[go: up one dir, main page]

TNSN87015A1 - Nouvelles n-heterocyclyl-4-piperidinamines, compositions contenant des n-heterocyclyl-4-piperidinamines, procede de traitement les utilisant et procede pour preparer des n-heterocyclyl-4- piperidinamines - Google Patents

Nouvelles n-heterocyclyl-4-piperidinamines, compositions contenant des n-heterocyclyl-4-piperidinamines, procede de traitement les utilisant et procede pour preparer des n-heterocyclyl-4- piperidinamines

Info

Publication number
TNSN87015A1
TNSN87015A1 TNTNSN87015A TNSN87015A TNSN87015A1 TN SN87015 A1 TNSN87015 A1 TN SN87015A1 TN TNSN87015 A TNTNSN87015 A TN TNSN87015A TN SN87015 A TNSN87015 A TN SN87015A TN SN87015 A1 TNSN87015 A1 TN SN87015A1
Authority
TN
Tunisia
Prior art keywords
piperidinamines
heterocyclyl
treating
preparing
novel
Prior art date
Application number
TNTNSN87015A
Other languages
English (en)
Inventor
Eduard Janssens Frans
Francis Hens Jozef
Leo Ghislanus Torremans Jozeph
Jan Pieter Heykants Jozef
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TNSN87015A1 publication Critical patent/TNSN87015A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

NOUVELLES N-HETEROCYCLYL-4- PIPERIDINAMINES, DES COMPOSITIONS CONTENANT DES N- HETEROCYCLYL -4-PIPERIDINAMINES, PROCEDE DE TRAITEMENT LES UTILISANT ET PROCEDE POUR PREPARER DES N-HETEROCYCLYL-4-PIPERIDINAMINES CES DERIVES DE PIPERIDINAMINES SONT DES COMPOSES DE FORMULE DANS LAQUELLE LES SYMBOLES SONT DEFINIS ET LEURS SELS D ADDITION D ACIDES PHARMACEUTIQUEMENT ACCEPTABLES ET LEURS FORMES ISOMERES STEREOCHIMIQUES,
TNTNSN87015A 1986-02-03 1987-02-03 Nouvelles n-heterocyclyl-4-piperidinamines, compositions contenant des n-heterocyclyl-4-piperidinamines, procede de traitement les utilisant et procede pour preparer des n-heterocyclyl-4- piperidinamines TNSN87015A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82549186A 1986-02-03 1986-02-03

Publications (1)

Publication Number Publication Date
TNSN87015A1 true TNSN87015A1 (fr) 1990-01-01

Family

ID=25244134

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN87015A TNSN87015A1 (fr) 1986-02-03 1987-02-03 Nouvelles n-heterocyclyl-4-piperidinamines, compositions contenant des n-heterocyclyl-4-piperidinamines, procede de traitement les utilisant et procede pour preparer des n-heterocyclyl-4- piperidinamines

Country Status (26)

Country Link
EP (1) EP0232937B1 (fr)
JP (2) JPH0794393B2 (fr)
CN (1) CN1018614B (fr)
AT (1) ATE79620T1 (fr)
AU (1) AU583706B2 (fr)
CA (1) CA1327579C (fr)
CY (1) CY1865A (fr)
DE (1) DE3781173T2 (fr)
DK (1) DK173674B1 (fr)
EG (1) EG17993A (fr)
ES (1) ES2052544T3 (fr)
FI (1) FI870448A7 (fr)
GR (1) GR3006158T3 (fr)
HK (1) HK114695A (fr)
HU (1) HU201067B (fr)
IE (1) IE60885B1 (fr)
IL (1) IL81448A (fr)
MA (1) MA20868A1 (fr)
NO (1) NO870407L (fr)
NZ (1) NZ219165A (fr)
PH (1) PH24738A (fr)
PT (1) PT84234B (fr)
TN (1) TNSN87015A1 (fr)
ZA (1) ZA87744B (fr)
ZM (1) ZM1287A1 (fr)
ZW (1) ZW2087A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (fr) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap Hexahydro-1h-azepines et pyrrolidines a substitution par des ((heterocyclyle bicyclique) methyle et -hetero
US4988689A (en) * 1987-07-01 1991-01-29 Janssen Pharmaceutica N.V. ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines
PH30434A (en) * 1989-04-07 1997-05-09 Janssen Pharmaceutica Nv Hydroxyalkylfuranyl derivatives
IT1229231B (it) * 1989-05-08 1991-07-26 Dompe Farmaceutici Spa Aminoimidazopiridine farmacologicamente attive
CA2043564A1 (fr) * 1990-07-06 1992-01-07 Alfons G. M. De Knaep 3-[(5-methyl-2-furyl)methyl]-n-(4-piperidyl)-3h-imidazo[4,5-b]pyridin-2-amine 2-hydroxypropane-1,2,3-tricarboxylate
NZ239540A (en) * 1990-09-24 1993-11-25 Neurosearch As 1-phenyl benzimidazole derivatives and medicaments
CA2143610C (fr) * 1992-09-03 2004-08-24 Raymond L. Woosley Utilisation de norastemizole pour le traitement de troubles allergiques
AU730229B2 (en) * 1992-09-03 2001-03-01 Sepracor, Inc. Use of norastemizole for the treatment of allergic disorders
FI955523A7 (fi) * 1993-05-20 1995-11-16 Kissei Pharmaceutical 1-(2-bentsimidatsolyyli)-1,5-diatsasyklo-oksataaniyhdisteet
TW429256B (en) * 1995-12-27 2001-04-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(benzimidazolyl- and imidazopyridinyl)-piperidine derivatives
WO1998042379A2 (fr) * 1997-03-26 1998-10-01 Sepracor Inc. Formulations chimiquement et thermiquement stables de norastemizole
US5817823A (en) * 1997-04-17 1998-10-06 Sepracor Inc. Method for synthesizing 2-substituted imidazoles
CZ20014573A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
ES2215683T3 (es) 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
CZ20014574A3 (cs) 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
WO2004113297A2 (fr) * 2003-06-24 2004-12-29 Neurosearch A/S Derives de noyaux aza et utilisation de ceux-ci comme inhibiteurs de la recapture des neurotransmetteurs monoaminergiques
EP1706403B9 (fr) 2003-12-22 2012-07-25 K.U.Leuven Research & Development Composes d'imidazo[4,5-c]pyridine et methodes de traitement antiviral
ATE426601T1 (de) 2004-12-21 2009-04-15 Gilead Sciences Inc Imidazoa4,5-cupyridinverbindung und verfahren zur antiviralen behandlung
JP5065908B2 (ja) * 2004-12-24 2012-11-07 プロシディオン・リミテッド Ｇタンパク質結合受容体作動薬
ATE478075T1 (de) 2005-03-08 2010-09-15 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin- (nk1)-antagonisten
ATE454384T1 (de) 2006-07-07 2010-01-15 Gilead Sciences Inc Neue pyridazinverbindung und ihre verwendung
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
AU2009296820B2 (en) * 2008-09-26 2014-03-20 Merck Sharp & Dohme Llc Novel cyclic benzimidazole derivatives useful anti-diabetic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1140119A (fr) * 1978-04-03 1983-01-25 Joseph Torremans Nouvelles n-heterocycle-4-piperidinamines
US4219559A (en) 1979-01-10 1980-08-26 Janssen Pharmaceutica N.V. N-Heterocyclyl-4-piperidinamines
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
IN156065B (fr) * 1982-07-12 1985-05-04 Janssen Pharmaceutica Nv
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (fr) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. N-(Hétérocycle bicyclyl)-4-pipéridinamines contenant des hétérocycles bicycliques
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PL144514B1 (en) * 1984-01-09 1988-06-30 Janssen Pharmaceutica Nv Method of obtaining novel derivatives of n-/4-piperidinolo/-2-imidazoloamine

Also Published As

Publication number Publication date
EG17993A (en) 1991-08-30
CA1327579C (fr) 1994-03-08
FI870448A7 (fi) 1987-08-04
EP0232937A3 (en) 1988-04-06
JPH0819126B2 (ja) 1996-02-28
AU583706B2 (en) 1989-05-04
ZM1287A1 (en) 1988-08-29
PH24738A (en) 1990-10-01
CY1865A (en) 1996-04-05
JPS62215575A (ja) 1987-09-22
HK114695A (en) 1995-07-21
MA20868A1 (fr) 1987-10-01
DK173674B1 (da) 2001-06-05
NO870407L (no) 1987-08-04
GR3006158T3 (fr) 1993-06-21
PT84234B (pt) 1989-09-14
ATE79620T1 (de) 1992-09-15
CN87100563A (zh) 1987-08-19
IE60885B1 (en) 1994-08-24
FI870448A0 (fi) 1987-02-02
EP0232937A2 (fr) 1987-08-19
JPH07179458A (ja) 1995-07-18
IL81448A (en) 1990-09-17
DE3781173D1 (de) 1992-09-24
IE870258L (en) 1987-08-03
AU6821887A (en) 1987-08-06
NZ219165A (en) 1990-04-26
IL81448A0 (en) 1987-09-16
ZA87744B (en) 1988-10-26
NO870407D0 (no) 1987-02-02
ZW2087A1 (en) 1988-08-31
EP0232937B1 (fr) 1992-08-19
HUT44544A (en) 1988-03-28
ES2052544T3 (es) 1994-07-16
CN1018614B (zh) 1992-10-14
JPH0794393B2 (ja) 1995-10-11
PT84234A (en) 1987-03-01
HU201067B (en) 1990-09-28
DK54187A (da) 1987-08-04
DK54187D0 (da) 1987-02-02
DE3781173T2 (de) 1992-12-17

Similar Documents

Publication Publication Date Title
TNSN87015A1 (fr) Nouvelles n-heterocyclyl-4-piperidinamines, compositions contenant des n-heterocyclyl-4-piperidinamines, procede de traitement les utilisant et procede pour preparer des n-heterocyclyl-4- piperidinamines
MA26718A1 (fr) Derives de quinoleine-2-one a substituant heteroaryle nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN96172A1 (fr) Composes heterocycliques, procede pour leur preparation et compositions pharmaceutiques les contenant.
IL116122A0 (en) Intermediates to heterocyclic-cyclic amine derivatives
FR2439189A1 (fr) Nouveaux derives de la 5h-2,3-benzodiazepine et procede pour la preparation de ces derives et compositions pharmaceutiques les contenant
HU913396D0 (en) Process for the production of azasteroide compounds and medical preparations containing them as active agents
BE901224A (fr) Nouveaux derives d'indole utiles comme medicaments et intermediaires et procedes pour leur preparation.
TNSN98082A1 (fr) DERIVES SUBSTITUES EN C - 4 DE 9 - DESOXO - 9a - aza - 9a HOMOERYTHROMYCINE A.
TNSN98083A1 (fr) Derives de 6-0 methylerythromycine a, procede pour leur preparation et compositions pharmaceutiques les contenant.
RO84097A (fr) Procede pour la preparation des derives de pyrolidine
FR2397403A1 (fr) Nouveaux derives de 1-acyl 2-cyano-aziridine, procede pour leur preparation et compositions pharmaceutiques contenant ces composes
DK213087A (da) 1,4-disubstituerede piperazinderivater og farmaceutisk acceptable syreadditionssalte deraf, deres fremstilling og anvendelse
DE3570437D1 (en) 1-hydroxy-1,1-diphosphonic-acid derivatives, process for their preparation and pharmaceutical preparations, especially for the treatment of bone tumours
KR920006360A (ko) 스쿠알렌 합성효소 억제제
PT77226A (fr) Procede pour preparer derives d'acides omega-amines et compositions contenant ces derives
FR2361879A2 (fr) Nouvelles 4,5,6,7- tetrahydro-7-oxo (ou hydroxy)benzo (b)thienyl-4-amines utiles notamment comme agents de croissance pour animaux et leur procede de preparation
ES8301244A1 (es) Procedimiento para la obtencion de derivados de sisomicina.
FR2446829A1 (fr) Derives de polymethylene disubstitues en alpha, omega, procede pour leur preparation et compositions pharmaceutiques les contenant
TNSN99083A1 (fr) Derives d'hygromycine a et leur procede de preparation.
CS649787A2 (en) Method of new 4,5-dihydrooxazole derivatives production
HUT59911A (en) Process for producing azol-derivatives of cycloalkylenes and pharmaceutical compositions containing them
RO91140A (fr) Procede pour la preparation des sels de pyridinium
MA20210A1 (fr) Procede de preparation de nouveaux derives de l'acide 4 - phenyl 4-oxo buten-2-oique.
IT1247697B (it) Composizioni farmaceutiche comprendenti 3-ammino-e-caprolattami per il potenziamento dei processi di apprendimento e della memoria.
TNSN98061A1 (fr) Derives d'erythromycine nouveaux, procede pour leur preparation et compositions pharmaceutiques les contenant.