TH129241A - 1,2,4-triazolone derivatives - Google Patents
1,2,4-triazolone derivativesInfo
- Publication number
- TH129241A TH129241A TH1301001645A TH1301001645A TH129241A TH 129241 A TH129241 A TH 129241A TH 1301001645 A TH1301001645 A TH 1301001645A TH 1301001645 A TH1301001645 A TH 1301001645A TH 129241 A TH129241 A TH 129241A
- Authority
- TH
- Thailand
- Prior art keywords
- disease
- formula
- disorder
- cerebral
- provides
- Prior art date
Links
Abstract
DC60 (11/06/56) การประดิษฐ์นี้ จัดเตรียมอนุพันธ์ 1,2,4-ไตรแอโซโลนที่แทนด้วยสูตร (1A) ที่มีกิจกรรมเป็น ปฏิปักษ์ (antagonistic activity) ต่ออาร์จินีน-แวโซเพรซซิน 1b รีเซพเตอร์ หรือ เกลือของสารที่ยอมรับ ได้เชิงเภสัชกรรม และให้องค์ประกอบเชิงเภสัชกรรมที่ประกอบรวมด้วย สารประกอบ หรือ เกลือ เป็นส่วนผสมมีฤทธิ์ โดยเฉพาะอย่างยิ่ง สารเพื่อการรักษา หรือการป้องกัน ที่แสดงเภสัช จลนพลศาสตร์ที่ (pharmacokinetics) ที่นิยมในโรค เช่น mood disorder, anxiety disorder, schizophernia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema,head injury, inflammation, immune-related disease, หรือ alopecia [สูตร 1] สูตรเคมี (1A)DC60 (11/06/56) The present invention provides 1,2,4-triazolone derivatives represented by formula (1A) having antagonistic activity towards the arginine-vasopressin 1b receptor or salts thereof which are pharmaceutically acceptable and provide pharmaceutical compositions comprising such compounds or salts as active ingredients, particularly therapeutic or preventative agents exhibiting pharmacokinetics favourable for diseases such as mood disorder, anxiety disorder, schizophernia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastrointestinal disease, drug addiction, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune-related disease, or alopecia [Formula 1] Chemical formula (1A)
Claims (1)
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TH129241A true TH129241A (en) | 2013-11-14 |
| TH104112B TH104112B (en) | 2024-10-21 |
Family
ID=
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12013500571A1 (en) | 1,2,4-triazolone derivative | |
| PH12015502628A1 (en) | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | |
| CY1109624T1 (en) | Substituted thiophene derivatives as glycogen receptor antagonists, preparations and therapeutic uses | |
| MX2015016344A (en) | Imidazopyrrolidinone derivatives and their use in the treatment of disease. | |
| PH12014500921A1 (en) | Azole derivative | |
| WO2006082523A3 (en) | Pharmaceutical sustained release composition of metformin | |
| WO2013100566A8 (en) | Phenyl alkyl carbamate derivative compound and pharmaceutical composition containing the same | |
| WO2007106181A3 (en) | Glucagon receptor antagonists, preparation and therapeutic uses | |
| WO2010098600A3 (en) | Substituted azole derivatives, pharmaceutical composition containing the derivatives, and method for treating parkinson's disease using the same | |
| WO2009017236A1 (en) | Pyridopyrimidin-4-one derivatives | |
| UY30847A1 (en) | USE OF DIANHYDROHEXITE MONONITRATE DERIVATIVES AS AGENTS FOR THE TREATMENT OF INTESTINAL DISORDERS | |
| UA107702C2 (en) | DERIVATIVES OF BENZAMIDE | |
| TH129241A (en) | 1,2,4-triazolone derivatives | |
| MX2012012410A (en) | Therapeutic agent and preventative agent for alzheimer's disease. | |
| TH104112B (en) | 1,2,4-triazolone derivatives | |
| EP2842938A4 (en) | NOVEL BETA-ALANINE DERIVATIVES, THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AS ACTIVE INGREDIENT | |
| DOP2014000116A (en) | INHIBITORS OF THE PEPTIDE DESFORMILASA | |
| WO2013074905A3 (en) | Compounds, compositions, pharmaceutical compositions, and methods of use | |
| WO2008105392A1 (en) | 3-amino-2-indolylbutyrolactam derivative, process for production of the same, and pharmaceutical agent comprising the same as active ingredient | |
| TH139453A (en) | Pharmaceutical formulas | |
| TH106997A (en) | New quinazoline -2,4-diploid derivatives and pharmaceutical constituents for the prevention or treatment of neurological brain disease. | |
| TH137278A (en) | 2,3-dihydro-1H-inden-1-il-2,7-diasaspai [3.5] nonane | |
| TH105749A (en) | Tri-Substitute 1,2,4 Triacole | |
| TH106084A (en) | Antitumor agents | |
| TH111755A (en) | Triazolopiridazine as PAR 1 inhibitors, their preparations and their use as drugs. |