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TR199900614T2 - Crystalline substance Cefditoren pivoxil and its production. - Google Patents

Crystalline substance Cefditoren pivoxil and its production.

Info

Publication number
TR199900614T2
TR199900614T2 TR1999/00614T TR9900614T TR199900614T2 TR 199900614 T2 TR199900614 T2 TR 199900614T2 TR 1999/00614 T TR1999/00614 T TR 1999/00614T TR 9900614 T TR9900614 T TR 9900614T TR 199900614 T2 TR199900614 T2 TR 199900614T2
Authority
TR
Turkey
Prior art keywords
production
cefditoren pivoxil
crystalline substance
substance
new
Prior art date
Application number
TR1999/00614T
Other languages
Turkish (tr)
Inventor
Yasui Kiyoshi
Onodera Masahiro
Sukegawa Masamichi
Watanabe Tatsuo
Yamamoto Yuichi
Murai Yasushi
Iinuma Katsuharu
Original Assignee
Meiji Seika Kaisha, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha, Ltd. filed Critical Meiji Seika Kaisha, Ltd.
Publication of TR199900614T2 publication Critical patent/TR199900614T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Yeni bir madde olarak, yüksek bir safliga ve depolama üzerine artmis bir termal stabiliteye sahip olan yeni, kristal halinde bir Cefditoren pivoksil maddesi ve bu maddenin yapilmasi için bir islem temin edilmektedir.As a new substance, a new crystalline Cefditoren pivoxil substance having a high purity and increased thermal stability upon storage and a process for making this substance are provided.

TR1999/00614T 1996-09-20 1997-09-19 Crystalline substance Cefditoren pivoxil and its production. TR199900614T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24956196 1996-09-20

Publications (1)

Publication Number Publication Date
TR199900614T2 true TR199900614T2 (en) 1999-06-21

Family

ID=17194838

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00614T TR199900614T2 (en) 1996-09-20 1997-09-19 Crystalline substance Cefditoren pivoxil and its production.

Country Status (25)

Country Link
US (2) US6294669B1 (en)
EP (1) EP0937083B1 (en)
JP (1) JP3403206B2 (en)
KR (1) KR100441907B1 (en)
CN (1) CN1116299C (en)
AR (1) AR008483A1 (en)
AT (1) ATE238310T1 (en)
AU (1) AU714735B2 (en)
BR (1) BR9712072A (en)
CA (1) CA2265686C (en)
CZ (1) CZ295199B6 (en)
DE (1) DE69721290T2 (en)
EA (1) EA001526B1 (en)
ES (1) ES2198593T3 (en)
HU (1) HU224196B1 (en)
ID (1) ID22064A (en)
IL (1) IL129016A (en)
NZ (1) NZ334883A (en)
PL (1) PL189548B1 (en)
PT (1) PT937083E (en)
RO (1) RO120196B1 (en)
SK (1) SK284973B6 (en)
TR (1) TR199900614T2 (en)
UA (1) UA55426C2 (en)
WO (1) WO1998012200A1 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100441907B1 (en) * 1996-09-20 2004-07-27 메이지 세이까 가부시끼가이샤 A crystalline substance of cefditoren pivoxyl and the production of the same
EA002881B1 (en) * 1998-01-07 2002-10-31 Мейдзи Сейка Кайся Лтд. Crystallographically stable amorphous cephalosporin compositions and process for producing the same
PE20010635A1 (en) * 1999-10-08 2001-08-15 Smithkline Beecham Corp USEFUL FAB I INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS
HU226640B1 (en) * 1999-10-18 2009-05-28 Egis Gyogyszergyar Nyilvanosan Process for producing amorphous atorvastatin calcium salt
JP2001131071A (en) * 1999-10-29 2001-05-15 Meiji Seika Kaisha Ltd Amorphous substance and medical composition containing amorphous substance
DK1560584T3 (en) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitors
ATE499116T1 (en) * 2002-08-16 2011-03-15 Immunogen Inc HIGH REACTIVITY AND SOLUBILITY CROSS-LINKERS AND THEIR USE IN THE PRODUCTION OF CONJUGATES FOR THE TARGETED DELIVERY OF SMALL MOLECULAR DRUGS
ES2358470T3 (en) * 2002-10-02 2011-05-11 Meiji Seika Kaisha Ltd. ANTIBACTERIAL MEDICINAL COMPOSITION WITH IMPROVED ORAL ABSORPTIVITY.
US7244842B2 (en) * 2002-11-15 2007-07-17 Orchid Chemicals & Pharmaceuticals Ltd. Amorphous hydrate of a cephalosporin antibiotic
DK1575951T3 (en) * 2002-12-06 2014-09-15 Debiopharm Int Sa HETEROCYCLIC COMPOUNDS, METHODS OF PRODUCING THEREOF AND THEIR USE IN THERAPY
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
EP1606293B1 (en) * 2003-03-27 2009-08-19 Basilea Pharmaceutica AG Cephalosporin in crystalline form
US8088387B2 (en) * 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
WO2005016936A2 (en) * 2003-08-14 2005-02-24 Ranbaxy Laboratories Limited Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof
ATE539738T1 (en) 2003-10-08 2012-01-15 Meiji Seika Pharma Co Ltd NON-CRYSTALLINE ANTIBACTERIAL COMPOSITION WITH CEFDITOREN-PIVOXIL
WO2005044824A2 (en) * 2003-11-07 2005-05-19 Ranbaxy Laboratories Limited Processes for the preparation of highly pure 3-(2-substituted vinyl) cephalosporin
JP2005162696A (en) * 2003-12-04 2005-06-23 Nichiko Pharmaceutical Co Ltd Cefditoren pivoxil pharmaceutical preparation excellent in dissolution property
KR101299399B1 (en) 2004-06-04 2013-08-22 아피늄 파마슈티컬스, 인크. Therapeutic Agents, and Methods of Making and Using the Same
WO2006024900A1 (en) * 2004-08-31 2006-03-09 Ranbaxy Laboratories Limited Highly pure cefditoren pivoxil
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
US20080069879A1 (en) * 2006-05-02 2008-03-20 Ravishekhar Bhiwgade Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof
WO2008009122A1 (en) 2006-07-20 2008-01-24 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab i inhibitors
EP2125802A4 (en) * 2007-02-16 2014-08-20 Debiopharm Int Sa Salts, prodrugs and polymorphs of fab i inhibitors
EP2520578A1 (en) 2011-05-06 2012-11-07 Lupin Limited Process for purification of cephalosporins
CN103421025B (en) * 2012-05-21 2016-05-11 上海医药工业研究院 Prepare the method for 7 α-methoxy cephalosporin C
BR122021020778B1 (en) 2012-06-19 2022-07-12 Debiopharm International Sa PRO-Drug DERIVATIVES OF (E)-N-METHYL-N-((3-METHYLBENZOFURAN-2-YL) METHYL)-3-(7-OXO-5,6,7,8-TETRAHYDRO-1,8- NAFTIRINDIN-3-IL) ACRYLAMIDE
KR101561963B1 (en) * 2013-05-23 2015-10-22 영진약품공업 주식회사 Novel crystalline from of cefditoren pivoxyl and preparation method thereof
CN103665002B (en) * 2013-12-18 2016-02-03 成都医路康医学技术服务有限公司 A kind of preparation method of Cefditoren pivoxil Cephalosporins
EP3244879A1 (en) 2015-01-16 2017-11-22 Ögün, Yusuf Toktamis Cefditoren pivoxil compositions with improved stability and production methods thereof
SI3419628T1 (en) 2016-02-26 2021-03-31 Debiopharm International Sa Medicament for treatment of diabetic foot infections
PH12021551922A1 (en) 2019-02-14 2022-05-23 Debiopharm Int Sa Afabicin formulation, method for making the same
UA129222C2 (en) 2019-06-14 2025-02-12 Дебіофарм Інтернешнл С.А. Afabicin for use for treating bacterial infections involving biofilm

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58487B1 (en) * 1984-09-07 1993-09-22 Kaisha Maiji Seika New cephalosporin compounds and the production thereof
ES2157989T3 (en) * 1993-09-29 2001-09-01 Meiji Seika Kaisha NEW DERIVATIVES OF CEFALOSPORINA.
ES2155839T3 (en) * 1993-11-17 2001-06-01 Biochemie Gmbh SEPARATION OF CEPHALOSPORINE ISOMERS.
KR100441907B1 (en) * 1996-09-20 2004-07-27 메이지 세이까 가부시끼가이샤 A crystalline substance of cefditoren pivoxyl and the production of the same

Also Published As

Publication number Publication date
ID22064A (en) 1999-08-26
EA001526B1 (en) 2001-04-23
UA55426C2 (en) 2003-04-15
PL189548B1 (en) 2005-08-31
KR20000048496A (en) 2000-07-25
PL332314A1 (en) 1999-08-30
NZ334883A (en) 2000-09-29
DE69721290D1 (en) 2003-05-28
ES2198593T3 (en) 2004-02-01
CZ295199B6 (en) 2005-06-15
EP0937083A1 (en) 1999-08-25
CN1116299C (en) 2003-07-30
HUP9903454A2 (en) 2000-03-28
CZ97599A3 (en) 1999-08-11
RO120196B1 (en) 2005-10-28
JP2001500521A (en) 2001-01-16
SK284973B6 (en) 2006-03-02
SK35499A3 (en) 2000-03-13
AU4222297A (en) 1998-04-14
CA2265686A1 (en) 1998-03-26
US20020002279A1 (en) 2002-01-03
PT937083E (en) 2003-08-29
HUP9903454A3 (en) 2001-04-28
US6441162B2 (en) 2002-08-27
CN1234036A (en) 1999-11-03
HU224196B1 (en) 2005-06-28
CA2265686C (en) 2006-10-31
EA199900311A1 (en) 1999-10-28
AU714735B2 (en) 2000-01-13
IL129016A0 (en) 2000-02-17
IL129016A (en) 2003-01-12
JP3403206B2 (en) 2003-05-06
US6294669B1 (en) 2001-09-25
DE69721290T2 (en) 2004-01-22
BR9712072A (en) 1999-08-24
WO1998012200A1 (en) 1998-03-26
AR008483A1 (en) 2000-01-19
KR100441907B1 (en) 2004-07-27
EP0937083B1 (en) 2003-04-23
HK1022912A1 (en) 2000-08-25
ATE238310T1 (en) 2003-05-15

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