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SV2010003459A - Derivados de pirimidina 934 - Google Patents

Derivados de pirimidina 934

Info

Publication number
SV2010003459A
SV2010003459A SV2010003459A SV2010003459A SV2010003459A SV 2010003459 A SV2010003459 A SV 2010003459A SV 2010003459 A SV2010003459 A SV 2010003459A SV 2010003459 A SV2010003459 A SV 2010003459A SV 2010003459 A SV2010003459 A SV 2010003459A
Authority
SV
El Salvador
Prior art keywords
descriptive memory
pirimidine derivatives
ring
pirimidine
derivatives
Prior art date
Application number
SV2010003459A
Other languages
English (en)
Inventor
Bernard Christophe Barlaam
Richard Ducray
Ason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SV2010003459A publication Critical patent/SV2010003459A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN COMPUESTO DE FORMULA (I) EN LA QUE UNO DE A1, A2, O A3 ES N, Y LOS OTROS SE SELECCIONAN INDEPENDIENTEMENTE DE CH O N; EL ANILLO B ES UN ANILLO CARBOCILICO O HETEROCÍCLICO DE 5 O 6 MIEMBROS CONDENSADO QUE ESTÁ OPCIONALMENTE SUSTITUIDO COMO SE DEFINE EN LA MEMORIA DESCRIPTIVA, Y R1, R1, R3 Y R4 Y N SON COMO SE DEFINE EN LA MEMORIA DESCRIPTIVA. LOS COMPUESTOS SON INHIBIDORES DE EPHB4 O EPHA2, Y POR LO TANTO PUEDES SER ÚTILES EN COMPOSICIONES FARMACÉUTICAS PARA EL TRATAMIENTO DE AFECCIONES TALES COMO CANCER.
SV2010003459A 2007-07-16 2010-01-15 Derivados de pirimidina 934 SV2010003459A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07301236 2007-07-16

Publications (1)

Publication Number Publication Date
SV2010003459A true SV2010003459A (es) 2010-04-30

Family

ID=40260140

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2010003459A SV2010003459A (es) 2007-07-16 2010-01-15 Derivados de pirimidina 934

Country Status (18)

Country Link
US (1) US7718653B2 (es)
EP (1) EP2183242A2 (es)
JP (1) JP2010533700A (es)
KR (1) KR20100042272A (es)
CN (1) CN101796046A (es)
AU (1) AU2008277446A1 (es)
BR (1) BRPI0814821A2 (es)
CA (1) CA2693880A1 (es)
CO (1) CO6260075A2 (es)
CR (1) CR11220A (es)
DO (1) DOP2010000022A (es)
EA (1) EA201000101A1 (es)
EC (1) ECSP109958A (es)
MX (1) MX2010000658A (es)
NI (1) NI201000011A (es)
SV (1) SV2010003459A (es)
WO (1) WO2009010789A2 (es)
ZA (1) ZA201000107B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927547B2 (en) 2010-05-21 2015-01-06 Noviga Research Ab Pyrimidine derivatives
US9006241B2 (en) 2011-03-24 2015-04-14 Noviga Research Ab Pyrimidine derivatives
RU2625309C2 (ru) 2011-04-22 2017-07-13 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Замещенные диаминокарбоксамидные и диаминокарбонитрильные производные пиримидинов, их композиции и способы лечения с их помощью
EP2705521B1 (de) 2011-05-03 2021-06-23 Phoenix Contact GmbH & Co. KG Anordnung und verfahren zur kontaklosen energieübertragung mit einer kopplungsminimierten matrix aus planaren sendespulen
CN103222842B (zh) 2013-04-18 2015-09-09 安翰光电技术（武汉）有限公司 一种控制胶囊内窥镜在人体消化道运动的装置及方法
NZ715903A (en) 2014-01-30 2017-06-30 Signal Pharm Llc Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use
US9513297B2 (en) 2014-12-16 2016-12-06 Signal Pharmaceuticals, Llc Methods for measurement of inhibition of c-Jun N-terminal kinase in skin
ES2877642T3 (es) 2014-12-16 2021-11-17 Signal Pharm Llc Formulaciones de 2-(terc-butilamino)-4-((1R,3R,4R)-3-hidroxi-4-metilciclohexilamino)-pirimidin-5-carboxamida
CA2975260C (en) 2015-01-29 2024-05-21 Signal Pharmaceuticals Llc Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide
EP3325432B1 (en) 2015-07-24 2020-09-02 Celgene Corporation Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein
CN106543089A (zh) * 2016-11-04 2017-03-29 山东铂源药业有限公司 一种达沙替尼中间体的合成方法
EP4163278A4 (en) * 2020-05-29 2024-07-17 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Pyrimidine compound as axl inhibitor
CN116178434A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的单对甲苯磺酸盐及其晶型
CN116178433A (zh) * 2021-11-26 2023-05-30 南京正大天晴制药有限公司 Axl激酶抑制剂的盐及其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001237041B9 (en) * 2000-02-17 2005-07-28 Amgen Inc. Kinase inhibitors
DK1487818T3 (da) 2002-03-05 2007-08-20 Astrazeneca Ab Alkylammoniumsalte af omeprazol og esomeprazol
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
BRPI0413616B8 (pt) * 2003-08-15 2021-05-25 Irm Llc 2,4-pirimidinadiaminas, seus usos, e composição farmacêutica
US7521457B2 (en) 2004-08-20 2009-04-21 Boehringer Ingelheim International Gmbh Pyrimidines as PLK inhibitors
GB0419161D0 (en) * 2004-08-27 2004-09-29 Novartis Ag Organic compounds
AU2006227628A1 (en) 2005-03-16 2006-09-28 Targegen, Inc. Pyrimidine compounds and methods of use
WO2006129100A1 (en) * 2005-06-03 2006-12-07 Glaxo Group Limited Novel compounds
WO2007028445A1 (en) * 2005-07-15 2007-03-15 Glaxo Group Limited 6-indolyl-4-yl-amino-5-halogeno-2-pyrimidinyl-amino derivatives
PE20070362A1 (es) 2005-07-15 2007-04-23 Glaxo Group Ltd COMPUESTOS DERIVADOS DE INDAZOL-4-IL-2,4-PIRIMIDINDIAMINA COMO INHIBIDORES DE TIROSINA QUINASA (QUINASA Syk)
US20090149467A1 (en) 2005-09-15 2009-06-11 Merck & Co., Inc. Tyrosine Kinase Inhibitors
BR122021011787B1 (pt) * 2005-11-01 2022-01-25 Impact Biomedicines, Inc Inibidores de biaril meta pirimidina de cinases, composição farmacêutica e processo para preparar uma composição farmacêutica
TW200736232A (en) 2006-01-26 2007-10-01 Astrazeneca Ab Pyrimidine derivatives
WO2007085540A1 (en) 2006-01-27 2007-08-02 Glaxo Group Limited 1h-indaz0l-4-yl-2 , 4-pyrimidinediamine derivatives
TW200840581A (en) * 2007-02-28 2008-10-16 Astrazeneca Ab Novel pyrimidine derivatives
US7947698B2 (en) * 2007-03-23 2011-05-24 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the JAK pathway
NZ581397A (en) 2007-04-27 2012-02-24 Astrazeneca Ab Pyrimidine compounds for the inhibition of Eph receptors and for the treatment of cancer

Also Published As

Publication number Publication date
AU2008277446A1 (en) 2009-01-22
BRPI0814821A2 (pt) 2015-02-03
US20090023719A1 (en) 2009-01-22
DOP2010000022A (es) 2010-02-15
WO2009010789A3 (en) 2009-05-07
EA201000101A1 (ru) 2010-08-30
MX2010000658A (es) 2010-03-26
WO2009010789A2 (en) 2009-01-22
CA2693880A1 (en) 2009-01-22
CN101796046A (zh) 2010-08-04
EP2183242A2 (en) 2010-05-12
NI201000011A (es) 2010-12-07
ZA201000107B (en) 2010-09-29
ECSP109958A (es) 2010-03-31
CR11220A (es) 2010-05-20
CO6260075A2 (es) 2011-03-22
KR20100042272A (ko) 2010-04-23
US7718653B2 (en) 2010-05-18
JP2010533700A (ja) 2010-10-28

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