SK165596A3 - Sterol derivatives used for regulation of meiosis in the mammalian zygotes - Google Patents

Sterol derivatives used for regulation of meiosis in the mammalian zygotes Download PDF

Info

Publication number: SK165596A3
Authority: SK; Slovakia
Prior art keywords: formula; group; sterol derivatives; carbon atoms; miosis
Prior art date: 1994-06-23

Application number

SK1655-96A

Other languages

English (en)

Slovak (sk)

Inventor

Anne G Byskov

Claus Y Andersen

Lars Nordholm

Henning Thogersen

Ole Wassmann

Ivan V Diers

Erling Guddal

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-23

Filing date

1995-06-23

Publication date

1997-08-06

1995-06-23 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1997-08-06 Publication of SK165596A3 publication Critical patent/SK165596A3/sk

Links

229930182558 Sterol Natural products 0.000 title claims abstract description 39
235000003702 sterols Nutrition 0.000 title claims abstract description 39
150000003432 sterols Chemical class 0.000 title claims abstract description 38
230000018046 regulation of meiosis Effects 0.000 title 1
210000000287 oocyte Anatomy 0.000 claims abstract description 26
230000001105 regulatory effect Effects 0.000 claims abstract description 7
230000003547 miosis Effects 0.000 claims description 52
206010027646 Miosis Diseases 0.000 claims description 51
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 40
125000004432 carbon atom Chemical group C* 0.000 claims description 37
150000001875 compounds Chemical class 0.000 claims description 34
-1 nicotinoyl Chemical group 0.000 claims description 23
238000000034 method Methods 0.000 claims description 15
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239000001257 hydrogen Substances 0.000 claims description 9
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
125000002252 acyl group Chemical group 0.000 claims description 6
229910052799 carbon Inorganic materials 0.000 claims description 6
230000001276 controlling effect Effects 0.000 claims description 6
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DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 1
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DBGVGMSCBYYSLD-UHFFFAOYSA-N tributylstannane Chemical compound CCCC[SnH](CCCC)CCCC DBGVGMSCBYYSLD-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/001—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class spiro-linked
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Cosmetics (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

SK1655-96A 1994-06-23 1995-06-23 Sterol derivatives used for regulation of meiosis in the mammalian zygotes SK165596A3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK75394		1994-06-23
DK24195		1995-03-09
PCT/DK1995/000265 WO1996000235A1 (en)	1994-06-23	1995-06-23	Sterol derivatives used for regulation of meiosis

Publications (1)

Publication Number	Publication Date
SK165596A3 true SK165596A3 (en)	1997-08-06

Family

ID=26063596

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SK1655-96A SK165596A3 (en)	1994-06-23	1995-06-23	Sterol derivatives used for regulation of meiosis in the mammalian zygotes

Country Status (26)

Country	Link
US (1)	US5716777A (pt)
EP (1)	EP0767798B1 (pt)
JP (1)	JP3987105B2 (pt)
KR (1)	KR100408369B1 (pt)
CN (1)	CN1068333C (pt)
AT (1)	ATE248852T1 (pt)
AU (1)	AU694240B2 (pt)
BG (1)	BG101067A (pt)
BR (1)	BR9508074A (pt)
CA (1)	CA2192941C (pt)
CZ (1)	CZ289407B6 (pt)
DE (1)	DE69531682T2 (pt)
DK (1)	DK0767798T3 (pt)
ES (1)	ES2204955T3 (pt)
FI (1)	FI117159B (pt)
HU (1)	HUT76343A (pt)
IL (1)	IL114294A (pt)
IS (1)	IS4404A (pt)
MX (1)	MX9700174A (pt)
NO (1)	NO314534B1 (pt)
PL (1)	PL186688B1 (pt)
RU (1)	RU2194510C2 (pt)
SI (1)	SI9520077A (pt)
SK (1)	SK165596A3 (pt)
UA (1)	UA51622C2 (pt)
WO (1)	WO1996000235A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU717180B2 (en) *	1995-03-06	2000-03-16	Novo Nordisk A/S	Stimulation of meiosis
WO1997000883A1 (en) *	1995-06-23	1997-01-09	Novo Nordisk A/S	Meiosis regulating compounds
US6645953B2 (en) *	1995-06-23	2003-11-11	Novo Nordisk A/S	Meiosis regulating compounds
RU2182909C2 (ru) *	1995-06-23	2002-05-27	Ново Нордиск А/С	Стероиды, способ регулирования мейоза
HUP9904616A3 (en)	1996-12-20	2001-02-28	Novo Nordisk As	Meiosis regulating cholestane-derivatives
WO1998052965A1 (en) *	1997-05-16	1998-11-26	Akzo Nobel N.V.	20-ARALKYL-5α-PREGNANE DERIVATIVES
EP0988312B1 (en) *	1997-06-04	2002-04-03	Akzo Nobel N.V.	17beta-allyloxy(thio)alkyl-androstane derivatives for the modulation of meiosis
DE69806640T2 (de)	1997-12-18	2003-03-13	Akzo Nobel N.V., Arnheim/Arnhem	17beta-aryl(arylmethyl)oxy(thio)alkyl-androstanderivative
ATE256144T1 (de) *	1998-05-13	2003-12-15	Novo Nordisk As	Verwendung von verbindungen mit der fähigkeit die meiose zu regulieren
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1995
- 1995-05-23 US US08/448,217 patent/US5716777A/en not_active Expired - Fee Related
- 1995-06-23 AT AT95922448T patent/ATE248852T1/de not_active IP Right Cessation
- 1995-06-23 EP EP95922448A patent/EP0767798B1/en not_active Expired - Lifetime
- 1995-06-23 KR KR1019960707361A patent/KR100408369B1/ko not_active Expired - Fee Related
- 1995-06-23 DK DK95922448T patent/DK0767798T3/da active
- 1995-06-23 SK SK1655-96A patent/SK165596A3/sk unknown
- 1995-06-23 CN CN95193731A patent/CN1068333C/zh not_active Expired - Fee Related
- 1995-06-23 DE DE69531682T patent/DE69531682T2/de not_active Expired - Fee Related
- 1995-06-23 JP JP50272496A patent/JP3987105B2/ja not_active Expired - Lifetime
- 1995-06-23 CA CA002192941A patent/CA2192941C/en not_active Expired - Fee Related
- 1995-06-23 HU HU9603584A patent/HUT76343A/hu not_active Application Discontinuation
- 1995-06-23 PL PL95317830A patent/PL186688B1/pl not_active IP Right Cessation
- 1995-06-23 SI SI9520077A patent/SI9520077A/sl unknown
- 1995-06-23 WO PCT/DK1995/000265 patent/WO1996000235A1/en not_active Ceased
- 1995-06-23 AU AU27343/95A patent/AU694240B2/en not_active Ceased
- 1995-06-23 UA UA96124771A patent/UA51622C2/uk unknown
- 1995-06-23 RU RU97101087/14A patent/RU2194510C2/ru not_active IP Right Cessation
- 1995-06-23 BR BR9508074A patent/BR9508074A/pt not_active IP Right Cessation
- 1995-06-23 CZ CZ19963725A patent/CZ289407B6/cs not_active IP Right Cessation
- 1995-06-23 MX MX9700174A patent/MX9700174A/es not_active IP Right Cessation
- 1995-06-23 ES ES95922448T patent/ES2204955T3/es not_active Expired - Lifetime
- 1995-06-23 IL IL11429495A patent/IL114294A/en not_active IP Right Cessation
1996
- 1996-12-18 BG BG101067A patent/BG101067A/xx unknown
- 1996-12-20 FI FI965144A patent/FI117159B/fi active IP Right Grant
- 1996-12-20 NO NO19965516A patent/NO314534B1/no unknown
- 1996-12-23 IS IS4404A patent/IS4404A/is unknown

Also Published As

Publication number	Publication date
CA2192941A1 (en)	1996-01-04
JPH10502060A (ja)	1998-02-24
CA2192941C (en)	2009-04-14
NO965516L (no)	1997-02-21
FI117159B (fi)	2006-07-14
EP0767798B1 (en)	2003-09-03
HUT76343A (en)	1997-08-28
FI965144A0 (fi)	1996-12-20
CN1151164A (zh)	1997-06-04
NO314534B1 (no)	2003-04-07
WO1996000235A1 (en)	1996-01-04
UA51622C2 (uk)	2002-12-16
JP3987105B2 (ja)	2007-10-03
CZ289407B6 (cs)	2002-01-16
BG101067A (en)	1997-08-29
EP0767798A1 (en)	1997-04-16
PL317830A1 (en)	1997-04-28
AU694240B2 (en)	1998-07-16
CZ372596A3 (en)	1997-07-16
IS4404A (is)	1996-12-23
CN1068333C (zh)	2001-07-11
AU2734395A (en)	1996-01-19
IL114294A (en)	2002-09-12
ES2204955T3 (es)	2004-05-01
US5716777A (en)	1998-02-10
FI965144L (fi)	1997-02-20
IL114294A0 (en)	1995-10-31
NO965516D0 (no)	1996-12-20
HU9603584D0 (en)	1997-02-28
MX9700174A (es)	1997-04-30
KR100408369B1 (ko)	2004-04-28
DE69531682D1 (de)	2003-10-09
DK0767798T3 (da)	2003-12-22
DE69531682T2 (de)	2004-07-15
SI9520077A (sl)	1998-06-30
BR9508074A (pt)	1997-08-12
PL186688B1 (pl)	2004-02-27
ATE248852T1 (de)	2003-09-15
RU2194510C2 (ru)	2002-12-20

Publication	Publication Date	Title
SK165596A3 (en)	1997-08-06	Sterol derivatives used for regulation of meiosis in the mammalian zygotes
EP0857173B1 (en)	2003-11-19	Meiosis regulating compounds
KR20000069616A (ko)	2000-11-25	감수분열 조절화합물
US20030004148A1 (en)	2003-01-02	Regulation of meiosis
RU2289587C2 (ru)	2006-12-20	Стероидные соединения, способы их получения, фармацевтическая композиция, способы регуляции и совершенствования воспроизведения, промежуточные соединения
RU2349597C2 (ru)	2009-03-20	Тиоморфолиновые производные стероидов, их применение для получения регулирующих мейоз лекарственных средств и способ получения этих соединений
HUP0102704A2 (hu)	2002-01-28	Meiózist befolyásoló szteroidok és alkalmazásuk
KR20020013541A (ko)	2002-02-20	14β-Ｈ-스테롤, 그를 포함하는 제약 조성물, 및 감수분열조절 약제 제조에 있어서 그의 유도체의 용도
KR20010101820A (ko)	2001-11-14	불포화 콜레스탄 유도체 및 감수분열 조절 약제 제조에있어서 그의 용도
MXPA06001145A (en)	2007-04-20	Thiomorpholino steroid compounds, the use thereof for the preparation of meiosis-regulating medicaments and method for the preparation thereof
MXPA98000123A (en)	1998-10-15	Compounds that regulate the meio