SU565915A1 - Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity - Google Patents
Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activityInfo
- Publication number
- SU565915A1 SU565915A1 SU7402075856A SU2075856A SU565915A1 SU 565915 A1 SU565915 A1 SU 565915A1 SU 7402075856 A SU7402075856 A SU 7402075856A SU 2075856 A SU2075856 A SU 2075856A SU 565915 A1 SU565915 A1 SU 565915A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- activity
- diethylsilanes
- carbalcoximethoxy
- neutropic
- alpha
- Prior art date
Links
- 230000000694 effects Effects 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 description 5
- UCXUKTLCVSGCNR-UHFFFAOYSA-N diethylsilane Chemical class CC[SiH2]CC UCXUKTLCVSGCNR-UHFFFAOYSA-N 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- XWVOEFLBOSSYGM-UHFFFAOYSA-N 4-morpholinyl-(3,4,5-trimethoxyphenyl)methanone Chemical compound COC1=C(OC)C(OC)=CC(C(=O)N2CCOCC2)=C1 XWVOEFLBOSSYGM-UHFFFAOYSA-N 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000002276 neurotropic effect Effects 0.000 description 2
- 229950001577 trimetozine Drugs 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- MBDOYVRWFFCFHM-SNAWJCMRSA-N (2E)-hexenal Chemical compound CCC\C=C\C=O MBDOYVRWFFCFHM-SNAWJCMRSA-N 0.000 description 1
- 241001331845 Equus asinus x caballus Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101100531623 Mus musculus Rsbn1 gene Proteins 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000003901 oxalic acid esters Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
Description
Изобретение относитс к элементноор ганической химии, к новым химическим с динени м, а именно к ди-(- сс -карбалкок метокси)-диэтилсиланам общей формулы (С2Нд)2Йиосн2Соор)2, Т -СдН9,С5Н,рСбН,,СдН,9, .про вл ющим нейрогроггаую активность, ко рые могут найти применение при изготов лении лекарственных препаратов, относ щ с к. группе малых транквилизаторов. Известны кремнийорганические производные об -оксикислот обжей формулы ( С2Н5)2б((ОСНСИ2СООС2Н5)2, R fi ti Однако указаний об их биологической гивности не имеетс . Цэль изобретени - расширение арсена средств воздействи на живой организм. Эта достигаетс сс -карбалкокси1 магокс ч)-диэтилсиланами; формулг-. (Т), йро вл юлпим нейротроп ую активность. Соединени формулы (I) получают по известной реакции 2 путем взаимодействи диэтилсилана со сложным эфиром щавелевой кислоты в присутствии хлористого цинка в качестве катализатора. Пример 1. znceg (C &4H 1C H C OCOCOOCH,(f ((OCH2COOC H Дй-( ас -карбалкоксиметокси)-диэтилсипаны представл ют собой прозрачные бесцветные жидкости, растворимые в органических растворител х : ксилоле, толуоле, бензоле и спирте и не растворимые в воде При сто нии на воздухе не измен ютс , не гигроскопичны. Рациональные названа , эмпирические формулы, физико-химические константы соединений формулы ( Г) представлены в таб. 1.Исследовани биологического действи ци-( cxi -карбалкоксиме-:экси)-диэтилсиланов формулы (1) ;ПроведеныНа мышахтетрагибридах и крысах линии Внстер, Соединени формулы (1) угнетают у животкьк элементарный оборонительный условный и ориентировочно-исследовательский рефлексы, потенцируют снотворное деиствке гексенала, понижают чувствительностк нервно-мышечных синалсов к электрическо му раздражению,, про вл ют умеренно выраженный . анальгетическвй (эффект, предохран ют животных от гибели при воздействии The invention relates to elemental organic chemistry, to new chemical compounds, namely, di - (- cc-methoxy) -butyl methoxylsilanes of the general formula (C2Hd) 2HiCl2Soor) 2, T-CdH9, C5H, rSbN, CdH, 9, They have a neurorogogic activity that can be used in the manufacture of drugs that belong to the group of small tranquilizers. The organosilicon derivatives of the about -oxyacids of the burning of the formula (C2H5) 2b are known ((OCNIS2COOC2H5) 2, R fi ti However, there is no indication of their biological activity. The purpose of the invention is the expansion of the arsenic of the action on a living organism. diethylsilanes; formulas- (T), iro vyulpim neurotropic activity. The compounds of formula (I) are obtained by the known reaction of 2 by reacting diethylsilane with oxalic acid ester in the presence of zinc chloride as a catalyst. Example 1. znceg (C & 4H 1C HC OCOCOOCH, (f ((OCH2COOC H Dy- (ac -carbalkalkoxymethoxy) -diethylsipanes are clear, colorless liquids soluble in organic solvents: xylene, toluene, benzene and alcohol, and not soluble in water On standing in the air they do not change, are not hygroscopic. The rational formulas are named, empirical formulas, and physicochemical constants of the compounds of formula (D) are presented in Table 1. Studies of the biological effects of cy- (cxi -carbalkoxime-: exi) - diethylsilanes of the formula (1); Held on mouse tetrahybrid hybrids and rats ling and Westster. Compounds of formula (1) inhibit elementary defensive conditioned and exploratory reflexes in the stomach, potentiate the hypnotic effect of hexenal, decrease the sensitivity of the neuromuscular muscles to electrical irritation, exhibit a moderately pronounced analgesic effect (the effect of protecting animals from death when exposed
электрического тока. Результаты испытаний даны в табл. 2.electric current. The test results are given in table. 2
Наибольшую активность про вл ет7 ди- (оС -карбутоксиметокси)-диэтилсилан. Соединени формулы .{) по своей активности; превосход т действие триоксазина (дл характеристики нейтронной активности триоксазина в табл. 2 использованы, данные Б,А. Баргтейл (1973).The most activity is 7 di- (oC -carbutoxymethoxy) -diethylsilane. Compounds of formula. {) By their activity; superior to the effect of trioxazin (for the characterization of the neutron activity of trioxazin in Table 2 used, data B, A. Bargteyl (1973).
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4 о-р мул изобретени 4 Oral Mule of Invention
Ди- { рС -карбалкоксиметокси)-диэтилсиланы обшей формулыDi- {pC -carbalkoxymethoxy) diethylsilanes of the general formula
(C2H5)2SUOCH2C60R)2,(C2H5) 2SUOCH2C60R) 2,
Т -CjjH jCjH JI ,,з ,С9Н,9, про вл ющие нейротропную активность.T -CjjH jCjH JI ,, h, C9H, 9, exhibiting neurotropic activity.
10ten
Источники информации:, прин тые во вни мание при экспертизе:Sources of information: taken into consideration during examination:
1.Лапкин И.И. и др. Взаимодействие диэтилсилана со сложными эфирами ,d. -оксикислот , ЖОХ 1971. 41 с. 1263.1.Lapkin I.I. et al. Diethylsilane interaction with esters, d. -oxyacids, JOH 1971. 41 p. 1263.
2.Лапкин И. И. и др. Взаимодействие диэтилсилана со сложными эфирами кислот, ЖОХ. 1969, № 3-4, с. 549.2. Lapkin I. I. et al. Interaction of diethylsilane with esters of acids, JOH. 1969, No. 3-4, p. 549.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU7402075856A SU565915A1 (en) | 1974-10-07 | 1974-10-07 | Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU7402075856A SU565915A1 (en) | 1974-10-07 | 1974-10-07 | Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU565915A1 true SU565915A1 (en) | 1977-07-25 |
Family
ID=20600951
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU7402075856A SU565915A1 (en) | 1974-10-07 | 1974-10-07 | Di-alpha-carbalcoximethoxy-diethylsilanes displaying neutropic activity |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU565915A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2751347C2 (en) * | 2016-09-13 | 2021-07-13 | Хенкель Аг Унд Ко. Кгаа | Silanes and curable compositions including the mentioned silanes |
-
1974
- 1974-10-07 SU SU7402075856A patent/SU565915A1/en active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2751347C2 (en) * | 2016-09-13 | 2021-07-13 | Хенкель Аг Унд Ко. Кгаа | Silanes and curable compositions including the mentioned silanes |
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