SV2019005808A - Nuevos analógos de urocortina - 2 modificados con ácido graso para el tratamiento de diabetes y enfermedad renal cronica - Google Patents
Nuevos analógos de urocortina - 2 modificados con ácido graso para el tratamiento de diabetes y enfermedad renal cronicaInfo
- Publication number
- SV2019005808A SV2019005808A SV2019005808A SV2019005808A SV2019005808A SV 2019005808 A SV2019005808 A SV 2019005808A SV 2019005808 A SV2019005808 A SV 2019005808A SV 2019005808 A SV2019005808 A SV 2019005808A SV 2019005808 A SV2019005808 A SV 2019005808A
- Authority
- SV
- El Salvador
- Prior art keywords
- etoxi
- modified
- fatty acid
- amino
- urocortine
- Prior art date
Links
- 235000014113 dietary fatty acids Nutrition 0.000 title abstract 2
- 229930195729 fatty acid Natural products 0.000 title abstract 2
- 239000000194 fatty acid Substances 0.000 title abstract 2
- 150000004665 fatty acids Chemical group 0.000 title abstract 2
- 208000020832 chronic kidney disease Diseases 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- -1 AMINO Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002699 waste material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57509—Corticotropin releasing factor [CRF] (Urotensin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2228—Corticotropin releasing factor [CRF] (Urotensin)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
Abstract
LA PRESENTE INVENCIÓN PROPORCIONA UN COMPUESTO O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DE FÓRMULA: X1 I V X2 S L D V P I G L L Q I L X3 E Q E K Q E K E K Q Q A K * T N A X4 I L A Q V-NH2, EN DONDE EL X1 INDICA QUE EL RESIDUO I ES MODIFICADO YA SEA POR ACETILACIÓN O METILACIÓN EN EL EXTREMO N-TERMINAL; EN DONDE X2 ES L O T; EN DONDE X3 ES L O I; EN DONDE X4 ES Q O E; Y EN DONDE UN RESIDUO K MODIFICADO (¿K*¿) EN LA POSICIÓN 29 ES MODIFICADO A TRAVÉS DE LA CONJUGACIÓN AL GRUPO EPSILÓN ¿ AMINO DE LA CADENA LATERAL K CON UN GRUPO DE LA FÓRMULA ¿X5-X6, EN DONDE X5 SE SELECCIONA DEL GRUPO QUE CONSISTE DE UNO A CUATRO AMINOÁCIDOS; UNA A CUATRO PORCIONES DE ( [2 ¿ (2-AMINO-ETOXI) - ETOXI] ¿ ACETIL); Y COMBINACIONES DE UNO A CUATRO AMINOÁCIDOS Y UNA A CUATRO PORCIONES DE ( [2 ¿ (2-AMINO-ETOXI) ¿ ETOXI] ¿ ACETIL); Y X6 ES UNA ÁCIDO GRASO DE C14-C24. EN ALGUNAS MODALIDADES, EL GRUPO DE LA FÓRMULA ¿X5-X6 ES ( [2 ¿ (2-AMINO-ETOXI) ¿ ETOXI] ¿ ACETIL) 2- (YE)2 ¿ CO ¿ (CH2)X ¿ CO2H DONDE X ES 16 O 18
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662362711P | 2016-07-15 | 2016-07-15 | |
| US201662431682P | 2016-12-08 | 2016-12-08 | |
| US201762491385P | 2017-04-28 | 2017-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2019005808A true SV2019005808A (es) | 2019-04-04 |
Family
ID=59501524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2019005808A SV2019005808A (es) | 2016-07-15 | 2019-01-11 | Nuevos analógos de urocortina - 2 modificados con ácido graso para el tratamiento de diabetes y enfermedad renal cronica |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10894817B2 (es) |
| EP (1) | EP3484495B1 (es) |
| JP (1) | JP2019525919A (es) |
| KR (1) | KR20190017982A (es) |
| CN (1) | CN109475592B (es) |
| AU (1) | AU2017295708B2 (es) |
| BR (1) | BR112018076693A2 (es) |
| CA (1) | CA3030965C (es) |
| CL (1) | CL2019000043A1 (es) |
| CO (1) | CO2018014026A2 (es) |
| CR (1) | CR20190015A (es) |
| DO (1) | DOP2019000007A (es) |
| EC (1) | ECSP19003047A (es) |
| ES (1) | ES2901477T3 (es) |
| IL (1) | IL264025A (es) |
| JO (1) | JOP20170153A1 (es) |
| MA (1) | MA45673A (es) |
| MX (1) | MX2019000661A (es) |
| PE (1) | PE20190470A1 (es) |
| PH (1) | PH12019500074A1 (es) |
| SG (1) | SG11201811737SA (es) |
| SV (1) | SV2019005808A (es) |
| TW (1) | TW201811821A (es) |
| WO (1) | WO2018013803A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
| HUE064656T2 (hu) | 2016-03-28 | 2024-04-28 | Incyte Corp | Pirrolotriazin vegyületek mint TAM inhibitorok |
| KR102739325B1 (ko) | 2017-09-27 | 2024-12-09 | 인사이트 코포레이션 | Tam 억제제로서 유용한 피롤로트리아진 유도체의 염 |
| WO2019140024A1 (en) * | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| WO2019140030A1 (en) * | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| WO2019140023A1 (en) * | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| WO2019140025A1 (en) * | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| WO2019140021A1 (en) * | 2018-01-12 | 2019-07-18 | Eli Lilly And Company | Combination therapy |
| ES3031110T3 (en) | 2018-06-29 | 2025-07-04 | Incyte Corp | Formulations of an axl/mer inhibitor |
| US20200027555A1 (en) * | 2018-07-17 | 2020-01-23 | Lewis Pharmaceutical Information, Inc. | Patient centric drug analysis platform |
| AU2021230385A1 (en) | 2020-03-06 | 2022-09-22 | Incyte Corporation | Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors |
| CN116472053A (zh) | 2020-08-19 | 2023-07-21 | 赛诺菲公司 | Crf2受体激动剂及其在治疗中的用途 |
| WO2022159395A1 (en) | 2021-01-20 | 2022-07-28 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| WO2023285347A1 (en) | 2021-07-12 | 2023-01-19 | Novo Nordisk A/S | Novel fatty acid modified urocortin 2 derivatives and the uses thereof |
| EP4259647A4 (en) | 2021-09-15 | 2025-03-26 | Viking Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES |
| EP4234574A1 (en) | 2022-02-23 | 2023-08-30 | Corteria Pharmaceuticals | Crf2 receptor agonists and their use in therapy |
| WO2025104264A1 (en) | 2023-11-17 | 2025-05-22 | Gubra A/S | Hcrhr2 selective polypeptides |
| JP2025082834A (ja) * | 2023-11-17 | 2025-05-29 | イーライ リリー アンド カンパニー | 糖尿病又は肥満の治療のための化合物 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995034651A2 (en) | 1994-06-14 | 1995-12-21 | Neurocrine Biosciences, Inc. | Corticotropin-releasing factor2 receptors |
| AU6277796A (en) * | 1995-06-13 | 1997-01-15 | Salk Institute For Biological Studies, The | Urocortin peptides |
| US20040034882A1 (en) | 1999-07-15 | 2004-02-19 | Vale Wylie W. | Corticotropin releasing factor receptor 2 deficient mice and uses thereof |
| KR100879232B1 (ko) * | 2000-08-04 | 2009-01-20 | 리서치 디벨럽먼트 파운데이션 | 우로코르틴 단백질 및 이를 포함하는 약제학적 조성물 |
| US20020082409A1 (en) | 2000-10-26 | 2002-06-27 | Hsu Sheau Yu | Stresscopins and their uses |
| AU2002306853B2 (en) | 2001-03-15 | 2006-07-06 | Research Development Foundation | Urocortin-III and uses thereof |
| US7192924B2 (en) | 2002-01-16 | 2007-03-20 | The Procter & Gamble Company | Corticotropin releasing factor 2 receptor agonists |
| GR1004664B (en) | 2002-11-26 | 2004-09-02 | Bionature E A Ltd | The charakteristics and advantages of our invention are illustrated by the following description, methods and results of our research, attached figures and supporting references |
| WO2005103690A2 (en) | 2004-04-24 | 2005-11-03 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with corticotropin releasing hormone receptor 2 (crhr2) |
| US7869958B2 (en) | 2004-08-09 | 2011-01-11 | Research Development Foundation | Structure-based modulators of B1 G-protein coupled receptors |
| CN101137668B (zh) | 2005-02-08 | 2011-08-17 | 研究发展基金会 | 与可溶性G蛋白偶联受体（sGPCR）有关的组合物与方法 |
| US7815905B2 (en) | 2006-01-27 | 2010-10-19 | Research Development Foundation | Methods of increasing insulin sensitivity or decreasing insulin secretion by administering corticotropin releasing factor receptor-2 inhibitors |
| EP2114437A2 (en) * | 2006-10-16 | 2009-11-11 | ConjuChem Biotechnologies Inc. | Modified corticotropin releasing factor peptides and uses thereof |
| EP2167094A2 (en) | 2007-06-13 | 2010-03-31 | Research Development Foundation | Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating crf receptor signaling |
| US10040838B2 (en) | 2008-11-04 | 2018-08-07 | Janssen Pharmaceutica Nv | CRHR2 peptide agonists and uses thereof |
| WO2011025905A1 (en) * | 2009-08-28 | 2011-03-03 | Research Development Foundation | Urocortin 2 analogs and uses thereof |
| EP2496248A2 (en) | 2009-11-04 | 2012-09-12 | Janssen Pharmaceutica, N.V. | Method for treating heart failure with stresscopin-like peptides |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| CN102753527B (zh) | 2010-02-02 | 2014-12-24 | 诺华股份有限公司 | 用作crf受体拮抗剂的环己基酰胺衍生物 |
| WO2013063046A1 (en) | 2011-10-24 | 2013-05-02 | Research Development Foundation | Methods for increasing insulin secretion by co-stimulation of corticotropin-releasing factor receptors |
| KR20160137908A (ko) | 2014-04-03 | 2016-12-01 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 당뇨병-연관 심기능 장애 및 울혈성 심부전을 치료하기 위한 우로코르틴-2 및 연관 유전자들을 인코딩하는 바이러스 벡터들의 전신 전달 |
| AR104932A1 (es) * | 2015-06-22 | 2017-08-23 | Lilly Co Eli | Compuestos co-agonistas del glucagón y péptido-1 similar al glugacón (glp-1) |
| WO2017220706A1 (en) * | 2016-06-22 | 2017-12-28 | Novo Nordisk A/S | Pharmaceutical compositions of fgf21 derivatives and uses thereof |
-
2016
- 2016-07-15 JO JOP/2017/0153A patent/JOP20170153A1/ar unknown
-
2017
- 2017-06-30 TW TW106121914A patent/TW201811821A/zh unknown
- 2017-07-13 AU AU2017295708A patent/AU2017295708B2/en not_active Ceased
- 2017-07-13 CN CN201780043923.7A patent/CN109475592B/zh active Active
- 2017-07-13 CR CR20190015A patent/CR20190015A/es unknown
- 2017-07-13 JP JP2019501685A patent/JP2019525919A/ja not_active Withdrawn
- 2017-07-13 MA MA045673A patent/MA45673A/fr unknown
- 2017-07-13 CA CA3030965A patent/CA3030965C/en active Active
- 2017-07-13 WO PCT/US2017/041922 patent/WO2018013803A1/en not_active Ceased
- 2017-07-13 MX MX2019000661A patent/MX2019000661A/es unknown
- 2017-07-13 EP EP17746231.4A patent/EP3484495B1/en active Active
- 2017-07-13 ES ES17746231T patent/ES2901477T3/es active Active
- 2017-07-13 BR BR112018076693-3A patent/BR112018076693A2/pt not_active Application Discontinuation
- 2017-07-13 KR KR1020197001249A patent/KR20190017982A/ko not_active Withdrawn
- 2017-07-13 US US15/648,542 patent/US10894817B2/en active Active
- 2017-07-13 PE PE2019000060A patent/PE20190470A1/es unknown
- 2017-07-13 SG SG11201811737SA patent/SG11201811737SA/en unknown
-
2018
- 2018-12-21 CO CONC2018/0014026A patent/CO2018014026A2/es unknown
- 2018-12-30 IL IL264025A patent/IL264025A/en unknown
-
2019
- 2019-01-07 CL CL2019000043A patent/CL2019000043A1/es unknown
- 2019-01-10 DO DO2019000007A patent/DOP2019000007A/es unknown
- 2019-01-11 PH PH12019500074A patent/PH12019500074A1/en unknown
- 2019-01-11 SV SV2019005808A patent/SV2019005808A/es unknown
- 2019-01-15 EC ECSENADI20193047A patent/ECSP19003047A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2017295708A1 (en) | 2018-12-20 |
| WO2018013803A1 (en) | 2018-01-18 |
| PH12019500074A1 (en) | 2019-07-29 |
| ECSP19003047A (es) | 2019-01-31 |
| KR20190017982A (ko) | 2019-02-20 |
| CL2019000043A1 (es) | 2019-06-07 |
| CR20190015A (es) | 2019-02-27 |
| EP3484495A1 (en) | 2019-05-22 |
| US10894817B2 (en) | 2021-01-19 |
| SG11201811737SA (en) | 2019-01-30 |
| CO2018014026A2 (es) | 2019-01-18 |
| ES2901477T3 (es) | 2022-03-22 |
| JOP20170153A1 (ar) | 2019-01-30 |
| JP2019525919A (ja) | 2019-09-12 |
| BR112018076693A2 (pt) | 2019-04-02 |
| AU2017295708B2 (en) | 2019-05-09 |
| CA3030965A1 (en) | 2018-01-18 |
| CN109475592A (zh) | 2019-03-15 |
| DOP2019000007A (es) | 2019-04-15 |
| PE20190470A1 (es) | 2019-04-04 |
| MA45673A (fr) | 2021-05-26 |
| CN109475592B (zh) | 2022-08-09 |
| IL264025A (en) | 2019-01-31 |
| CA3030965C (en) | 2022-04-26 |
| TW201811821A (zh) | 2018-04-01 |
| EP3484495B1 (en) | 2021-09-08 |
| MX2019000661A (es) | 2019-05-15 |
| US20180016318A1 (en) | 2018-01-18 |
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