SI9420001B - Polipeptidni antagonisti bombezina - Google Patents

Polipeptidni antagonisti bombezina Download PDF

Info

Publication number: SI9420001B
Authority: SI; Slovenia
Prior art keywords: alkyl; phenyl; hydrogen; peptide; moiety
Prior art date: 1993-03-15

Application number

SI9420001A

Other languages

English (en)

Slovenian (sl)

Other versions

SI9420001A (en

Inventor

Andrew V. Schally

Zhi Cai Ren

Original Assignee

The Administrators Of

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-15

Filing date

1994-03-07

Publication date

1999-08-31

1994-03-07 Application filed by The Administrators Of filed Critical The Administrators Of

1995-08-31 Publication of SI9420001A publication Critical patent/SI9420001A/sl

1999-08-31 Publication of SI9420001B publication Critical patent/SI9420001B/sl

Links

239000005557 antagonist Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 claims abstract 28
239000001257 hydrogen Substances 0.000 claims abstract 27
150000002431 hydrogen Chemical group 0.000 claims abstract 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 17
108090000765 processed proteins & peptides Proteins 0.000 claims abstract 15
-1 naphthyl-C1-10-alkyl Chemical group 0.000 claims abstract 9
125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract 8
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 8
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 7
125000003277 amino group Chemical group 0.000 claims abstract 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 6
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 5
150000003839 salts Chemical class 0.000 claims abstract 4
239000002253 acid Substances 0.000 claims abstract 3
150000007513 acids Chemical class 0.000 claims abstract 3
125000002252 acyl group Chemical group 0.000 claims abstract 3
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims abstract 2
150000008575 L-amino acids Chemical group 0.000 claims abstract 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims abstract 2
125000001041 indolyl group Chemical group 0.000 claims abstract 2
125000001624 naphthyl group Chemical group 0.000 claims abstract 2
125000004076 pyridyl group Chemical group 0.000 claims abstract 2
125000001544 thienyl group Chemical group 0.000 claims abstract 2
125000000217 alkyl group Chemical group 0.000 claims 12
229940123804 Bombesin antagonist Drugs 0.000 claims 3
COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims 3
239000002790 bombesin antagonist Substances 0.000 claims 3
125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 1
150000001413 amino acids Chemical class 0.000 claims 1
239000007788 liquid Substances 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
229920001184 polypeptide Polymers 0.000 claims 1
102000004196 processed proteins & peptides Human genes 0.000 claims 1
239000007787 solid Substances 0.000 claims 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- C07K7/086—Bombesin; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Biophysics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

SI9420001A 1993-03-15 1994-03-07 Polipeptidni antagonisti bombezina SI9420001B (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/031,325 US5369094A (en)	1990-11-29	1993-03-15	Polypeptide bombesin antagonists
PCT/US1994/002511 WO1994021674A1 (en)	1993-03-15	1994-03-07	Polypeptide bombesin antagonists

Publications (2)

Publication Number	Publication Date
SI9420001A SI9420001A (en)	1995-08-31
SI9420001B true SI9420001B (sl)	1999-08-31

Family

ID=21858823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9420001A SI9420001B (sl)	1993-03-15	1994-03-07	Polipeptidni antagonisti bombezina

Country Status (27)

Country	Link
US (1)	US5369094A (pt)
EP (1)	EP0646127B1 (pt)
JP (1)	JP3838656B2 (pt)
KR (1)	KR100306506B1 (pt)
AT (1)	ATE167874T1 (pt)
AU (1)	AU666270B2 (pt)
BR (1)	BR9404341A (pt)
CA (1)	CA2135787C (pt)
CZ (1)	CZ286750B6 (pt)
DE (1)	DE69411342T2 (pt)
DK (1)	DK0646127T3 (pt)
EE (1)	EE03180B1 (pt)
ES (1)	ES2120615T3 (pt)
FI (1)	FI945378A0 (pt)
HR (1)	HRP940164B1 (pt)
HU (1)	HU218288B (pt)
IL (2)	IL108851A (pt)
NO (1)	NO313418B1 (pt)
NZ (2)	NZ263668A (pt)
PL (1)	PL180372B1 (pt)
RU (1)	RU2114118C1 (pt)
SI (1)	SI9420001B (pt)
SK (1)	SK282267B6 (pt)
TW (1)	TW325478B (pt)
UA (1)	UA34456C2 (pt)
WO (1)	WO1994021674A1 (pt)
ZA (1)	ZA941767B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5723578A (en) *	1987-09-24	1998-03-03	The Administrators Of Tulane Educational Fund	Peptide analogs of bombesin
US5877277A (en)	1987-09-24	1999-03-02	Biomeasure, Inc.	Octapeptide bombesin analogs
US5650395A (en) *	1995-03-13	1997-07-22	Hurel; Steven	Treatment of pulmonary hypertension
US6989371B1 (en)	1996-08-16	2006-01-24	Dabur Research Foundation	Bombesin analogs for treatment of cancer
WO1998047524A1 (en) *	1997-04-22	1998-10-29	Curators Of The University Of Missouri	Gastrin receptor-avid peptide conjugates
RU2172322C1 (ru) *	1999-12-27	2001-08-20	Энтофарм Ко., Лтд.	Аллофероны-иммуномодулирующие пептиды
HUP0303500A2 (hu) *	2000-11-17	2004-01-28	Warner-Lambert Company Llc	Eljárás szexuális rendellenességek kezelésére bombezin-antagonisták segítségével
US7850947B2 (en)	2003-01-13	2010-12-14	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US8420050B2 (en) *	2003-01-13	2013-04-16	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
ATE435035T1 (de) *	2003-01-13	2009-07-15	Bracco Imaging Spa	Verbesserte linker für radiopharmazeutische verbindungen
US7226577B2 (en) *	2003-01-13	2007-06-05	Bracco Imaging, S. P. A.	Gastrin releasing peptide compounds
US7922998B2 (en) *	2003-01-13	2011-04-12	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US20060239923A1 (en) *	2003-01-13	2006-10-26	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
US7611692B2 (en) *	2003-01-13	2009-11-03	Bracco Imaging S.P.A.	Gastrin releasing peptide compounds
KR100817232B1 (ko)	2003-04-22	2008-03-27	소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스.	펩타이드 벡터
US7795385B2 (en) *	2004-12-17	2010-09-14	Bexar Global, Inc.	Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder
RU2281690C1 (ru) *	2005-08-19	2006-08-20	Евгений Иванович Гусев	Способ определения показаний для лечения ишемического инсульта в восстановительном периоде препаратом "нейромидин"
FR2918566B1 (fr) *	2007-07-11	2009-10-09	Pierre Fabre Medicament Sa	Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine.
EP2100900A1 (en) *	2008-03-07	2009-09-16	Universitätsspital Basel	Bombesin analog peptide antagonist conjugates
EP2198878A1 (en) *	2008-12-18	2010-06-23	University Of Miami	Polypeptide bombesin antagonists
AU2010303822A1 (en)	2009-10-07	2012-03-15	Merck Sharp & Dohme Corp.	Novel TRPA1 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5162497A (en) *	1987-09-24	1992-11-10	The Administrators Of The Tulane Educational Fund	Bradykinin analogs with non-peptide bond
WO1989002897A1 (en) *	1987-09-24	1989-04-06	The Administrators Of The Tulane Educational Fund	Therapeutic peptides
US5084555A (en) *	1989-08-21	1992-01-28	The Administrators Of The Tulane Educational Fund	An octapeptide bombesin analog
AU618029B2 (en) *	1987-11-02	1991-12-12	Imperial Chemical Industries Plc	Polypeptide compounds
GB8813356D0 (en) *	1988-06-06	1988-07-13	Ici Plc	Polypeptide compounds
GR1000608B (el) *	1988-07-21	1992-08-31	Erba Carlo Spa	Μεθοδος για την παρασκευη ανταγωνιστων bombesin.
ATE165836T1 (de) *	1988-10-14	1998-05-15	Univ Tulane	Peptide als arzneimittel
US5217955A (en) *	1989-09-15	1993-06-08	Biomeasure, Inc.	Treatment of cancer with peptide analog of bombesin, grp, litorin or neuromedin
US5244883A (en) *	1990-11-29	1993-09-14	The Administrators Of The Tulane Educational Fund	Nonapeptide bombesin antagonists

1993
- 1993-03-15 US US08/031,325 patent/US5369094A/en not_active Expired - Lifetime
1994
- 1994-02-23 TW TW083101048A patent/TW325478B/zh not_active IP Right Cessation
- 1994-03-03 IL IL10885194A patent/IL108851A/xx not_active IP Right Cessation
- 1994-03-07 JP JP52109194A patent/JP3838656B2/ja not_active Expired - Fee Related
- 1994-03-07 HU HU9403244A patent/HU218288B/hu not_active IP Right Cessation
- 1994-03-07 UA UA94119008A patent/UA34456C2/uk unknown
- 1994-03-07 BR BR9404341-8A patent/BR9404341A/pt not_active Application Discontinuation
- 1994-03-07 CZ CZ19942807A patent/CZ286750B6/cs not_active IP Right Cessation
- 1994-03-07 SI SI9420001A patent/SI9420001B/sl not_active IP Right Cessation
- 1994-03-07 RU RU94046091A patent/RU2114118C1/ru not_active IP Right Cessation
- 1994-03-07 AU AU64446/94A patent/AU666270B2/en not_active Ceased
- 1994-03-07 DE DE69411342T patent/DE69411342T2/de not_active Expired - Fee Related
- 1994-03-07 EP EP94912199A patent/EP0646127B1/en not_active Expired - Lifetime
- 1994-03-07 ES ES94912199T patent/ES2120615T3/es not_active Expired - Lifetime
- 1994-03-07 SK SK1364-94A patent/SK282267B6/sk unknown
- 1994-03-07 AT AT94912199T patent/ATE167874T1/de not_active IP Right Cessation
- 1994-03-07 DK DK94912199T patent/DK0646127T3/da active
- 1994-03-07 PL PL94306209A patent/PL180372B1/pl not_active IP Right Cessation
- 1994-03-07 WO PCT/US1994/002511 patent/WO1994021674A1/en not_active Ceased
- 1994-03-07 KR KR1019940704104A patent/KR100306506B1/ko not_active Expired - Fee Related
- 1994-03-07 NZ NZ263668A patent/NZ263668A/en unknown
- 1994-03-07 NZ NZ299913A patent/NZ299913A/en not_active IP Right Cessation
- 1994-03-07 CA CA002135787A patent/CA2135787C/en not_active Expired - Fee Related
- 1994-03-10 HR HR08/031,325A patent/HRP940164B1/xx not_active IP Right Cessation
- 1994-03-14 ZA ZA941767A patent/ZA941767B/xx unknown
- 1994-11-10 NO NO19944293A patent/NO313418B1/no unknown
- 1994-11-15 FI FI945378A patent/FI945378A0/fi unknown
- 1994-11-23 EE EE9400166A patent/EE03180B1/xx not_active IP Right Cessation
2003
- 2003-03-19 IL IL15499503A patent/IL154995A0/xx unknown

Also Published As

Publication number	Publication date
HUT69727A (en)	1995-09-28
JP3838656B2 (ja)	2006-10-25
KR100306506B1 (ko)	2001-12-01
WO1994021674A1 (en)	1994-09-29
AU666270B2 (en)	1996-02-01
NO313418B1 (no)	2002-09-30
PL306209A1 (en)	1995-03-06
ZA941767B (en)	1994-10-06
EP0646127B1 (en)	1998-07-01
PL180372B1 (pl)	2001-01-31
JPH07507330A (ja)	1995-08-10
SK282267B6 (sk)	2001-12-03
EP0646127A1 (en)	1995-04-05
SK136494A3 (en)	1995-08-09
CA2135787A1 (en)	1994-09-29
CA2135787C (en)	2008-08-12
ES2120615T3 (es)	1998-11-01
CZ286750B6 (en)	2000-06-14
KR950701646A (ko)	1995-04-28
HU218288B (en)	2000-07-28
TW325478B (en)	1998-01-21
IL154995A0 (en)	2003-10-31
ATE167874T1 (de)	1998-07-15
DE69411342T2 (de)	1998-11-19
FI945378A7 (fi)	1994-11-15
NZ263668A (en)	1997-06-24
EE03180B1 (et)	1999-04-15
FI945378A0 (fi)	1994-11-15
HRP940164B1 (en)	2000-02-29
BR9404341A (pt)	1999-08-31
RU94046091A (ru)	1996-09-27
US5369094A (en)	1994-11-29
DE69411342D1 (de)	1998-08-06
IL108851A0 (en)	1994-06-24
UA34456C2 (uk)	2001-03-15
RU2114118C1 (ru)	1998-06-27
HRP940164A2 (en)	1996-08-31
NO944293D0 (no)	1994-11-10
IL108851A (en)	2003-05-29
DK0646127T3 (da)	1999-04-12
NO944293L (no)	1995-01-02
NZ299913A (en)	2000-07-28
CZ280794A3 (en)	1995-07-12
AU6444694A (en)	1994-10-11
SI9420001A (en)	1995-08-31

Publication	Publication Date	Title
SI9420001B (sl)	1999-08-31	Polipeptidni antagonisti bombezina
KR900006363A (ko)	1990-05-08	신규한 펩티다제 억제제
CA2097192A1 (en)	1992-05-30	Bombesin antagonists
GB1528336A (en)	1978-10-11	Compounds compositions and methods of their use
GB1378025A (en)	1974-12-18	Polymyxin derivatives
CA2067901A1 (en)	1992-11-03	Novel polypeptides with affinity to lipopolysaccharides and their uses
RU92016593A (ru)	1995-05-20	Новый полипептид со сродством с липополисахаридами и фармацевтическая композиция для ингибирования вич на его основе
EP0297456A3 (en)	1990-09-26	Immunosuppressant peptides
GB2125799A (en)	1984-03-14	Novel polypeptides processes for their production pharmaceutical compositions comprising said polypeptides and their use
EP0076557A3 (en)	1983-05-25	Peptides and pseudopeptides in which the n terminus bears two substituents
KR920701242A (ko)	1992-08-11	환원된 비가역성 봄베신 길항제
DE3467581D1 (en)	1987-12-23	Gastric secretion inhibiting peptide derivatives, process for their preparation and medicines containing them
GB992957A (en)	1965-05-26	New decapeptides and their manufacture
JP2006505556A5 (pt)	2006-11-24
GB1430522A (en)	1976-03-31	N-substituted aspartyl peptide amides
ES416516A1 (es)	1976-03-01	Un procedimiento para la preparacion de nonapeptidos.
GB1357121A (en)	1974-06-19	Peptide enzyme inhibitors
GB997849A (en)	1965-07-07	Polypeptides
GB917013A (en)	1963-01-30	Cyclic decapeptides and process for their manufacture
KITAGAWA et al.	1978	Alternative Synthesis of Substance P
GB1273873A (en)	1972-05-10	Corticotropically highly active octadecapeptides
北川幸己 et al.	1978	Alternative synthesis of substance P.
GB1046303A (en)	1966-10-19	Polypeptides
GB1532148A (en)	1978-11-15	1-substituted enkepholin derivatives

Legal Events

Date	Code	Title	Description
2005-01-10	IF	Valid on the event date
2008-12-31	KO00	Lapse of patent	Effective date: 20081112