SU420169A3 - METHOD FOR OBTAINING TRICYCLIC DERIVATIVES OF AAMINOSPIRATES 12 The invention relates to the preparation of new T'rAcclimate amino alcohol alcohols of the general formula IC-CCNgHgCHN ^ OI10 where A, X and Y have the indicated values, and Hal - chlorine or bromine interacts with the interactions of the interactions of the groups, and the Hal - chlorine or bromine has interactions that have interactions, and the Hal - chlorine or bromine has interactions that have interactions, and the Hal - chlorine or bromine has interactions that have interactions that have the specified values; P1HoN— (CH2) “—CH20H in which p is as defined above. The reaction is carried out in an appropriate organic solvent, such as nitro methane, acetonitrile or dimethylformamide. In the presence of a hydrogen halide acceptor formed during p actions This acceptor may be an excess of co-amino alcohol (III), a tertiary amine, a pyridine base, an alkali or alkaline earth metal carbonate or bicarbonate. The reaction is exothermic and takes place at a temperature between 20 and 100 ° C. Producers of general formula I can be isolated in free form or in the form of salts with mineral or organic acids. - Google Patents

Description

Mill, such as hydrochloric acid, hydrobromic acid, sarna, phosphorus, acetic acid, propionic acid, maleic acid, fumaric acid, methanesulfonic acid, BiHHFiaH, lushunna, oxalic acid and benzoic acid.

In addition, derivatives of general formula I, in which X and Y are different or A is an asymmetric bridge, may exist in the form of optical isomers.

Example 1. A solution of 30.6 g (0.133 mol) of 5-chloro-dibelzo-a (d, d) -cycloheptadiene in 300 L1L of nitromethane is added with stirring to a warm solution of 35 g (0.267 mol) of 7-amnepheptanol in 30 ml of nitromethiol. The reaction is slightly exothermic. As a result, 7-aminoheptanol hydrochloride falls out.

The reaction mixture is left overnight, then filtered, the filtrate is evaporated to dryness in vacuo. Water and ether are added to the precipitate. The organic phase is decanted, washed to neutrality, dried with sodium sulfate, then evaporated in vacuo.

35 g of dibenzo - (a, d) -cycloheptadienyl - 5 - amino-7 - heptanol are obtained, the content of which in the pure product determined by titration with perchloric acid is 95%.

This crude base after treatment with a solution of hydrogen chloride gas in ether and recrystallization from water gives 23.4 g of dibenzo - (a, d) chlorohydrate cycloheptadienyl - 5-7 aminoheptanol, which melts at 210 ° C.

Examples 2-4. The following derivatives are obtained by the method described in example 1:

dibenzo - (a, d) - cycloheptadienyl - 5 - 4 - amnnobutanol, so pl. the corresponding hydrochloride, 185 ° C, was obtained from 5-chloro-1-benzo (a, d) -cycloheptadmen and 4-a. minobutanol;

Dibenzo- (a, d) - cycloheptadienyl - 5 -5-amyiopentanol, t. Kip. with 0.05 mm Hg. Art. 168-170 ° C, n22i) 1.5836, obtained from 5-chlorodibenzo - (a, d) - cycloheptadiene and 5 - aminopentanol;

dibenzo - (a, d) - cycloheptadiene - 5 - 11 - aminoundecanol, t. Pl. the corresponding hydrochloride 120 ° C (aceto-nitrile) is obtained from 5 - chlordibeiso - (a, d) - cycloheptadiene and 11 - aminoundecaiol.

Subject 1 and sbretien

The method of obtaining trcyclic derivatives of amino alcohols of general formula I

СН Ш - () - СН20Н

where A is the radical - (CHg) ", - CH CH SP -, - (SP2) /, O -, - (CH2) pS-, S02 or NR in which t is the number 1, 2 nli 3, p is the number 1 or 2, R is lower alkyl containing from 1 to 5 carbon atoms,

n is an integer from 3 to 10 inclusive,

X and Y are hydrogen or halogen, or their salts, characterized in that the halide derivative of the general formula I

where A, X and Y have the specified value, and Pa1 is chlorine or brO: M,

subjected to interaction with "- amino alcohol of General formula 1P

PaM- (SP2), g - SIGON

where p - has the specified value, followed by separation of the target product in free form or in the form of salt.