SK11152001A3 - Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1 - Google Patents

Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1 Download PDF

Info

Publication number: SK11152001A3
Authority: SK; Slovakia
Prior art keywords: compound; group; formula; ethyl; chlorophenyl
Prior art date: 1999-02-05

Application number

SK1115-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Alan Wellington Faull

Jason Grant Kettle

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-05

Filing date

2000-01-31

Publication date

2001-12-03

2000-01-31 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2001-12-03 Publication of SK11152001A3 publication Critical patent/SK11152001A3/sk

Links

150000002475 indoles Chemical class 0.000 title description 2
229940123313 MCP-1 antagonist Drugs 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 115
-1 carboxy, tetrazolyl Chemical group 0.000 claims abstract description 78
101710155857 C-C motif chemokine 2 Proteins 0.000 claims abstract description 36
150000003839 salts Chemical class 0.000 claims abstract description 25
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 21
239000000651 prodrug Substances 0.000 claims abstract description 21
229940002612 prodrug Drugs 0.000 claims abstract description 21
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 14
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims abstract description 13
239000001257 hydrogen Substances 0.000 claims abstract description 13
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 13
230000001404 mediated effect Effects 0.000 claims abstract description 10
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract description 9
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims abstract description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 6
201000010099 disease Diseases 0.000 claims abstract description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 5
208000027866 inflammatory disease Diseases 0.000 claims abstract description 5
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims abstract description 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 5
210000001744 T-lymphocyte Anatomy 0.000 claims abstract description 4
230000004913 activation Effects 0.000 claims abstract description 4
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims abstract description 4
230000001105 regulatory effect Effects 0.000 claims abstract description 3
238000000034 method Methods 0.000 claims description 46
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238000002360 preparation method Methods 0.000 claims description 13
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 12
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 9
125000006239 protecting group Chemical group 0.000 claims description 9
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
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229910052736 halogen Inorganic materials 0.000 claims description 4
125000005843 halogen group Chemical group 0.000 claims description 4
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
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JUJBNYBVVQSIOU-UHFFFAOYSA-M sodium;4-[2-(4-iodophenyl)-3-(4-nitrophenyl)tetrazol-2-ium-5-yl]benzene-1,3-disulfonate Chemical compound [Na+].C1=CC([N+](=O)[O-])=CC=C1N1[N+](C=2C=CC(I)=CC=2)=NC(C=2C(=CC(=CC=2)S([O-])(=O)=O)S([O-])(=O)=O)=N1 JUJBNYBVVQSIOU-UHFFFAOYSA-M 0.000 description 1
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CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

SK1115-2001A 1999-02-05 2000-01-31 Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1 SK11152001A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9902461.4A GB9902461D0 (en)	1999-02-05	1999-02-05	Chemical compounds
PCT/GB2000/000265 WO2000046196A1 (en)	1999-02-05	2000-01-31	Indole derivatives and their use as mcp-1 antagonists

Publications (1)

Publication Number	Publication Date
SK11152001A3 true SK11152001A3 (sk)	2001-12-03

Family

ID=10847084

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1115-2001A SK11152001A3 (sk)	1999-02-05	2000-01-31	Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1

Country Status (27)

Country	Link
US (1)	US6737435B1 (xx)
EP (1)	EP1150952B1 (xx)
JP (1)	JP2002536359A (xx)
KR (1)	KR20010094755A (xx)
CN (1)	CN1339025A (xx)
AR (1)	AR022461A1 (xx)
AT (1)	ATE280757T1 (xx)
AU (1)	AU770856B2 (xx)
BR (1)	BR0007984A (xx)
CA (1)	CA2356898A1 (xx)
CZ (1)	CZ20012807A3 (xx)
DE (1)	DE60015296T2 (xx)
EE (1)	EE200100403A (xx)
GB (1)	GB9902461D0 (xx)
HU (1)	HUP0105079A3 (xx)
ID (1)	ID30401A (xx)
IL (1)	IL144611A0 (xx)
IS (1)	IS5980A (xx)
MY (1)	MY133209A (xx)
NO (1)	NO20013809L (xx)
NZ (1)	NZ512680A (xx)
PL (1)	PL350184A1 (xx)
RU (1)	RU2235090C2 (xx)
SK (1)	SK11152001A3 (xx)
TR (1)	TR200102233T2 (xx)
WO (1)	WO2000046196A1 (xx)
ZA (1)	ZA200105311B (xx)

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1999
- 1999-02-05 GB GBGB9902461.4A patent/GB9902461D0/en not_active Ceased
2000
- 2000-01-31 EE EEP200100403A patent/EE200100403A/xx unknown
- 2000-01-31 RU RU2001124567/04A patent/RU2235090C2/ru not_active IP Right Cessation
- 2000-01-31 PL PL00350184A patent/PL350184A1/xx not_active Application Discontinuation
- 2000-01-31 ID IDW00200101667A patent/ID30401A/id unknown
- 2000-01-31 SK SK1115-2001A patent/SK11152001A3/sk unknown
- 2000-01-31 BR BR0007984-7A patent/BR0007984A/pt not_active IP Right Cessation
- 2000-01-31 AR ARP000100407A patent/AR022461A1/es not_active Application Discontinuation
- 2000-01-31 US US09/889,599 patent/US6737435B1/en not_active Expired - Fee Related
- 2000-01-31 DE DE60015296T patent/DE60015296T2/de not_active Expired - Lifetime
- 2000-01-31 NZ NZ512680A patent/NZ512680A/en unknown
- 2000-01-31 HU HU0105079A patent/HUP0105079A3/hu unknown
- 2000-01-31 JP JP2000597267A patent/JP2002536359A/ja active Pending
- 2000-01-31 IL IL14461100A patent/IL144611A0/xx unknown
- 2000-01-31 AT AT00901259T patent/ATE280757T1/de not_active IP Right Cessation
- 2000-01-31 CA CA002356898A patent/CA2356898A1/en not_active Abandoned
- 2000-01-31 WO PCT/GB2000/000265 patent/WO2000046196A1/en not_active Ceased
- 2000-01-31 CN CN00803463A patent/CN1339025A/zh active Pending
- 2000-01-31 CZ CZ20012807A patent/CZ20012807A3/cs unknown
- 2000-01-31 AU AU21213/00A patent/AU770856B2/en not_active Ceased
- 2000-01-31 EP EP20000901259 patent/EP1150952B1/en not_active Expired - Lifetime
- 2000-01-31 TR TR2001/02233T patent/TR200102233T2/xx unknown
- 2000-01-31 KR KR1020017009862A patent/KR20010094755A/ko not_active Withdrawn
- 2000-02-04 MY MYPI20000404A patent/MY133209A/en unknown
2001
- 2001-06-26 IS IS5980A patent/IS5980A/is unknown
- 2001-06-27 ZA ZA200105311A patent/ZA200105311B/en unknown
- 2001-08-03 NO NO20013809A patent/NO20013809L/no not_active Application Discontinuation

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Publication number	Publication date
AU2121300A (en)	2000-08-25
WO2000046196A1 (en)	2000-08-10
KR20010094755A (ko)	2001-11-01
GB9902461D0 (en)	1999-03-24
RU2001124567A (ru)	2004-01-10
US6737435B1 (en)	2004-05-18
CN1339025A (zh)	2002-03-06
HUP0105079A3 (en)	2002-11-28
AU770856B2 (en)	2004-03-04
EP1150952B1 (en)	2004-10-27
DE60015296D1 (de)	2004-12-02
JP2002536359A (ja)	2002-10-29
DE60015296T2 (de)	2006-02-02
ZA200105311B (en)	2002-09-27
HUP0105079A2 (hu)	2002-04-29
ATE280757T1 (de)	2004-11-15
TR200102233T2 (tr)	2001-12-21
EP1150952A1 (en)	2001-11-07
NO20013809D0 (no)	2001-08-03
PL350184A1 (en)	2002-11-18
CZ20012807A3 (cs)	2001-10-17
IS5980A (is)	2001-06-26
IL144611A0 (en)	2002-05-23
EE200100403A (et)	2002-10-15
ID30401A (id)	2001-11-29
BR0007984A (pt)	2001-11-06
NO20013809L (no)	2001-10-02
MY133209A (en)	2007-10-31
RU2235090C2 (ru)	2004-08-27
NZ512680A (en)	2003-11-28
CA2356898A1 (en)	2000-08-10
AR022461A1 (es)	2002-09-04

Publication	Publication Date	Title
SK11152001A3 (sk)	2001-12-03	Indolové deriváty, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie ako antagonistov mcp-1
EP1054667B1 (en)	2003-04-16	Bicyclic pyrrole compounds, pharmaceutical compositions containing them and their use as antiinflammatory and immunomodulating agents
EP1150953B1 (en)	2003-09-24	Indole derivatives and their use as mcp-1 receptor antagonists
EP1150954B1 (en)	2004-10-13	Anti-imflammatory indole derivatives
EP1173421B1 (en)	2007-10-03	Indole derivatives as anti-inflammation agents
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