TR199800339T1 - Hybrid ionic forms of trovafloxacin. - Google Patents
Hybrid ionic forms of trovafloxacin.Info
- Publication number
- TR199800339T1 TR199800339T1 TR1998/00339T TR9800339T TR199800339T1 TR 199800339 T1 TR199800339 T1 TR 199800339T1 TR 1998/00339 T TR1998/00339 T TR 1998/00339T TR 9800339 T TR9800339 T TR 9800339T TR 199800339 T1 TR199800339 T1 TR 199800339T1
- Authority
- TR
- Turkey
- Prior art keywords
- trovafloxacin
- hybrid ionic
- ionic forms
- relates
- hygroscopic
- Prior art date
Links
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 title abstract 2
- 229960000497 trovafloxacin Drugs 0.000 title abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000004686 pentahydrates Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Physical Water Treatments (AREA)
- Processing Of Solid Wastes (AREA)
Abstract
Isbu bulus, kendi kristalin higroskopik ve higroskopik olmayan polimorflari ve pentahidrattan meydana gelen gruptan seçilen (I) formülüne sahip bir trovafloksasinin melez iyonik biçimi ile ve bunlarin hazirlanmasi ilgilidir. Bulus bundan baska memelilerde bakteri enfeksiyonlarini tedavi etmek için bulusun bilesimlerini ihtiva eden ispençiyari kompozisyonlar ve bunlarin kullanim yöntemleri ile de ilgilidir.This invention relates to the hybrid ionic form of a trovafloxacin of formula (I) selected from the group consisting of its own crystalline hygroscopic and non-hygroscopic polymorphs and pentahydrate, and their preparation. The invention also relates to pharmaceutical compositions and methods for using them to treat bacterial infections in mammals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US297595P | 1995-08-29 | 1995-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR199800339T1 true TR199800339T1 (en) | 1998-06-22 |
Family
ID=21703460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR1998/00339T TR199800339T1 (en) | 1995-08-29 | 1996-07-29 | Hybrid ionic forms of trovafloxacin. |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP0850060A1 (en) |
| JP (1) | JP3188476B2 (en) |
| KR (1) | KR100343909B1 (en) |
| CN (1) | CN1190889A (en) |
| AP (1) | AP636A (en) |
| AR (1) | AR003985A1 (en) |
| AU (1) | AU704115B2 (en) |
| BR (1) | BR9609998A (en) |
| CA (1) | CA2229786C (en) |
| CO (1) | CO4480739A1 (en) |
| CZ (1) | CZ56698A3 (en) |
| DZ (1) | DZ2087A1 (en) |
| GT (1) | GT199600072A (en) |
| HR (1) | HRP960395B1 (en) |
| HU (1) | HUP9900170A3 (en) |
| IL (1) | IL122651A (en) |
| MA (1) | MA23966A1 (en) |
| MY (1) | MY113874A (en) |
| NO (1) | NO309814B1 (en) |
| NZ (1) | NZ312199A (en) |
| OA (1) | OA10669A (en) |
| PE (1) | PE12598A1 (en) |
| PL (1) | PL325170A1 (en) |
| RU (1) | RU2144921C1 (en) |
| SK (1) | SK23898A3 (en) |
| TN (1) | TNSN96109A1 (en) |
| TR (1) | TR199800339T1 (en) |
| WO (1) | WO1997007800A1 (en) |
| YU (1) | YU48396A (en) |
| ZA (1) | ZA967282B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN1998000106A (en) | 1997-08-01 | 1999-01-08 | Pfizer Prod Inc | PARENTERAL COMPOSITIONS OF ALATROFLAXACINO |
| US7019142B2 (en) | 1998-01-16 | 2006-03-28 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
| PA8466701A1 (en) * | 1998-01-21 | 2000-09-29 | Pfizer Prod Inc | TROVAFLOXACINO MESYLATE TABLET |
| US6114531A (en) * | 1998-07-28 | 2000-09-05 | Pfizer Inc. | Process for preparing quinolone and naphthyridone carboxylic acids |
| HN1999000141A (en) * | 1998-09-03 | 2000-06-19 | Pfizer Prod Inc | PROCEDURE FOR PREPARING SALTS OF TROVAFLOXACIN FOR ADDITION OF ACIDS. |
| US6239141B1 (en) | 1999-06-04 | 2001-05-29 | Pfizer Inc. | Trovafloxacin oral suspensions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| AU623474B2 (en) * | 1989-01-16 | 1992-05-14 | Laboratoire Roger Bellon | New benzo(1,8)naphthyridine derivatives, their preparation and compositions containing them |
| US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
| DK0833837T3 (en) | 1995-06-15 | 2002-09-02 | Pfizer | Process for the preparation of derivatives of azabicyclonaphthydridine carboxylic acid comprising a dipeptide |
-
1996
- 1996-07-29 CA CA002229786A patent/CA2229786C/en not_active Expired - Fee Related
- 1996-07-29 NZ NZ312199A patent/NZ312199A/en unknown
- 1996-07-29 SK SK238-98A patent/SK23898A3/en unknown
- 1996-07-29 EP EP96923020A patent/EP0850060A1/en not_active Withdrawn
- 1996-07-29 BR BR9609998A patent/BR9609998A/en unknown
- 1996-07-29 TR TR1998/00339T patent/TR199800339T1/en unknown
- 1996-07-29 RU RU98103873/04A patent/RU2144921C1/en not_active IP Right Cessation
- 1996-07-29 KR KR10-1998-0701468A patent/KR100343909B1/en not_active Expired - Fee Related
- 1996-07-29 CZ CZ98566A patent/CZ56698A3/en unknown
- 1996-07-29 CN CN96195624A patent/CN1190889A/en active Pending
- 1996-07-29 AU AU63676/96A patent/AU704115B2/en not_active Ceased
- 1996-07-29 WO PCT/IB1996/000756 patent/WO1997007800A1/en not_active Ceased
- 1996-07-29 PL PL96325170A patent/PL325170A1/en unknown
- 1996-07-29 IL IL12265196A patent/IL122651A/en not_active IP Right Cessation
- 1996-07-29 HU HU9900170A patent/HUP9900170A3/en unknown
- 1996-07-29 JP JP50343697A patent/JP3188476B2/en not_active Expired - Fee Related
- 1996-08-23 GT GT199600072A patent/GT199600072A/en unknown
- 1996-08-26 AR ARP960104121A patent/AR003985A1/en unknown
- 1996-08-26 PE PE1996000633A patent/PE12598A1/en not_active Application Discontinuation
- 1996-08-28 ZA ZA9607282A patent/ZA967282B/en unknown
- 1996-08-28 TN TNTNSN96109A patent/TNSN96109A1/en unknown
- 1996-08-28 YU YU48396A patent/YU48396A/en unknown
- 1996-08-28 DZ DZ960131A patent/DZ2087A1/en active
- 1996-08-28 MY MYPI96003579A patent/MY113874A/en unknown
- 1996-08-28 MA MA24344A patent/MA23966A1/en unknown
- 1996-08-29 CO CO96046149A patent/CO4480739A1/en unknown
- 1996-08-29 AP APAP/P/1996/000853A patent/AP636A/en active
- 1996-08-29 HR HR960395A patent/HRP960395B1/en not_active IP Right Cessation
-
1998
- 1998-02-27 OA OA9800026A patent/OA10669A/en unknown
- 1998-02-27 NO NO980862A patent/NO309814B1/en not_active Application Discontinuation
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