SK6598A3 - P16 expression constructs and their application in cancer therapy - Google Patents

P16 expression constructs and their application in cancer therapy Download PDF

Info

Publication number: SK6598A3
Authority: SK; Slovakia
Prior art keywords: those; cell; nucleic acid; promoter; expression construct
Prior art date: 1995-07-17

Application number

SK65-98A

Other languages

English (en)

Slovak (sk)

Inventor

Xiaomei Jin

Jack Roth

Original Assignee

Univ Texas

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-17

Filing date

1996-07-17

Publication date

1998-09-09

1996-07-17 Application filed by Univ Texas filed Critical Univ Texas

1998-09-09 Publication of SK6598A3 publication Critical patent/SK6598A3/sk

Links

230000014509 gene expression Effects 0.000 title claims abstract description 141
238000011275 oncology therapy Methods 0.000 title abstract description 3
206010028980 Neoplasm Diseases 0.000 claims abstract description 81
238000000034 method Methods 0.000 claims abstract description 76
239000013598 vector Substances 0.000 claims abstract description 53
238000000338 in vitro Methods 0.000 claims abstract description 24
230000002950 deficient Effects 0.000 claims abstract description 13
230000010076 replication Effects 0.000 claims abstract description 12
210000004027 cell Anatomy 0.000 claims description 237
150000007523 nucleic acids Chemical class 0.000 claims description 113
102000039446 nucleic acids Human genes 0.000 claims description 101
108020004707 nucleic acids Proteins 0.000 claims description 101
108020004414 DNA Proteins 0.000 claims description 74
241000701161 unidentified adenovirus Species 0.000 claims description 54
201000011510 cancer Diseases 0.000 claims description 39
239000000203 mixture Substances 0.000 claims description 33
230000003612 virological effect Effects 0.000 claims description 32
230000000692 anti-sense effect Effects 0.000 claims description 23
239000002299 complementary DNA Substances 0.000 claims description 22
208000020816 lung neoplasm Diseases 0.000 claims description 20
239000012623 DNA damaging agent Substances 0.000 claims description 19
206010058467 Lung neoplasm malignant Diseases 0.000 claims description 19
201000005202 lung cancer Diseases 0.000 claims description 19
210000004881 tumor cell Anatomy 0.000 claims description 19
210000003527 eukaryotic cell Anatomy 0.000 claims description 17
239000008194 pharmaceutical composition Substances 0.000 claims description 16
230000005855 radiation Effects 0.000 claims description 15
230000001177 retroviral effect Effects 0.000 claims description 15
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 14
238000002347 injection Methods 0.000 claims description 14
239000007924 injection Substances 0.000 claims description 14
239000003085 diluting agent Substances 0.000 claims description 13
239000000872 buffer Substances 0.000 claims description 11
230000002401 inhibitory effect Effects 0.000 claims description 11
201000001441 melanoma Diseases 0.000 claims description 11
238000010276 construction Methods 0.000 claims description 10
241000124008 Mammalia Species 0.000 claims description 9
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 9
229960004316 cisplatin Drugs 0.000 claims description 9
230000008488 polyadenylation Effects 0.000 claims description 8
108091026890 Coding region Proteins 0.000 claims description 7
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 7
208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 7
229960002949 fluorouracil Drugs 0.000 claims description 7
239000003550 marker Substances 0.000 claims description 7
NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims description 6
RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims description 6
230000004663 cell proliferation Effects 0.000 claims description 6
VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 6
238000010253 intravenous injection Methods 0.000 claims description 6
206010005003 Bladder cancer Diseases 0.000 claims description 5
229940009456 adriamycin Drugs 0.000 claims description 5
229960005420 etoposide Drugs 0.000 claims description 5
201000005112 urinary bladder cancer Diseases 0.000 claims description 5
239000013603 viral vector Substances 0.000 claims description 5
230000035755 proliferation Effects 0.000 claims description 4
230000022532 regulation of transcription, DNA-dependent Effects 0.000 claims description 4
239000002904 solvent Substances 0.000 claims description 4
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 3
108010092160 Dactinomycin Proteins 0.000 claims description 3
RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims description 3
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 3
229940127093 camptothecin Drugs 0.000 claims description 3
229960000640 dactinomycin Drugs 0.000 claims description 3
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 3
229960004857 mitomycin Drugs 0.000 claims description 3
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 2
229960004679 doxorubicin Drugs 0.000 claims description 2
YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 claims description 2
YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 claims description 2
229960001237 podophyllotoxin Drugs 0.000 claims description 2
YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 claims description 2
241001529453 unidentified herpesvirus Species 0.000 claims description 2
229960001722 verapamil Drugs 0.000 claims description 2
239000013043 chemical agent Substances 0.000 claims 2
101100328536 Mus musculus Cntd1 gene Proteins 0.000 claims 1
206010046865 Vaccinia virus infection Diseases 0.000 claims 1
208000007089 vaccinia Diseases 0.000 claims 1
238000001727 in vivo Methods 0.000 abstract description 26
230000002068 genetic effect Effects 0.000 abstract description 6
230000005764 inhibitory process Effects 0.000 abstract description 5
230000001105 regulatory effect Effects 0.000 abstract description 4
230000009466 transformation Effects 0.000 abstract description 3
230000009702 cancer cell proliferation Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 description 135
102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 description 120
102000004169 proteins and genes Human genes 0.000 description 42
241000700605 Viruses Species 0.000 description 40
235000018102 proteins Nutrition 0.000 description 39
238000012546 transfer Methods 0.000 description 36
235000001014 amino acid Nutrition 0.000 description 26
238000011282 treatment Methods 0.000 description 23
241000699670 Mus sp. Species 0.000 description 21
229940024606 amino acid Drugs 0.000 description 21
150000001413 amino acids Chemical class 0.000 description 21
230000000295 complement effect Effects 0.000 description 20
208000015181 infectious disease Diseases 0.000 description 20
108020004635 Complementary DNA Proteins 0.000 description 19
238000010804 cDNA synthesis Methods 0.000 description 19
230000001404 mediated effect Effects 0.000 description 19
108090000765 processed proteins & peptides Proteins 0.000 description 19
230000006870 function Effects 0.000 description 18
239000002502 liposome Substances 0.000 description 18
230000027455 binding Effects 0.000 description 17
241001430294 unidentified retrovirus Species 0.000 description 17
239000003795 chemical substances by application Substances 0.000 description 16
230000035772 mutation Effects 0.000 description 16
241001465754 Metazoa Species 0.000 description 15
230000000694 effects Effects 0.000 description 15
239000002609 medium Substances 0.000 description 15
108091032973 (ribonucleotides)n+m Proteins 0.000 description 14
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 14
239000002953 phosphate buffered saline Substances 0.000 description 14
102000004196 processed proteins & peptides Human genes 0.000 description 14
238000013518 transcription Methods 0.000 description 14
230000035897 transcription Effects 0.000 description 14
238000012217 deletion Methods 0.000 description 13
230000037430 deletion Effects 0.000 description 13
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 12
239000013612 plasmid Substances 0.000 description 12
108020004705 Codon Proteins 0.000 description 11
108020003175 receptors Proteins 0.000 description 11
102000005962 receptors Human genes 0.000 description 11
238000006467 substitution reaction Methods 0.000 description 11
230000001225 therapeutic effect Effects 0.000 description 11
108091034117 Oligonucleotide Proteins 0.000 description 10
230000022131 cell cycle Effects 0.000 description 10
238000009396 hybridization Methods 0.000 description 10
239000000463 material Substances 0.000 description 10
238000012360 testing method Methods 0.000 description 10
210000001519 tissue Anatomy 0.000 description 10
102100025064 Cellular tumor antigen p53 Human genes 0.000 description 9
101000980932 Homo sapiens Cyclin-dependent kinase inhibitor 2A Proteins 0.000 description 9
101000733249 Homo sapiens Tumor suppressor ARF Proteins 0.000 description 9
241001135569 Human adenovirus 5 Species 0.000 description 9
239000000427 antigen Substances 0.000 description 9
108091007433 antigens Proteins 0.000 description 9
102000036639 antigens Human genes 0.000 description 9
238000013459 approach Methods 0.000 description 9
230000015572 biosynthetic process Effects 0.000 description 9
238000001415 gene therapy Methods 0.000 description 9
230000012010 growth Effects 0.000 description 9
238000011534 incubation Methods 0.000 description 9
238000004806 packaging method and process Methods 0.000 description 9
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 8
238000001514 detection method Methods 0.000 description 8
239000003623 enhancer Substances 0.000 description 8
210000003494 hepatocyte Anatomy 0.000 description 8
230000010354 integration Effects 0.000 description 8
239000003446 ligand Substances 0.000 description 8
210000004962 mammalian cell Anatomy 0.000 description 8
239000000047 product Substances 0.000 description 8
108091092562 ribozyme Proteins 0.000 description 8
239000000243 solution Substances 0.000 description 8
238000001890 transfection Methods 0.000 description 8
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 7
108091007914 CDKs Proteins 0.000 description 7
108090000994 Catalytic RNA Proteins 0.000 description 7
102000053642 Catalytic RNA Human genes 0.000 description 7
108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 7
102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 7
108090000790 Enzymes Proteins 0.000 description 7
125000003275 alpha amino acid group Chemical group 0.000 description 7
238000004458 analytical method Methods 0.000 description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
239000012634 fragment Substances 0.000 description 7
210000004185 liver Anatomy 0.000 description 7
239000002773 nucleotide Substances 0.000 description 7
125000003729 nucleotide group Chemical group 0.000 description 7
239000002245 particle Substances 0.000 description 7
230000014616 translation Effects 0.000 description 7
238000005406 washing Methods 0.000 description 7
239000004475 Arginine Substances 0.000 description 6
241000701022 Cytomegalovirus Species 0.000 description 6
102000053602 DNA Human genes 0.000 description 6
230000005778 DNA damage Effects 0.000 description 6
231100000277 DNA damage Toxicity 0.000 description 6
230000004543 DNA replication Effects 0.000 description 6
102000004190 Enzymes Human genes 0.000 description 6
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 6
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 6
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 6
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 6
108091028043 Nucleic acid sequence Proteins 0.000 description 6
241000700159 Rattus Species 0.000 description 6
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 6
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 6
230000001580 bacterial effect Effects 0.000 description 6
230000001413 cellular effect Effects 0.000 description 6
210000000349 chromosome Anatomy 0.000 description 6
201000010099 disease Diseases 0.000 description 6
229940088598 enzyme Drugs 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
238000009472 formulation Methods 0.000 description 6
210000005260 human cell Anatomy 0.000 description 6
230000001965 increasing effect Effects 0.000 description 6
208000002154 non-small cell lung carcinoma Diseases 0.000 description 6
108700042657 p16 Genes Proteins 0.000 description 6
239000000126 substance Substances 0.000 description 6
230000008685 targeting Effects 0.000 description 6
230000001131 transforming effect Effects 0.000 description 6
238000013519 translation Methods 0.000 description 6
108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 description 5
239000004471 Glycine Substances 0.000 description 5
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 5
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 5
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 5
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 5
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 5
239000004472 Lysine Substances 0.000 description 5
229920001213 Polysorbate 20 Polymers 0.000 description 5
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 5
108010040002 Tumor Suppressor Proteins Proteins 0.000 description 5
102000001742 Tumor Suppressor Proteins Human genes 0.000 description 5
235000004279 alanine Nutrition 0.000 description 5
239000007864 aqueous solution Substances 0.000 description 5
230000033228 biological regulation Effects 0.000 description 5
238000004113 cell culture Methods 0.000 description 5
230000010261 cell growth Effects 0.000 description 5
238000002512 chemotherapy Methods 0.000 description 5
238000011161 development Methods 0.000 description 5
230000018109 developmental process Effects 0.000 description 5
210000002919 epithelial cell Anatomy 0.000 description 5
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 5
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 5
PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 5
239000002644 phorbol ester Substances 0.000 description 5
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 5
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 5
238000001959 radiotherapy Methods 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
239000000523 sample Substances 0.000 description 5
241000894007 species Species 0.000 description 5
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 5
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
241000700721 Hepatitis B virus Species 0.000 description 4
241000282412 Homo Species 0.000 description 4
241000598171 Human adenovirus sp. Species 0.000 description 4
241000699666 Mus <mouse, genus> Species 0.000 description 4
108700005077 Viral Genes Proteins 0.000 description 4
230000004075 alteration Effects 0.000 description 4
238000003556 assay Methods 0.000 description 4
230000008859 change Effects 0.000 description 4
239000011248 coating agent Substances 0.000 description 4
238000000576 coating method Methods 0.000 description 4
230000006378 damage Effects 0.000 description 4
239000003937 drug carrier Substances 0.000 description 4
238000001476 gene delivery Methods 0.000 description 4
239000001963 growth medium Substances 0.000 description 4
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
230000000977 initiatory effect Effects 0.000 description 4
238000001990 intravenous administration Methods 0.000 description 4
239000006193 liquid solution Substances 0.000 description 4
210000004072 lung Anatomy 0.000 description 4
230000003211 malignant effect Effects 0.000 description 4
210000003205 muscle Anatomy 0.000 description 4
210000000056 organ Anatomy 0.000 description 4
230000008439 repair process Effects 0.000 description 4
238000007920 subcutaneous administration Methods 0.000 description 4
230000005740 tumor formation Effects 0.000 description 4
238000011144 upstream manufacturing Methods 0.000 description 4
NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 3
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
108020005544 Antisense RNA Proteins 0.000 description 3
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 3
108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 3
102000003903 Cyclin-dependent kinases Human genes 0.000 description 3
108090000266 Cyclin-dependent kinases Proteins 0.000 description 3
238000002965 ELISA Methods 0.000 description 3
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 3
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 3
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 3
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 3
108700019961 Neoplasm Genes Proteins 0.000 description 3
102000048850 Neoplasm Genes Human genes 0.000 description 3
241001028048 Nicola Species 0.000 description 3
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 3
239000004473 Threonine Substances 0.000 description 3
102000006601 Thymidine Kinase Human genes 0.000 description 3
108020004440 Thymidine kinase Proteins 0.000 description 3
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 3
108020005202 Viral DNA Proteins 0.000 description 3
230000005856 abnormality Effects 0.000 description 3
239000004480 active ingredient Substances 0.000 description 3
230000001154 acute effect Effects 0.000 description 3
230000003321 amplification Effects 0.000 description 3
210000004102 animal cell Anatomy 0.000 description 3
239000002246 antineoplastic agent Substances 0.000 description 3
239000012736 aqueous medium Substances 0.000 description 3
108010084541 asialoorosomucoid Proteins 0.000 description 3
235000009582 asparagine Nutrition 0.000 description 3
229960001230 asparagine Drugs 0.000 description 3
230000004071 biological effect Effects 0.000 description 3
230000000903 blocking effect Effects 0.000 description 3
239000001506 calcium phosphate Substances 0.000 description 3
229910000389 calcium phosphate Inorganic materials 0.000 description 3
235000011010 calcium phosphates Nutrition 0.000 description 3
244000309466 calf Species 0.000 description 3
239000000969 carrier Substances 0.000 description 3
210000000170 cell membrane Anatomy 0.000 description 3
239000003153 chemical reaction reagent Substances 0.000 description 3
235000018417 cysteine Nutrition 0.000 description 3
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
229940127089 cytotoxic agent Drugs 0.000 description 3
231100000135 cytotoxicity Toxicity 0.000 description 3
230000003013 cytotoxicity Effects 0.000 description 3
230000007547 defect Effects 0.000 description 3
238000004520 electroporation Methods 0.000 description 3
239000013604 expression vector Substances 0.000 description 3
238000000684 flow cytometry Methods 0.000 description 3
102000037865 fusion proteins Human genes 0.000 description 3
108020001507 fusion proteins Proteins 0.000 description 3
108700004026 gag Genes Proteins 0.000 description 3
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 3
210000002443 helper t lymphocyte Anatomy 0.000 description 3
206010073071 hepatocellular carcinoma Diseases 0.000 description 3
238000002744 homologous recombination Methods 0.000 description 3
230000006801 homologous recombination Effects 0.000 description 3
238000003780 insertion Methods 0.000 description 3
230000037431 insertion Effects 0.000 description 3
230000002452 interceptive effect Effects 0.000 description 3
238000002955 isolation Methods 0.000 description 3
229960000310 isoleucine Drugs 0.000 description 3
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 3
101150066555 lacZ gene Proteins 0.000 description 3
238000012423 maintenance Methods 0.000 description 3
210000001161 mammalian embryo Anatomy 0.000 description 3
238000004519 manufacturing process Methods 0.000 description 3
229930182817 methionine Natural products 0.000 description 3
238000003199 nucleic acid amplification method Methods 0.000 description 3
239000000546 pharmaceutical excipient Substances 0.000 description 3
150000003904 phospholipids Chemical class 0.000 description 3
229920001184 polypeptide Polymers 0.000 description 3
239000002243 precursor Substances 0.000 description 3
239000003755 preservative agent Substances 0.000 description 3
230000006798 recombination Effects 0.000 description 3
238000005215 recombination Methods 0.000 description 3
230000002829 reductive effect Effects 0.000 description 3
230000022983 regulation of cell cycle Effects 0.000 description 3
210000002966 serum Anatomy 0.000 description 3
239000013605 shuttle vector Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
230000010473 stable expression Effects 0.000 description 3
239000000725 suspension Substances 0.000 description 3
238000003786 synthesis reaction Methods 0.000 description 3
230000000699 topical effect Effects 0.000 description 3
230000002103 transcriptional effect Effects 0.000 description 3
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
230000004614 tumor growth Effects 0.000 description 3
239000004474 valine Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
229930024421 Adenine Natural products 0.000 description 2
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 description 2
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
108091003079 Bovine Serum Albumin Proteins 0.000 description 2
208000003174 Brain Neoplasms Diseases 0.000 description 2
108090000565 Capsid Proteins Proteins 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
208000005623 Carcinogenesis Diseases 0.000 description 2
102100023321 Ceruloplasmin Human genes 0.000 description 2
108050006400 Cyclin Proteins 0.000 description 2
102000016736 Cyclin Human genes 0.000 description 2
108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 description 2
229940083347 Cyclin-dependent kinase 4 inhibitor Drugs 0.000 description 2
102100026804 Cyclin-dependent kinase 6 Human genes 0.000 description 2
101710154003 Cyclin-dependent kinase inhibitor 2A Proteins 0.000 description 2
238000001712 DNA sequencing Methods 0.000 description 2
241000702421 Dependoparvovirus Species 0.000 description 2
241000725618 Duck hepatitis B virus Species 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
208000032612 Glial tumor Diseases 0.000 description 2
206010018338 Glioma Diseases 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
102100037907 High mobility group protein B1 Human genes 0.000 description 2
101710168537 High mobility group protein B1 Proteins 0.000 description 2
108010088652 Histocompatibility Antigens Class I Proteins 0.000 description 2
102000008949 Histocompatibility Antigens Class I Human genes 0.000 description 2
108010027412 Histocompatibility Antigens Class II Proteins 0.000 description 2
102000018713 Histocompatibility Antigens Class II Human genes 0.000 description 2
108090001061 Insulin Proteins 0.000 description 2
102000003996 Interferon-beta Human genes 0.000 description 2
108090000467 Interferon-beta Proteins 0.000 description 2
102000014150 Interferons Human genes 0.000 description 2
108010050904 Interferons Proteins 0.000 description 2
108091092195 Intron Proteins 0.000 description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
102000043131 MHC class II family Human genes 0.000 description 2
108091054438 MHC class II family Proteins 0.000 description 2
108700018351 Major Histocompatibility Complex Proteins 0.000 description 2
206010027476 Metastases Diseases 0.000 description 2
241000713333 Mouse mammary tumor virus Species 0.000 description 2
241000699660 Mus musculus Species 0.000 description 2
108010069196 Neural Cell Adhesion Molecules Proteins 0.000 description 2
102100023616 Neural cell adhesion molecule L1-like protein Human genes 0.000 description 2
108700020796 Oncogene Proteins 0.000 description 2
108700026244 Open Reading Frames Proteins 0.000 description 2
241001631646 Papillomaviridae Species 0.000 description 2
102000003992 Peroxidases Human genes 0.000 description 2
108010071690 Prealbumin Proteins 0.000 description 2
102000007584 Prealbumin Human genes 0.000 description 2
206010060862 Prostate cancer Diseases 0.000 description 2
108010076504 Protein Sorting Signals Proteins 0.000 description 2
230000006819 RNA synthesis Effects 0.000 description 2
108700025701 Retinoblastoma Genes Proteins 0.000 description 2
108050002653 Retinoblastoma protein Proteins 0.000 description 2
230000018199 S phase Effects 0.000 description 2
241000700584 Simplexvirus Species 0.000 description 2
238000000692 Student's t-test Methods 0.000 description 2
108700026226 TATA Box Proteins 0.000 description 2
108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
108700025716 Tumor Suppressor Genes Proteins 0.000 description 2
102000044209 Tumor Suppressor Genes Human genes 0.000 description 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
241000700618 Vaccinia virus Species 0.000 description 2
241000251539 Vertebrata <Metazoa> Species 0.000 description 2
108010067390 Viral Proteins Proteins 0.000 description 2
208000036142 Viral infection Diseases 0.000 description 2
229960000643 adenine Drugs 0.000 description 2
239000011543 agarose gel Substances 0.000 description 2
108010005233 alanylglutamic acid Proteins 0.000 description 2
229940009098 aspartate Drugs 0.000 description 2
230000008901 benefit Effects 0.000 description 2
230000005540 biological transmission Effects 0.000 description 2
229960002685 biotin Drugs 0.000 description 2
235000020958 biotin Nutrition 0.000 description 2
239000011616 biotin Substances 0.000 description 2
210000004556 brain Anatomy 0.000 description 2
230000036952 cancer formation Effects 0.000 description 2
231100000504 carcinogenesis Toxicity 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
239000003593 chromogenic compound Substances 0.000 description 2
239000013599 cloning vector Substances 0.000 description 2
239000003184 complementary RNA Substances 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
-1 comprising 56 full B Proteins 0.000 description 2
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
230000000120 cytopathologic effect Effects 0.000 description 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
230000001086 cytosolic effect Effects 0.000 description 2
230000034994 death Effects 0.000 description 2
231100000517 death Toxicity 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
238000013461 design Methods 0.000 description 2
239000003814 drug Substances 0.000 description 2
108700004025 env Genes Proteins 0.000 description 2
210000000981 epithelium Anatomy 0.000 description 2
239000012091 fetal bovine serum Substances 0.000 description 2
239000012467 final product Substances 0.000 description 2
230000004927 fusion Effects 0.000 description 2
229930195712 glutamate Natural products 0.000 description 2
101150028578 grp78 gene Proteins 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
230000003463 hyperproliferative effect Effects 0.000 description 2
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
238000002649 immunization Methods 0.000 description 2
230000003053 immunization Effects 0.000 description 2
238000003018 immunoassay Methods 0.000 description 2
230000001976 improved effect Effects 0.000 description 2
230000006698 induction Effects 0.000 description 2
230000001939 inductive effect Effects 0.000 description 2
230000002458 infectious effect Effects 0.000 description 2
239000007972 injectable composition Substances 0.000 description 2
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
229940079322 interferon Drugs 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
230000002601 intratumoral effect Effects 0.000 description 2
210000003292 kidney cell Anatomy 0.000 description 2
230000002147 killing effect Effects 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
239000010410 layer Substances 0.000 description 2
208000032839 leukemia Diseases 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000006194 liquid suspension Substances 0.000 description 2
238000011068 loading method Methods 0.000 description 2
210000005265 lung cell Anatomy 0.000 description 2
210000004698 lymphocyte Anatomy 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
230000014759 maintenance of location Effects 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
108020004999 messenger RNA Proteins 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
210000005170 neoplastic cell Anatomy 0.000 description 2
230000001613 neoplastic effect Effects 0.000 description 2
230000009871 nonspecific binding Effects 0.000 description 2
238000011580 nude mouse model Methods 0.000 description 2
239000002674 ointment Substances 0.000 description 2
108700025694 p53 Genes Proteins 0.000 description 2
230000026731 phosphorylation Effects 0.000 description 2
238000006366 phosphorylation reaction Methods 0.000 description 2
108700004029 pol Genes Proteins 0.000 description 2
229920001223 polyethylene glycol Polymers 0.000 description 2
239000000843 powder Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
230000008569 process Effects 0.000 description 2
238000012545 processing Methods 0.000 description 2
230000000644 propagated effect Effects 0.000 description 2
239000002510 pyrogen Substances 0.000 description 2
238000003127 radioimmunoassay Methods 0.000 description 2
102000016914 ras Proteins Human genes 0.000 description 2
230000010837 receptor-mediated endocytosis Effects 0.000 description 2
230000009467 reduction Effects 0.000 description 2
208000023504 respiratory system disease Diseases 0.000 description 2
230000004044 response Effects 0.000 description 2
108091008146 restriction endonucleases Proteins 0.000 description 2
238000010839 reverse transcription Methods 0.000 description 2
230000019491 signal transduction Effects 0.000 description 2
238000002741 site-directed mutagenesis Methods 0.000 description 2
210000001082 somatic cell Anatomy 0.000 description 2
238000000527 sonication Methods 0.000 description 2
210000000952 spleen Anatomy 0.000 description 2
230000001629 suppression Effects 0.000 description 2
238000001356 surgical procedure Methods 0.000 description 2
238000002626 targeted therapy Methods 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
230000032258 transport Effects 0.000 description 2
239000002753 trypsin inhibitor Substances 0.000 description 2
102000003390 tumor necrosis factor Human genes 0.000 description 2
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 2
230000029812 viral genome replication Effects 0.000 description 2
230000009385 viral infection Effects 0.000 description 2
210000002845 virion Anatomy 0.000 description 2
AUXMWYRZQPIXCC-KNIFDHDWSA-N (2s)-2-amino-4-methylpentanoic acid;(2s)-2-aminopropanoic acid Chemical compound C[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O AUXMWYRZQPIXCC-KNIFDHDWSA-N 0.000 description 1
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 description 1
ZYPDJSJJXZWZJJ-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-3-piperidin-4-yloxypyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C(=NN(C=1)CC(=O)N1CC2=C(CC1)NN=N2)OC1CCNCC1 ZYPDJSJJXZWZJJ-UHFFFAOYSA-N 0.000 description 1
CPOBTYJRKAJERX-UHFFFAOYSA-N 3-ethyl-n-[(3-ethyl-1,3-benzothiazol-2-ylidene)amino]-1,3-benzothiazol-2-imine Chemical compound S1C2=CC=CC=C2N(CC)C1=NN=C1SC2=CC=CC=C2N1CC CPOBTYJRKAJERX-UHFFFAOYSA-N 0.000 description 1
101150033839 4 gene Proteins 0.000 description 1
LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 description 1
CKOMXBHMKXXTNW-UHFFFAOYSA-N 6-methyladenine Chemical compound CNC1=NC=NC2=C1N=CN2 CKOMXBHMKXXTNW-UHFFFAOYSA-N 0.000 description 1
206010069754 Acquired gene mutation Diseases 0.000 description 1
102000007469 Actins Human genes 0.000 description 1
108010085238 Actins Proteins 0.000 description 1
206010052747 Adenocarcinoma pancreas Diseases 0.000 description 1
206010001258 Adenoviral infections Diseases 0.000 description 1
BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 description 1
SVBXIUDNTRTKHE-CIUDSAMLSA-N Ala-Arg-Glu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(O)=O SVBXIUDNTRTKHE-CIUDSAMLSA-N 0.000 description 1
JBGSZRYCXBPWGX-BQBZGAKWSA-N Ala-Arg-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)C)CCCN=C(N)N JBGSZRYCXBPWGX-BQBZGAKWSA-N 0.000 description 1
PAIHPOGPJVUFJY-WDSKDSINSA-N Ala-Glu-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(O)=O PAIHPOGPJVUFJY-WDSKDSINSA-N 0.000 description 1
HXNNRBHASOSVPG-GUBZILKMSA-N Ala-Glu-Leu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O HXNNRBHASOSVPG-GUBZILKMSA-N 0.000 description 1
ZVFVBBGVOILKPO-WHFBIAKZSA-N Ala-Gly-Ala Chemical compound C[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(O)=O ZVFVBBGVOILKPO-WHFBIAKZSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
201000004384 Alopecia Diseases 0.000 description 1
102100033312 Alpha-2-macroglobulin Human genes 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
102100023635 Alpha-fetoprotein Human genes 0.000 description 1
241000272525 Anas platyrhynchos Species 0.000 description 1
108020004491 Antisense DNA Proteins 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
RWCLSUOSKWTXLA-FXQIFTODSA-N Arg-Asp-Ala Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(O)=O RWCLSUOSKWTXLA-FXQIFTODSA-N 0.000 description 1
JNNVNVRBYUJYGS-CIUDSAMLSA-N Asp-Leu-Ala Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(O)=O JNNVNVRBYUJYGS-CIUDSAMLSA-N 0.000 description 1
JSNWZMFSLIWAHS-HJGDQZAQSA-N Asp-Thr-Leu Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)O)NC(=O)[C@H](CC(=O)O)N)O JSNWZMFSLIWAHS-HJGDQZAQSA-N 0.000 description 1
241000271566 Aves Species 0.000 description 1
241000711404 Avian avulavirus 1 Species 0.000 description 1
108090001008 Avidin Chemical group 0.000 description 1
102100038080 B-cell receptor CD22 Human genes 0.000 description 1
108700020463 BRCA1 Proteins 0.000 description 1
102000036365 BRCA1 Human genes 0.000 description 1
101150072950 BRCA1 gene Proteins 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
206010006187 Breast cancer Diseases 0.000 description 1
208000026310 Breast neoplasm Diseases 0.000 description 1
125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
201000009030 Carcinoma Diseases 0.000 description 1
108010059892 Cellulase Proteins 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
101710163595 Chaperone protein DnaK Proteins 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
102000012422 Collagen Type I Human genes 0.000 description 1
108010022452 Collagen Type I Proteins 0.000 description 1
102000029816 Collagenase Human genes 0.000 description 1
108060005980 Collagenase Proteins 0.000 description 1
241000557626 Corvus corax Species 0.000 description 1
102000003910 Cyclin D Human genes 0.000 description 1
108090000259 Cyclin D Proteins 0.000 description 1
QFMCHXSGIZPBKG-ZLUOBGJFSA-N Cys-Ala-Asp Chemical compound C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CS)N QFMCHXSGIZPBKG-ZLUOBGJFSA-N 0.000 description 1
201000003883 Cystic fibrosis Diseases 0.000 description 1
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
239000012624 DNA alkylating agent Substances 0.000 description 1
230000007067 DNA methylation Effects 0.000 description 1
230000006820 DNA synthesis Effects 0.000 description 1
241000450599 DNA viruses Species 0.000 description 1
230000004568 DNA-binding Effects 0.000 description 1
108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
SHIBSTMRCDJXLN-UHFFFAOYSA-N Digoxigenin Natural products C1CC(C2C(C3(C)CCC(O)CC3CC2)CC2O)(O)C2(C)C1C1=CC(=O)OC1 SHIBSTMRCDJXLN-UHFFFAOYSA-N 0.000 description 1
108090000204 Dipeptidase 1 Proteins 0.000 description 1
241000275449 Diplectrum formosum Species 0.000 description 1
206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 1
102000001301 EGF receptor Human genes 0.000 description 1
108060006698 EGF receptor Proteins 0.000 description 1
241000406206 Ecotropic murine leukemia virus Species 0.000 description 1
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
108700041152 Endoplasmic Reticulum Chaperone BiP Proteins 0.000 description 1
102100021451 Endoplasmic reticulum chaperone BiP Human genes 0.000 description 1
102100039328 Endoplasmin Human genes 0.000 description 1
101710091045 Envelope protein Proteins 0.000 description 1
102400001368 Epidermal growth factor Human genes 0.000 description 1
101800003838 Epidermal growth factor Proteins 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
208000000461 Esophageal Neoplasms Diseases 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
108091029865 Exogenous DNA Proteins 0.000 description 1
108700024394 Exon Proteins 0.000 description 1
238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
230000010190 G1 phase Effects 0.000 description 1
102000013446 GTP Phosphohydrolases Human genes 0.000 description 1
108091006109 GTPases Proteins 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
206010064571 Gene mutation Diseases 0.000 description 1
108700028146 Genetic Enhancer Elements Proteins 0.000 description 1
108700039691 Genetic Promoter Regions Proteins 0.000 description 1
208000031448 Genomic Instability Diseases 0.000 description 1
241000713813 Gibbon ape leukemia virus Species 0.000 description 1
UTKUTMJSWKKHEM-WDSKDSINSA-N Glu-Ala-Gly Chemical compound OC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(O)=O UTKUTMJSWKKHEM-WDSKDSINSA-N 0.000 description 1
QJCKNLPMTPXXEM-AUTRQRHGSA-N Glu-Glu-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CCC(O)=O QJCKNLPMTPXXEM-AUTRQRHGSA-N 0.000 description 1
ATVYZJGOZLVXDK-IUCAKERBSA-N Glu-Leu-Gly Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O ATVYZJGOZLVXDK-IUCAKERBSA-N 0.000 description 1
CBOVGULVQSVMPT-CIUDSAMLSA-N Glu-Pro-Asn Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(O)=O CBOVGULVQSVMPT-CIUDSAMLSA-N 0.000 description 1
108010015776 Glucose oxidase Proteins 0.000 description 1
239000004366 Glucose oxidase Substances 0.000 description 1
JPVGHHQGKPQYIL-KBPBESRZSA-N Gly-Phe-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CC=CC=C1 JPVGHHQGKPQYIL-KBPBESRZSA-N 0.000 description 1
IRJWAYCXIYUHQE-WHFBIAKZSA-N Gly-Ser-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CN IRJWAYCXIYUHQE-WHFBIAKZSA-N 0.000 description 1
YXTFLTJYLIAZQG-FJXKBIBVSA-N Gly-Thr-Arg Chemical compound NCC(=O)N[C@@H]([C@H](O)C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N YXTFLTJYLIAZQG-FJXKBIBVSA-N 0.000 description 1
229920002527 Glycogen Polymers 0.000 description 1
108010046163 Glycogen Phosphorylase Proteins 0.000 description 1
102000003886 Glycoproteins Human genes 0.000 description 1
108090000288 Glycoproteins Proteins 0.000 description 1
108010062347 HLA-DQ Antigens Proteins 0.000 description 1
108010067802 HLA-DR alpha-Chains Proteins 0.000 description 1
101150112743 HSPA5 gene Proteins 0.000 description 1
101710178376 Heat shock 70 kDa protein Proteins 0.000 description 1
101710152018 Heat shock cognate 70 kDa protein Proteins 0.000 description 1
102100021519 Hemoglobin subunit beta Human genes 0.000 description 1
108091005904 Hemoglobin subunit beta Proteins 0.000 description 1
206010019695 Hepatic neoplasm Diseases 0.000 description 1
101710155188 Hexon-interlacing protein Proteins 0.000 description 1
AWHJQEYGWRKPHE-LSJOCFKGSA-N His-Ala-Arg Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O AWHJQEYGWRKPHE-LSJOCFKGSA-N 0.000 description 1
SVHKVHBPTOMLTO-DCAQKATOSA-N His-Arg-Asp Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O SVHKVHBPTOMLTO-DCAQKATOSA-N 0.000 description 1
VOEGKUNRHYKYSU-XVYDVKMFSA-N His-Asp-Ala Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(O)=O VOEGKUNRHYKYSU-XVYDVKMFSA-N 0.000 description 1
YADRBUZBKHHDAO-XPUUQOCRSA-N His-Gly-Ala Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](C)C(O)=O YADRBUZBKHHDAO-XPUUQOCRSA-N 0.000 description 1
108010033040 Histones Proteins 0.000 description 1
101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 1
101000907783 Homo sapiens Cystic fibrosis transmembrane conductance regulator Proteins 0.000 description 1
101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 1
101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 1
101000609255 Homo sapiens Plasminogen activator inhibitor 1 Proteins 0.000 description 1
101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 1
108091006905 Human Serum Albumin Proteins 0.000 description 1
102000008100 Human Serum Albumin Human genes 0.000 description 1
241000701096 Human adenovirus 7 Species 0.000 description 1
241000701024 Human betaherpesvirus 5 Species 0.000 description 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
RPZFUIQVAPZLRH-GHCJXIJMSA-N Ile-Asp-Ala Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)O)N RPZFUIQVAPZLRH-GHCJXIJMSA-N 0.000 description 1
108700002232 Immediate-Early Genes Proteins 0.000 description 1
108700005091 Immunoglobulin Genes Proteins 0.000 description 1
229930010555 Inosine Natural products 0.000 description 1
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
102000004877 Insulin Human genes 0.000 description 1
102100034349 Integrase Human genes 0.000 description 1
102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 description 1
108010002352 Interleukin-1 Proteins 0.000 description 1
108010002350 Interleukin-2 Proteins 0.000 description 1
102000000588 Interleukin-2 Human genes 0.000 description 1
108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
108090001005 Interleukin-6 Proteins 0.000 description 1
LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
108010001831 LDL receptors Proteins 0.000 description 1
101710128836 Large T antigen Proteins 0.000 description 1
VZBIUJURDLFFOE-IHRRRGAJSA-N Leu-His-Arg Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O VZBIUJURDLFFOE-IHRRRGAJSA-N 0.000 description 1
239000000232 Lipid Bilayer Substances 0.000 description 1
206010050017 Lung cancer metastatic Diseases 0.000 description 1
206010025323 Lymphomas Diseases 0.000 description 1
108091054437 MHC class I family Proteins 0.000 description 1
101150115920 MTS1 gene Proteins 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
108010031099 Mannose Receptor Proteins 0.000 description 1
VWWGEKCAPBMIFE-SRVKXCTJSA-N Met-Met-Met Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(O)=O VWWGEKCAPBMIFE-SRVKXCTJSA-N 0.000 description 1
108091092878 Microsatellite Proteins 0.000 description 1
241000713869 Moloney murine leukemia virus Species 0.000 description 1
206010073148 Multiple endocrine neoplasia type 2A Diseases 0.000 description 1
101100078999 Mus musculus Mx1 gene Proteins 0.000 description 1
101100353154 Mus musculus Preb gene Proteins 0.000 description 1
WUGMRIBZSVSJNP-UHFFFAOYSA-N N-L-alanyl-L-tryptophan Natural products C1=CC=C2C(CC(NC(=O)C(N)C)C(O)=O)=CNC2=C1 WUGMRIBZSVSJNP-UHFFFAOYSA-N 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
102000006570 Non-Histone Chromosomal Proteins Human genes 0.000 description 1
108010008964 Non-Histone Chromosomal Proteins Proteins 0.000 description 1
102000007999 Nuclear Proteins Human genes 0.000 description 1
108010089610 Nuclear Proteins Proteins 0.000 description 1
206010030155 Oesophageal carcinoma Diseases 0.000 description 1
206010061534 Oesophageal squamous cell carcinoma Diseases 0.000 description 1
108010067372 Pancreatic elastase Proteins 0.000 description 1
206010061902 Pancreatic neoplasm Diseases 0.000 description 1
101710177166 Phosphoprotein Proteins 0.000 description 1
102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
241001505332 Polyomavirus sp. Species 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
108010015078 Pregnancy-Associated alpha 2-Macroglobulins Proteins 0.000 description 1
208000000236 Prostatic Neoplasms Diseases 0.000 description 1
101710188315 Protein X Proteins 0.000 description 1
102100027584 Protein c-Fos Human genes 0.000 description 1
108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 1
101710185720 Putative ethidium bromide resistance protein Proteins 0.000 description 1
101150020201 RB gene Proteins 0.000 description 1
102000009572 RNA Polymerase II Human genes 0.000 description 1
108010009460 RNA Polymerase II Proteins 0.000 description 1
239000012979 RPMI medium Substances 0.000 description 1
101000868151 Rattus norvegicus Somatotropin Proteins 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
102000009661 Repressor Proteins Human genes 0.000 description 1
108010034634 Repressor Proteins Proteins 0.000 description 1
206010038997 Retroviral infections Diseases 0.000 description 1
241000712907 Retroviridae Species 0.000 description 1
208000005074 Retroviridae Infections Diseases 0.000 description 1
241000283984 Rodentia Species 0.000 description 1
241000714474 Rous sarcoma virus Species 0.000 description 1
101100111629 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) KAR2 gene Proteins 0.000 description 1
FIXILCYTSAUERA-FXQIFTODSA-N Ser-Ala-Arg Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O FIXILCYTSAUERA-FXQIFTODSA-N 0.000 description 1
LVVBAKCGXXUHFO-ZLUOBGJFSA-N Ser-Ala-Asp Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(O)=O LVVBAKCGXXUHFO-ZLUOBGJFSA-N 0.000 description 1
QPFJSHSJFIYDJZ-GHCJXIJMSA-N Ser-Asp-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CO QPFJSHSJFIYDJZ-GHCJXIJMSA-N 0.000 description 1
NIOYDASGXWLHEZ-CIUDSAMLSA-N Ser-Met-Glu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(O)=O NIOYDASGXWLHEZ-CIUDSAMLSA-N 0.000 description 1
FHXGMDRKJHKLKW-QWRGUYRKSA-N Ser-Tyr-Gly Chemical compound OC[C@H](N)C(=O)N[C@H](C(=O)NCC(O)=O)CC1=CC=C(O)C=C1 FHXGMDRKJHKLKW-QWRGUYRKSA-N 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
108010032838 Sialoglycoproteins Proteins 0.000 description 1
102000007365 Sialoglycoproteins Human genes 0.000 description 1
208000000453 Skin Neoplasms Diseases 0.000 description 1
206010041067 Small cell lung cancer Diseases 0.000 description 1
238000002105 Southern blotting Methods 0.000 description 1
208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
108010090804 Streptavidin Proteins 0.000 description 1
108091008874 T cell receptors Proteins 0.000 description 1
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
210000001744 T-lymphocyte Anatomy 0.000 description 1
IGROJMCBGRFRGI-YTLHQDLWSA-N Thr-Ala-Ala Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O IGROJMCBGRFRGI-YTLHQDLWSA-N 0.000 description 1
VRUFCJZQDACGLH-UVOCVTCTSA-N Thr-Leu-Thr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O VRUFCJZQDACGLH-UVOCVTCTSA-N 0.000 description 1
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
102100023132 Transcription factor Jun Human genes 0.000 description 1
101710195626 Transcriptional activator protein Proteins 0.000 description 1
108090000992 Transferases Proteins 0.000 description 1
102000004338 Transferrin Human genes 0.000 description 1
108090000901 Transferrin Proteins 0.000 description 1
102000013394 Troponin I Human genes 0.000 description 1
108010065729 Troponin I Proteins 0.000 description 1
HQJOVVWAPQPYDS-ZFWWWQNUSA-N Trp-Gly-Arg Chemical compound [H]N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O HQJOVVWAPQPYDS-ZFWWWQNUSA-N 0.000 description 1
QSFJHIRIHOJRKS-ULQDDVLXSA-N Tyr-Leu-Arg Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O QSFJHIRIHOJRKS-ULQDDVLXSA-N 0.000 description 1
108010046334 Urease Proteins 0.000 description 1
DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 1
102100035071 Vimentin Human genes 0.000 description 1
108010065472 Vimentin Proteins 0.000 description 1
108010003533 Viral Envelope Proteins Proteins 0.000 description 1
241000269370 Xenopus <genus> Species 0.000 description 1
VRGWBRLULZUWAJ-XFFXIZSCSA-N [(2s)-2-[(1r,3z,5s,8z,12z,15s)-5,17-dihydroxy-4,8,12,15-tetramethyl-16-oxo-18-bicyclo[13.3.0]octadeca-3,8,12,17-tetraenyl]propyl] acetate Chemical compound C1\C=C(C)/CC\C=C(C)/CC[C@H](O)\C(C)=C/C[C@@H]2C([C@@H](COC(C)=O)C)=C(O)C(=O)[C@]21C VRGWBRLULZUWAJ-XFFXIZSCSA-N 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000003070 absorption delaying agent Substances 0.000 description 1
230000003213 activating effect Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
229940021704 adenovirus vaccine Drugs 0.000 description 1
230000002411 adverse Effects 0.000 description 1
230000001270 agonistic effect Effects 0.000 description 1
108010076324 alanyl-glycyl-glycine Proteins 0.000 description 1
230000000172 allergic effect Effects 0.000 description 1
108010026331 alpha-Fetoproteins Proteins 0.000 description 1
108010090535 alpha-albumin Proteins 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000003042 antagnostic effect Effects 0.000 description 1
230000001772 anti-angiogenic effect Effects 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
239000004599 antimicrobial Substances 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000003816 antisense DNA Substances 0.000 description 1
239000000074 antisense oligonucleotide Substances 0.000 description 1
238000012230 antisense oligonucleotides Methods 0.000 description 1
239000003443 antiviral agent Substances 0.000 description 1
239000008365 aqueous carrier Substances 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
108010009111 arginyl-glycyl-glutamic acid Proteins 0.000 description 1
108010069926 arginyl-glycyl-serine Proteins 0.000 description 1
108010068380 arginylarginine Proteins 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
235000003704 aspartic acid Nutrition 0.000 description 1
108010093581 aspartyl-proline Proteins 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
208000010668 atopic eczema Diseases 0.000 description 1
230000003416 augmentation Effects 0.000 description 1
OHDRQQURAXLVGJ-HLVWOLMTSA-N azane;(2e)-3-ethyl-2-[(e)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound [NH4+].[NH4+].S/1C2=CC(S([O-])(=O)=O)=CC=C2N(CC)C\1=N/N=C1/SC2=CC(S([O-])(=O)=O)=CC=C2N1CC OHDRQQURAXLVGJ-HLVWOLMTSA-N 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
WPIHMWBQRSAMDE-YCZTVTEBSA-N beta-D-galactosyl-(1->4)-beta-D-galactosyl-N-(pentacosanoyl)sphingosine Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)\C=C\CCCCCCCCCCCCC WPIHMWBQRSAMDE-YCZTVTEBSA-N 0.000 description 1
DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
102000006635 beta-lactamase Human genes 0.000 description 1
239000003012 bilayer membrane Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000008827 biological function Effects 0.000 description 1
239000012472 biological sample Substances 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
210000000234 capsid Anatomy 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
101150055766 cat gene Proteins 0.000 description 1
230000025084 cell cycle arrest Effects 0.000 description 1
230000032823 cell division Effects 0.000 description 1
230000022534 cell killing Effects 0.000 description 1
239000013553 cell monolayer Substances 0.000 description 1
230000010307 cell transformation Effects 0.000 description 1
229940106157 cellulase Drugs 0.000 description 1
239000002738 chelating agent Substances 0.000 description 1
238000003889 chemical engineering Methods 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
230000000973 chemotherapeutic effect Effects 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
230000002759 chromosomal effect Effects 0.000 description 1
238000010367 cloning Methods 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
229960002424 collagenase Drugs 0.000 description 1
230000005757 colony formation Effects 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
230000002301 combined effect Effects 0.000 description 1
230000002860 competitive effect Effects 0.000 description 1
230000001143 conditioned effect Effects 0.000 description 1
238000011109 contamination Methods 0.000 description 1
239000006071 cream Substances 0.000 description 1
229960003624 creatine Drugs 0.000 description 1
239000006046 creatine Substances 0.000 description 1
239000012228 culture supernatant Substances 0.000 description 1
210000004748 cultured cell Anatomy 0.000 description 1
238000011461 current therapy Methods 0.000 description 1
208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
229960003067 cystine Drugs 0.000 description 1
UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 description 1
229940104302 cytosine Drugs 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000001934 delay Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000011981 development test Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
230000029087 digestion Effects 0.000 description 1
QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
SHIBSTMRCDJXLN-KCZCNTNESA-N digoxigenin Chemical group C1([C@@H]2[C@@]3([C@@](CC2)(O)[C@H]2[C@@H]([C@@]4(C)CC[C@H](O)C[C@H]4CC2)C[C@H]3O)C)=CC(=O)OC1 SHIBSTMRCDJXLN-KCZCNTNESA-N 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
239000002612 dispersion medium Substances 0.000 description 1
238000009826 distribution Methods 0.000 description 1
VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
230000002222 downregulating effect Effects 0.000 description 1
230000003828 downregulation Effects 0.000 description 1
229940079593 drug Drugs 0.000 description 1
241001493065 dsRNA viruses Species 0.000 description 1
230000008482 dysregulation Effects 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
210000002257 embryonic structure Anatomy 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
229940116977 epidermal growth factor Drugs 0.000 description 1
201000004101 esophageal cancer Diseases 0.000 description 1
208000007276 esophageal squamous cell carcinoma Diseases 0.000 description 1
XJRPTMORGOIMMI-UHFFFAOYSA-N ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate Chemical compound CCOC(=O)C=1SC(N)=NC=1C(F)(F)F XJRPTMORGOIMMI-UHFFFAOYSA-N 0.000 description 1
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
229940093471 ethyl oleate Drugs 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
201000000497 familial melanoma Diseases 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
239000000945 filler Substances 0.000 description 1
RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 1
230000005714 functional activity Effects 0.000 description 1
VRGWBRLULZUWAJ-UHFFFAOYSA-N fusaproliferin Natural products C1C=C(C)CCC=C(C)CCC(O)C(C)=CCC2C(C(COC(C)=O)C)=C(O)C(=O)C21C VRGWBRLULZUWAJ-UHFFFAOYSA-N 0.000 description 1
101150098622 gag gene Proteins 0.000 description 1
108010074605 gamma-Globulins Proteins 0.000 description 1
229960002963 ganciclovir Drugs 0.000 description 1
IRSCQMHQWWYFCW-UHFFFAOYSA-N ganciclovir Chemical compound O=C1NC(N)=NC2=C1N=CN2COC(CO)CO IRSCQMHQWWYFCW-UHFFFAOYSA-N 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000012637 gene transfection Methods 0.000 description 1
238000007429 general method Methods 0.000 description 1
238000010353 genetic engineering Methods 0.000 description 1
231100000025 genetic toxicology Toxicity 0.000 description 1
230000001738 genotoxic effect Effects 0.000 description 1
231100000734 genotoxic potential Toxicity 0.000 description 1
210000004602 germ cell Anatomy 0.000 description 1
239000003862 glucocorticoid Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229940116332 glucose oxidase Drugs 0.000 description 1
235000019420 glucose oxidase Nutrition 0.000 description 1
108010017007 glucose-regulated proteins Proteins 0.000 description 1
235000013922 glutamic acid Nutrition 0.000 description 1
239000004220 glutamic acid Substances 0.000 description 1
229940096919 glycogen Drugs 0.000 description 1
108010082286 glycyl-seryl-alanine Proteins 0.000 description 1
PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
229910052737 gold Inorganic materials 0.000 description 1
239000010931 gold Substances 0.000 description 1
210000004013 groin Anatomy 0.000 description 1
230000003676 hair loss Effects 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
230000003067 hemagglutinative effect Effects 0.000 description 1
210000003958 hematopoietic stem cell Anatomy 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
102000043283 human SERPINE1 Human genes 0.000 description 1
150000002431 hydrogen Chemical class 0.000 description 1
239000001863 hydroxypropyl cellulose Substances 0.000 description 1
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
230000006607 hypermethylation Effects 0.000 description 1
230000006951 hyperphosphorylation Effects 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
230000001900 immune effect Effects 0.000 description 1
238000013115 immunohistochemical detection Methods 0.000 description 1
239000003547 immunosorbent Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000011261 inert gas Substances 0.000 description 1
230000036512 infertility Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
229960003786 inosine Drugs 0.000 description 1
238000002743 insertional mutagenesis Methods 0.000 description 1
229940125396 insulin Drugs 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
230000001678 irradiating effect Effects 0.000 description 1
239000007951 isotonicity adjuster Substances 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000003902 lesion Effects 0.000 description 1
210000005229 liver cell Anatomy 0.000 description 1
208000019423 liver disease Diseases 0.000 description 1
208000014018 liver neoplasm Diseases 0.000 description 1
230000033001 locomotion Effects 0.000 description 1
208000037841 lung tumor Diseases 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
229960001708 magnesium carbonate Drugs 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
208000006178 malignant mesothelioma Diseases 0.000 description 1
208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
210000005075 mammary gland Anatomy 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000013507 mapping Methods 0.000 description 1
210000004779 membrane envelope Anatomy 0.000 description 1
230000034217 membrane fusion Effects 0.000 description 1
230000001394 metastastic effect Effects 0.000 description 1
206010061289 metastatic neoplasm Diseases 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000000520 microinjection Methods 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
230000011278 mitosis Effects 0.000 description 1
230000000394 mitotic effect Effects 0.000 description 1
238000002156 mixing Methods 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
238000010172 mouse model Methods 0.000 description 1
206010051747 multiple endocrine neoplasia Diseases 0.000 description 1
210000000663 muscle cell Anatomy 0.000 description 1
239000003471 mutagenic agent Substances 0.000 description 1
231100000707 mutagenic chemical Toxicity 0.000 description 1
230000022628 negative regulation of growth rate Effects 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
208000025402 neoplasm of esophagus Diseases 0.000 description 1
230000009826 neoplastic cell growth Effects 0.000 description 1
208000002761 neurofibromatosis 2 Diseases 0.000 description 1
208000022032 neurofibromatosis type 2 Diseases 0.000 description 1
210000004498 neuroglial cell Anatomy 0.000 description 1
210000002569 neuron Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
210000004940 nucleus Anatomy 0.000 description 1
235000015097 nutrients Nutrition 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
239000003921 oil Substances 0.000 description 1
235000019198 oils Nutrition 0.000 description 1
231100000590 oncogenic Toxicity 0.000 description 1
230000002246 oncogenic effect Effects 0.000 description 1
210000000287 oocyte Anatomy 0.000 description 1
150000002895 organic esters Chemical class 0.000 description 1
230000008520 organization Effects 0.000 description 1
230000002018 overexpression Effects 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
201000002094 pancreatic adenocarcinoma Diseases 0.000 description 1
201000002528 pancreatic cancer Diseases 0.000 description 1
208000008443 pancreatic carcinoma Diseases 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
239000000816 peptidomimetic Substances 0.000 description 1
125000001151 peptidyl group Chemical group 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
108040007629 peroxidase activity proteins Proteins 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
150000004713 phosphodiesters Chemical group 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
230000003334 potential effect Effects 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002028 premature Effects 0.000 description 1
230000001566 pro-viral effect Effects 0.000 description 1
230000002062 proliferating effect Effects 0.000 description 1
229930185346 proliferin Natural products 0.000 description 1
XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 1
208000023958 prostate neoplasm Diseases 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000001243 protein synthesis Methods 0.000 description 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
150000003230 pyrimidines Chemical class 0.000 description 1
238000011002 quantification Methods 0.000 description 1
230000003439 radiotherapeutic effect Effects 0.000 description 1
230000037425 regulation of transcription Effects 0.000 description 1
230000003362 replicative effect Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
208000037803 restenosis Diseases 0.000 description 1
238000003757 reverse transcription PCR Methods 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
238000003118 sandwich ELISA Methods 0.000 description 1
238000007789 sealing Methods 0.000 description 1
238000005204 segregation Methods 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
210000002027 skeletal muscle Anatomy 0.000 description 1
210000003491 skin Anatomy 0.000 description 1
201000000849 skin cancer Diseases 0.000 description 1
230000000391 smoking effect Effects 0.000 description 1
239000007787 solid Substances 0.000 description 1
230000037439 somatic mutation Effects 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
238000003153 stable transfection Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000001360 synchronised effect Effects 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
238000009121 systemic therapy Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000010863 targeted diagnosis Methods 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
229940113082 thymine Drugs 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
239000005495 thyroid hormone Substances 0.000 description 1
229940036555 thyroid hormone Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
210000003437 trachea Anatomy 0.000 description 1
230000005026 transcription initiation Effects 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000003151 transfection method Methods 0.000 description 1
239000012581 transferrin Substances 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
230000010474 transient expression Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
108010036387 trimethionine Proteins 0.000 description 1
230000004565 tumor cell growth Effects 0.000 description 1
230000005748 tumor development Effects 0.000 description 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
230000005760 tumorsuppression Effects 0.000 description 1
WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
239000010937 tungsten Substances 0.000 description 1
229940035893 uracil Drugs 0.000 description 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
229940045145 uridine Drugs 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
210000003501 vero cell Anatomy 0.000 description 1
108700026220 vif Genes Proteins 0.000 description 1
210000005048 vimentin Anatomy 0.000 description 1
201000001862 viral hepatitis Diseases 0.000 description 1
238000001429 visible spectrum Methods 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000001262 western blot Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

SK65-98A 1995-07-17 1996-07-17 P16 expression constructs and their application in cancer therapy SK6598A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US50288195A	1995-07-17	1995-07-17
PCT/US1996/011787 WO1997003635A2 (fr)	1995-07-17	1996-07-17	PRODUITS DE SYNTHESE A EXPRESSION DE p16 ET LEUR APPLICATION DANS LA THERAPIE ANTICANCEREUSE

Publications (1)

Publication Number	Publication Date
SK6598A3 true SK6598A3 (en)	1998-09-09

Family

ID=23999797

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK65-98A SK6598A3 (en)	1995-07-17	1996-07-17	P16 expression constructs and their application in cancer therapy

Country Status (15)

Country	Link
US (1)	US6251871B1 (fr)
EP (1)	EP0839207A2 (fr)
JP (1)	JPH11510380A (fr)
KR (1)	KR19990029028A (fr)
CN (1)	CN1203632A (fr)
AU (1)	AU724324B2 (fr)
BR (1)	BR9609853A (fr)
CA (1)	CA2227193A1 (fr)
CZ (1)	CZ15498A3 (fr)
HU (1)	HUP9901908A3 (fr)
NO (1)	NO980218L (fr)
NZ (1)	NZ313828A (fr)
PL (1)	PL324750A1 (fr)
SK (1)	SK6598A3 (fr)
WO (1)	WO1997003635A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6689561B1 (en) *	1994-04-14	2004-02-10	The Regents Of The University Of California	Tumor suppressor gene and methods for detection of cancer, monitoring of tumor progression and cancer treatment
US7163925B1 (en) *	1995-07-17	2007-01-16	Board Of Regents, The University Of Texas System	p16 expression constructs and their application in cancer therapy
GB9519275D0 (en)	1995-09-21	1995-11-22	Univ Dundee	Substances and their therapeutic use
AU7258996A (en) †	1995-10-06	1997-04-28	Arch Development Corporation	Methods and compositions for viral enhancement of cell killing
CA2283090A1 (fr) *	1997-02-20	1998-08-27	Hepavec Aktiengesellschaft Fur Gentherapie	Methode permettant de provoquer une mort cellulaire programmee dans des cellules malignes par reduction du rapport proteines rb/proteines induisant l'apoptose
JP3410739B2 (ja)	1997-03-14	2003-05-26	ユニリーバー・ナームローゼ・ベンノートシャープ	凍結食品
US6489305B1 (en)	1998-05-08	2002-12-03	Canji, Inc.	Methods and compositions for the treatment of ocular diseases
KR19990086165A (ko) *	1998-05-26	1999-12-15	성재갑	Cdk４ 의 저해제인 p16의 카복시말단이 절단된 결손형cδp１６ 단백질, 그의 유전자
US6420345B1 (en) *	1999-03-01	2002-07-16	Cell Genesys, Inc.	Methods and reagents for inhibiting angiogenesis
US20040266834A1 (en) *	1999-10-14	2004-12-30	Copland John A.	Thiazolidinediones alone or in cabination with other therapeutic agents for cancer therapy
EP1365794A2 (fr) *	2000-07-21	2003-12-03	Lue, Tom	Methodes et compositions destinees a prevenir et traiter la dyserection chez l'homme et les troubles de l'excitation sexuelle chez la femme
US7223406B2 (en) *	2000-07-21	2007-05-29	The Regents Of The University Of California	Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder
US20040005294A1 (en) *	2002-02-25	2004-01-08	Ho-Young Lee	IGFBP-3 in the diagnosis and treatment of cancer
US20030219696A1 (en) *	2002-05-23	2003-11-27	Moreland Gerald W.	Method and apparatus for preventing backflow in dental saliva evacuators
NZ546983A (en)	2003-11-24	2009-05-31	Canji Inc	Reduction of dermal scarring
JP5117189B2 (ja)	2004-08-27	2013-01-09	サイクラセルリミテッド	プリン及びピリミジンｃｄｋ阻害剤、並びに自己免疫疾患の治療のためのそれらの使用
US7695965B2 (en) *	2006-03-02	2010-04-13	Cythera, Inc.	Methods of producing pancreatic hormones
CN103293308B (zh) *	2013-05-24	2014-11-26	尉军	一种检测肿瘤标志物p16抗原表位氨基酸序列及应用
CN104558147B (zh) *	2015-01-20	2017-11-07	刘林林	一种检测宫颈癌标志物cdkn2a抗原表位多肽及应用
EP3295181A4 (fr)	2015-05-14	2018-11-14	Expression Pathology, Inc.	Dosage srm/mrm de la protéine du récepteur du facteur de croissance des fibroblastes 2 (fgfr2)
AU2016268215B2 (en)	2015-05-22	2019-10-31	Expression Pathology, Inc.	SRM/MRM assay for the cyclin-dependent kinase inhibitor 2A (p16) protein

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0273085A1 (fr)	1986-12-29	1988-07-06	IntraCel Corporation	Procédé pour faire entrer des acides nucléiques dans des cellules eucaryotes
US5399346A (en)	1989-06-14	1995-03-21	The United States Of America As Represented By The Department Of Health And Human Services	Gene therapy
US5747469A (en)	1991-03-06	1998-05-05	Board Of Regents, The University Of Texas System	Methods and compositions comprising DNA damaging agents and p53
US6211334B1 (en)	1992-10-16	2001-04-03	Cold Spring Harbor	Cell-cycle regulatory proteins, and uses related thereto
KR100331363B1 (ko)	1992-10-16	2002-12-05	콜드 스프링 하버 래보레이토리	사이클린복합체재배열및그것과관련된용도
FR2705686B1 (fr)	1993-05-28	1995-08-18	Transgene Sa	Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.
MY119195A (en) *	1993-12-30	2005-04-30	Shell Int Research	Lightweight, wide-bodied compliant tower.
WO1995025429A1 (fr)	1994-03-18	1995-09-28	Myriad Genetics, Inc.	Gene mts, mutations desdits genes et procedes de diagnostic du cancer a l'aide de sequences du gene mts
RU2161309C2 (ru)	1994-03-18	2000-12-27	Исследовательский Фонд Университета Юты,	Мутации гена мтs в зародышевой линии и способ выявления предрасположенности к злокачественным опухолям в гене мтs
US6689561B1 (en) *	1994-04-14	2004-02-10	The Regents Of The University Of California	Tumor suppressor gene and methods for detection of cancer, monitoring of tumor progression and cancer treatment
EP0758382A1 (fr)	1994-04-29	1997-02-19	Sidney Kimmel Cancer Center	Amelioration de la sensibilite de cellules tumorales a des therapies
DE19501073A1 (de) *	1995-01-16	1996-08-01	Nova C O R D Ag	Bildverarbeitungsverfahren zur Ermittlung der Strukturfestigkeit eines Prüfobjektes mit diffus streuender Oberfläche
WO1996025507A2 (fr) *	1995-02-17	1996-08-22	The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Procedes de preparation et d'utilisation de vecteurs adenoviraux recombines
US5672508A (en)	1996-01-23	1997-09-30	Mitotix, Inc.	Inhibitors of cell-cycle progression, and uses related thereto
PL193767B1 (pl)	1997-02-18	2007-03-30	Canji	Zastosowanie kompozycji farmaceutycznej do leczenia rakowych lub hiperproliferujących komórek ssaków i kompozycja farmaceutyczna do leczenia rakowychlub hiperproliferujących komórek ssaków

1996
- 1996-07-17 KR KR1019980700331A patent/KR19990029028A/ko not_active Withdrawn
- 1996-07-17 CA CA002227193A patent/CA2227193A1/fr not_active Abandoned
- 1996-07-17 JP JP9506807A patent/JPH11510380A/ja active Pending
- 1996-07-17 SK SK65-98A patent/SK6598A3/sk unknown
- 1996-07-17 CZ CZ98154A patent/CZ15498A3/cs unknown
- 1996-07-17 BR BR9609853-8A patent/BR9609853A/pt not_active Application Discontinuation
- 1996-07-17 NZ NZ313828A patent/NZ313828A/xx unknown
- 1996-07-17 EP EP96926086A patent/EP0839207A2/fr not_active Withdrawn
- 1996-07-17 HU HU9901908A patent/HUP9901908A3/hu unknown
- 1996-07-17 PL PL96324750A patent/PL324750A1/xx unknown
- 1996-07-17 WO PCT/US1996/011787 patent/WO1997003635A2/fr not_active Ceased
- 1996-07-17 AU AU66478/96A patent/AU724324B2/en not_active Ceased
- 1996-07-17 CN CN96196536A patent/CN1203632A/zh active Pending
1997
- 1997-08-13 US US08/910,722 patent/US6251871B1/en not_active Expired - Fee Related
1998
- 1998-01-16 NO NO980218A patent/NO980218L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CZ15498A3 (cs)	1998-07-15
BR9609853A (pt)	1999-10-13
AU724324B2 (en)	2000-09-14
EP0839207A2 (fr)	1998-05-06
CN1203632A (zh)	1998-12-30
PL324750A1 (en)	1998-06-08
HUP9901908A2 (hu)	1999-09-28
US6251871B1 (en)	2001-06-26
HUP9901908A3 (en)	2000-02-28
WO1997003635A2 (fr)	1997-02-06
AU6647896A (en)	1997-02-18
WO1997003635A3 (fr)	1997-05-15
CA2227193A1 (fr)	1997-02-06
NZ313828A (en)	1999-02-25
JPH11510380A (ja)	1999-09-14
NO980218L (no)	1998-03-16
KR19990029028A (ko)	1999-04-15
NO980218D0 (no)	1998-01-16

Publication	Publication Date	Title
AU724324B2 (en)	2000-09-14	p16 expression constructs and their application in cancer therapy
ES2264145T3 (es)	2006-12-16	Metodos y composiciones para el tratamiento de cancer.
AU694216B2 (en)	1998-07-16	Compositions comprising DNA damaging agents and P53
EP0921821B1 (fr)	2004-10-13	Apoptose induite par 2-methoxyestradiol dans les cellules cancereuses
PL186151B1 (pl)	2003-11-28	Zrekombinowane adenowirusy, kompozycje zawierające zrekombinowane adenowirusy, komórka gospodarza zainfekowana zrekombinowanym adenowirusem oraz sposób otrzymywania biologicznie aktywnego białka p53 typu dzikiego
WO2002019965A2 (fr)	2002-03-14	Réaction du type choc thermique et réplication virale
US7163925B1 (en)	2007-01-16	p16 expression constructs and their application in cancer therapy
WO1997016547A1 (fr)	1997-05-09	VECTEURS D'EXPRESSION ADENOVIRAUX ANTISENS DU K-ras ET LEUR APPLICATION EN THERAPIE ANTICANCEREUSE
WO1997016547A9 (fr)	1997-07-10	VECTEURS D'EXPRESSION ADENOVIRAUX ANTISENS DU K-ras ET LEUR APPLICATION EN THERAPIE ANTICANCEREUSE
AU5001099A (en)	2000-02-07	Repression of cell transformation with human pea3
KR100488341B1 (ko)	2005-05-11	피972 유전자를 포함하는 유전자 전달체, 피972 유전자를 세포내에서 생산할 수 있는 아데노바이러스
HK1100393A (en)	2007-09-21	Method and compositions for the diagnosis and treatment of cancer