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TN2009000451A1 - Intrvenous and oral dosing of a direct-acting and reversible p2y12 inhibitor - Google Patents

Intrvenous and oral dosing of a direct-acting and reversible p2y12 inhibitor

Info

Publication number
TN2009000451A1
TN2009000451A1 TNP2009000451A TN2009000451A TN2009000451A1 TN 2009000451 A1 TN2009000451 A1 TN 2009000451A1 TN P2009000451 A TNP2009000451 A TN P2009000451A TN 2009000451 A TN2009000451 A TN 2009000451A TN 2009000451 A1 TN2009000451 A1 TN 2009000451A1
Authority
TN
Tunisia
Prior art keywords
reversible
intrvenous
inhibitor
acting
direct
Prior art date
Application number
TNP2009000451A
Other languages
English (en)
Inventor
Robert M Scarborough
Daniel D Gretler
Pamela B Conley
Patrick Andre
Athiwat Hutchaleelaha
David R Phillips
Anjali Pandey
Huang Wolin
Original Assignee
Portola Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portola Pharm Inc filed Critical Portola Pharm Inc
Publication of TN2009000451A1 publication Critical patent/TN2009000451A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TNP2009000451A 2007-05-02 2009-10-30 Intrvenous and oral dosing of a direct-acting and reversible p2y12 inhibitor TN2009000451A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91564907P 2007-05-02 2007-05-02
US94792107P 2007-07-03 2007-07-03
PCT/US2008/062518 WO2008137753A2 (fr) 2007-05-02 2008-05-02 Dosage oral et intraveineux de l'inhibiteur p2y12 réversible et à action directe

Publications (1)

Publication Number Publication Date
TN2009000451A1 true TN2009000451A1 (en) 2011-03-31

Family

ID=39587015

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2009000451A TN2009000451A1 (en) 2007-05-02 2009-10-30 Intrvenous and oral dosing of a direct-acting and reversible p2y12 inhibitor

Country Status (17)

Country Link
US (2) US20090048216A1 (fr)
EP (1) EP2079464A2 (fr)
JP (1) JP2010526101A (fr)
KR (1) KR20100029746A (fr)
CN (1) CN101795682A (fr)
AU (1) AU2008247483A1 (fr)
BR (1) BRPI0811476A2 (fr)
CA (1) CA2686203A1 (fr)
CO (1) CO6241104A2 (fr)
EA (1) EA200901473A1 (fr)
EC (1) ECSP099778A (fr)
GT (1) GT200900284A (fr)
IL (1) IL201834A0 (fr)
MA (1) MA31663B1 (fr)
MX (1) MX2009011843A (fr)
TN (1) TN2009000451A1 (fr)
WO (1) WO2008137753A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1951254T3 (da) * 2005-11-03 2012-05-07 Portola Pharm Inc (4-(6-halo-7-substitueret-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl)¨-5-chlorthiophen-2-yl-sulfonylureaer og former og fremgangsmåder der er relateret dertil
AU2008223831B2 (en) * 2007-03-06 2012-07-05 Novartis Ag Bicyclic organic compounds suitable for the treatment of inflammatory or allergic conditions
CN101720324A (zh) * 2007-05-02 2010-06-02 波托拉医药品公司 [4-(6-氟-7-甲基氨基-2,4-二氧代-1,4-二氢-2h-喹唑啉-3-基)-苯基]-5-氯-噻吩-2-基-磺酰基脲盐、其相关的形式和方法
US20090156620A1 (en) * 2007-05-02 2009-06-18 Portola Pharmaceuticals, Inc. [4-(6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea salts, forms and methods related thereto
US9427448B2 (en) * 2009-11-11 2016-08-30 The Medicines Company Methods of treating, reducing the incidence of, and/or preventing ischemic events
KR20110115578A (ko) * 2008-12-30 2011-10-21 트롬보로직 에이피에스 장기 부전이 발달할 증가된 위험이 있는 중증 질환 환자의 확인 방법 및 이의 치료를 위한 화합물
ES2773040T3 (es) 2009-11-11 2020-07-09 Chiesi Farm Spa Métodos de tratamiento o prevención de trombosis de stent
US10376532B2 (en) 2009-11-11 2019-08-13 Chiesi Farmaceutici, S.P.A. Methods of treating, reducing the incidence of, and/or preventing ischemic events
ES2548845T3 (es) * 2009-12-23 2015-10-21 Ratiopharm Gmbh Forma de dosificación farmacéutica sólida de ticagrelor y ácido acetilsalicílico
EP2523657A1 (fr) 2010-01-12 2012-11-21 Portola Pharmaceuticals, Inc. Composition pharmaceutique et forme galénique de l'élinogrel et leurs méthodes d'application
WO2011137459A1 (fr) * 2010-04-30 2011-11-03 Portola Pharmaceuticals, Inc. Formes galéniques de l'élinogrel et leurs méthodes d'administration injectables
EP2646827A1 (fr) * 2010-12-01 2013-10-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Procédé et trousses pour déterminer la sensibilité des plaquettes à une activation dans un patient
CN103339126B (zh) * 2010-12-03 2016-06-29 博尔托拉制药公司 式(i)化合物的固态形式及其药物组合物、剂型和使用方法
TWI765002B (zh) 2017-03-15 2022-05-21 瑞士商愛杜西亞製藥有限公司 受體拮抗劑之皮下投藥
MX2019015448A (es) 2017-06-23 2020-02-19 Chiesi Farm Spa Metodo para la prevencion de trombosis de desviacion de la arteria sistemica a pulmonar.
CN107462648B (zh) * 2017-08-21 2019-09-27 盐城锦明药业有限公司 一种Cangrelor中间体腺苷-2-硫酮的高效液相色谱检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6906063B2 (en) 2000-02-04 2005-06-14 Portola Pharmaceuticals, Inc. Platelet ADP receptor inhibitors
DK1951254T3 (da) 2005-11-03 2012-05-07 Portola Pharm Inc (4-(6-halo-7-substitueret-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl)¨-5-chlorthiophen-2-yl-sulfonylureaer og former og fremgangsmåder der er relateret dertil

Also Published As

Publication number Publication date
CO6241104A2 (es) 2011-01-20
IL201834A0 (en) 2010-06-16
US20120009172A1 (en) 2012-01-12
CA2686203A1 (fr) 2008-11-13
CN101795682A (zh) 2010-08-04
GT200900284A (es) 2012-01-31
JP2010526101A (ja) 2010-07-29
BRPI0811476A2 (pt) 2014-11-04
ECSP099778A (es) 2010-01-29
KR20100029746A (ko) 2010-03-17
AU2008247483A1 (en) 2008-11-13
EA200901473A1 (ru) 2010-06-30
WO2008137753A2 (fr) 2008-11-13
WO2008137753A3 (fr) 2009-02-12
MX2009011843A (es) 2010-04-22
MA31663B1 (fr) 2010-09-01
US20090048216A1 (en) 2009-02-19
EP2079464A2 (fr) 2009-07-22

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