SK17922000A3 - FILLED TANK - Google Patents

Abstract

A pre-filled plastic syringe (1) which includes: a) a barrel (1a); b) a moveable stopper (3) which seals the barrel at one end; c) a needle fitting (13) which is integral with the barrel and which is located at the end of the syringe remote from the moveable stopper; and d) a closure (9) which seals the syringe at its needle fitting end; wherein an injectable liquid (10) is housed within the barrel between the moveable stopper and the closure and wherein the closure is located within the needle fitting and/or the barrel of the syringe.

Description

Technical field

The present invention relates to pre-filled reservoirs, cartridges and syringes. In particular, it relates to a new form of syringe which can be pre-filled, equipped with a hypodermal needle and packaged as a ready-to-use product.

BACKGROUND OF THE INVENTION

Rather, the applicant has submitted various proposals for the manufacture of shaped plastic syringes. For example, reference is made to Applicant's earlier patent applications PCT / AU92 / 00007 and PCT / AU95 / 00723. In both of these previous cases, the pre-filled syringe was sealed at the needle end by a cap in the form of a stem detachable from the syringe. While the applicant's previous suggestions have been significant improvements to the pre-filled products available prior to these novelties, the use of a stem to seal the syringe has created some difficulties. First, the stem protruding from the end of the syringe is susceptible to accidental impacts, both during manufacture and in use, and this may result in contamination or inattentive opening of the unit. Second, in a system such as that disclosed in PCT / AU95 / 00723, for example, it is necessary to remove the stem from the needle adapter before attaching the hypodermic needle. This means that the needle must be attached separately just before use. This can be inconvenient and there is also the possibility of contamination during needle insertion.

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SUMMARY OF THE INVENTION

It is an object of the present invention to provide a prefilled syringe that is sealed in a manner that targets at least some of the difficulties described in the above-mentioned units.

In accordance with the present invention, there is provided a prefilled plastic syringe which comprises

(a) syringe body;

b) a movable plug that seals the body at one end;

c) a needle adapter which is part of the syringe body and which is located at the other end as the movable plug; and

d) a cap that seals the syringe at the end where the needle adapter is; wherein the injection fluid is placed in the body between the movable plug and the closure, and wherein the closure is located in the needle adapter and / or in the syringe body.

The needle adapter preferably comprises a hollow truncated cone whose interior communicates with the interior of the syringe body. Most preferably, the needle adapter is in the form of a truncated cone surrounded by a peripheral wall separated from the cone by a space. An example of such an adapter is a luer needle adapter. The luer adapter includes a thread on the inner surface of the peripheral wall that is compatible with the thread of the hypodermic needle to be attached to the needle adapter. The hypodermic needles used in conjunction with the luer needle adapter are attached to one end of the support, which is conical, hollow, and fits the central cone of the luer adapter. The lower portion of the needle support includes an edge that is shaped to fit into the

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the inner surface of the peripheral wall so that rotating the hypodermic needle relative to the needle adapter facilitates the insertion of the needle.

Most preferably, the syringe uses a luer-type needle adapter and the syringe is used in conjunction with a hypodermic needle mounted on a conical support as described above.

The closure may be a separate component located in the syringe body or needle adapter via, for example, a frictional fit or other suitable means. In such a case, it is preferred that the closure be made of such a material and of a thickness that it can be easily pierced.

Preferably, however, the closure is a portion of a wall that is peripherally connected to the inner surface of the syringe body or the inner surface of the needle adapter, and which extends through the opening of the syringe body or through the needle adapter. Most preferably, the closure is located entirely within the syringe needle adapter. In an embodiment where the needle adapter comprises a hollow conical cone communicating with the interior of the syringe body, it is preferred that the closure be an integral part of the wall that is attached to the inner surface of the cone and extends through its opening. In this embodiment, a portion of the wall may be located at any position along the inner wall of the needle adapter. Preferably, the edge is attached to the inner surface of the truncated cone and is located at least 2.0 mm, and more preferably at least 4.0 mm from the open end of the truncated cone so as to reduce the possibility of breaking off the wall portion from the inner wall ).

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In order to allow the syringe to be easily opened when it is desired to dispense the injection fluid, it is desirable that the closure be either punctured with the back needle of a standard double-sided hypodermic needle (in this case, the closure is closed close to the open end of the needle adapter). alternatively separated or partially broken off from the inner surface of the truncated cone or syringe body by means of a suitable tool.

In a particularly preferred embodiment, the syringe comprises a truncated conical needle adapter and the closure is a portion of a wall that extends through the inner lumen of the cone and is peripherally connected to the inner surface of the cone.

In this embodiment, it is desirable that a portion of the wall include a portion weakened at the periphery or adjacent to its attachment to the inner surface of the cone. The weakened portion thus forms a "fault line along which the closure can be separated (at least partially) from the inner surface of the cone. The thickness of the wall portion is preferably between 0.8 mm to 1.5 mm, except for the weakened portion, where the thickness is preferably between 0.05 to 0.2 mm. Although it is possible to use a weakened portion that occupies the entire perimeter of the wall portion, this option is not preferred,. since applying force to a portion of the wall in such an embodiment of the invention may result in complete separation of the closure from the needle adapter. Although this may not adversely affect the operation of the syringe, it is considered undesirable for the cap to float freely in the injection fluid. For this reason, it is preferred that the weakened portion engages around the circumference of 330-350 ° so that if the closure is broken off the inner surface of the cone along the weakened portion, it would still remain attached to the interior of the needle adapter and function as a hinge of the adjacent surface. cone that is not weakened.

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The seal represented by a portion of the wall can be broken by applying a force against the portion of the wall. For this purpose a tool can be used, which can be a rod with a smaller diameter than the inner cone diameter and which is of sufficient length to reach part of the wall. Such a tool preferably has a flat end to contact most of the surface of the closure. Once the cap is detached, a hypodermic needle can be attached to the needle adapter, making the syringe ready for immediate use.

Alternatively and most preferably, where the closure is rim mounted to the needle adapter, the pre-filled syringe also includes a hollow closure passage, a hypodermic needle and a needle cavity with an internal cavity when said hypodermic needle is to be attached to one end of the needle support and said needle support is located above, but not fully engaged with, the needle adapter, wherein the first end of said closure passage is located in said inner cavity and the second end of the closure passage is disposed in said needle adapter, wherein the closure passage is fluid in communication with the hypodermic needle and is so long that moving the needle support towards the end of the movable plug syringe will cause the seal passage to break the seal provided by the seal.

Desirably, the length of the closure passage is such that the full fit of the needle support into the needle adapter provides sufficient movement of the needle support (and hence the closure passage) to allow the seal provided by the closure to break.

The cavity in the needle support preferably comprises an end plate in which the opening is centrally located. hypodermic

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the needle may be secured and secured at one end of the opening so that it protrudes from the cavity. The closure passage is preferably disposed in a cavity with a first end bordering the end face of the housing in the inner passage aligned with the opening in the end face of the needle support. The other end of the closure passage is preferably adjacent to or adjacent to the closure surface. In this way, moving the needle support toward the movable plug of the syringe causes the end plate to press against the first end of the closure passage and thereby exert pressure on the closure. By fully moving the support towards the needle adapter, the closure passage moves sufficiently to break the connection at the edge of the closure passage to the needle adapter, thereby facilitating direct communication of fluid from the syringe body to the hypodermic needle through the open closure through the closure passage.

The closure passage may be an integral part of the needle support and may overhang it, but is preferably a separate component.

Preferably, the closure passage includes a central passage and ribs extending outwardly therefrom so that contact between the closure passage and the inner surface of the needle adapter is minimized. This reduces friction between surfaces. As an alternative, other closures may be used which do not include a passage in their design but simply allow fluid to flow. An example of such an alternative closure is a rigid rod having a smaller diameter than the smallest diameter of the passage in the needle adapter with a directed rib that is configured to contact the inner surface of the needle adapter.

It is desirable that the pre-filled syringe also include a housing placed over a hypodermic needle. A circumferential strip indicating tampering may be placed around the bottom of the housing so that previous removal of the housing may. be recognized by the absence of the strip or its breakage.

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The form of the invention utilizing the closure passage provides significant advantages in ease of use and avoidance of contamination. In particular, it is possible to prepare all components for injection, to assemble and fill the syringe in an aseptic environment. The pre-filled and assembled syringe can also be hermetically sealed with a clean plastic material such as cellophane before transporting the product from a clean environment.

The pre-filled product can also be delivered to practitioners with a hypodermic needle in position above the needle adapter, but not fully fitted. In use, the hypodermic needle may be pushed or twisted toward the needle adapter while the product is hermetically sealed. Completely attaching the hypodermic needle to the needle adapter causes the seal formed by the cap to be broken so that when the package is opened, it provides removal of the hypodermic needle cover (if present) with an open, pre-filled syringe ready for use and inaccessible contamination which could be caused by components or products into the syringe after opening the package.

The pre-filled plastic syringe of the present invention is preferably made of a thermoplastic material such as polypropylene. Other preferred materials include translucent and transparent plastics such as PET, polyamides, or TPX. Other preferred materials are well known to those skilled in the art.

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BRIEF DESCRIPTION OF THE DRAWINGS

Examples of the invention are now described by reference to particularly preferred embodiments of the invention in which the pre-filled syringes are assembled and packaged in a sterile environment and available for immediate use. Embodiments of the invention are shown in the following figures, in which:

Fig. 1 is a schematic diagram illustrating a pre-filled syringe packaged in an outer container;

Fig. 2 is a schematic diagram illustrating the pre-filled syringe shown in FIG. 1 with the packaging removed and before opening the syringe;

Fig. 3 is an end view of the pre-filled syringe shown in FIG. 2 from the perspective of the piston end;

Fig. 4 is an enlarged schematic view of the needle adapter and pre-filled syringe cap shown in FIG. 2;

Fig. 5 is an enlarged view of the central cone of the needle adapter shown in FIG. 4 and the closure attached;

Fig. 6 is a schematic diagram illustrating the end with the needle adapter of the pre-filled syringe shown in FIG. 2 with a hypodermic needle and a needle support located at the end of the syringe needle adapter, but before fully deploying;

Fig. 7 is a schematic diagram illustrating the needle adapter and the components of the hypodermic needle shown in FIG. 6 after placing the hypodermic needle and needle support firmly on the syringe needle adapter;

Fig. 8 is a schematic diagram illustrating the end of a pre-filled syringe with a needle adapter and the passage where injection fluid can flow after opening the closure;

Fig. 9 is a schematic diagram illustrating a closure passage;

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Fig. 10 is a cross-sectional view of a removable strap used to secure the cap in a position above the hypodermic needle prior to use;

Fig. 11 is a schematic diagram illustrating an alternative embodiment of the invention using a double-sided hypodermic needle;

Fig. 12 is a schematic diagram representing the end of the pre-filled syringe with the needle adapter shown in FIG. 11;

Fig. 13 is a schematic diagram representing the end of the truncated cone in the needle adapter shown in FIG. 12; and FIG. 14 is a schematic diagram representing a double-sided hypodermic needle with support and cover.

DETAILED DESCRIPTION OF THE INVENTION

Fig. 1 is a schematic diagram illustrating how a preferred embodiment of the invention can be presented to physicians and other medical care providers. The pre-filled syringe 7 is preferably manufactured by preparing all the injectable ingredients in an aseptic environment, assembling and filling the syringe in an aseptic environment, and packaging the syringe in an outer container 17.

The syringe 1 illustrated in FIG. 2, without a protective cover, comprises a syringe body 1a and a plunger rod 2 attached to the movable plug 3. The movable plug 3 seals the syringe body at one end - the other end of the syringe body being sealed by a closure 9 which is integral with the central truncated cone 13a of the needle adapter 13. the other end of the syringe. The body of the syringe 1a is filled. Injection fluid 10 and this fluid is disposed in the body of the syringe 1a between the movable plug 3 and the closure 9.

The hypodermic needle 5 is secured to the needle support f. The needle support 7 includes an inner cavity 7a (best shown in Fig. 6) and is located at the end of the truncated cone 13a of the needle adapter 13. The hypodermic needle 5 is hollow and communicates fluidly with the cavity 7a.

The hollow closure passage shown as a separate tube 21 (again best seen in Fig. 6) is positioned between the needle support 7 and the closure 9, and the use of this tube in conjunction with the needle support 7 to separate the closure 9 is described below.

The hypodermic needle 5 is protected by a cover 6 which is held in position by the circumferential strip 6, which is shown in detail in FIG. 10th

The needle adapter 13 also includes an outer peripheral wall

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Fig. 3 illustrates a syringe from the end of the plunger rod of the syringe, shows thumb pressure 12, finger support brackets 16, and ribs facilitating gripping 18. These features are presented simply as an example of a particular embodiment of the invention, but it will be appreciated that any piston rod or movable plug as known in the art are considered adequate for the purposes of the present invention.

Fig. 4 illustrates the end with the needle adapter of the pre-filled syringe shown in FIG. 2. The needle adapter comprises a central truncated cone 13a and an outer peripheral wall 15.

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This is a characteristic of a standard luer needle adapter and is therefore suitable for use in conjunction with a standard hypodermic and needle support of the type shown in FIG. 2. The outer peripheral wall 15 comprises a helical rib 20 which facilitates by means of a screw mechanism the engagement of the needle support 7 on the needle adapter 13. The needle adapter 13 has an opening 22 between the outer peripheral wall 15 and the central truncated cone 13a.

In contrast to a standard luer lock, it is provided by the closure 9 in the form of an integral end portion of the wall located in the central truncated cone 13a.

Although the closure 2 is an integral part of the central truncated cone 13a, the closure 2 is attached as best seen in FIG. An adjacent part of the closure 9 to the inner surface of the truncated cone 13a is the break line 8, which is a peripheral portion of lower thickness, so that applying force against the closure 9 towards the end of the pre-filled syringe with movable plug ^ reduced thickness. In said embodiment, the syringe is made of polypropylene and the closure 9 has a thickness of about 1.2 mm. The break line has a thickness of about 0.1 mm. Preferably, the frangible line does not extend over the entire circumference of the closure 9, so that when a force is applied against the closure, at least a portion of the closure remains attached to the inner surface of the truncated cone 13a, The diameter of the inner passage of the central truncated cone 13a is slightly larger on the body side of the syringe of the closure 9, so that it has been adapted to fit the closure when separated and turned back by the tube 21.

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The function of the syringe is shown in more detail in FIG. 6, 7 and

8. FIG. 6 shows the end of a syringe with a needle adapter with a cap 9 sealing the syringe. This is how the product can be delivered to end users. The needle support 7 is positioned over the central truncated cone 13a, but the edge 7b of the needle support 7 does not fit into the helical portion 20 of the outer peripheral wall 15. The tube 21 is positioned with the first end of the abutment against the end of the cavity 7a and the second end in abutment against the tab. 21 has a central duct 21a which is positioned such that the fluid communicates directly with the duct 5a in the hypodermic needle 5. The tamper-evident circumferential strip 6 holds the cover 6 in position.

In FIG. 7 shows the end of the pre-filled syringe with the needle adapter after separating a portion of the closure 9 from the inner surface of the central truncated cone 13a. This separation is preferably achieved by applying a force to the housing 6 or the peripheral strip 4 in the direction of the end of the pre-filled syringe with the movable stopper. This force then turns the needle support 2 further on the truncated cone 13a. For engagement with the threaded bolt 20, it is preferred that the force is used in conjunction with rotation so that the needle support 7 is screwed into the central cone 13a and towards the end of the movable plug syringe. This movement of the support 7 causes a force to be applied to the tube 21 and subsequently to the closure 9, causing it to tear away from the inner surface of the central truncated cone 13a along the break line 13. In the preferred embodiment shown in FIG. 7 does not extend the break line 2 over the entire perimeter of the closure and thus functions as a hinge, as can be clearly seen in FIG. The pipe 21 is preferably tapered at the end. This facilitates easy insertion of the tube 21 into the truncated cone 13a when the product is assembled, but it also means that the tube 21 is less likely to separate the cap 9 from the truncated cone 13a.

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The open closure 9 is maintained between the inner surface of the truncated cone 13a and the outer surface of the tube 21 once the needle support 7 has been firmly mounted on the needle adapter 13.

In FIG. 8 shows the ready-to-use end of the pre-filled syringe 1 with the needle adapter. The tamper-evident circumferential strip 8 is removed together with the cover 6 (as opposed to FIG. 7). The injection fluid 10 can now be expelled from the syringe 1 in the direction of the arrow shown in FIG. 8 by moving the plunger rod 2 towards the end of the needle adapter syringe. The injection fluid 10 moves in the direction of the arrow in FIG. 8 through the channel 21a and hence the hypodermic needle 5.

In FIG. 9 shows schematically the tube 21 and FIG. 10 is an enlarged cross-sectional view of the circumferential strip 8 indicating tampering. This strip comprises an inner rib 14 and an edge of the end 14a adapted to the clip about the edge 6a of the cover 6.

An alternative embodiment of the invention is shown in FIG. 11-14. In this embodiment, the features described in the first embodiment are numbered in a similar manner. The primary difference between the embodiment shown in FIG. 11 to 14 and the embodiment of the invention shown in FIG. 1 to 10 relates to the position of the closure 9 and the use of a double-sided hypodermic needle.

In FIG. 11, there is shown a pre-filled syringe 6 having a syringe body 1a, a plunger rod 2 and a movable plug 3. The needle adapter 13 comprises a central truncated cone 13a and an outer peripheral wall 15. The hypodermic needle 5 is attached to the needle support 7. Unlike the embodiment shown in FIG. 1 to 10, the hypodermic needle 5 extends beyond the needle support T and has a sharpened end 5b located in the cavity 7a. When the product is assembled and filled, the tip 5b of the hypodermic needle 5 is located near but not in contact with the cap 9 when the product is assembled and filled.

The needle adapter 13 and the central truncated cone 13a are shown in detail in FIG. 12 and 13. In order to ensure proper piercing of the cap 9 with the sharpened end 5b of the hypodermic needle 5 when the needle support 2 is fully attached to the needle adapter 13, it is important that the cap 9 is positioned near the end of the central cone 13a. Although it can be located at the very end of the central cone 13a, it is preferred to be located a short distance from the cone, for example 0.5 mm from the end of the cone 13a.

It will be appreciated that in use, the insertion of the needle support 7 entirely onto the needle adapter 13 will cause the sharpened end 5b of the hypodermic needle 5 to move through and through the closure 9, thereby breaking the seal formed by the closure 9 so that injection fluid 10 can be expelled from the syringe in as described with respect to the first embodiment of the invention.

Fig. 14 is an enlarged representation of a hypodermic needle 5, a needle support 2 of the housing 6.

It is clear from the foregoing that preferred embodiments of the invention, as illustrated and described above, can be manufactured, assembled, and packaged in an aseptic or clean environment. This product can be transported and stored with minimal risk of contamination and the packaging can protect the syringe from any contamination and can only be removed when the syringe is ready for use. Since the syringe opening mechanism is actuated by attaching the needle support 14 to the needle adapter 13, it does not occur before *;

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Various modifications of the form of the invention described herein can be made without departing from the scope of the present invention as defined in the following claims.

Claims (35)

1. Pre-filled plastic syringe, containing: (a) syringe body; b) a movable plug that seals the syringe body at one end; (c) a needle adapter which is an integral part of the syringe body and which is located at the end of the syringe remote from the movable plug; and d) a cap that seals the syringe at its end with the needle adapter; wherein the injection fluid is located in the syringe body between the movable plug and the closure, and wherein the closure is part of a wall located in the syringe body and / or in the syringe needle adapter. A pre-filled plastic syringe as claimed in claim 1, wherein a portion of the wall is edge joined to the inner surface of the syringe body or the inner surface of the needle adapter. A pre-filled plastic syringe as claimed in claim 2, wherein a portion of the wall extends over and is located in the opening of the body of the syringe or needle adapter. A pre-filled plastic syringe as claimed in any one of the preceding claims 1 to 3, wherein the closure is disposed entirely within the syringe needle adapter. · · «• • • • • • • And is so thick, A prefilled plastic syringe, which is any of claims 1 to 4, made of such a material easily punctured. an object where there is part of the wall that it can be Pre-filled plastic claims 1 to 5, truncated cone, of fluid with the inside of the body formed by the closure. a syringe which where the needle adapter is the object comprises a hollow whose interior communicates by sealing the syringe after withdrawal Pre-filled plastic claims 1 to 6, a truncated cone surrounded by a space from the cone. a syringe which is where the needle adapter is a peripheral wall object in a separate form A pre-filled plastic syringe which is any one of claims 1 to 7, wherein the separate component is disposed within the body or the needle adapter. the subject is a syringe cap The plastic pre-filled syringe of claim 1, wherein the needle adapter comprises a hollow truncated cone with an open end that communicates via fluid to the interior of the syringe body after the seal formed by the closure is removed and the closure is an integral part of the wall that is connected to the inner surface truncated cone and extends through its opening. The plastic pre-filled syringe of claim 9, wherein a portion of the wall is positioned at any position along the entire length of the inner wall of the truncated cone. • ·············································· · · ·· ··· ·· ·· ··· ·· ··· A plastic pre-filled syringe as claimed in claim 10 which is peripherally attached to the inner surface of the truncated cone and is located at least 2.0 mm from its open end. The plastic pre-filled syringe of claim 10, wherein a portion of the wall is edge joined to the inner surface of the truncated cone and is located at least 4.0 mm from its open end. A plastic pre-filled syringe as claimed in any one of the preceding claims, wherein the needle adapter is a luer-type needle adapter. A plastic pre-filled syringe as claimed in any one of the preceding claims, in which the closure can be pierced by the rear needle of a double-sided hypodermic needle. A plastic pre-filled syringe as claimed in any one of the preceding claims, wherein the closure may be detached or partially detached from the inner surface of the needle adapter or syringe body using a suitable tool. A plastic pre-filled syringe as claimed in any one of claims 10 to 13, wherein the closure is part of a wall that extends through the inner trunking of the truncated cone and is edge mounted to its inner surface. The plastic pre-filled syringe of claim 16, wherein said wall portion comprises a peripheral weakened portion at the point of attachment or a portion of said wall. ···················································································································································································. The plastic pre-tensile syringe of claim 17, wherein said wall portion has a thickness of between 0.8 mm to 1.5 mm, except for the weakened portion, wherein it has a thickness of between 0.05 to 0.2 mm. The plastic preloaded syringe of claim 18, wherein said weakened portion does not extend around the entire portion of the wall. The plastic preloaded syringe of claim 19, wherein the weakened portion has a circumferential range between 330 and 350 °, so that when the closure is broken off from the inner surface of the needle adapter along the weakened portion, the closure remains affixed to the inner surface of the needle adapter and function as a hinge for this portion adjacent to the inner portion of the needle adapter that is not weakened. The pre-tensile plastic syringe of any of the preceding claims, further comprising a hollow closure passage, a hypodermic needle, and an inner cavity needle support, wherein said hypodermic needle is attached to one end of the needle support and said needle support is positioned above the needle. an adapter, wherein the first end of said closure passage is located in said inner cavity of the needle support and the second end of the closure passage is disposed in said needle adapter, and wherein the closure passage communicates via fluid with the hypodermic needle and has a length such that movement of the needle support towards the end syringes with movable stopper n • ············································ · ·· ··· ·· ·· ··· ·· ··· causes the seal passage to remove the seal provided by the seal. The plastic pre-filled syringe of claim 21, wherein the length of the closure passage is such that the full fit of the needle support into the needle adapter provides sufficient movement of the closure passage to disengage the seal provided by the closure. The plastic pre-filled syringe of claim 22, wherein the cavity in the needle support comprises an end plate in which a bore is centrally located. A plastic pre-filled syringe as claimed in claim 23, wherein the hypodermic needle is secured and secured in the hole of the needle support and extends from the cavity. The plastic pre-filled syringe of claim 24, wherein the closure passage is located in a cavity with a first end adjacent the end face of the cavity with an internal channel in a location with an opening in the end face of the needle support. A plastic pre-filled syringe as claimed in claim 25, wherein one end of the closure passage adjoins or adjoins the surface of the closure. A plastic pre-filled syringe as claimed in claims 21 to 26, wherein said closure passage is an integral part of the syringe and extends from the needle support. 28th A plastic pre-filled syringe of claims 21 to 26, wherein it is • ·· • · • ··· ·· ···· • · · • · ··· • · • · • · • · • B ·· ·· ··· · · · · the object of which is said closing passage through a separate component. A plastic pre-filled syringe as claimed in claims 21 to 28, wherein said closure passage comprises a central conduit and ribs extending from said conduit. The plastic pre-filled syringe of claims 21 to 29, further comprising a housing positioned above the hypodermic needle. A plastic pre-filled syringe as claimed in any one of the preceding claims, wherein the filled and assembled syringe is hermetically sealed with a clean plastic container. A method of using a plastic pre-filled syringe as claimed in any one of claims 21 to 30, wherein said hypodermic needle is pushed or turned into the needle adapter while the hermetically sealed package is still in place. The method of claim 32, wherein moving the hypodermic needle into the needle adapter causes the closure passage to cancel the seal provided by the closure. A prefilled plastic syringe as claimed in any of the preceding claims and made of a thermoplastic material. 35. The prefilled plastic syringe described herein with reference to what is shown in any of the figures.