TN2013000385A1 - Processes for the manufacture of macrocyclic depsipeptides and new intermediates - Google Patents

Processes for the manufacture of macrocyclic depsipeptides and new intermediates

Info

Publication number: TN2013000385A1
Authority: TN; Tunisia
Prior art keywords: manufacture; processes; new intermediates; depsipeptides; macrocyclic depsipeptides
Prior art date: 2011-04-20

Application number

TNP2013000385A

Other languages

English (en)

Inventor

Murat Acemoglu

Heribert Hellstern

Felix Kollmer

John Lopez

Robert Schreiber

Christian Sprecher

Hans Stettler

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-20

Filing date

2013-09-25

Publication date

2015-01-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46317455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2013000385(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-09-25 Application filed by Novartis Ag filed Critical Novartis Ag

2015-01-20 Publication of TN2013000385A1 publication Critical patent/TN2013000385A1/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Cookers (AREA)
Cereal-Derived Products (AREA)

TNP2013000385A 2011-04-20 2013-09-25 Processes for the manufacture of macrocyclic depsipeptides and new intermediates TN2013000385A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161477319P	2011-04-20	2011-04-20
PCT/IB2012/051977 WO2012143888A1 (fr)	2011-04-20	2012-04-19	Procédés de préparation de depsipeptides macrocycliques et nouveaux intermédiaires

Publications (1)

Publication Number	Publication Date
TN2013000385A1 true TN2013000385A1 (en)	2015-01-20

Family

ID=46317455

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TNP2013000385A TN2013000385A1 (en)	2011-04-20	2013-09-25	Processes for the manufacture of macrocyclic depsipeptides and new intermediates

Country Status (22)

Country	Link
US (2)	US8614289B2 (fr)
EP (1)	EP2699585A1 (fr)
JP (2)	JP5951006B2 (fr)
KR (1)	KR101580729B1 (fr)
CN (2)	CN103476789B (fr)
AR (1)	AR086168A1 (fr)
AU (1)	AU2012245980B2 (fr)
BR (1)	BR112013026660A2 (fr)
CA (1)	CA2833109A1 (fr)
CL (2)	CL2013003037A1 (fr)
CO (1)	CO6801799A2 (fr)
EA (2)	EA201500734A1 (fr)
GT (1)	GT201300256A (fr)
IL (1)	IL228727A0 (fr)
MA (1)	MA35034B1 (fr)
MX (1)	MX337526B (fr)
PE (1)	PE20141206A1 (fr)
PH (1)	PH12013502101A1 (fr)
SG (1)	SG193918A1 (fr)
TN (1)	TN2013000385A1 (fr)
TW (1)	TW201249863A (fr)
WO (1)	WO2012143888A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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WO2009024527A1 (fr)	2007-08-17	2009-02-26	Novartis Ag	Dépsipeptides cycliques
US8680054B2 (en)	2011-04-20	2014-03-25	Novartis Ag	Suspension type topical formulations comprising cyclic depsipeptide
AR086168A1 (es)	2011-04-20	2013-11-27	Novartis Ag	Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US9067978B2 (en)	2012-10-09	2015-06-30	Novartis Ag	Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) *	2012-10-09	2015-03-24	Novartis Ag	Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
CN106029684A (zh)	2014-04-08	2016-10-12	诺华股份有限公司	用于生产大环缩酚酸肽和新中间体的新型缩醛类方法
SG10202103403SA (en) *	2015-05-20	2021-05-28	Boehringer Ingelheim Animal Health Usa Inc	Anthelmintic depsipeptide compounds
US10683325B2 (en)	2015-09-17	2020-06-16	Massachusetts Institute Of Technology	Methods and systems for solid phase peptide synthesis
KR102031186B1 (ko) *	2017-01-11	2019-11-08	주식회사 엘지생활건강	단백질 강도 강화용 조성물
WO2020018888A1 (fr)	2018-07-20	2020-01-23	The Board Of Regents Of The University Of Oklahoma	Peptides antimicrobiens et méthodes d'utilisation

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DE4421113A1 (de)	1994-06-16	1995-12-21	Biotechnolog Forschung Gmbh	Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
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GB0108234D0 (en) *	2001-04-02	2001-05-23	Pharma Mar Sa	Process for producing trunkamide A compounds
US20040110228A1 (en)	2002-04-01	2004-06-10	Mcalpine Shelli R.	Combinatorial organic synthesis of unique biologically active compounds
JP5044214B2 (ja)	2003-06-06	2012-10-10	アレクシス・アクチボラゲット	皮膚状態または癌の処置のためのｓｃｃｅ阻害剤としての縮合複素環化合物の使用
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WO2009024527A1 (fr)	2007-08-17	2009-02-26	Novartis Ag	Dépsipeptides cycliques
DE102007052391A1 (de)	2007-10-31	2009-05-07	Henkel Ag & Co. Kgaa	Mattwachs
US20110112121A1 (en)	2009-07-06	2011-05-12	Joerg Berghausen	Pharmaceutical Compositions and Solid Forms
KR101004362B1 (ko)	2010-03-19	2010-12-28	가톨릭대학교 산학협력단	자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제
US20120064136A1 (en)	2010-09-10	2012-03-15	Nanobio Corporation	Anti-aging and wrinkle treatment methods using nanoemulsion compositions
WO2012035468A2 (fr)	2010-09-14	2012-03-22	Trima - Israel Pharmaceutical Products Maabarot Ltd.	Composition topique moussante
KR20200044145A (ko)	2011-01-24	2020-04-28	안테리오스, 인코퍼레이티드	나노입자 조성물, 이의 제형, 및 그의 용도
DK2667854T3 (en)	2011-01-24	2019-04-23	Anterios Inc	NANO PARTICLE FORMATIONS
AR086168A1 (es)	2011-04-20	2013-11-27	Novartis Ag	Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8680054B2 (en)	2011-04-20	2014-03-25	Novartis Ag	Suspension type topical formulations comprising cyclic depsipeptide
US8987413B2 (en)	2012-10-09	2015-03-24	Novartis Ag	Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en)	2012-10-09	2015-06-30	Novartis Ag	Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
CN106029684A (zh)	2014-04-08	2016-10-12	诺华股份有限公司	用于生产大环缩酚酸肽和新中间体的新型缩醛类方法

2012
- 2012-04-18 AR ARP120101326A patent/AR086168A1/es unknown
- 2012-04-18 US US13/449,937 patent/US8614289B2/en not_active Expired - Fee Related
- 2012-04-19 CN CN201280019062.6A patent/CN103476789B/zh not_active Expired - Fee Related
- 2012-04-19 MA MA36321A patent/MA35034B1/fr unknown
- 2012-04-19 EA EA201500734A patent/EA201500734A1/ru unknown
- 2012-04-19 MX MX2013012188A patent/MX337526B/es active IP Right Grant
- 2012-04-19 CA CA2833109A patent/CA2833109A1/fr not_active Abandoned
- 2012-04-19 PH PH1/2013/502101A patent/PH12013502101A1/en unknown
- 2012-04-19 CN CN201510232322.3A patent/CN104804072A/zh active Pending
- 2012-04-19 SG SG2013070453A patent/SG193918A1/en unknown
- 2012-04-19 BR BR112013026660A patent/BR112013026660A2/pt not_active IP Right Cessation
- 2012-04-19 PE PE2013002370A patent/PE20141206A1/es not_active Application Discontinuation
- 2012-04-19 TW TW101114027A patent/TW201249863A/zh unknown
- 2012-04-19 EA EA201391554A patent/EA025546B1/ru not_active IP Right Cessation
- 2012-04-19 KR KR1020137030625A patent/KR101580729B1/ko not_active Expired - Fee Related
- 2012-04-19 EP EP12727933.9A patent/EP2699585A1/fr not_active Withdrawn
- 2012-04-19 AU AU2012245980A patent/AU2012245980B2/en not_active Ceased
- 2012-04-19 WO PCT/IB2012/051977 patent/WO2012143888A1/fr not_active Ceased
- 2012-04-19 JP JP2014505772A patent/JP5951006B2/ja not_active Expired - Fee Related
2013
- 2013-09-25 TN TNP2013000385A patent/TN2013000385A1/fr unknown
- 2013-10-03 IL IL228727A patent/IL228727A0/en unknown
- 2013-10-18 CL CL2013003037A patent/CL2013003037A1/es unknown
- 2013-10-18 GT GT201300256A patent/GT201300256A/es unknown
- 2013-10-24 CO CO13252979A patent/CO6801799A2/es unknown
- 2013-11-18 US US14/082,315 patent/US9278997B2/en active Active
2015
- 2015-03-18 CL CL2015000688A patent/CL2015000688A1/es unknown
2016
- 2016-03-07 JP JP2016043330A patent/JP2016164158A/ja active Pending

Also Published As

Publication number	Publication date
AU2012245980A1 (en)	2013-10-03
PH12013502101A1 (en)	2017-10-25
JP5951006B2 (ja)	2016-07-13
AR086168A1 (es)	2013-11-27
US8614289B2 (en)	2013-12-24
MX337526B (es)	2016-03-09
CO6801799A2 (es)	2013-11-29
BR112013026660A2 (pt)	2016-09-06
KR101580729B1 (ko)	2015-12-28
US20120277406A1 (en)	2012-11-01
PE20141206A1 (es)	2014-09-28
TW201249863A (en)	2012-12-16
EA025546B1 (ru)	2017-01-30
AU2012245980B2 (en)	2015-01-29
JP2014511899A (ja)	2014-05-19
EA201500734A1 (ru)	2015-11-30
JP2016164158A (ja)	2016-09-08
US9278997B2 (en)	2016-03-08
MA35034B1 (fr)	2014-04-03
CN103476789B (zh)	2016-11-09
KR20130140204A (ko)	2013-12-23
CN103476789A (zh)	2013-12-25
EA201391554A1 (ru)	2014-11-28
GT201300256A (es)	2015-02-19
CN104804072A (zh)	2015-07-29
US20140080995A1 (en)	2014-03-20
MX2013012188A (es)	2013-11-04
SG193918A1 (en)	2013-11-29
IL228727A0 (en)	2013-12-31
EP2699585A1 (fr)	2014-02-26
CA2833109A1 (fr)	2012-10-26
CL2015000688A1 (es)	2015-06-05
WO2012143888A1 (fr)	2012-10-26
CL2013003037A1 (es)	2014-10-03

Publication	Publication Date	Title
TN2013000385A1 (en)	2015-01-20	Processes for the manufacture of macrocyclic depsipeptides and new intermediates
WO2014057418A3 (fr)	2014-07-10	Procédés en phase de solution pour la fabrication de depsipeptides macrocycliques, et nouveaux intermédiaires associés
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EA033455B1 (ru)	2019-10-31	Кристаллические формы замещенных 5-фтор-1h-пиразолопиридинов, способы их получения, их применение для получения лекарственного средства, лекарственное средство и способ лечения на их основе
IN2015DN01812A (fr)	2015-05-29
IN2012KN02804A (fr)	2015-05-01
UA105785C2 (uk)	2014-06-25	Спосіб очищення ліпопептидів
MX2015002110A (es)	2015-05-11	Benzoxazinonas de carbamato.
EA201500234A1 (ru)	2015-09-30	Способ получения бензоксазинонов
NZ711192A (en)	2019-04-26	Process for making benzoxazepin compounds
PH12013500554A1 (en)	2013-05-06	Process for preparing pan-cdk inhibitors of the formula (i) and intermediates in the preparation
MX344858B (es)	2017-01-09	Nuevo procedimiento para la síntesis de rifaximina y una nueva forma pseudocristalina de rifaximina obtenida con el mismo.
MY164954A (en)	2018-02-28	Method for purifying organic diphosphite compounds
MX363058B (es)	2019-03-06	Carbamatos, proceso para su preparación y uso para la preparación de benzoxazinonas.
PL2797863T5 (pl)	2019-06-28	Sposób wytwarzania 1,3-butadienu
MX2012010317A (es)	2012-12-17	ß-HIDROXIALQUILAMIDAS, METODO PARA SU PRODUCCION Y SU USO.
AU2012248013B2 (en)	2016-07-14	Intermediate for synthesizing caspofungin and preparation method therefor
MX2014000916A (es)	2014-05-12	Proceso para la produccion continua de polieteroles.
WO2012107445A3 (fr)	2012-11-15	Substrat souple pour la culture cellulaire et son procédé de préparation
WO2013072766A3 (fr)	2013-08-15	Procédé de fabrication de cabazitaxel et de ses intermédiaires
IL230159A0 (en)	2014-03-06	Method for the production of 2-amino-5-cyano-n,3-dimethylbenzamide
MX2014003936A (es)	2014-04-30	Procedimiento para preparar ditiina-tetracarboximidas.
WO2013054204A3 (fr)	2013-06-13	Procédé de fabrication d'un intermédiaire du cabazitaxel
WO2014102820A3 (fr)	2015-02-19	Intermédiaire du rivaroxaban et sa préparation
MX352620B (es)	2017-11-30	Polimeros de condensacion de acido mandelico.