SU1681502A1 - 3-(2, 5-dimethoxybenzoyl)-4-dimethylaminomethyl-5- hydroxy-6-bromobenzofuran hydrochloride showing analgetic, local anesthetic, anticonvulsant, antiarrythmic, stimulating coronary, cerebral and renal blood circulation effects - Google Patents
3-(2, 5-dimethoxybenzoyl)-4-dimethylaminomethyl-5- hydroxy-6-bromobenzofuran hydrochloride showing analgetic, local anesthetic, anticonvulsant, antiarrythmic, stimulating coronary, cerebral and renal blood circulation effectsInfo
- Publication number
- SU1681502A1 SU1681502A1 SU4744306/04A SU4744306A SU1681502A1 SU 1681502 A1 SU1681502 A1 SU 1681502A1 SU 4744306/04 A SU4744306/04 A SU 4744306/04A SU 4744306 A SU4744306 A SU 4744306A SU 1681502 A1 SU1681502 A1 SU 1681502A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- dimethoxybenzoyl
- bromobenzofuran
- dimethylaminomethyl
- hydroxy
- antiarrythmic
- Prior art date
Links
- MKDFZPAGKWRYFH-UHFFFAOYSA-N [6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-benzofuran-3-yl]-(2,5-dimethoxyphenyl)methanone;hydrochloride Chemical compound Cl.COC1=CC=C(OC)C(C(=O)C=2C3=C(CN(C)C)C(O)=C(Br)C=C3OC=2)=C1 MKDFZPAGKWRYFH-UHFFFAOYSA-N 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title 1
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- 230000001773 anti-convulsant effect Effects 0.000 title 1
- 239000001961 anticonvulsive agent Substances 0.000 title 1
- 229960003965 antiepileptics Drugs 0.000 title 1
- 230000002490 cerebral effect Effects 0.000 title 1
- 239000003589 local anesthetic agent Substances 0.000 title 1
- 230000008327 renal blood flow Effects 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- ZZXSSXYHBWCWGF-UHFFFAOYSA-N (2,5-dimethoxyphenyl)-(5-hydroxy-1-benzofuran-3-yl)methanone Chemical compound COC1=CC=C(OC)C(C(=O)C=2C3=CC(O)=CC=C3OC=2)=C1 ZZXSSXYHBWCWGF-UHFFFAOYSA-N 0.000 abstract 1
- PVFOHMXILQEIHX-UHFFFAOYSA-N 8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9-[2-(2-bromophenyl)ethyl]purin-6-amine Chemical compound C=1C=2OCOC=2C=C(Br)C=1SC1=NC=2C(N)=NC=NC=2N1CCC1=CC=CC=C1Br PVFOHMXILQEIHX-UHFFFAOYSA-N 0.000 abstract 1
- 238000005902 aminomethylation reaction Methods 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
FIELD: organic chemistry. SUBSTANCE: product: heterocyclic compound, 3-(2,5-dimethoxybenzoyl)-4-dimethylaminomethyl-5-hydroxy-6-bromobenzofuran hydrochloride. Synthesis is carried out by bromination of 3-(2,5-dimethoxybenzoyl)-5-hydroxybenzofuran following by aminomethylation of bromo-derivative prepared. EFFECT: improved method of synthesis. 14 tbl
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU4744306/04A SU1681502A1 (en) | 1989-07-26 | 1989-07-26 | 3-(2, 5-dimethoxybenzoyl)-4-dimethylaminomethyl-5- hydroxy-6-bromobenzofuran hydrochloride showing analgetic, local anesthetic, anticonvulsant, antiarrythmic, stimulating coronary, cerebral and renal blood circulation effects |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU4744306/04A SU1681502A1 (en) | 1989-07-26 | 1989-07-26 | 3-(2, 5-dimethoxybenzoyl)-4-dimethylaminomethyl-5- hydroxy-6-bromobenzofuran hydrochloride showing analgetic, local anesthetic, anticonvulsant, antiarrythmic, stimulating coronary, cerebral and renal blood circulation effects |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1681502A1 true SU1681502A1 (en) | 1994-06-15 |
Family
ID=60532219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU4744306/04A SU1681502A1 (en) | 1989-07-26 | 1989-07-26 | 3-(2, 5-dimethoxybenzoyl)-4-dimethylaminomethyl-5- hydroxy-6-bromobenzofuran hydrochloride showing analgetic, local anesthetic, anticonvulsant, antiarrythmic, stimulating coronary, cerebral and renal blood circulation effects |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1681502A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7696365B2 (en) | 2003-08-01 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors |
| US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| US7723366B2 (en) | 2001-02-20 | 2010-05-25 | Chugai Seiyaku Kabushiki Kaisha | Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases |
| US7786145B2 (en) | 2003-08-01 | 2010-08-31 | Chugai Seiyaku Kabushiki Kaisha | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors |
| US8080665B2 (en) | 2003-08-01 | 2011-12-20 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors |
-
1989
- 1989-07-26 SU SU4744306/04A patent/SU1681502A1/en active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7709510B2 (en) | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| US7723366B2 (en) | 2001-02-20 | 2010-05-25 | Chugai Seiyaku Kabushiki Kaisha | Azole compounds as malonyl-CoA decarboxylase inhibitors for treating metabolic diseases |
| US8110686B2 (en) | 2001-02-20 | 2012-02-07 | Chugai Seiyaki Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| US7696365B2 (en) | 2003-08-01 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Heterocyclic compounds useful as malonyl-CoA decarboxylase inhibitors |
| US7786145B2 (en) | 2003-08-01 | 2010-08-31 | Chugai Seiyaku Kabushiki Kaisha | Cyanoguanidine-based azole compounds useful as malonyl-CoA decarboxylase inhibitors |
| US8080665B2 (en) | 2003-08-01 | 2011-12-20 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-CoA decarboxylase inhibitors |
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