SV2017005489A - Terapias de combinación para el tratamiento de cánceres - Google Patents
Terapias de combinación para el tratamiento de cánceresInfo
- Publication number
- SV2017005489A SV2017005489A SV2017005489A SV2017005489A SV2017005489A SV 2017005489 A SV2017005489 A SV 2017005489A SV 2017005489 A SV2017005489 A SV 2017005489A SV 2017005489 A SV2017005489 A SV 2017005489A SV 2017005489 A SV2017005489 A SV 2017005489A
- Authority
- SV
- El Salvador
- Prior art keywords
- cancer treatment
- combination therapies
- cancer
- treatment
- malignities
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000002648 combination therapy Methods 0.000 title 1
- XSMSNFMDVXXHGJ-UHFFFAOYSA-N 6-(1h-indazol-6-yl)-n-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyrazin-8-amine Chemical compound C1COCCN1C(C=C1)=CC=C1NC1=NC(C=2C=C3NN=CC3=CC=2)=CN2C1=NC=C2 XSMSNFMDVXXHGJ-UHFFFAOYSA-N 0.000 abstract 1
- HPLNQCPCUACXLM-PGUFJCEWSA-N ABT-737 Chemical compound C([C@@H](CCN(C)C)NC=1C(=CC(=CC=1)S(=O)(=O)NC(=O)C=1C=CC(=CC=1)N1CCN(CC=2C(=CC=CC=2)C=2C=CC(Cl)=CC=2)CC1)[N+]([O-])=O)SC1=CC=CC=C1 HPLNQCPCUACXLM-PGUFJCEWSA-N 0.000 abstract 1
- 239000012664 BCL-2-inhibitor Substances 0.000 abstract 1
- 229940123711 Bcl2 inhibitor Drugs 0.000 abstract 1
- 229950004136 entospletinib Drugs 0.000 abstract 1
- 230000002489 hematologic effect Effects 0.000 abstract 1
- 229950004847 navitoclax Drugs 0.000 abstract 1
- JLYAXFNOILIKPP-KXQOOQHDSA-N navitoclax Chemical compound C([C@@H](NC1=CC=C(C=C1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C1=CC=C(C=C1)N1CCN(CC1)CC1=C(CCC(C1)(C)C)C=1C=CC(Cl)=CC=1)CSC=1C=CC=CC=1)CN1CCOCC1 JLYAXFNOILIKPP-KXQOOQHDSA-N 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- LQBVNQSMGBZMKD-UHFFFAOYSA-N venetoclax Chemical compound C=1C=C(Cl)C=CC=1C=1CC(C)(C)CCC=1CN(CC1)CCN1C(C=C1OC=2C=C3C=CNC3=NC=2)=CC=C1C(=O)NS(=O)(=O)C(C=C1[N+]([O-])=O)=CC=C1NCC1CCOCC1 LQBVNQSMGBZMKD-UHFFFAOYSA-N 0.000 abstract 1
- 229960001183 venetoclax Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE PROPORCIONAN EN EL PRESENTE DOCUMENTO MÉTODOS QUE SE RELACIONAN CON UNA ESTRATEGIA TERAPÉUTICA PARA EL TRATAMIENTO DEL CÁNCER, INCLUYENDO MALIGNIDADES HEMATOLÓGICAS. EN PARTICULAR, LOS MÉTODOS INCLUYEN LA ADMINISTRACIÓN DE ENTOSPLETINIB Y UN INHIBIDOR DE BCL-2, TAL COMO VENETOCLAX, NAVITOCLAX Y ABT-737
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562111604P | 2015-02-03 | 2015-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2017005489A true SV2017005489A (es) | 2017-10-17 |
Family
ID=55398445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2017005489A SV2017005489A (es) | 2015-02-03 | 2017-07-28 | Terapias de combinación para el tratamiento de cánceres |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20160220573A1 (es) |
| EP (1) | EP3253385A1 (es) |
| JP (1) | JP2018503653A (es) |
| KR (1) | KR20170104616A (es) |
| CN (1) | CN107205992A (es) |
| AU (1) | AU2016215643A1 (es) |
| BR (1) | BR112017016019A2 (es) |
| CA (1) | CA2974828A1 (es) |
| CL (1) | CL2017001943A1 (es) |
| CO (1) | CO2017007662A2 (es) |
| CR (1) | CR20170352A (es) |
| CU (1) | CU20170099A7 (es) |
| EA (1) | EA201791516A1 (es) |
| EC (1) | ECSP17048849A (es) |
| GT (1) | GT201700167A (es) |
| IL (1) | IL253573A0 (es) |
| MA (1) | MA41449A (es) |
| MD (1) | MD20170073A2 (es) |
| MX (1) | MX2017009724A (es) |
| PE (1) | PE20171241A1 (es) |
| PH (1) | PH12017550063A1 (es) |
| SG (1) | SG11201706107SA (es) |
| SV (1) | SV2017005489A (es) |
| TW (1) | TW201639573A (es) |
| WO (1) | WO2016126552A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009325133B2 (en) | 2008-12-08 | 2016-02-04 | Gilead Connecticut, Inc. | Imidazopyrazine Syk inhibitors |
| KR101717809B1 (ko) | 2010-03-11 | 2017-03-17 | 질레드 코네티컷 인코포레이티드 | 이미다조피리딘 syk 억제제 |
| WO2015017460A1 (en) | 2013-07-30 | 2015-02-05 | Gilead Connecticut, Inc. | Polymorph of syk inhibitors |
| JP6159028B2 (ja) | 2013-07-31 | 2017-07-05 | ギリアード サイエンシーズ, インコーポレイテッド | Syk阻害剤 |
| JP6298539B2 (ja) | 2013-12-04 | 2018-03-20 | ギリアード サイエンシーズ, インコーポレイテッド | がんを処置する方法 |
| UY35898A (es) | 2013-12-23 | 2015-07-31 | Gilead Sciences Inc | ?compuestos inhibidores de syk y composiciones que los comprenden?. |
| EA201790086A1 (ru) | 2014-07-14 | 2017-07-31 | Джилид Сайэнс, Инк. | Комбинации для лечения раковых заболеваний |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Hdac抑制劑與pd-l1抑制劑之組合治療 |
| US10111882B2 (en) | 2016-09-14 | 2018-10-30 | Gilead Sciences, Inc. | SYK inhibitors |
| US10759798B2 (en) * | 2016-09-14 | 2020-09-01 | Hangzhou Solipharma Co., Ltd. | ABT-199 addition salt and crystal form thereof, preparation method thereof, and pharmaceutical composition thereof |
| CN110612109A (zh) * | 2017-04-28 | 2019-12-24 | 锕医药有限责任公司 | 使用BCL-2抑制剂连同α-发射放射免疫治疗来治疗癌症的方法 |
| CN111051311A (zh) | 2017-08-25 | 2020-04-21 | 吉利德科学公司 | Syk抑制剂的多晶型物 |
| US11318134B2 (en) | 2018-01-10 | 2022-05-03 | Recurium Ip Holdings, Llc | Benzamide compounds |
| AU2020225455A1 (en) | 2019-02-22 | 2021-09-09 | Kronos Bio, Inc. | Solid forms of condensed pyrazines as Syk inhibitors |
| AU2020293230A1 (en) | 2019-06-12 | 2022-01-27 | Juno Therapeutics, Inc. | Combination therapy of a cell-mediated cytotoxic therapy and an inhibitor of a prosurvival BCL2 family protein |
| US12514863B2 (en) | 2019-12-04 | 2026-01-06 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical combination and use thereof |
| WO2022133030A1 (en) | 2020-12-16 | 2022-06-23 | Juno Therapeutics, Inc. | Combination therapy of a cell therapy and a bcl2 inhibitor |
| AU2022255990A1 (en) * | 2021-04-05 | 2023-10-26 | Pinotbio, Inc. | Combined therapy of 4'-thio-5-aza-2'-deoxycytidine and venetoclax |
| KR20240144146A (ko) * | 2022-02-02 | 2024-10-02 | 오노 야꾸힝 고교 가부시키가이샤 | Malt1 저해약을 유효 성분으로서 포함하는 암 치료제 |
| US20250302954A1 (en) | 2022-05-11 | 2025-10-02 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5182297A (en) | 1988-02-25 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4943593A (en) | 1988-02-25 | 1990-07-24 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5021456A (en) | 1988-02-25 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5059714A (en) | 1988-02-25 | 1991-10-22 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5252608A (en) | 1988-02-25 | 1993-10-12 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4965288A (en) | 1988-02-25 | 1990-10-23 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US5120764A (en) | 1988-11-01 | 1992-06-09 | Merrell Dow Pharmaceuticals Inc. | Inhibitors of lysyl oxidase |
| US4997854A (en) | 1989-08-25 | 1991-03-05 | Trustees Of Boston University | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates |
| FR2828206B1 (fr) | 2001-08-03 | 2004-09-24 | Centre Nat Rech Scient | Utilisation d'inhibiteurs des lysyl oxydases pour la culture cellulaire et le genie tissulaire |
| US7973161B2 (en) | 2003-11-13 | 2011-07-05 | Abbott Laboratories | Apoptosis promoters |
| GB0326780D0 (en) * | 2003-11-18 | 2003-12-24 | Imp College Innovations Ltd | Biological materials and uses thereof |
| WO2005113556A1 (en) | 2004-05-13 | 2005-12-01 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| US20090142345A1 (en) | 2005-03-15 | 2009-06-04 | Takeda Pharmaceutical Company Limited | Prophylactic/therapeutic agent for cancer |
| KR101509440B1 (ko) | 2005-05-12 | 2015-04-07 | 애브비 바하마스 리미티드 | 아폽토시스 촉진제 |
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| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
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| LT2643322T (lt) | 2010-11-23 | 2018-01-10 | Abbvie Inc. | Apoptozę skatinančio agento druskos ir kristalinės formos |
| EP2749572A4 (en) | 2011-08-23 | 2015-04-01 | Chugai Pharmaceutical Co Ltd | NEW ANTI-DDR1 ANTIBODY WITH ANTITUMORACTIVITY |
| GB201115529D0 (en) | 2011-09-08 | 2011-10-26 | Imp Innovations Ltd | Antibodies, uses and methods |
| CA2850763A1 (en) | 2011-10-04 | 2013-04-11 | Gilead Calistoga Llc | Novel quinoxaline inhibitors of pi3k |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| WO2013116562A1 (en) | 2012-02-03 | 2013-08-08 | Gilead Calistoga Llc | Compositions and methods of treating a disease with (s)-4 amino-6-((1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile |
| JP2015529195A (ja) * | 2012-08-14 | 2015-10-05 | ギリアード カリストガ エルエルシー | 癌を処置するための組合せ治療 |
| CN104768581A (zh) * | 2012-09-07 | 2015-07-08 | 吉宁特有限公司 | II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗 |
| WO2014047624A1 (en) | 2012-09-24 | 2014-03-27 | Gilead Sciences, Inc. | Anti-ddr1 antibodies |
| JP6125663B2 (ja) | 2012-12-21 | 2017-05-10 | ギリアード カリストガ エルエルシー | ホスファチジルイノシトール3−キナーゼ阻害剤としての置換ピリミジンアミノアルキル−キナゾロン |
| US9029384B2 (en) | 2012-12-21 | 2015-05-12 | Gilead Calistoga, LLC. | Phosphatidylinositol 3-kinase inhibitors |
| HK1223911A1 (zh) | 2013-06-14 | 2017-08-11 | Gilead Sciences, Inc. | 磷脂醯肌醇3-激酶抑制剂 |
| WO2015017466A1 (en) | 2013-07-30 | 2015-02-05 | Gilead Connecticut, Inc. | Formulation of syk inhibitors |
| WO2015017460A1 (en) | 2013-07-30 | 2015-02-05 | Gilead Connecticut, Inc. | Polymorph of syk inhibitors |
-
2016
- 2016-01-21 TW TW105101876A patent/TW201639573A/zh unknown
- 2016-01-28 MA MA041449A patent/MA41449A/fr unknown
- 2016-01-29 CR CR20170352A patent/CR20170352A/es unknown
- 2016-01-29 WO PCT/US2016/015727 patent/WO2016126552A1/en not_active Ceased
- 2016-01-29 CN CN201680007860.5A patent/CN107205992A/zh active Pending
- 2016-01-29 CA CA2974828A patent/CA2974828A1/en not_active Abandoned
- 2016-01-29 JP JP2017539623A patent/JP2018503653A/ja active Pending
- 2016-01-29 EA EA201791516A patent/EA201791516A1/ru unknown
- 2016-01-29 AU AU2016215643A patent/AU2016215643A1/en not_active Abandoned
- 2016-01-29 CU CUP2017000099A patent/CU20170099A7/es unknown
- 2016-01-29 SG SG11201706107SA patent/SG11201706107SA/en unknown
- 2016-01-29 BR BR112017016019A patent/BR112017016019A2/pt not_active Application Discontinuation
- 2016-01-29 US US15/010,906 patent/US20160220573A1/en not_active Abandoned
- 2016-01-29 EP EP16705384.2A patent/EP3253385A1/en not_active Withdrawn
- 2016-01-29 MX MX2017009724A patent/MX2017009724A/es unknown
- 2016-01-29 PE PE2017001282A patent/PE20171241A1/es not_active Application Discontinuation
- 2016-01-29 MD MDA20170073A patent/MD20170073A2/ro not_active Application Discontinuation
- 2016-01-29 US US15/548,401 patent/US20180117052A1/en not_active Abandoned
- 2016-01-29 KR KR1020177023454A patent/KR20170104616A/ko not_active Ceased
-
2017
- 2017-07-19 IL IL253573A patent/IL253573A0/en unknown
- 2017-07-27 GT GT201700167A patent/GT201700167A/es unknown
- 2017-07-28 EC ECIEPI201748849A patent/ECSP17048849A/es unknown
- 2017-07-28 SV SV2017005489A patent/SV2017005489A/es unknown
- 2017-07-28 CL CL2017001943A patent/CL2017001943A1/es unknown
- 2017-07-28 CO CONC2017/0007662A patent/CO2017007662A2/es unknown
- 2017-07-31 PH PH12017550063A patent/PH12017550063A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL253573A0 (en) | 2017-09-28 |
| TW201639573A (zh) | 2016-11-16 |
| US20160220573A1 (en) | 2016-08-04 |
| EA201791516A1 (ru) | 2018-01-31 |
| ECSP17048849A (es) | 2017-10-31 |
| EP3253385A1 (en) | 2017-12-13 |
| JP2018503653A (ja) | 2018-02-08 |
| US20180117052A1 (en) | 2018-05-03 |
| CA2974828A1 (en) | 2016-08-11 |
| MD20170073A2 (ro) | 2018-02-28 |
| CR20170352A (es) | 2017-09-29 |
| CN107205992A (zh) | 2017-09-26 |
| CU20170099A7 (es) | 2018-03-13 |
| MA41449A (fr) | 2017-12-12 |
| PE20171241A1 (es) | 2017-08-24 |
| KR20170104616A (ko) | 2017-09-15 |
| SG11201706107SA (en) | 2017-08-30 |
| GT201700167A (es) | 2017-11-02 |
| BR112017016019A2 (pt) | 2018-03-20 |
| MX2017009724A (es) | 2017-11-17 |
| CL2017001943A1 (es) | 2018-03-02 |
| PH12017550063A1 (en) | 2018-02-05 |
| WO2016126552A1 (en) | 2016-08-11 |
| CO2017007662A2 (es) | 2017-10-20 |
| AU2016215643A1 (en) | 2017-08-10 |
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