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SV1997000034A - SUBSTITUTED OXOBUTY ACIDS AS METALOPROTEASE MATRIX - Google Patents

SUBSTITUTED OXOBUTY ACIDS AS METALOPROTEASE MATRIX

Info

Publication number
SV1997000034A
SV1997000034A SV1997000034A SV1997000034A SV1997000034A SV 1997000034 A SV1997000034 A SV 1997000034A SV 1997000034 A SV1997000034 A SV 1997000034A SV 1997000034 A SV1997000034 A SV 1997000034A SV 1997000034 A SV1997000034 A SV 1997000034A
Authority
SV
El Salvador
Prior art keywords
disorders
metaloprotease
computer
oxobuty
acids
Prior art date
Application number
SV1997000034A
Other languages
Spanish (es)
Inventor
Brian R Dixon
Jinshan Chen
Zandt Michael Van
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of SV1997000034A publication Critical patent/SV1997000034A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

LA PRESENTE INVENCION PRESENTA COMPOSICIONES FARMACEUTICAS Y METODOS PARA TRATAR CIERTOS TRASTORNOS QUE COMPRENDEN ADMINISTRAR UNA CANTIDAD DE UN COMPUETO O COMPOSICIONES DE LA PRESENTE INVENCION QUE SEA EFICAZ PARA INHIBIR LA ACTIVIDAD DE POR LO MENOS UNA METALOPROTEASA DE MATRIZ, QUE DA COMO RESULTADO LA OBTENCION DEL EFECTO DESEADO, ESTE COMPUETO ES INDICADO PARA COMBATIR LOS TRANSTORNOS DE LOS CUAELS CONTRIBUYEN LAS MMP, TALES COMO OSTEOARTRITIS, LA ARTRITIS REUMATITOIDEA, LA ARTRITIS SEPTICA, LAS ENFEREMEDADES PERIODONTALES, ALS ULCERAS DE CORNEA, LA PROTEINURIA, LA ENFERMEDADES DE ANURISMA AORTICO, LA EPIDERMOLISIS VESICUALR DISTROFICA, LOS TRASTORNO QUE PRODUCEN RESPUESTAS INFLAMATORIAS, LAS OSTEOPENIAS EN LAS QUE MEDIA LA ACTIVIDAD MMP, LA ENFERMEDAD DE LA ARTICULACION TEMPOROMADIBULAR, LAS ENFEREMEDADES DESMIELIZANTES DEL SISTEMA NERVIOSO; LAS ETASTASIS DE TUMORES O LA PERDIDAD DEGENERATIVA DE CARTILAGOS POSTERIOR A LA LESION ARTICULAR TRAUMATICA.THE PRESENT INVENTION PRESENTS PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING CERTAIN DISORDERS THAT INCLUDE ADMINISTERING A QUANTITY OF A COMPUTER OR COMPOSITIONS OF THE PRESENT INVENTION THAT IS EFFECTIVE TO INHIBIT THE ACTIVITY OF AT LEAST A MATRATING METALOPROTEASE DESIRED, THIS COMPUTER IS INDICATED TO COMBAT THE DISORDERS OF THE CUAELS CONTRIBUTING THE MMP, SUCH AS OSTEOARTRITIS, ARTHRITIS, SEPTICA, THE PERIODONTAL DISEASES, ALS ULCERAS, AURIAL LAURS DISTROFICA, THE DISORDERS THAT PRODUCE INFLAMMATORY RESPONSES, THE OSTEOPENIAS IN WHICH THE MMP ACTIVITY MEDIATES, THE DISEASE OF THE TEMPOROMADIBULAR JOINT, THE DEMYELIZING DISEASES OF THE NERVOUS SYSTEM; THE EASTASASIS OF TUMORS OR THE DEGENERATIVE LOSS OF CARTILAGOS AFTER THE TRAUMATIC ARTICULAR INJURY.

SV1997000034A 1996-05-15 1997-05-12 SUBSTITUTED OXOBUTY ACIDS AS METALOPROTEASE MATRIX SV1997000034A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64838496A 1996-05-15 1996-05-15

Publications (1)

Publication Number Publication Date
SV1997000034A true SV1997000034A (en) 1999-07-05

Family

ID=24600568

Family Applications (1)

Application Number Title Priority Date Filing Date
SV1997000034A SV1997000034A (en) 1996-05-15 1997-05-12 SUBSTITUTED OXOBUTY ACIDS AS METALOPROTEASE MATRIX

Country Status (18)

Country Link
EP (1) EP0912487A1 (en)
JP (1) JP3417951B2 (en)
CN (1) CN1163466C (en)
AR (1) AR007096A1 (en)
AU (1) AU727648B2 (en)
CA (1) CA2253869C (en)
CO (1) CO4990925A1 (en)
HR (1) HRP970246B1 (en)
ID (1) ID20291A (en)
MY (1) MY132470A (en)
PA (1) PA8429401A1 (en)
PE (1) PE65998A1 (en)
SV (1) SV1997000034A (en)
TN (1) TNSN97085A1 (en)
TW (1) TW467892B (en)
WO (1) WO1997043238A1 (en)
YU (1) YU18797A (en)
ZA (1) ZA974032B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288063B1 (en) 1998-05-27 2001-09-11 Bayer Corporation Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors
GB0321538D0 (en) * 2003-09-13 2003-10-15 Glaxo Group Ltd Therapeutically useful compounds
WO2009022740A1 (en) * 2007-08-15 2009-02-19 Kyorin Pharmaceutical Co., Ltd. Preventive, inhibitor or remedy for cerebral aneurysm comprising ibudilast as the active ingredient
CA2944617A1 (en) 2014-04-03 2015-10-08 Bayer Pharma Aktiengesellschaft Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof
EP3126358A1 (en) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids for the treatment of respiratoy tract diseases
EP3126339A1 (en) 2014-04-03 2017-02-08 Bayer Pharma Aktiengesellschaft 2,5-disubstituted cyclopentane carboxylic acids and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU678884B2 (en) * 1994-01-22 1997-06-12 British Biotech Pharmaceuticals Limited Metalloproteinase inhibitors
BR9612188A (en) 1995-12-22 1999-07-13 Warner Lambert Co Aromatic ketoacids and their derivatives as matrix metalloproteinase inhibitors
CO5011071A1 (en) 1996-05-15 2001-02-28 Bayer Corp INHIBITION OF METALOPROTEINAS OF MATRIX BY ACIDS 2- (W / AROILALQUIL) -4-BIARIL-4-OXOBUTIRICOS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
ID20291A (en) 1998-11-19
HRP970246A2 (en) 1998-04-30
WO1997043238A1 (en) 1997-11-20
CN1163466C (en) 2004-08-25
JPH11509870A (en) 1999-08-31
CN1225622A (en) 1999-08-11
CO4990925A1 (en) 2000-12-26
TNSN97085A1 (en) 2005-03-15
YU18797A (en) 1999-11-22
HRP970246B1 (en) 2002-04-30
TW467892B (en) 2001-12-11
PA8429401A1 (en) 2000-05-24
MY132470A (en) 2007-10-31
ZA974032B (en) 1998-02-19
AU727648B2 (en) 2000-12-21
AR007096A1 (en) 1999-10-13
CA2253869C (en) 2003-04-22
EP0912487A1 (en) 1999-05-06
PE65998A1 (en) 1998-10-20
JP3417951B2 (en) 2003-06-16
CA2253869A1 (en) 1997-11-20
AU3121997A (en) 1997-12-05

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