SMT201300072B - Sale difosfato di N-[6-(cis-2,6-dimetilmorfolin-4-il)piridin-3-il]-2-metil-4'-(tri-fluorometossi)[1,1'-bifenil]-3-carbossammide - Google Patents

Sale difosfato di N-[6-(cis-2,6-dimetilmorfolin-4-il)piridin-3-il]-2-metil-4'-(tri-fluorometossi)[1,1'-bifenil]-3-carbossammide

Info

Publication number: SMT201300072B
Authority: SM; San Marino
Prior art keywords: dimethylmorfolin; carbossammide; bifenyl; fluoromethoxy; pyridin
Prior art date: 2008-09-17

Application number

SM201300072T

Other languages

English (en)

Italian (it)

Inventor

Raeann Wu

Joginder Singh Bajwa

Stephanie Kay Dodd

Liladhar Mulidhar Waykole

La Cruz Marilyn De

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-09-17

Filing date

2013-06-26

Publication date

2013-09-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41228716&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201300072(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-06-26 Application filed by Novartis Ag filed Critical Novartis Ag

2013-09-06 Publication of SMT201300072B publication Critical patent/SMT201300072B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SM201300072T 2008-09-17 2013-06-26 Sale difosfato di N-[6-(cis-2,6-dimetilmorfolin-4-il)piridin-3-il]-2-metil-4'-(tri-fluorometossi)[1,1'-bifenil]-3-carbossammide SMT201300072B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US9758008P	2008-09-17	2008-09-17
PCT/US2009/056918 WO2010033481A1 (en)	2008-09-17	2009-09-15	Salts of n-[6-cis-2,6-dimethylmorpholin-4yl)pyridine-3yl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide

Publications (1)

Publication Number	Publication Date
SMT201300072B true SMT201300072B (it)	2013-09-06

Family

ID=41228716

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201300072T SMT201300072B (it)	2008-09-17	2013-06-26	Sale difosfato di N-[6-(cis-2,6-dimetilmorfolin-4-il)piridin-3-il]-2-metil-4'-(tri-fluorometossi)[1,1'-bifenil]-3-carbossammide

Country Status (39)

Country	Link
US (3)	US8063043B2 (es)
EP (1)	EP2342198B1 (es)
JP (2)	JP4897938B2 (es)
KR (2)	KR101129088B1 (es)
CN (1)	CN102159570B (es)
AR (2)	AR073591A1 (es)
AU (1)	AU2009293444B2 (es)
BR (2)	BR122020009045B1 (es)
CA (1)	CA2736751C (es)
CL (1)	CL2011000551A1 (es)
CO (1)	CO6351744A2 (es)
CR (1)	CR20110126A (es)
CU (1)	CU23860B1 (es)
DK (1)	DK2342198T3 (es)
DO (1)	DOP2011000082A (es)
EA (1)	EA020048B1 (es)
EC (1)	ECSP11010985A (es)
ES (1)	ES2418485T3 (es)
GE (1)	GEP20125592B (es)
HN (1)	HN2011000745A (es)
HR (1)	HRP20130597T1 (es)
IL (1)	IL211412A (es)
JO (1)	JO2889B1 (es)
MA (1)	MA32717B1 (es)
MX (1)	MX2011002805A (es)
MY (1)	MY151100A (es)
NI (1)	NI201100051A (es)
NZ (1)	NZ591420A (es)
PE (1)	PE20110292A1 (es)
PH (1)	PH12012500399A1 (es)
PL (1)	PL2342198T3 (es)
PT (1)	PT2342198E (es)
SI (1)	SI2342198T1 (es)
SM (1)	SMT201300072B (es)
SV (1)	SV2011003857A (es)
TW (1)	TWI367883B (es)
UA (1)	UA103049C2 (es)
WO (1)	WO2010033481A1 (es)
ZA (1)	ZA201101579B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI433674B (zh)	2006-12-28	2014-04-11	Infinity Discovery Inc	環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類
CN101993415B (zh) *	2010-09-15	2013-08-14	北京韩美药品有限公司	作为Hedgehog通路抑制剂的化合物以及包含该化合物的药物组合物及其应用
JP6310484B2 (ja) *	2013-02-25	2018-04-11	サンファーマグローバルエフゼットイー	オンコロジー薬物の経口製剤および懸濁剤
WO2015092720A1 (en) *	2013-12-19	2015-06-25	Novartis Ag	Metabolites of sonidegib (lde225)
CN105906616B (zh) *	2015-03-30	2018-09-04	苏州晶云药物科技有限公司	Lde225单磷酸盐的晶型及其制备方法
US10369147B2 (en)	2015-06-04	2019-08-06	PellePharm, Inc.	Topical formulations for delivery of hedgehog inhibitor compounds and use thereof
EP3429571B1 (en)	2016-03-15	2025-10-08	Oryzon Genomics, S.A.	Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases
WO2017163258A1 (en) *	2016-03-22	2017-09-28	Msn Laboratories Private Limited	Process for the preparation of n-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2- methyl-4'-(trifiuoromethoxy) [1,1' -biphenyi]-3-carboxamide and its polymorphs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4933259B2 (ja) *	2003-10-02	2012-05-16	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	ピロール置換インドリノン化合物の塩および多形
GB0412468D0 (en) *	2004-06-04	2004-07-07	Astrazeneca Ab	Chemical compounds
UA93548C2 (uk) *	2006-05-05	2011-02-25	Айерем Елелсі	Сполуки та композиції як модулятори хеджхогівського сигнального шляху
PE20080948A1 (es) *	2006-07-25	2008-09-10	Irm Llc	Derivados de imidazol como moduladores de la senda de hedgehog

2009
- 2009-09-15 PL PL09792531T patent/PL2342198T3/pl unknown
- 2009-09-15 DK DK09792531.7T patent/DK2342198T3/da active
- 2009-09-15 PT PT97925317T patent/PT2342198E/pt unknown
- 2009-09-15 MX MX2011002805A patent/MX2011002805A/es active IP Right Grant
- 2009-09-15 CN CN200980144876.0A patent/CN102159570B/zh active Active
- 2009-09-15 GE GEAP200912188A patent/GEP20125592B/en unknown
- 2009-09-15 JO JO2009340A patent/JO2889B1/en active
- 2009-09-15 CA CA2736751A patent/CA2736751C/en active Active
- 2009-09-15 SI SI200930626T patent/SI2342198T1/sl unknown
- 2009-09-15 EA EA201100501A patent/EA020048B1/ru not_active IP Right Cessation
- 2009-09-15 PE PE2011000619A patent/PE20110292A1/es active IP Right Grant
- 2009-09-15 ES ES09792531T patent/ES2418485T3/es active Active
- 2009-09-15 EP EP09792531A patent/EP2342198B1/en active Active
- 2009-09-15 AR ARP090103530A patent/AR073591A1/es not_active Application Discontinuation
- 2009-09-15 KR KR1020117008623A patent/KR101129088B1/ko active Active
- 2009-09-15 BR BR122020009045-6A patent/BR122020009045B1/pt active IP Right Grant
- 2009-09-15 NZ NZ591420A patent/NZ591420A/en unknown
- 2009-09-15 KR KR1020127000312A patent/KR20120015363A/ko not_active Ceased
- 2009-09-15 US US13/061,572 patent/US8063043B2/en active Active
- 2009-09-15 JP JP2011527035A patent/JP4897938B2/ja active Active
- 2009-09-15 AU AU2009293444A patent/AU2009293444B2/en active Active
- 2009-09-15 BR BRPI0918629A patent/BRPI0918629B8/pt active IP Right Grant
- 2009-09-15 WO PCT/US2009/056918 patent/WO2010033481A1/en not_active Ceased
- 2009-09-15 MY MYPI20110929 patent/MY151100A/en unknown
- 2009-09-15 UA UAA201103086A patent/UA103049C2/uk unknown
- 2009-09-15 HR HRP20130597AT patent/HRP20130597T1/hr unknown
- 2009-09-15 PH PH1/2012/500399A patent/PH12012500399A1/en unknown
- 2009-09-16 TW TW098131254A patent/TWI367883B/zh active
2011
- 2011-02-24 IL IL211412A patent/IL211412A/en active IP Right Grant
- 2011-03-01 ZA ZA2011/01579A patent/ZA201101579B/en unknown
- 2011-03-09 CR CR20110126A patent/CR20110126A/es unknown
- 2011-03-11 NI NI201100051A patent/NI201100051A/es unknown
- 2011-03-15 HN HN2011000745A patent/HN2011000745A/es unknown
- 2011-03-15 CU CU2011000055A patent/CU23860B1/es active IP Right Grant
- 2011-03-16 CL CL2011000551A patent/CL2011000551A1/es unknown
- 2011-03-16 DO DO2011000082A patent/DOP2011000082A/es unknown
- 2011-03-17 SV SV2011003857A patent/SV2011003857A/es unknown
- 2011-03-25 CO CO11036968A patent/CO6351744A2/es not_active Application Discontinuation
- 2011-04-15 EC EC2011010985A patent/ECSP11010985A/es unknown
- 2011-04-15 MA MA33778A patent/MA32717B1/fr unknown
- 2011-10-13 US US13/272,814 patent/US20120035174A1/en not_active Abandoned
- 2011-12-22 JP JP2011282061A patent/JP2012097104A/ja active Pending
2012
- 2012-05-02 US US13/462,483 patent/US20120214810A1/en not_active Abandoned
2013
- 2013-06-26 SM SM201300072T patent/SMT201300072B/xx unknown
2018
- 2018-10-18 AR ARP180103036A patent/AR113778A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
GEP20125592B (en)	2012-07-25
PL2342198T3 (pl)	2013-08-30
CL2011000551A1 (es)	2011-07-15
KR20120015363A (ko)	2012-02-21
KR101129088B1 (ko)	2012-03-23
US8063043B2 (en)	2011-11-22
US20120035174A1 (en)	2012-02-09
ES2418485T3 (es)	2013-08-14
PT2342198E (pt)	2013-07-10
TW201016686A (en)	2010-05-01
AR113778A2 (es)	2020-06-10
US20110178085A1 (en)	2011-07-21
IL211412A0 (en)	2011-05-31
IL211412A (en)	2014-07-31
CU20110055A7 (es)	2011-12-28
CR20110126A (es)	2011-04-27
CO6351744A2 (es)	2011-12-20
BR122020009045A2 (pt)	2020-11-10
JO2889B1 (en)	2015-03-15
JP4897938B2 (ja)	2012-03-14
EA201100501A1 (ru)	2011-10-31
TWI367883B (en)	2012-07-11
ZA201101579B (en)	2011-11-30
HN2011000745A (es)	2014-01-06
SV2011003857A (es)	2011-05-16
CU23860B1 (es)	2013-02-26
JP2012502912A (ja)	2012-02-02
CA2736751C (en)	2012-10-23
AU2009293444A1 (en)	2010-03-25
HK1156628A1 (en)	2012-06-15
CN102159570A (zh)	2011-08-17
PE20110292A1 (es)	2011-05-17
CA2736751A1 (en)	2010-03-25
JP2012097104A (ja)	2012-05-24
ECSP11010985A (es)	2011-05-31
UA103049C2 (uk)	2013-09-10
WO2010033481A1 (en)	2010-03-25
SI2342198T1 (sl)	2013-07-31
NI201100051A (es)	2011-09-08
PH12012500399A1 (en)	2014-04-28
KR20110056325A (ko)	2011-05-26
NZ591420A (en)	2012-07-27
CN102159570B (zh)	2014-01-15
MX2011002805A (es)	2011-04-11
AU2009293444B2 (en)	2012-03-15
EA020048B1 (ru)	2014-08-29
BRPI0918629B1 (pt)	2021-04-13
DOP2011000082A (es)	2011-04-15
US20120214810A1 (en)	2012-08-23
AR073591A1 (es)	2010-11-17
EP2342198A1 (en)	2011-07-13
HRP20130597T1 (en)	2013-07-31
MY151100A (en)	2014-04-15
DK2342198T3 (da)	2013-07-01
BR122020009045B1 (pt)	2022-08-02
EP2342198B1 (en)	2013-04-03
BRPI0918629A2 (pt)	2020-10-27
MA32717B1 (fr)	2011-10-02
BRPI0918629B8 (pt)	2021-05-25

Publication	Publication Date	Title
SMT201300072B (it)	2013-09-06	Sale difosfato di N-[6-(cis-2,6-dimetilmorfolin-4-il)piridin-3-il]-2-metil-4'-(tri-fluorometossi)[1,1'-bifenil]-3-carbossammide
HRP20190378T1 (hr)	2019-04-19	Prolijekovi tetrahidrokanabinola, pripravci koji sadržavaju prolijekove tetrahidrokanabinola i postupci za njihovu uporabu
BRPI0907563A2 (pt)	2015-08-04	Derivados de 4,5-di-hidro-xazol-2-il amina
ATE541850T1 (de)	2012-02-15	Pyrroloä2,3-cüpyridinderivate als p38-kinase- hemmende mittel
BRPI0810349A2 (pt)	2014-10-14	"artigo"
PT2044036E (pt)	2011-08-23	Derivados de [4,5′]bipirimidinil-6,4′-diamina como inibidores de proteína quinase
DK2238213T3 (da)	2017-11-06	Trans-chlor-3,3,3-trifluorpropen til anvendelse i køleindretninger
HRP20160859T1 (hr)	2016-09-23	Modificirani proteini rsv f i postupci njihove upotrebe
PL2252597T3 (pl)	2014-09-30	Pochodne pirazyny i ich zastosowanie jako inhibitorów kinaz białkowych
EP2332425A4 (en)	2015-07-15	flavoring
DE602008005634D1 (de)	2011-04-28	1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
IL211674A0 (en)	2011-06-30	3-amino-indazole or 3-amino-4,5,6,7- tetrahydro-indazole derivatives
IL209421A (en)	2015-06-30	Kionoxalindone derivatives, medicines containing them and their use
BRPI0908050A2 (pt)	2015-08-11	Furo-e tieno[3,2-c]piridinas
IL206808A0 (en)	2010-12-30	Indolyl-pyridone derivatives having checkpoint kinase 1 inhibitory activity
IL212070A (en)	2014-07-31	Phenyl and pyridyl history of 7-piperidinoalkyl-4,3-dihydroquinolone
BRPI0907217A2 (pt)	2015-07-14	Modelo de cabeça em o.
DE102008005493A8 (de)	2010-03-25	4-(Pyrrolo[2,3-c] pyridine-3-yl)-pyrimidin-2-yl-amin-derivate
IL206531A0 (en)	2010-12-30	Cyclic pyridyl-n-(1,3,4)-thiadiazol-2-yl-benzene sulfonamides, processes for their preparation and their use as pharmaceuticals
BRPI0914354A2 (pt)	2015-10-20	"métodos e artigos"
EP2184277A4 (en)	2012-01-04	ARYLPYRIMIDINE DERIVATIVES, METHODS OF PREPARATION AND PHARMACEUTICAL USES OF THE DERIVATIVES
DE602006014832D1 (de)	2010-07-22	Rauchartikel
BRPI0913401A2 (pt)	2015-11-24	pregn-4 eno-21, 17-carbolactonas substituídas no anel c e preparados farmacêuticos contendo as mesmas
BRPI0907749A2 (pt)	2015-07-21	Derivados de 3,8-diaminotetrahidroquinolina
HRP20150021T1 (xx)	2015-03-27	Spojevi fenantrenona, pripravci i postupci