SU1651890A1 - Method for treatment of heart valve bioprothesis - Google Patents
Method for treatment of heart valve bioprothesis Download PDFInfo
- Publication number
- SU1651890A1 SU1651890A1 SU884447369A SU4447369A SU1651890A1 SU 1651890 A1 SU1651890 A1 SU 1651890A1 SU 884447369 A SU884447369 A SU 884447369A SU 4447369 A SU4447369 A SU 4447369A SU 1651890 A1 SU1651890 A1 SU 1651890A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- heart valve
- solution
- days
- bioprothesis
- treatment
- Prior art date
Links
- 210000003709 heart valve Anatomy 0.000 title claims abstract description 5
- 238000000034 method Methods 0.000 title claims description 7
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims abstract description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229920002307 Dextran Polymers 0.000 abstract description 4
- 238000013130 cardiovascular surgery Methods 0.000 abstract description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 244000309466 calf Species 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
Изобретение относитс к сердечно-сосудистой хирургии и касаетс обработки клапанов сердца. Цель - увеличение срока функционировани биопротеза. Биопротезы клапанов сердца обрабатывают в растворе глутарового альдегида и дополнительно обрабатывают 1-10%-ным раствором диаль- дегид декстрана при 30°С в течение 30 сут.This invention relates to cardiovascular surgery and concerns the processing of heart valves. The goal is to increase the life of the bioprosthesis. Heart valve bioprostheses are treated in a solution of glutaraldehyde and further treated with a 1-10% solution of dialdehyde dextran at 30 ° C for 30 days.
Description
Изобретение относитс к медицине, в частности к сердечно-сосудистой хирургии, и касаетс способа предоперационной обработки ксеноклапанов сердца.The invention relates to medicine, in particular to cardiovascular surgery, and relates to a method for the preoperative treatment of heart valve xenoklapans.
Целью изобретени вл етс увеличение срока функционировани биопротеза в организме.The aim of the invention is to extend the life of the bioprosthesis in the body.
Пример (по прототипу). Ксенопери- кард теленка фиксируют в 0,625%-ном растворе глутарового альдегида на фосфатном буфере рН 7,4 в течение 14 сут.Example (prototype). The calf xenopericard is fixed in a 0.625% glutaraldehyde solution on phosphate buffer pH 7.4 for 14 days.
П р и м е р 2. Ксеноперикард теленка фиксируют в 0,625%-ном растворе глутарового альдегида на фосфатном буфере рН 7,4 в течение 14 сут. затем помещают в 1 %-ный раствор диальдегид декстрана при 30°С в течение 30 сут Диальдегид декстран получают предварительно из декстрана методом периодатного окислени PRI mme R 2. Xenopericard calf is fixed in a 0.625% solution of glutaraldehyde in phosphate buffer pH 7.4 for 14 days. then placed in a 1% dehydran dialdehyde solution at 30 ° C for 30 days. Dialdehyde dextran is prepared in advance from dextran using the periodate oxidation method.
Примерз Ксеноперикард теленка фиксируют в 0,625%-ном растворе глутарового альдегида на фосфатном буфере рН 7,4 в течение 14 сут затем помещают в 10%-ныйA calf xenopericard is fixed in a 0.625% glutaraldehyde solution in phosphate buffer pH 7.4 for 14 days, then placed in a 10%
раствор диальдегид декстрана при 30°С в течение 30 сут.dialdehyde dextran solution at 30 ° C for 30 days.
Полученные образцы имплантировали в подкожную клетчатку подопытных крыс сроком на 60 сут, после забо животных их извлекали, высушивали, гомогенизировали с 1N HCI и измер ли уровень содержани кальци флуориметрически на кальциевом анализаторе Corning 940, США.The obtained samples were implanted into the subcutaneous tissue of experimental rats for a period of 60 days, after the animals were taken, they were removed, dried, homogenized with 1N HCI, and the calcium content was measured fluorimetrically using a Corning calcium analyzer USA.
В среднем (число наблюдений 6), содержание кальци в мкг/мг сухой ткани по примеру 1 составило 132,74+15,91, по примеру 2 - 89,7+11,6, по примеру 3 - 85,7+13,6. Анализ полученных результатов свидетель- ствуетотом, что предлагаемый способ способствует торможению процессов кальцификации в биоткани по сравнению с прототипом.On average (the number of observations 6), the calcium content in µg / mg of dry tissue in example 1 was 132.74 + 15.91, in example 2 - 89.7 + 11.6, in example 3 - 85.7 + 13, 6 Analysis of the results obtained suggests that the proposed method contributes to the inhibition of calcification processes in biotissue compared with the prototype.
Предлагаемый способ позвол ет получить биоклапан сердца с неограниченным сроком полноценной функции, что избавит пациентов от повторной операции.The proposed method allows one to obtain a biological valve of the heart with an unlimited period of full function, which will relieve patients from re-operation.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU884447369A SU1651890A1 (en) | 1988-06-22 | 1988-06-22 | Method for treatment of heart valve bioprothesis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU884447369A SU1651890A1 (en) | 1988-06-22 | 1988-06-22 | Method for treatment of heart valve bioprothesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU1651890A1 true SU1651890A1 (en) | 1991-05-30 |
Family
ID=21384228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU884447369A SU1651890A1 (en) | 1988-06-22 | 1988-06-22 | Method for treatment of heart valve bioprothesis |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU1651890A1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004028A1 (en) * | 1994-07-29 | 1996-02-15 | Baxter International Inc. | Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods |
| US5782931A (en) * | 1996-07-30 | 1998-07-21 | Baxter International Inc. | Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
-
1988
- 1988-06-22 SU SU884447369A patent/SU1651890A1/en active
Non-Patent Citations (1)
| Title |
|---|
| Патент US N 3966401. кл. 8/94, 11, 1968 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004028A1 (en) * | 1994-07-29 | 1996-02-15 | Baxter International Inc. | Methods for treating implantable biological tissues to mitigate the calcification thereof and bioprosthetic articles treated by such methods |
| US7029434B2 (en) | 1994-07-29 | 2006-04-18 | Edwards Lifesciences Corporation | Methods for treating implantable biological tissues to mitigate post—implantation calcification |
| US5782931A (en) * | 1996-07-30 | 1998-07-21 | Baxter International Inc. | Methods for mitigating calcification and improving durability in glutaraldehyde-fixed bioprostheses and articles manufactured by such methods |
| US5935168A (en) * | 1996-07-30 | 1999-08-10 | Baxter International Inc. | Glutaraldehyde-fixed bioprostheses |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
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