SV2010003780A - A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD - Google Patents
A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOODInfo
- Publication number
- SV2010003780A SV2010003780A SV2010003780A SV2010003780A SV2010003780A SV 2010003780 A SV2010003780 A SV 2010003780A SV 2010003780 A SV2010003780 A SV 2010003780A SV 2010003780 A SV2010003780 A SV 2010003780A SV 2010003780 A SV2010003780 A SV 2010003780A
- Authority
- SV
- El Salvador
- Prior art keywords
- salt
- glycinate
- blood
- metformin
- glucose
- Prior art date
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 3
- 239000008280 blood Substances 0.000 title abstract 3
- 210000004369 blood Anatomy 0.000 title abstract 3
- 239000008103 glucose Substances 0.000 title abstract 3
- KOFRCHIVYXPUNL-UHFFFAOYSA-N 2-aminoacetic acid;3-(diaminomethylidene)-1,1-dimethylguanidine Chemical class NCC(O)=O.CN(C)C(=N)N=C(N)N KOFRCHIVYXPUNL-UHFFFAOYSA-N 0.000 title abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical class NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical class CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 238000010792 warming Methods 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960003105 metformin Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA SÍNTESIS DE UNA NUEVA SAL DE GLICINATO 1,1-5 DIMETILBIGUANID, LLAMADA GLICINATO DE METFORMINA DISEÑADA PARA EL CONTROL DE LA GLUCOSA EN SANGRE. ESTA SAL EXHIBE VENTAJAS SOBRE OTRAS SALES DE METFORMINA. ESTAS VENTAJAS SE REFIEREN, EN PRIMER LUGAR, AL HECHO DE QUE EL CONTRAIÓN EXHIBE EFECTOS HIPOGLUCEMIENTES POR SI MISMOS, EL EFECTO HIPOGLUCEMIENTE ES MÁS PRONUNCIADO. ADEMÁS ESTA SAL EXHIBE UNA MEJOR ABSORCIÓN, ALCANZANDO UNA CONCENTRACIÓN PLASMÁTICA MÁS ALTA QUE AQUELLA PRODUCIDA CON CLORHIDRATO DE METFROMINA. LA SÍNTESIS SE LLEVO A CABO A PARTIR DE CLORHIDRATO DE METFORMINA LIBERANDO EL CONTRAIÓN HIDROCLORURO, USANDO UNA COLUMNA DE INTERCAMBIO IÓNICO, LA METFORMINA LIBERADA SE DISOLVIÓ EN MEDIO ACUOSO Y SUBSECUENTEMENTE SE ADICIONO GLICINA A TEMPERATURA AMBIENTE Y AGITACIÓN CONSTANTE, EL PRODUCTO RESULTANTE SE CALIENTA PRODUCIENDO UNA SOLUCIÓN CONCENTRADA DEL PRODUCTO, SE ADICIONA UN SOLVENTE ORGÁNICO PARA CREAR INSOLUBILIDAD Y FAVORECER LA CRISTALIZACIÓN EN UN MEDIO SATURADO, EL EXCESO DE GLICINA PRECIPITA Y SE OBTIENE LA SAL GLICINATO DE METFROMINA DESPUÉS DE FILTRAR Y CONCENTRAR DICHA SAL. LA SAL GLICINATO DE METFORMINA PRESENTA UN EFECTO FARMACOLÓGICO MAS PRONUNCIADO EN LA REDUCCIÓN DE LOS NIVELES DE GLUCOSA EN SANGRETHE SYNTHESIS OF A NEW GLYCINATE SALT 1,1-5 DIMETILBIGUANID, CALLED METHFORMINE GLYCINATE DESIGNED FOR THE CONTROL OF GLUCOSE IN BLOOD. THIS SALT SHOWS ADVANTAGES OVER OTHER METFORMIN SALTS. THESE ADVANTAGES REFER, IN THE FIRST PLACE, TO THE FACT THAT THE CONTRRAION EXHIBITS HYPOGLUCEMENT EFFECTS FOR THEMSELVES, THE HYPOGLUCENT EFFECT IS MORE PRONOUNCED. IN ADDITION, THIS SALT EXHIBITS A BETTER ABSORPTION, REACHING A HIGHER PLASMATIC CONCENTRATION THAT THAT PRODUCED WITH METHROMROMINE CHLORHYDRATE. THE SYNTHESIS WAS CARRIED OUT FROM METFORMIN CHLORHYDRATE RELEASING HYDROCHLORIDE CONTRAION, USING AN IONIC EXCHANGE COLUMN, METHODORINE RELEASED DISSOLVED IN AQUOUS MEANS AND SUBSEQUENTLY ADDITIONED WARMING AGAINST WARMING PRODUCTION A CONCENTRATED SOLUTION OF THE PRODUCT, AN ORGANIC SOLVENT IS ADDED TO CREATE INSOLUBILITY AND PROMOTE CRYSTALLIZATION IN A SATURATED ENVIRONMENT, THE EXCESS OF PREGNITED GLYCIN AND THE METHROMROMINE GLYCINATE SALT IS OBTAINED AFTER FILTERING AND CONCENTRATING THIS SALT. METFORMIN GLYCINATE SALT PRESENTS A MORE PRONOUNCED PHARMACOLOGICAL EFFECT IN REDUCING GLUCOSE LEVELS IN BLOOD
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SV2010003780A SV2010003780A (en) | 2010-12-22 | 2010-12-22 | A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SV2010003780A SV2010003780A (en) | 2010-12-22 | 2010-12-22 | A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SV2010003780A true SV2010003780A (en) | 2011-07-27 |
Family
ID=44741921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SV2010003780A SV2010003780A (en) | 2010-12-22 | 2010-12-22 | A NEW METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD |
Country Status (1)
| Country | Link |
|---|---|
| SV (1) | SV2010003780A (en) |
-
2010
- 2010-12-22 SV SV2010003780A patent/SV2010003780A/en active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant |