[go: up one dir, main page]

TN2009000072A1 - 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl)]carbamoyl}amino)-3-fluorophenoxy}-n-methylpyridine-2-carboxamide monohydrate - Google Patents

4-[4-({[4-chloro-3-(trifluoromethyl)phenyl)]carbamoyl}amino)-3-fluorophenoxy}-n-methylpyridine-2-carboxamide monohydrate

Info

Publication number
TN2009000072A1
TN2009000072A1 TN2009000072A TN2009000072A TN2009000072A1 TN 2009000072 A1 TN2009000072 A1 TN 2009000072A1 TN 2009000072 A TN2009000072 A TN 2009000072A TN 2009000072 A TN2009000072 A TN 2009000072A TN 2009000072 A1 TN2009000072 A1 TN 2009000072A1
Authority
TN
Tunisia
Prior art keywords
fluorophenoxy
methylpyridine
carbamoyl
trifluoromethyl
chloro
Prior art date
Application number
TN2009000072A
Other languages
English (en)
Inventor
Alfons Grunenberg
Juergen Stiehl
Katharina Tenbieg
Birgit Keil
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38972960&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TN2009000072(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of TN2009000072A1 publication Critical patent/TN2009000072A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
TN2009000072A 2006-10-11 2009-02-27 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl)]carbamoyl}amino)-3-fluorophenoxy}-n-methylpyridine-2-carboxamide monohydrate TN2009000072A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06021296 2006-10-11
PCT/EP2007/008503 WO2008043446A1 (fr) 2006-10-11 2007-09-29 4-[4-({[4-chloro-3-(trifluorométhyl)phényl]carbamoyl}amino)-3-fluorophénoxy]-n-méthylpyridine-2-carboxamide monohydraté

Publications (1)

Publication Number Publication Date
TN2009000072A1 true TN2009000072A1 (en) 2010-08-19

Family

ID=38972960

Family Applications (1)

Application Number Title Priority Date Filing Date
TN2009000072A TN2009000072A1 (en) 2006-10-11 2009-02-27 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl)]carbamoyl}amino)-3-fluorophenoxy}-n-methylpyridine-2-carboxamide monohydrate

Country Status (37)

Country Link
US (3) US9957232B2 (fr)
EP (1) EP2097381B1 (fr)
JP (1) JP5346293B2 (fr)
KR (1) KR101418623B1 (fr)
CN (1) CN101547903B (fr)
AR (1) AR062927A1 (fr)
AU (1) AU2007306716B2 (fr)
BR (1) BRPI0719828B1 (fr)
CA (1) CA2666170C (fr)
CL (1) CL2007002930A1 (fr)
CO (1) CO6150132A2 (fr)
CR (1) CR10663A (fr)
CY (1) CY1114637T1 (fr)
DK (1) DK2097381T3 (fr)
ES (1) ES2427358T3 (fr)
GT (1) GT200900057A (fr)
HN (1) HN2009000499A (fr)
IL (1) IL197369A (fr)
JO (1) JO3021B1 (fr)
MA (1) MA30878B1 (fr)
MX (1) MX2009002642A (fr)
MY (1) MY152595A (fr)
NZ (1) NZ576153A (fr)
PA (1) PA8750301A1 (fr)
PE (1) PE20081459A1 (fr)
PL (1) PL2097381T3 (fr)
PT (1) PT2097381E (fr)
RU (1) RU2466992C2 (fr)
SG (1) SG175584A1 (fr)
SI (1) SI2097381T1 (fr)
SV (1) SV2009003187A (fr)
TN (1) TN2009000072A1 (fr)
TW (1) TWI428322B (fr)
UA (1) UA95984C2 (fr)
UY (1) UY30633A1 (fr)
WO (1) WO2008043446A1 (fr)
ZA (1) ZA200902469B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1636585E (pt) * 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
PL1663978T3 (pl) 2003-07-23 2008-04-30 Bayer Healthcare Llc Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów
KR101381454B1 (ko) * 2004-09-29 2014-04-04 바이엘 인텔렉쳐 프로퍼티 게엠베하 열역학적으로 안정한 형태의 ｂａｙ 43-9006 토실레이트
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
EP2089363A1 (fr) * 2006-11-14 2009-08-19 Bayer Schering Pharma Aktiengesellschaft Polymorphe ii de 4-[4-({[4-chloro-3-(trifluorométhyl)phényl]carbamoyl}amino)-3-fluorophénoxy]-n-méthylpyridine-2-carboxamide
US8680124B2 (en) 2007-01-19 2014-03-25 Bayer Healthcare Llc Treatment of cancers with acquired resistance to kit inhibitors
AU2015201426B2 (en) * 2010-04-15 2016-07-07 Bayer Healthcare Llc Process for the preparation of 4- {4-[({[4 -chloro-3 -(trifluoromethyl)-phenyl]amino} carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
EP2595628A1 (fr) 2010-07-19 2013-05-29 Bayer HealthCare LLC Associations médicamenteuses contenant une oméga-carboxyaryl diphénylurée fluorosubstituée utilisées pour le traitement et la prévention de maladies et d'affections
KR20130099117A (ko) 2010-10-01 2013-09-05 바이엘 인텔렉쳐 프로퍼티 게엠베하 치환된 ｎ-(2-아릴아미노)아릴 설폰아미드 함유 배합물
WO2013000917A1 (fr) * 2011-06-28 2013-01-03 Bayer Intellectual Property Gmbh Composition pharmaceutique topique ophtalmologique contenant du régorafénib
UY35006A (es) 2012-09-06 2014-03-31 Bayer Healthcare Llc Composición farmacéutica recubierta que contiene regorafenib
WO2014048881A1 (fr) 2012-09-25 2014-04-03 Bayer Pharma Aktiengesellschaft Combinaison de régorafénib et d'acide acétylsalicylique destinée au traitement du cancer
UY35183A (es) 2012-12-21 2014-07-31 Bayer Healthcare Llc Composición farmacéutica oftalmológica tópica que contiene regorafenib
IN2013CH04511A (fr) * 2013-10-04 2015-04-10 Hetero Research Foundation
CN103923000A (zh) * 2014-01-29 2014-07-16 苏州晶云药物科技有限公司 几种新晶型及其制备方法
CN104829523B (zh) * 2014-04-30 2017-10-31 药源药物化学（上海）有限公司 瑞戈非尼盐及其晶型、制备方法
WO2016005874A1 (fr) 2014-07-09 2016-01-14 Shilpa Medicare Limited Procédé pour la préparation du régorafénib et ses formes cristallines
WO2016038590A1 (fr) 2014-09-12 2016-03-17 Mylan Laboratories Ltd Procédé de préparation de la forme cristalline i du régorafénib
CN104546776B (zh) * 2015-02-10 2017-08-22 杭州朱养心药业有限公司 瑞戈非尼片剂药物组合物和制法
CN105985287B (zh) * 2015-02-13 2018-07-17 上海京新生物医药有限公司 一种瑞戈非尼新晶型
CN107118153A (zh) * 2016-02-25 2017-09-01 石药集团中奇制药技术（石家庄）有限公司 一种瑞戈非尼一水合物晶型及其制备方法
CN105879049B (zh) * 2016-05-13 2019-03-26 浙江大学 一种瑞戈非尼与β-环糊精的包合物及其制备方法
BR112019025478A8 (pt) 2017-06-02 2022-12-06 Bayer Ag Combinação de regorafenib e inibidores de pd-1/pd-l1(2) para tratamento de câncer
EP3861989A1 (fr) 2020-02-07 2021-08-11 Bayer Aktiengesellschaft Composition pharmaceutique contenant du régorafénib et un agent de stabilisation
WO2021160708A1 (fr) 2020-02-14 2021-08-19 Bayer Aktiengesellschaft Combinaison de régorafenib et de msln-ttc pour traiter le cancer
CN111995571B (zh) * 2020-08-07 2021-12-03 天津理工大学 一种瑞戈非尼与马来酸的共晶及其制备方法

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6705789A (fr) 1967-03-08 1968-09-09
US4223153A (en) 1979-02-09 1980-09-16 Eli Lilly And Company Crystalline forms of N-2-(6-methoxy)benzothiazolyl N'-phenyl urea
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US4835180A (en) * 1986-10-02 1989-05-30 Sterling Drug Inc. N-(ω-cyanoalkyl)aminophenols and use as inhibitors of lipoxygenase activity
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
CO4410190A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
AU1153097A (en) * 1996-06-07 1998-01-05 Eisai Co. Ltd. Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production
NZ334346A (en) 1996-09-23 2000-05-26 Lilly Co Eli Olanzapine dihydrate D comprising 2-methyl-4-(4-methyl-1-piperazinyl)-1OH-thieno[2,3-b][1,5]benzodiazepine and a formulation for use in treating central nervous system disorders
US6344476B1 (en) * 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US6187799B1 (en) * 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
US20120046290A1 (en) * 1997-12-22 2012-02-23 Jacques Dumas Inhibition of p38 kinase activity using substituted heterocyclic ureas
US7329670B1 (en) * 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20070244120A1 (en) * 2000-08-18 2007-10-18 Jacques Dumas Inhibition of raf kinase using substituted heterocyclic ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
ATE556713T1 (de) * 1999-01-13 2012-05-15 Bayer Healthcare Llc Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer
EP1140840B1 (fr) * 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. Diphenylurees a substituants -g(v)-carboxyaryles, inhibitrices de kinase raf
ME00275B (fr) * 1999-01-13 2011-02-10 Bayer Corp DIPHENYLUREES A SUBSTITUANTS ω-CARBOXYARYLES, INHIBITRICES DE KINASE RAF
US8124630B2 (en) * 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7928239B2 (en) * 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
IN190389B (fr) * 1999-07-14 2003-07-26 Ranbaxy Lab Ltd
CA2396079A1 (fr) 2000-01-07 2001-07-19 Transform Pharmaceuticals, Inc. Formation, identification et analyse a productivites elevees de formes solides diverses
US7235576B1 (en) * 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
DE60216139T3 (de) 2001-12-03 2018-11-15 Bayer Healthcare Llc Arylharnstoff-verbindungen in kombination mit anderen zytostatisch oder zytotoxisch wirksamen stoffen zur behandlungen menschlicher krebserkrankungen
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
US7928277B1 (en) * 2002-02-11 2011-04-19 Cox Jr Henry Wilmore Method for reducing contamination
SI1580188T1 (sl) * 2002-02-11 2012-02-29 Bayer Healthcare Llc Aril sečnine kot kinazni inhibitorji
WO2003068229A1 (fr) * 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation N-oxydes de pyridine, de quinoline, et d'isoquinoline en tant qu'inhibiteurs de kinase
AU2003209116A1 (en) * 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas with angiogenesis inhibiting activity
DE60318035T2 (de) * 2002-05-03 2008-12-11 Janssen Pharmaceutica N.V. Polymermikroemulsionen
US7557129B2 (en) * 2003-02-28 2009-07-07 Bayer Healthcare Llc Cyanopyridine derivatives useful in the treatment of cancer and other disorders
PT1636585E (pt) 2003-05-20 2008-03-27 Bayer Pharmaceuticals Corp Diarilureias com actividade inibidora de cinase
PL1663978T3 (pl) * 2003-07-23 2008-04-30 Bayer Healthcare Llc Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów
WO2006125540A1 (fr) 2005-05-27 2006-11-30 Bayer Healthcare Ag Traitement de combinaison comprenant un compose diaryluree et des inhibiteurs de pi3- ou akt-kinase ou de mtor (rapamycines) pour le traitement du cancer
CA2542494A1 (fr) * 2003-10-15 2005-05-06 Bayer Healthcare Ag Derives de tetrahydro-naphthalene et d'uree
TWI338004B (en) 2004-02-06 2011-03-01 Bristol Myers Squibb Co Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors
US7838524B2 (en) * 2004-04-30 2010-11-23 Bayer Healthcare Llc Substituted pyrazolyl urea derivatives useful in the treatment of cancer
JP5128948B2 (ja) * 2004-08-27 2013-01-23 ニッポネックス インコーポレイテッド 癌の治療のための新規な薬剤組成物
MY191349A (en) 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
US8124782B2 (en) * 2004-09-29 2012-02-28 Bayer Pharma Aktiengesellschaft Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide
KR101381454B1 (ko) * 2004-09-29 2014-04-04 바이엘 인텔렉쳐 프로퍼티 게엠베하 열역학적으로 안정한 형태의 ｂａｙ 43-9006 토실레이트
UA93673C2 (ru) 2005-03-07 2011-03-10 Баер Шеринг Фарма Акциенгезельшафт Фармацевтическая композиция, которая содержит омега-карбоксиарилзамещенную дифенилмочевину, для лечения paka
AU2006251428A1 (en) * 2005-05-27 2006-11-30 Bayer Healthcare Ag Combination therapy comprising diaryl ureas for treating diseases
AU2006304764A1 (en) * 2005-10-21 2007-04-26 Bayer Healthcare Llc Methods for prediction and prognosis of cancer, and monitoring cancer therapy
US20090068146A1 (en) * 2005-10-31 2009-03-12 Scott Wilhelm Diaryl ureas and combinations
WO2007053573A2 (fr) * 2005-10-31 2007-05-10 Bayer Pharmaceuticals Corporation Traitement du cancer au moyen de sorafenib
US8329408B2 (en) * 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
AU2006312058A1 (en) * 2005-11-02 2007-05-18 Bayer Healthcare Llc Methods for prediction and prognosis of cancer, and monitoring cancer therapy
EP1948170A1 (fr) * 2005-11-10 2008-07-30 Bayer HealthCare AG Diaryle-uree permettant de traiter l'hypertension pulmonaire
DK1948176T3 (da) * 2005-11-10 2011-04-18 Bayer Schering Pharma Ag Diarylurinstoffer til behandling af pulmonær hypertension
MX2008006239A (es) * 2005-11-14 2008-12-12 Bayer Healthcare Llc Metodos para prediccion y pronostico de cancer y monitoreo de terapia contra el cancer.
US20100144749A1 (en) * 2005-11-14 2010-06-10 Scott Wilhelm Treatment of cancers with acquired resistance to kit inhibitors
US20110195110A1 (en) * 2005-12-01 2011-08-11 Roger Smith Urea compounds useful in the treatment of cancer
WO2007068383A1 (fr) * 2005-12-15 2007-06-21 Bayer Healthcare Ag Urees de diaryle pour le traitement d'infections virales
WO2007068380A1 (fr) * 2005-12-15 2007-06-21 Bayer Healthcare Ag Diaryle-uree pour le traitement d'infections virales
US20090227637A1 (en) * 2005-12-15 2009-09-10 Olaf Weber Diaryl ureas for treating virus infections
JP5331485B2 (ja) * 2005-12-21 2013-10-30 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 癌および他の障害の処置に有用な置換ピリミジン誘導体
MX2008014953A (es) * 2006-05-26 2009-03-05 Bayer Healthcare Llc Combinaciones de medicamentos con diarilureas sustituidas para el tratamiento de cancer.
AR062927A1 (es) 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
US20100063112A1 (en) * 2006-11-09 2010-03-11 Bayer Schering Pharma Aktiengesellschaft Polymorph iii of 4-[4-(amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide
EP2089363A1 (fr) * 2006-11-14 2009-08-19 Bayer Schering Pharma Aktiengesellschaft Polymorphe ii de 4-[4-({[4-chloro-3-(trifluorométhyl)phényl]carbamoyl}amino)-3-fluorophénoxy]-n-méthylpyridine-2-carboxamide
JP2010514691A (ja) * 2006-12-20 2010-05-06 バイエル ヘルスケア リミティド ライアビリティ カンパニー ４−｛４−〔（｛３−ｔｅｒｔ−ブチル−１−〔３−（ヒドロキシメチル）フェニル〕−１Ｈ−ピラゾール−５−イル｝カルバモイル）アミノ〕−３−フルオロフェノキシ｝−Ｎ−メチルピリジン−２−カルボキサミド並びに癌の治療のためのそれのプロドラッグ及び塩
ES2371723T3 (es) * 2006-12-20 2012-01-09 Bayer Healthcare, Llc 4-{4-[({3-terc-butil-1-[3-(hidroximetil)fenil]-1h-pirazol-5-il}carbamoil)amino]-3-clorofenoxi}-n-metilpiridina-2-carboxamida como un inhibidor de vegfr cinasa para el tratamiento contra el cáncer.
US8680124B2 (en) * 2007-01-19 2014-03-25 Bayer Healthcare Llc Treatment of cancers with acquired resistance to kit inhibitors
US20100173954A1 (en) * 2007-01-19 2010-07-08 Bayer Healthcare Llc Treatment of cancers having resistance to chemotherapeutic agents
WO2009092070A1 (fr) * 2008-01-17 2009-07-23 Sicor Inc. Polymorphes de forme iii de tosylate de sorafénib, solvate de méthanol tosylate de sorafénib et solvate d'éthanol tosylate de sorafénib, et procédés de préparation associés
WO2009156070A1 (fr) * 2008-06-25 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Diaryle-urée pour le traitement de l'insuffisance cardiaque
US20110257035A1 (en) * 2008-10-21 2011-10-20 Bayer Healthcare Llc Identification of signature genes associated with hepatocellular carcinoma
AU2010299484A1 (en) * 2009-09-24 2012-05-03 Ranbaxy Laboratories Limited Polymorphs of sorafenib acid addition salts
US8552197B2 (en) * 2009-11-12 2013-10-08 Ranbaxy Laboratories Limited Sorafenib ethylsulfonate salt, process for preparation and use
WO2011146725A1 (fr) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarqueurs pour un inhibiteur à multiples kinases
EP2595628A1 (fr) 2010-07-19 2013-05-29 Bayer HealthCare LLC Associations médicamenteuses contenant une oméga-carboxyaryl diphénylurée fluorosubstituée utilisées pour le traitement et la prévention de maladies et d'affections

Also Published As

Publication number Publication date
KR101418623B1 (ko) 2014-07-14
PE20081459A1 (es) 2008-12-18
PL2097381T3 (pl) 2013-11-29
ZA200902469B (en) 2010-06-30
AR062927A1 (es) 2008-12-17
AU2007306716B2 (en) 2013-06-20
JO3021B1 (ar) 2016-09-05
HK1136287A1 (en) 2010-06-25
KR20090061043A (ko) 2009-06-15
JP2010505888A (ja) 2010-02-25
AU2007306716A1 (en) 2008-04-17
CA2666170C (fr) 2016-05-24
UY30633A1 (es) 2008-05-31
UA95984C2 (en) 2011-09-26
US20100173953A1 (en) 2010-07-08
HN2009000499A (es) 2012-03-07
IL197369A (en) 2015-06-30
CR10663A (es) 2009-07-31
EP2097381B1 (fr) 2013-06-19
RU2009117388A (ru) 2010-11-20
MY152595A (en) 2014-10-31
CN101547903B (zh) 2014-01-15
CN101547903A (zh) 2009-09-30
EP2097381A1 (fr) 2009-09-09
TWI428322B (zh) 2014-03-01
CL2007002930A1 (es) 2008-04-04
US20140315958A1 (en) 2014-10-23
US20180194730A1 (en) 2018-07-12
TW200831465A (en) 2008-08-01
RU2466992C2 (ru) 2012-11-20
PT2097381E (pt) 2013-09-17
BRPI0719828B1 (pt) 2022-05-17
JP5346293B2 (ja) 2013-11-20
GT200900057A (es) 2009-12-09
BRPI0719828A2 (pt) 2014-02-04
CY1114637T1 (el) 2016-10-05
SG175584A1 (en) 2011-11-28
NZ576153A (en) 2012-02-24
ES2427358T3 (es) 2013-10-30
DK2097381T3 (da) 2013-09-23
MA30878B1 (fr) 2009-11-02
SI2097381T1 (sl) 2013-11-29
PA8750301A1 (es) 2009-01-23
US9957232B2 (en) 2018-05-01
CO6150132A2 (es) 2010-04-20
CA2666170A1 (fr) 2008-04-17
SV2009003187A (es) 2009-11-26
MX2009002642A (es) 2009-05-28
IL197369A0 (en) 2009-12-24
WO2008043446A1 (fr) 2008-04-17

Similar Documents

Publication Publication Date Title
TN2009000072A1 (en) 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl)]carbamoyl}amino)-3-fluorophenoxy}-n-methylpyridine-2-carboxamide monohydrate
SG155996A1 (en) Thermodynamically stable form of bay 43-9006 tosylate
SG155997A1 (en) Process for the preparation of 4-{4-[({[4-chloro-3- (trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n- methylpyridine-2-carboxamide
IL253119A0 (en) 4-{4[({[4-chloro-3-(trifluoroacetyl)phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-n-methylpyridine-2-carboxamide, its salts and monohydrate and preparations including it
ZA200804030B (en) Improved process for the preparation of 4-(benzimidazolylmethylamino)benzamides and the salts thereof
LTC1793824I2 (lt) Naujos farmacinės kompozicijos, apimančios 4-(4-(3-(4-chlor-3-trifluormetilfenil)ureido)-3-fluorfenoksi)piridin-2-karboksirūgštį, hiperproliferacinių sutrikimų gydymui
IL194850A (en) Benzoazepine-oxy-acetic acid derivatives used as delta-ppar agonists for raising c-hdl levels, lowering c-ldl levels, and lowering cholesterol levels and their pharmacological compounds
TWI347313B (en) Novel substituted phenoxyacetic acids,pharmaceutical composition comprising them,and use thereof
IL195786A (en) Annotations [2- (tetrazole-1-yl) phenyl] - n- methylcarboxamide and their pharmaceutical preparations
IL197213A (en) Binding protein that binds interleukin-13, a pharmaceutical preparation that contains it and its use in drug preparation
UA87865C2 (en) Hydrates and polymorphs of 4-[[(7r)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-4-6-oxo-2-piperidinyl]amino]-3-methoxy-n-(1-methyl-4-piperidinyl)-benzamide, methods for the production thereof, and use thereof as medicaments
WO2008148074A3 (fr) Inhibiteurs de mtor et methodes de traitement mettant en œuvre ces inhibiteurs
WO2007125105A3 (fr) Activateurs de la glucokinase benzamidique
WO2003062191A8 (fr) Esters hydroxamates d'acide n-(phenyl substitue en 4)-anthranilique
IL172604A (en) 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists, their preparation and pharmaceutical compositions comprising them
WO2015049698A3 (fr) Procédé pour le régorafénib
TW200637854A (en) Crystalline forms
CU20090039A7 (es) 4-[4-({[4-cloro-3-(trifluorometil)fenil]carbamoil}amino)-3-fluorofenoxi]-n-metilpiridina-2-carboxamida monohidrato
ZA200806876B (en) Crystal form of besipirdine chlorhydrate, process preparation and use thereof
TH98396A (th) 4-[4-({[4-คลอโร-3-(ไตรฟลูออโรเมทธิล)ฟีนิล]คาร์บาโมอิล}อะมิโน)-3-ฟลูออโรฟีนอกซี]-n-เมทธิลไพริดีน-2-คาร์บอกซาไมด์ โมโนไฮเดรท