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SV2007002420A - Derivados del 1,5-diarilpirrol, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados del 1,5-diarilpirrol, su preparacion y su aplicacion en terapeutica

Info

Publication number
SV2007002420A
SV2007002420A SV2006002420A SV2006002420A SV2007002420A SV 2007002420 A SV2007002420 A SV 2007002420A SV 2006002420 A SV2006002420 A SV 2006002420A SV 2006002420 A SV2006002420 A SV 2006002420A SV 2007002420 A SV2007002420 A SV 2007002420A
Authority
SV
El Salvador
Prior art keywords
replaced
rent
therapeutics
preparation
radical
Prior art date
Application number
SV2006002420A
Other languages
English (en)
Inventor
Francis Barth
Christian Congy
Laurent Hortala
Murielle Rinaldi-Carmona
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of SV2007002420A publication Critical patent/SV2007002420A/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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Abstract

LA PRESENTE INVENCION TIENE COMO OBJETIVO COMPUESTO QUE RESPONDEN A LA FORMULA: (VER FORMULA) EN LA QUE: -X REPRESENTA UN GRUPO -C-. -SO2-, -CN(R7)-, -C-N(R7)-; -R1 Y R6 REPRESENTAN UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; -R2 REPRESENTA UN RADICAL ELEGIDO ENTRE: UN ALQUILO (C1-C12); UN RADICAL CARBOCICLICO NO AROMATICO (C3-C12); UN CICLOALQUIL (C3-C7)-METILO; UN FENILO, UN BENCILO, UN BENCIDRILO, UN BENCIDRILMETILO, UN FENETILO; UN BENZODIOXOLILO, UN DIHIDROBENZOFURANILO O UN DIHIDROBENZODIOXINILO; UN 1,2,3,4-TETRAHIDRONAFTALENILO NO SUSTITUIDO; O UN RADICAL HETEROCICLICO, UN INDOLILO, UN BENZOTIAZOLILO NO SUSTITUIDO O SUSTITUIDO; ESTANDO DICHOS RADICALES NO SUSTITUIDOS O SUSTITUIDOS; -R3 REPRESENTA UN ALQUILO(C1-C5) O UN CICLOALQUILO (C3-C7); -R4 Y R5 REPRESENTAN UN FENILO NO SUSTITUIDO O SUSTITUIDO.PORCEDIMIENTO DE PREPARACION Y APLICACION EN TERAPEUTICA
SV2006002420A 2005-02-17 2006-02-17 Derivados del 1,5-diarilpirrol, su preparacion y su aplicacion en terapeutica SV2007002420A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0501660A FR2882054B1 (fr) 2005-02-17 2005-02-17 Derives de 1,5-diarylpyrrole, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
SV2007002420A true SV2007002420A (es) 2007-01-17

Family

ID=34954653

Family Applications (1)

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SV2006002420A SV2007002420A (es) 2005-02-17 2006-02-17 Derivados del 1,5-diarilpirrol, su preparacion y su aplicacion en terapeutica

Country Status (18)

Country Link
US (1) US7524971B2 (es)
EP (1) EP1853557A2 (es)
JP (1) JP2008530187A (es)
KR (1) KR20070103454A (es)
CN (1) CN101119967A (es)
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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2874012B1 (fr) * 2004-08-09 2008-08-22 Sanofi Synthelabo Derives de pyrrole, leur preparation et leur utlisation en therapeutique
FR2894579B1 (fr) * 2005-12-12 2008-01-18 Sanofi Aventis Sa Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique.
KR20090047458A (ko) 2006-08-08 2009-05-12 사노피-아벤티스 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
FR2930939B1 (fr) * 2008-05-09 2010-07-30 Sanofi Aventis Derives de pyrrole, leur preparation et leur application en therapeutique
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2011023754A1 (en) 2009-08-26 2011-03-03 Sanofi-Aventis Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
GB201103419D0 (es) 2011-02-28 2011-04-13 Univ Aberdeen
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
CA2921147C (en) 2012-08-20 2018-01-23 Thomas M. Espinosa Anchor holders and anchor assemblies for metal decks
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
JP2017531011A (ja) 2014-10-16 2017-10-19 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 麻酔のための新規の方法、化合物および組成物
CN104496879A (zh) * 2015-01-13 2015-04-08 佛山市赛维斯医药科技有限公司 一种含腈基苯和二烯氟代金刚烷结构的化合物和用途
CN104447484B (zh) * 2015-01-13 2016-06-08 佛山市赛维斯医药科技有限公司 含烷氧苯基和二烯金刚烷结构的化合物、其制备方法和用途
CN104447485A (zh) * 2015-01-13 2015-03-25 佛山市赛维斯医药科技有限公司 一种含腈基苯和二烯金刚烷结构的化合物、其制备方法和用途
CN104478782B (zh) * 2015-01-13 2016-03-16 佛山市赛维斯医药科技有限公司 一类含烷氧苯基和二烯氟代金刚烷结构的化合物和用途
CN104478781A (zh) * 2015-01-13 2015-04-01 佛山市赛维斯医药科技有限公司 二烯金刚烷类化合物、其制备方法和用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents

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FR2882054A1 (fr) 2006-08-18
DOP2006000043A (es) 2006-08-31
JP2008530187A (ja) 2008-08-07
RU2007134383A (ru) 2009-03-27
WO2006087476A3 (fr) 2007-08-09
CN101119967A (zh) 2008-02-06
US20080015245A1 (en) 2008-01-17
UY29373A1 (es) 2006-10-02
CA2597033A1 (fr) 2006-08-24
AR052673A1 (es) 2007-03-28
IL185034A0 (en) 2008-06-05
BRPI0608866A2 (pt) 2010-02-02
AU2006215521A1 (en) 2006-08-24
FR2882054B1 (fr) 2007-04-13
US7524971B2 (en) 2009-04-28
KR20070103454A (ko) 2007-10-23
TW200714585A (en) 2007-04-16
EP1853557A2 (fr) 2007-11-14
PA8663601A1 (es) 2006-11-09
WO2006087476A2 (fr) 2006-08-24

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