronic device having broadcast receiving function and display method of electronic program guide in the device |
| EP1908753B1 (en) | 2005-07-22 | 2014-12-17 | Mochida Pharmaceutical Co., Ltd. | Novel heterocyclidene acetamide derivative |
| RU2451014C2 (en) * | 2005-07-22 | 2012-05-20 | Мотида Фармасьютикал Ко., Лтд. | Novel heterocyclidene acetamide derivative |
| US9737531B2 (en) | 2012-07-12 | 2017-08-22 | Glytech, Llc | Composition and method for treatment of depression and psychosis in humans |
| AU2018284335A1 (en) | 2017-06-12 | 2020-01-30 | Glytech Llc. | Treatment of depression with NMDA antagonists and D2/5HT2A or selective 5HT2A antagonists |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0386839B1 (en) * | 1989-03-08 | 1997-01-15 | Merck Sharp & Dohme Ltd. | Tetrahydroquinoline derivatives useful for neurodegenerative disorders |
| BR9610733A (en) * | 1995-09-29 | 1999-07-13 | Glaxo Wellcome Spa | Compound processes for the preparation of it and for the treatment of a mammal pharmaceutical composition and use of a compound |
| GB9617305D0 (en) * | 1996-08-17 | 1996-09-25 | Glaxo Wellcome Spa | Heterocyclic compounds |
-
1997
- 1997-03-26 GB GBGB9706294.7A patent/GB9706294D0/en active Pending
-
1998
- 1998-03-24 CN CN98805302A patent/CN1257482A/en active Pending
- 1998-03-24 IL IL13191998A patent/IL131919A0/en unknown
- 1998-03-24 NZ NZ337793A patent/NZ337793A/en unknown
- 1998-03-24 WO PCT/EP1998/001700 patent/WO1998042673A1/en not_active Ceased
- 1998-03-24 ID IDW991108A patent/ID24306A/en unknown
- 1998-03-24 YU YU47699A patent/YU47699A/en unknown
- 1998-03-24 JP JP54323498A patent/JP2001518901A/en active Pending
- 1998-03-24 AP APAP/P/1999/001659A patent/AP9901659A0/en unknown
- 1998-03-24 TR TR1999/02315T patent/TR199902315T2/en unknown
- 1998-03-24 EP EP98919133A patent/EP0971896A1/en not_active Withdrawn
- 1998-03-24 AU AU72094/98A patent/AU731394B2/en not_active Ceased
- 1998-03-24 PL PL98335865A patent/PL335865A1/en unknown
- 1998-03-24 EA EA199900755A patent/EA199900755A1/en unknown
- 1998-03-24 BR BR9808424-0A patent/BR9808424A/en not_active IP Right Cessation
- 1998-03-24 CA CA002284710A patent/CA2284710A1/en not_active Abandoned
- 1998-03-24 KR KR1019997008630A patent/KR20010005567A/en not_active Withdrawn
- 1998-03-24 HU HU0001661A patent/HUP0001661A3/en unknown
-
1999
- 1999-09-17 IS IS5186A patent/IS5186A/en unknown
- 1999-09-24 NO NO994679A patent/NO994679L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ID24306A (en) | 2000-07-13 |
| IS5186A (en) | 1999-09-17 |
| HUP0001661A3 (en) | 2001-12-28 |
| NZ337793A (en) | 2001-02-23 |
| PL335865A1 (en) | 2000-05-22 |
| HUP0001661A2 (en) | 2000-09-28 |
| KR20010005567A (en) | 2001-01-15 |
| CA2284710A1 (en) | 1998-10-01 |
| CN1257482A (en) | 2000-06-21 |
| NO994679D0 (en) | 1999-09-24 |
| AU7209498A (en) | 1998-10-20 |
| GB9706294D0 (en) | 1997-05-14 |
| AP9901659A0 (en) | 1999-09-30 |
| JP2001518901A (en) | 2001-10-16 |
| IL131919A0 (en) | 2001-03-19 |
| EA199900755A1 (en) | 2000-08-28 |
| YU47699A (en) | 2001-12-26 |
| NO994679L (en) | 1999-11-24 |
| BR9808424A (en) | 2000-05-23 |
| WO1998042673A1 (en) | 1998-10-01 |
| AU731394B2 (en) | 2001-03-29 |
| EP0971896A1 (en) | 2000-01-19 |
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