SK80297A3 - Tetracyclic spiro compounds, process for their preparation and pharmaceutical composition containing the same - Google Patents
Tetracyclic spiro compounds, process for their preparation and pharmaceutical composition containing the same Download PDFInfo
- Publication number
- SK80297A3 SK80297A3 SK802-97A SK80297A SK80297A3 SK 80297 A3 SK80297 A3 SK 80297A3 SK 80297 A SK80297 A SK 80297A SK 80297 A3 SK80297 A3 SK 80297A3
- Authority
- SK
- Slovakia
- Prior art keywords
- methyl
- piperidine
- carbonyl
- furo
- indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426029.6A GB9426029D0 (en) | 1994-12-22 | 1994-12-22 | Novel compounds |
| GBGB9512920.1A GB9512920D0 (en) | 1995-06-24 | 1995-06-24 | Novel compounds |
| PCT/EP1995/004889 WO1996019477A1 (en) | 1994-12-22 | 1995-12-06 | Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK80297A3 true SK80297A3 (en) | 1998-12-02 |
Family
ID=26306239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK802-97A SK80297A3 (en) | 1994-12-22 | 1995-12-06 | Tetracyclic spiro compounds, process for their preparation and pharmaceutical composition containing the same |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5972951A (es) |
| EP (1) | EP0799226B1 (es) |
| JP (1) | JPH10510821A (es) |
| CN (1) | CN1175256A (es) |
| AP (1) | AP757A (es) |
| AR (1) | AR002011A1 (es) |
| AT (1) | ATE199085T1 (es) |
| AU (1) | AU697361B2 (es) |
| BG (1) | BG61977B1 (es) |
| BR (1) | BR9510419A (es) |
| CA (1) | CA2208244A1 (es) |
| CZ (1) | CZ192397A3 (es) |
| DE (1) | DE69520075T2 (es) |
| DZ (1) | DZ1957A1 (es) |
| ES (1) | ES2153907T3 (es) |
| FI (1) | FI972583A7 (es) |
| HU (1) | HUT77650A (es) |
| IL (1) | IL116486A0 (es) |
| MA (1) | MA23753A1 (es) |
| MX (1) | MX9704777A (es) |
| NO (1) | NO972910L (es) |
| NZ (1) | NZ298036A (es) |
| OA (1) | OA10610A (es) |
| PL (1) | PL321048A1 (es) |
| SK (1) | SK80297A3 (es) |
| TR (1) | TR199501597A2 (es) |
| WO (1) | WO1996019477A1 (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9519033D0 (en) * | 1995-09-18 | 1995-11-15 | Smithkline Beecham Plc | Treatment |
| GB9522845D0 (en) * | 1995-11-08 | 1996-01-10 | Smithkline Beecham Plc | Novel compounds |
| WO1997017351A1 (en) * | 1995-11-08 | 1997-05-15 | Smithkline Beecham Plc | Spiro piperidine derivatives as 5mt receptor antagonists |
| EP0862565A1 (en) * | 1995-11-22 | 1998-09-09 | Smithkline Beecham Plc | Tricyclic spiro compounds as 5ht 1d? receptor antagonists |
| GB9605883D0 (en) * | 1996-03-20 | 1996-05-22 | Smithkline Beecham Plc | Novel compounds |
| GB9606396D0 (en) * | 1996-03-27 | 1996-06-05 | Smithkline Beecham Plc | Novel compounds |
| US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
| FR2761069A1 (fr) * | 1997-03-20 | 1998-09-25 | Pf Medicament | Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments |
| CA2347095A1 (en) * | 1998-10-16 | 2000-04-27 | Takeda Chemical Industries, Ltd. | Nitrogen-containing condensed heterocyclic derivatives, their production and agent |
| DE10051981A1 (de) | 2000-10-20 | 2002-05-02 | Bayer Ag | Substituierte Phenyluracile |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| AR045690A1 (es) * | 2003-06-03 | 2005-11-09 | Rib X Pharmaceuticals Inc | Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| JP5304981B2 (ja) | 2005-12-26 | 2013-10-02 | 日産化学工業株式会社 | １，３−ビス（置換フェニル）−３−ヒドロキシプロパン−１−オンおよび２−プロペン−１−オン化合物およびその塩 |
| EP2146716A4 (en) | 2007-04-20 | 2010-08-11 | Deciphera Pharmaceuticals Llc | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYELOPROLIFERATIVE SYNDROME AND OTHER PROLIFERATIVE DISEASES |
| CA2963784A1 (en) | 2007-06-08 | 2008-12-18 | Mannkind Corporation | Ire-1.alpha. inhibitors |
| US8952175B2 (en) | 2007-06-27 | 2015-02-10 | Nissan Chemical Industries, Ltd. | Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound |
| CA2741029A1 (en) | 2008-10-17 | 2010-04-22 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| NZ599334A (en) | 2009-10-14 | 2014-03-28 | Xenon Pharmaceuticals Inc | Synthetic methods for spiro-oxindole compounds |
| RU2596488C2 (ru) | 2010-02-26 | 2016-09-10 | Ксенон Фармасьютикалз Инк. | Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| WO2019036024A1 (en) | 2017-08-17 | 2019-02-21 | Bristol-Myers Squibb Company | 2- (1,1'-BIPHENYL) -1H-BENZO [D] IMIDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS AGONISTS OF APELIN AND APJ FOR THE TREATMENT OF CARDIOVASCULAR DISEASES |
| CA3089630A1 (en) | 2018-01-31 | 2019-08-08 | Deciphera Pharmaceuticals, Llc | Combination therapy for the treatment of mastocytosis |
| SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| KR20220045189A (ko) | 2019-08-12 | 2022-04-12 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양을 치료하는 방법 |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| SMT202300467T1 (it) | 2019-12-30 | 2024-01-10 | Deciphera Pharmaceuticals Llc | Formulazioni di inibitori di chinasi amorfi e loro procedimenti d’uso |
| SMT202400484T1 (it) | 2019-12-30 | 2025-01-14 | Deciphera Pharmaceuticals Llc | Composizioni di 1-(4-bromo-5-(1-etil-7-(metilammino)-2-osso-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofenil)-3-fenilurea |
| CA3184151A1 (en) * | 2020-06-29 | 2022-01-06 | Chris Murphy | Probenecid compounds for the treatment of inflammasome-mediated lung disease |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
| PT533268E (pt) | 1991-09-18 | 2002-02-28 | Glaxo Group Ltd | Derivados de benzanilida como antagonistas de 5-ht1d |
-
1995
- 1995-12-06 CA CA002208244A patent/CA2208244A1/en not_active Abandoned
- 1995-12-06 PL PL95321048A patent/PL321048A1/xx unknown
- 1995-12-06 MX MX9704777A patent/MX9704777A/es unknown
- 1995-12-06 CN CN95197616A patent/CN1175256A/zh active Pending
- 1995-12-06 AU AU43433/96A patent/AU697361B2/en not_active Ceased
- 1995-12-06 US US08/849,932 patent/US5972951A/en not_active Expired - Fee Related
- 1995-12-06 CZ CZ971923A patent/CZ192397A3/cs unknown
- 1995-12-06 AT AT95942116T patent/ATE199085T1/de active
- 1995-12-06 DE DE69520075T patent/DE69520075T2/de not_active Expired - Fee Related
- 1995-12-06 WO PCT/EP1995/004889 patent/WO1996019477A1/en not_active Ceased
- 1995-12-06 BR BR9510419A patent/BR9510419A/pt not_active Application Discontinuation
- 1995-12-06 FI FI972583A patent/FI972583A7/fi unknown
- 1995-12-06 SK SK802-97A patent/SK80297A3/sk unknown
- 1995-12-06 ES ES95942116T patent/ES2153907T3/es not_active Expired - Lifetime
- 1995-12-06 NZ NZ298036A patent/NZ298036A/en unknown
- 1995-12-06 AP APAP/P/1997/001006A patent/AP757A/en active
- 1995-12-06 JP JP8519477A patent/JPH10510821A/ja active Pending
- 1995-12-06 EP EP95942116A patent/EP0799226B1/en not_active Expired - Lifetime
- 1995-12-06 HU HU9800158A patent/HUT77650A/hu unknown
- 1995-12-19 AR ARP950100629A patent/AR002011A1/es unknown
- 1995-12-19 TR TR95/01597A patent/TR199501597A2/xx unknown
- 1995-12-20 DZ DZ950140A patent/DZ1957A1/fr active
- 1995-12-20 MA MA24106A patent/MA23753A1/fr unknown
- 1995-12-21 IL IL11648695A patent/IL116486A0/xx unknown
-
1997
- 1997-06-20 NO NO972910A patent/NO972910L/no unknown
- 1997-06-20 OA OA70033A patent/OA10610A/en unknown
- 1997-07-01 BG BG101715A patent/BG61977B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ298036A (en) | 1998-11-25 |
| ES2153907T3 (es) | 2001-03-16 |
| BR9510419A (pt) | 1998-05-19 |
| AP757A (en) | 1999-09-06 |
| EP0799226B1 (en) | 2001-02-07 |
| AU697361B2 (en) | 1998-10-01 |
| NO972910D0 (no) | 1997-06-20 |
| AP9701006A0 (en) | 1997-07-31 |
| DE69520075D1 (de) | 2001-03-15 |
| AR002011A1 (es) | 1998-01-07 |
| MA23753A1 (fr) | 1996-07-01 |
| CZ192397A3 (en) | 1997-09-17 |
| FI972583L (fi) | 1997-08-19 |
| EP0799226A1 (en) | 1997-10-08 |
| US5972951A (en) | 1999-10-26 |
| DZ1957A1 (fr) | 2002-02-17 |
| PL321048A1 (en) | 1997-11-24 |
| ATE199085T1 (de) | 2001-02-15 |
| OA10610A (en) | 2002-09-06 |
| WO1996019477A1 (en) | 1996-06-27 |
| FI972583A0 (fi) | 1997-06-17 |
| DE69520075T2 (de) | 2001-08-02 |
| BG61977B1 (bg) | 1998-11-30 |
| HUT77650A (hu) | 1998-07-28 |
| CN1175256A (zh) | 1998-03-04 |
| CA2208244A1 (en) | 1996-06-27 |
| JPH10510821A (ja) | 1998-10-20 |
| BG101715A (bg) | 1998-02-27 |
| AU4343396A (en) | 1996-07-10 |
| TR199501597A2 (tr) | 1996-07-21 |
| NO972910L (no) | 1997-08-14 |
| FI972583A7 (fi) | 1997-08-19 |
| MX9704777A (es) | 1997-10-31 |
| IL116486A0 (en) | 1997-08-14 |
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