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SV2008003070A - Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248 - Google Patents

Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248

Info

Publication number
SV2008003070A
SV2008003070A SV2008003070A SV2008003070A SV2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A SV 2008003070 A SV2008003070 A SV 2008003070A
Authority
SV
El Salvador
Prior art keywords
hydroxiestero
cyclhexilpirazol
lactamas
ide
dehydrogenase
Prior art date
Application number
SV2008003070A
Other languages
English (en)
Inventor
Thomas Daniel Aicher
Alexei Pavlovvych Krasutsky
Thomas Edward Mabry
Ashraf Saeed
Peter Biagio Anzeveno
Renhua Li
Yanping Xu
Nancy June Snyder
Honggi Tian
Owen Brendan Wallace
Gregory Alan Sthephenson
Leonard Larry Winneroski Jr
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of SV2008003070A publication Critical patent/SV2008003070A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS COMPUESTOS DE FÓRMULA I: (VER FORMULA); QUE POSEEN ACTIVIDAD ANTAGONISTA DE 11BETA-HSD TIPO 1, ASI COMO TAMBIÉN MÉTODOS PARA PREPARAR TALES COMPUESTOS. EN OTRA MODALIDAD, LA INVENCIÓN DESCRIBE COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN COMPUESTOS DE FÓRMULA I, ASI COMO TAMBIÉN MÉTODOS PARA USAR LOS COMPUESTOS Y COMPOSICIONES PARA TRATAR DIABETES, HIPERGLICEMIA, OBESIDAD, HIPERTENSIÓN, HIPERLIPIDEMIA, SÍNDROME METABÓLICO, Y OTRAS CONDICIONES ASOCIADAS CON LA ACTIVIDAD DE 11BETA-HSD TIPO 1
SV2008003070A 2006-04-21 2008-10-21 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248 SV2008003070A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
SV2008003070A true SV2008003070A (es) 2010-01-18

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2008003070A SV2008003070A (es) 2006-04-21 2008-10-21 Derivados de lactamas de ciclohexilpirazol como inhibidores de 11-beta-hidroxiestero ide deshidrogenasa 1 ref. x-17248

Country Status (29)

Country Link
US (1) US7981918B2 (es)
EP (1) EP2029579B1 (es)
JP (1) JP5161869B2 (es)
KR (1) KR101055576B1 (es)
CN (1) CN101426783B (es)
AR (1) AR060618A1 (es)
AU (1) AU2007240550B2 (es)
BR (1) BRPI0710229A2 (es)
CA (1) CA2647677C (es)
CO (1) CO6140026A2 (es)
CR (1) CR10400A (es)
DO (1) DOP2007000078A (es)
EA (1) EA015675B1 (es)
EC (1) ECSP088839A (es)
ES (1) ES2533263T3 (es)
IL (1) IL194835A (es)
JO (1) JO3042B1 (es)
MA (1) MA30476B1 (es)
MX (1) MX2008013484A (es)
MY (1) MY148128A (es)
NO (1) NO20084403L (es)
NZ (1) NZ571175A (es)
PE (1) PE20080362A1 (es)
SV (1) SV2008003070A (es)
TN (1) TNSN08405A1 (es)
TW (1) TWI347321B (es)
UA (1) UA95798C2 (es)
WO (1) WO2007124254A2 (es)
ZA (1) ZA200808686B (es)

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CN101432277B (zh) 2006-04-25 2013-12-25 伊莱利利公司 11-β-羟甾类脱氢酶1的抑制剂
CN101432265B (zh) 2006-04-25 2011-12-14 伊莱利利公司 11-β-羟类固醇脱氢酶1的抑制剂
AU2007244904B2 (en) 2006-04-25 2012-05-31 Eli Lilly And Company Inhibitors of 11-Beta-hydroxysteroid dehydrogenase 1
DK2049513T3 (da) 2006-04-28 2012-02-27 Lilly Co Eli Piperidinylsubstituerede pyrrolidinoner som inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Also Published As

Publication number Publication date
HK1126493A1 (en) 2009-09-04
CA2647677C (en) 2014-03-18
TW200811141A (en) 2008-03-01
IL194835A0 (en) 2009-08-03
CR10400A (es) 2009-01-14
JP2009534398A (ja) 2009-09-24
AR060618A1 (es) 2008-07-02
WO2007124254A3 (en) 2007-12-27
EP2029579B1 (en) 2014-12-31
UA95798C2 (ru) 2011-09-12
KR101055576B1 (ko) 2011-08-08
ES2533263T3 (es) 2015-04-08
NO20084403L (no) 2008-11-14
MX2008013484A (es) 2008-10-30
MY148128A (en) 2013-02-28
NZ571175A (en) 2011-10-28
DOP2007000078A (es) 2007-11-15
TNSN08405A1 (en) 2010-04-14
CO6140026A2 (es) 2010-03-19
JP5161869B2 (ja) 2013-03-13
WO2007124254A2 (en) 2007-11-01
ZA200808686B (en) 2009-12-30
EP2029579A2 (en) 2009-03-04
CN101426783B (zh) 2013-10-30
JO3042B1 (ar) 2016-09-05
CA2647677A1 (en) 2007-11-01
BRPI0710229A2 (pt) 2011-08-02
US20090111800A1 (en) 2009-04-30
IL194835A (en) 2015-04-30
EA015675B1 (ru) 2011-10-31
KR20080109867A (ko) 2008-12-17
ECSP088839A (es) 2008-11-27
MA30476B1 (fr) 2009-06-01
US7981918B2 (en) 2011-07-19
TWI347321B (en) 2011-08-21
AU2007240550B2 (en) 2012-02-23
AU2007240550A1 (en) 2007-11-01
CN101426783A (zh) 2009-05-06
PE20080362A1 (es) 2008-04-25
EA200870460A1 (ru) 2009-04-28

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