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TNSN01090A1 - Formes polymorphes/hydrates du dihydrochlorure de n -[4-3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]acrylamide, procede pour leur preparation, de meme que leur utilisation pour la preparation de medicaments avec un effet d'inhibition irreversible de la tyrozine kinase. - Google Patents

Formes polymorphes/hydrates du dihydrochlorure de n -[4-3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]acrylamide, procede pour leur preparation, de meme que leur utilisation pour la preparation de medicaments avec un effet d'inhibition irreversible de la tyrozine kinase.

Info

Publication number
TNSN01090A1
TNSN01090A1 TNTNSN01090A TNSN01090A TNSN01090A1 TN SN01090 A1 TNSN01090 A1 TN SN01090A1 TN TNSN01090 A TNTNSN01090 A TN TNSN01090A TN SN01090 A TNSN01090 A TN SN01090A TN SN01090 A1 TNSN01090 A1 TN SN01090A1
Authority
TN
Tunisia
Prior art keywords
preparation
ylpropoxy
fluorophenylamino
quinazolin
morpholin
Prior art date
Application number
TNTNSN01090A
Other languages
English (en)
Inventor
Hubert Dr Barth
Klaus Dr Steiner
Simon Schneider
Dietmar Dr Huls
Andreas Dr Muhlenfeld
Manfred Dr Westermayer
Original Assignee
Godecke Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Godecke Gmbh filed Critical Godecke Gmbh
Publication of TNSN01090A1 publication Critical patent/TNSN01090A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

ON DECRIT DES FORMES POLYMORPHES/HYDRATES DU DIHYDROCHLORURE DE N-[4-(3-CHLORO-4-FLUOROPHENYLAMINO)-7-(3-MORPHOLIN-4-YLPROPOXY)-QUINAZOLIN-6-YL]ACRYLAMIDE, UN PROCEDE POUR LEUR PREPARATION, DE MEME QUE LEUR UTILISATION POUR LA PREPARATION DE MEDICAMENTS AVEC UN EFFET D'INHIBITION IRREVERSIBLE SUR LA TYROSINE KINASE.
TNTNSN01090A 2000-06-30 2001-06-15 Formes polymorphes/hydrates du dihydrochlorure de n -[4-3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]acrylamide, procede pour leur preparation, de meme que leur utilisation pour la preparation de medicaments avec un effet d'inhibition irreversible de la tyrozine kinase. TNSN01090A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10031971A DE10031971A1 (de) 2000-06-30 2000-06-30 Polymorphe Formen/Hydrate von N-[4-(3-Chlor-4-fluor-phenylamino)-7-(3-morpholin-4-yl-propoxy)-chinazolin-6-yl]-acrylamid Dihydrochlorid, Verfahren zu ihrer Herstellung sowie die Verwendung derselben zur Herstellung von Medikamenten mit irreversibler Tyrosinkinasehemmwirkung

Publications (1)

Publication Number Publication Date
TNSN01090A1 true TNSN01090A1 (fr) 2005-11-10

Family

ID=7647397

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN01090A TNSN01090A1 (fr) 2000-06-30 2001-06-15 Formes polymorphes/hydrates du dihydrochlorure de n -[4-3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]acrylamide, procede pour leur preparation, de meme que leur utilisation pour la preparation de medicaments avec un effet d'inhibition irreversible de la tyrozine kinase.

Country Status (39)

Country Link
US (1) US20040034022A1 (fr)
EP (1) EP1299363A1 (fr)
JP (1) JP2004501902A (fr)
KR (1) KR20030014403A (fr)
CN (1) CN1438994A (fr)
AP (1) AP2002002694A0 (fr)
AR (1) AR031854A1 (fr)
AU (1) AU2001283861A1 (fr)
BG (1) BG107352A (fr)
BR (1) BR0112082A (fr)
CA (1) CA2412535A1 (fr)
CZ (1) CZ20024037A3 (fr)
DE (1) DE10031971A1 (fr)
DZ (1) DZ3342A1 (fr)
EA (1) EA005294B1 (fr)
EC (1) ECSP024413A (fr)
EE (1) EE200200714A (fr)
GT (1) GT200100124A (fr)
HN (1) HN2001000134A (fr)
HR (1) HRP20021019A2 (fr)
HU (1) HUP0300900A3 (fr)
IL (1) IL152419A0 (fr)
IS (1) IS6596A (fr)
MA (1) MA26924A1 (fr)
MX (1) MXPA03000101A (fr)
NO (1) NO20026193L (fr)
NZ (1) NZ522001A (fr)
OA (1) OA12301A (fr)
PA (1) PA8520801A1 (fr)
PE (1) PE20020116A1 (fr)
PL (1) PL365127A1 (fr)
SK (1) SK17642002A3 (fr)
SV (1) SV2002000517A (fr)
TN (1) TNSN01090A1 (fr)
UA (1) UA73588C2 (fr)
UY (1) UY26803A1 (fr)
WO (1) WO2002000630A1 (fr)
YU (1) YU99802A (fr)
ZA (1) ZA200209717B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA06012756A (es) * 2004-05-06 2007-01-16 Warner Lambert Co 4-fenilamino-quinazolin-6-il-amidas.
DE102006000122A1 (de) * 2006-03-17 2007-09-20 Aug. Winkhaus Gmbh & Co. Kg Schlüssel für einen Schließzylinder und Schließzylinder für einen solchen Schlüssel
WO2017107986A1 (fr) * 2015-12-25 2017-06-29 山东轩竹医药科技有限公司 Cristaux de dérivé quinazoline et leur procédé de préparation
WO2017107985A1 (fr) * 2015-12-25 2017-06-29 山东轩竹医药科技有限公司 Cristaux d'un dérivé de quinazoline et leur procédé de préparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL190489B1 (pl) * 1996-04-12 2005-12-30 Warner Lambert Co Nieodwracalne inhibitory kinaz tyrozyny, kompozycja farmaceutyczna je zawierająca i ich zastosowanie
AU763626B2 (en) * 1998-11-19 2003-07-31 Warner-Lambert Company N-(4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4-yl- propoxy)-quinazolin-6-yl)-acrylamide, an irreversible inhibitor of tyrosine kinases

Also Published As

Publication number Publication date
BG107352A (bg) 2003-07-31
GT200100124A (es) 2002-06-27
ECSP024413A (es) 2003-03-31
EA005294B1 (ru) 2004-12-30
ZA200209717B (en) 2003-12-01
AU2001283861A1 (en) 2002-01-08
BR0112082A (pt) 2003-05-06
UY26803A1 (es) 2002-01-31
AP2002002694A0 (en) 2002-12-31
EE200200714A (et) 2004-08-16
CN1438994A (zh) 2003-08-27
CZ20024037A3 (cs) 2004-01-14
PA8520801A1 (es) 2003-06-30
YU99802A (sh) 2005-11-28
WO2002000630A1 (fr) 2002-01-03
EA200300094A1 (ru) 2003-04-24
NZ522001A (en) 2004-07-30
IS6596A (is) 2002-10-28
PL365127A1 (en) 2004-12-27
SV2002000517A (es) 2002-07-03
US20040034022A1 (en) 2004-02-19
JP2004501902A (ja) 2004-01-22
HUP0300900A3 (en) 2004-01-28
MXPA03000101A (es) 2004-09-13
UA73588C2 (en) 2005-08-15
OA12301A (en) 2003-11-10
MA26924A1 (fr) 2004-12-20
HN2001000134A (es) 2001-09-11
NO20026193D0 (no) 2002-12-23
EP1299363A1 (fr) 2003-04-09
DE10031971A1 (de) 2002-01-10
SK17642002A3 (sk) 2004-05-04
HRP20021019A2 (en) 2004-02-29
PE20020116A1 (es) 2002-02-27
CA2412535A1 (fr) 2002-01-03
IL152419A0 (en) 2003-05-29
KR20030014403A (ko) 2003-02-17
DZ3342A1 (fr) 2002-01-03
NO20026193L (no) 2003-01-27
HUP0300900A2 (hu) 2003-10-28
AR031854A1 (es) 2003-10-08

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TNSN01090A1 (fr) Formes polymorphes/hydrates du dihydrochlorure de n -[4-3-chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)-quinazolin-6-yl]acrylamide, procede pour leur preparation, de meme que leur utilisation pour la preparation de medicaments avec un effet d'inhibition irreversible de la tyrozine kinase.
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