TN2011000009A1 - Pyridazne derivatives as smo inhibitors - Google Patents
Pyridazne derivatives as smo inhibitorsInfo
- Publication number
- TN2011000009A1 TN2011000009A1 TN2011000009A TN2011000009A TN2011000009A1 TN 2011000009 A1 TN2011000009 A1 TN 2011000009A1 TN 2011000009 A TN2011000009 A TN 2011000009A TN 2011000009 A TN2011000009 A TN 2011000009A TN 2011000009 A1 TN2011000009 A1 TN 2011000009A1
- Authority
- TN
- Tunisia
- Prior art keywords
- methods
- agents
- pyridazne
- derivatives
- tumor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 241000027355 Ferocactus setispinus Species 0.000 abstract 2
- 208000005623 Carcinogenesis Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000036952 cancer formation Effects 0.000 abstract 1
- 231100000504 carcinogenesis Toxicity 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003463 hyperproliferative effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000005740 tumor formation Effects 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2009/059138 WO2010007120A1 (en) | 2008-07-18 | 2009-07-16 | Pyridazine derivatives as smo inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TN2011000009A1 true TN2011000009A1 (en) | 2012-09-05 |
Family
ID=55024324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TN2011000009A TN2011000009A1 (en) | 2009-07-16 | 2011-01-07 | Pyridazne derivatives as smo inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| TN (1) | TN2011000009A1 (en) |
-
2011
- 2011-01-07 TN TN2011000009A patent/TN2011000009A1/en unknown
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