SU1242113A1 - Method of investigating mucous membrane of nasal cavity - Google Patents

Description

The invention relates to medicine, namely to otolaryngology,

The aim of the invention is to study simultaneously the excretory, absorption and transport function of the nasal mucosa with a polymer soluble film containing methylene blue as an indicator. The method is carried out as follows.

A certain size piece of plastic film from hydroxypropyl methylcellulose (OPMC) containing methylene blue is introduced into the nasal cavity at the anterior end of the lower nasal concha; The mucous membrane and the location of the polymer film is stained by the absorption of methylene blue. The excretory function of the mucous membrane is assessed by the time required for the solution of a piece of polymer film of a certain size (3 cm), with an effective content-indicator (1 mg MBTmieHOBoro-blue per 1 cm film), mucus produced by the mucous membrane of the membrane the function is the transit time of the tinted mucus from the anterior end of the inferior nasal cancers to the nasopharynx; the suction function is the visual determination of the degree of staining of the mucous membrane in the location of the polymeric film: no staining, staining is weak, moderate, intense.

The method of preparation of the polymer film, g:

Methylene

blue1

OPMTS6

Distilled water. Up to 100

Under aseptic conditions, 6 g of OPMC are dissolved in 50 ml of water and mixed with a solution of methylene blue in 43 ml of water, filtered and poured into 1000 cm forms, dried by heating to 40-50 C.

There is 1 mg of methylene blue in 1 cm of the obtained polymer soluble film with a thickness of 0.1 MNf.

five

A piece of film measuring 1 0.3 cm is laid on the upper surface of the lower nasal shell perpendicular to its longitudinal axis, indent

from the front end at 1-1.5 cm. After 8–10 min, the film is enveloped with mucus and dissolves, the tinted mucus is moved by the movement of the cilia of the ciliated epithelium towards the side.

Well, nasopharynx. In a healthy mucous membrane, the tinted mucus from the anterior end of the inferior nasal concha sinks obliquely posteriorly and downwards, and then moves along the free

5 edge of the inferior nasal concha to its posterior end and the bottom of the nasal cavity. The production every 2-3 min. Posteriorine rhinoscopy, determine the time of appearance of tinted mucus in the no. Of the throat. Normal mucociliary mucosal activity ranges from 25 to 40 minutes and is equal to

average .

In the area of the mucous membrane where a piece of polymer film is located, with an adequate release of mucus, it stains blue due to the absorption of methylene blue, which is due to the fact that it is polymeric; the film laid on the surface of the mucous membrane is in direct contact with the epithema. with the lial cells and the protoplasmic processes located between the cilia on the surface of the epithelium, the 1st cells and regulating the processes of absorption and. .

The intensity of staining of the mucous membrane depends on the amount of secretion produced on its surface.

An acute inflammatory process characterized by abundant secretion

With mucus, the film dissolves quickly and tinted mucus flows down.

into the common nasal passage. In atrophic rhinitis, characterized by inhibition of secretion, the dissolution of the film occurs extremely slowly and the mucous membrane at the location of the film is intensely colored blue.

Example. Sick T. 53 years. -5 Diagnosis: chronic atrophic rhinitis. When rhinoscopy is determined: the mucous membrane is thinned, covered with earplugs with dry crusts, nasal

0

3..

moves are fine. After removal of the crusts, polymer films with dimensions of 1x0.3 cm are placed on the front ends of the lower nasal cavities. The films dissolve after: 55 min., The mucus does not move along the surface of the nasal concha, the mucous membrane is intensely colored p blue. The normal coloring of the mucous membrane acquires after 40 hours. After the treatment, the mucous membrane of the nasal cavity became more humid, cleared of crusts. When you repeat the examination, the films are diluted after 20 minutes, the tinted mucus is found in the nasopharynx, after 65 minutes, the mucous membrane is stained blue and blue. J becomes normal after 20 hours.

Correlation of excretory, absorption and

Norm

8-10

Acute rhinitis

4-5

Catarral or vasomotor rhinitis.

Hypertrophic rhinitis

Atrophic rhinitis

50-60

In comparative studies of the studied functions of the nasal mucosa by known and proposed methods for 13 patients, 13.4.

transport functions in 86 6ojibHbix with various forms of rhinitis. In acute rhinitis, chronic, catarrhal and vasomotor rhinitis with excessive secretion, there is a rapid resorption in patients with a polymer film, accumulation of secretions in the general nasal passage, inhibition of the migratory activity of the ciliated epithelium, reduction of the absorption capacity of the mucous membrane. In case of atrophic rhinitis, secretion inhibition and prolonged resorption of the polymer film, sharp depression or complete absence of the motor activity of the ciliated epithelium, intensive staining of the mucous membrane at the location of the polymer film are noted.

The average indices of the state of the studied functions in various forms of rhinitis are presented in Table 1. Table -G

Weak or moderate staining of the mucous membrane

60- & 5

No or weak staining

80-90

Also

50-55

Moderate staining

Intense staining

It was noted that the examination of the patient using the proposed method was carried out 3 times faster than using lime methods (Table 2).

Table 2

Research method

Famous:

study of the absorption function by the method of B.M.Sagalovich

research of excretory function by AAArutiunov method

study of the transport function

Editor G. Volkova

Compiled by I.Pozn to

Tehred O. Sopko Proofreader E. Roshko

Order 3635/6 Circulation 660 Subscription

: VNIIPI USSR State Committee

for inventions and discoveries 113035, Moscow, Zh-35, Raushsk nab., 4/5

Production and printing company, Uzhgorod, Projecto st., 4

Duration of research, min

90

. 40

40 50-60

Claims (1)

METHOD FOR STUDYING THE Mucous membrane of the NOSE CAVITY by applying an indicator, characterized in that, in order to study simultaneously excretory, suction and transport function mucous membrane of the nasal cavity, a soluble film of hydroxypropylmethylcellulose containing methylene blue is introduced into the nasal cavity at the front end of the lower nasal turbinate, and the excretory function is examined by its dissolution rate, and the transport function of the tinted mucus from the front end of the lower turbinate to the nasopharynx is transported the function and the degree of staining of the mucous membrane at the location of the polymer film examine the absorption function of the mucous membrane of the nasal cavity.