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TR199801749T2 - 4-Amino-pyrimidine-derivatives and drugs containing them - Google Patents

4-Amino-pyrimidine-derivatives and drugs containing them

Info

Publication number
TR199801749T2
TR199801749T2 TR1998/01749T TR9801749T TR199801749T2 TR 199801749 T2 TR199801749 T2 TR 199801749T2 TR 1998/01749 T TR1998/01749 T TR 1998/01749T TR 9801749 T TR9801749 T TR 9801749T TR 199801749 T2 TR199801749 T2 TR 199801749T2
Authority
TR
Turkey
Prior art keywords
pyrimidine
derivatives
amino
drugs containing
treatment
Prior art date
Application number
TR1998/01749T
Other languages
Turkish (tr)
Inventor
Himmelsbach Frank
Dahmann Georg
von R�den Thomas
Metz Thomas
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996108631 external-priority patent/DE19608631A1/en
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Publication of TR199801749T2 publication Critical patent/TR199801749T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Yukaridaki bulus, içinde Ra,Rb, A ve B'nin istem 1'de tanimlandigi gibi oldugu genel formül (I)'in 4-amino-pirimidin-türevleri, bunlarin tautomerleri, stereoizomerleri ve tuzlari, özellikle farmakolojik olarak degerli özelliklerde titrosinkinazlar ile bildirilen sinyal transdüksiyonun önleme etkisi özelliklerine sahip olan anorganik ya da organik asit ya da bazlar ile birlikte bunlarin fizyolojik olarak uygun tuzlari, bunlarin hastaliklarin özelliklede tümör hastaliklarinin tedavisi için kullanimi ve bunlanir elde edilmesi ile ilgilidir. FORMÜL.The above invention is reported by the 4-amino-pyrimidine-derivatives of the general formula (I) in which Ra, Rb, A, and B are as defined in claim 1, their tautomers, stereoisomers and salts, in particular pharmacologically valuable titrosynkinases. Inorganic or organic acids or bases, together with their signal transduction inhibitory properties, are concerned with their physiologically acceptable salts, their use for the treatment of diseases, and particularly their treatment of tumor diseases. FORMULA.

TR1998/01749T 1996-03-06 1997-03-03 4-Amino-pyrimidine-derivatives and drugs containing them TR199801749T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1996108631 DE19608631A1 (en) 1996-03-06 1996-03-06 New (heterocyclyl- pyrimidino or -pyrido)fused pyrimidine derivatives
DE19629652A DE19629652A1 (en) 1996-03-06 1996-07-23 4-Amino-pyrimidine derivatives, medicaments containing these compounds, their use and processes for their preparation

Publications (1)

Publication Number Publication Date
TR199801749T2 true TR199801749T2 (en) 1998-12-21

Family

ID=26023531

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/01749T TR199801749T2 (en) 1996-03-06 1997-03-03 4-Amino-pyrimidine-derivatives and drugs containing them

Country Status (19)

Country Link
EP (1) EP0885226A1 (en)
JP (1) JP2000506847A (en)
KR (1) KR19990087550A (en)
CN (1) CN1212695A (en)
AU (1) AU710274B2 (en)
BG (1) BG102708A (en)
BR (1) BR9708312A (en)
CA (1) CA2243994A1 (en)
CZ (1) CZ281798A3 (en)
DE (1) DE19629652A1 (en)
EE (1) EE9800277A (en)
HU (1) HUP9901820A3 (en)
IL (1) IL125404A0 (en)
NO (1) NO984084L (en)
NZ (1) NZ331546A (en)
PL (1) PL328771A1 (en)
SK (1) SK120598A3 (en)
TR (1) TR199801749T2 (en)
WO (1) WO1997032881A1 (en)

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Also Published As

Publication number Publication date
DE19629652A1 (en) 1998-01-29
CN1212695A (en) 1999-03-31
JP2000506847A (en) 2000-06-06
EE9800277A (en) 1999-02-15
KR19990087550A (en) 1999-12-27
IL125404A0 (en) 1999-03-12
NO984084D0 (en) 1998-09-04
AU1925197A (en) 1997-09-22
CA2243994A1 (en) 1997-09-12
EP0885226A1 (en) 1998-12-23
NO984084L (en) 1998-09-04
BR9708312A (en) 1999-08-03
AU710274B2 (en) 1999-09-16
HUP9901820A3 (en) 2001-10-29
SK120598A3 (en) 1999-06-11
BG102708A (en) 1999-09-30
NZ331546A (en) 2000-03-27
WO1997032881A1 (en) 1997-09-12
CZ281798A3 (en) 1999-02-17
HUP9901820A2 (en) 1999-09-28
PL328771A1 (en) 1999-02-15

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