SU136852A1 - The method of obtaining injection solutions of indigo carmine - Google Patents
The method of obtaining injection solutions of indigo carmineInfo
- Publication number
- SU136852A1 SU136852A1 SU654620A SU654620A SU136852A1 SU 136852 A1 SU136852 A1 SU 136852A1 SU 654620 A SU654620 A SU 654620A SU 654620 A SU654620 A SU 654620A SU 136852 A1 SU136852 A1 SU 136852A1
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- indigo carmine
- injection solutions
- obtaining injection
- solution
- obtaining
- Prior art date
Links
- 239000000243 solution Substances 0.000 title description 8
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 title description 7
- 229960003988 indigo carmine Drugs 0.000 title description 7
- 235000012738 indigotine Nutrition 0.000 title description 7
- 239000004179 indigotine Substances 0.000 title description 7
- 238000000034 method Methods 0.000 title description 7
- 238000002347 injection Methods 0.000 title description 3
- 239000007924 injection Substances 0.000 title description 3
- XWGJFPHUCFXLBL-UHFFFAOYSA-M rongalite Chemical compound [Na+].OCS([O-])=O XWGJFPHUCFXLBL-UHFFFAOYSA-M 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- -1 hydrogen ions Chemical class 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Изобретение касаетс способов получени инъекционных растворов индигокармина с добавлением стабилизирующих веществ.The invention relates to methods for producing injection solutions of indigo carmine with the addition of stabilizing substances.
При применении известных сиособов дл приготовлени инъекционных растворов нельз использовать сухой индигокармин, хранившийс s течение длительного времени. Кроме того, использу известный метод, ампулы с раствором приходитс запаивать под вакуумом, дл чего требуетс специальна аппаратура.When using the known methods for preparing injection solutions, it is impossible to use dry indigo carmine stored for a long time. In addition, using the well-known method, ampoules with a solution must be sealed under vacuum, for which special equipment is required.
В описываемом способе указанные недостатки исключаютс тем, что в качестве стабилизаторов используетс ронгалит и лимоннокислый натрий .In the described method, these disadvantages are excluded by the use of rongalite and sodium citrate as stabilizers.
Собственно стабилизатором вл етс ронгалит, добавл емый при приготовлении ампул с 0,4%-ным раствором индигокармина в количестве 0,05%. Однако раствор ронгалита устойчив лишь при значени х , поэтому дл создани необходимой концентрации водоро ;ных ионов в раствор в качестве буфера добавл етс лимоннокислый натрий в количестве 0,1%,The stabilizer itself is rongalite added during the preparation of ampoules with a 0.4% solution of indigo carmine in an amount of 0.05%. However, the rongalite solution is stable only at values, therefore, in order to create the necessary concentration of hydrogen ions, sodium citrate is added to the solution in an amount of 0.1%,
Полученный по описываемому способу 0,4%-кый инъекционный раствор индигокармина не дает осадка при хранении его в течение полутора лет при комнатной температуре и в течение шести мес цев при температуре 75°.The 0.4% injectable solution of indigo carmine obtained by the described method does not precipitate during storage for one and a half years at room temperature and for six months at a temperature of 75 °.
Предмет изобретени Subject invention
Способ получени инъекционных растворов индигокармина с добавлением стабилизирующих веществ, от л и ч а ю щи и с тем, что, с целью применени сухого индигокармина различных сроков хранени и исключени запайки ампул под вакуумом, используют в качестве стабилизаторов ронгалит и лимоннокисль1Й нагрий.The method of obtaining injectable solutions of indigo carmine with the addition of stabilizing substances, from l and h and with the fact that, in order to use dry indigo carmine of various storage times and eliminate sealing of ampoules under vacuum, rongalite and citric acid heating are used as stabilizers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU654620A SU136852A1 (en) | 1960-02-15 | 1960-02-15 | The method of obtaining injection solutions of indigo carmine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SU654620A SU136852A1 (en) | 1960-02-15 | 1960-02-15 | The method of obtaining injection solutions of indigo carmine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU136852A1 true SU136852A1 (en) | 1960-11-30 |
Family
ID=48293099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU654620A SU136852A1 (en) | 1960-02-15 | 1960-02-15 | The method of obtaining injection solutions of indigo carmine |
Country Status (1)
| Country | Link |
|---|---|
| SU (1) | SU136852A1 (en) |
-
1960
- 1960-02-15 SU SU654620A patent/SU136852A1/en active
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