SI9011830B - Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo - Google Patents
Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo Download PDFInfo
- Publication number
- SI9011830B SI9011830B SI9011830A SI9011830A SI9011830B SI 9011830 B SI9011830 B SI 9011830B SI 9011830 A SI9011830 A SI 9011830A SI 9011830 A SI9011830 A SI 9011830A SI 9011830 B SI9011830 B SI 9011830B
- Authority
- SI
- Slovenia
- Prior art keywords
- chem
- hydrogen
- carbon atoms
- group
- straight
- Prior art date
Links
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 108010016626 Dipeptides Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000004849 alkoxymethyl group Chemical group 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- -1 cyclic imide Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/823—Immunogenic carrier or carrier per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (2)
- p\pr:24190o99 1 PATENTNA ZAHTEVKA 1. N-acildipeptidi s formulo I (s,r) (R) R—CO-NH-CH—CONH—CH—R3 i I I Ri R2 v kateri R predstavlja (s,R) —CH-(CHa)b.-Y-(C3|i).-2 R4 kjer je R4 vodik, Y je -CH2-, -0-, -C0-, -C00-, -0C0-, -CONH-, m je celo Število od 1 do 4, nje celo število od 1 do 6, Z je vodik, -NH-X-RS, kjer je X -C0-, R5 je nerazvejen alkil s C2-io ogljikovimi atomi, adamantil, ciklopentil, cikloheksil, cikloheptil ali ciklooktil, ali je Z ciklični imid s formulama p\pr:24190o99 2©Λ ^11 Ri predstavlja vodik, nera2vejen ali razvejen alkil z 2 do 10 ogljikovimi atomi, hidroksimetil ali alkoksimetil, R2 predstavlja skupino -CO-A-, kjer je A skupina -0-¾ ali -NH-R7, kjer je R^ vodik, nerazvejen ali razvejen alkil z 1 do 10 ogljikovimi atomi ali benzil, R7 je vodik ali raven ali razvejen alkil z 1 do 10 ogljikovimi atomi, R3 predstavlja skupino -(CH2)p-CO-W, kjer je P 2 W je skupina -0-R8 ali NH-R9, kjer je Rg vodik ali nerazvejen ali razvejen alkil z 1 do 10 ogljikovimi atomi, p\pr:24190o99 3 R9 je vodik, nerazvejen ali razvejen alkil z 1 do 10 ogljikovimi atomi, adamantil, ciklopentil, cikloheksil, cikloheptil ali ciklooktil, ali njihove farmacevtsko sprejemljive soli z imunomodulatomim in antitumomim delovanjem.
- 2. Farmacevtski sestavki, označeni s tem, da vsebujejo kot aktivno sestavino terapevtsko učinkovito količino N-acildipeptida s formulo I po zahtevku 1 skupaj s farmacevtsko sprejemljivimi nosilci. Za Univerza v Ljubljani, Fakulteta za farmacijo LEK, tovarna farmacevtskih in kemičnih izdelkov, d. d.: PATENTNA PISARNA, LJUBLJANA, ČOPOVA 14
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU183090A YU183090A (sh) | 1990-09-27 | 1990-09-27 | Novi n-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, kojih vsebujejo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9011830A SI9011830A (en) | 1997-10-31 |
| SI9011830B true SI9011830B (sl) | 1999-12-31 |
Family
ID=25555754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9011830A SI9011830B (sl) | 1990-09-27 | 1990-09-27 | Novi N-acildipeptidi, postopki za njihovo pripravo in farmacevtski pripravki, ki jih vsebujejo |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5514654A (sl) |
| EP (1) | EP0477912B1 (sl) |
| JP (1) | JP2795421B2 (sl) |
| AT (1) | ATE204880T1 (sl) |
| DE (1) | DE69132707T2 (sl) |
| SI (1) | SI9011830B (sl) |
| YU (1) | YU183090A (sl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9301789A (es) * | 1992-04-03 | 1993-10-01 | Iaf Biochem Int | Nuevos oligopeptidos lipofilicos con actividad inmunomoduladora. |
| SI9300212A (en) * | 1993-04-22 | 1994-12-31 | Univ Ljubljani | Novel N-acyldipeptides, process for the preparation thereof and pharmaceutical composition containing the same |
| SG91244A1 (en) * | 1996-06-24 | 2002-09-17 | Givaudan Roure Int | Malodour preventing agents |
| AUPO161196A0 (en) * | 1996-08-13 | 1996-09-05 | Commonwealth Scientific And Industrial Research Organisation | Novel compounds |
| US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| WO2001035982A1 (fr) * | 1999-11-12 | 2001-05-25 | Fujimoto Brothers Co., Ltd. | Compositions medicinales anti-inflammatoires |
| US20100183714A1 (en) * | 2004-03-26 | 2010-07-22 | Lek Pharmaceuticals D.D. | Gastroresistant pharmaceutical dosage form comprising n-(2-(2- phthalimidoethoxy)-acetyl)-l-alanyl-d-glutamic acid (lk-423) |
| US20080124279A1 (en) * | 2006-11-17 | 2008-05-29 | Antoine Andremont | Colonic delivery using Zn/pectin beads with a Eudragit coating |
| BR112013012078A2 (pt) | 2010-11-15 | 2019-09-24 | Abbvie Inc | inibidores de nampt e rock |
| BR112018077032A2 (pt) * | 2016-06-23 | 2019-04-02 | Nutrivert Llc | método para aprimorar o crescimento ou a conversão alimentar em um animal, uso de pgn, mdp ou um análogo de mdp na preparação de um medicamento e pgn, mdp ou um análogo de mdp |
| US12492222B2 (en) | 2020-03-26 | 2025-12-09 | Nutrivert Inc. | Lipophilic enantiomers of desacetylglucosamine muramyl dipeptide with anti-inflammatory and growth promoting activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2460288A1 (fr) * | 1979-06-29 | 1981-01-23 | Rhone Poulenc Ind | Nouveaux dipeptides, leur preparation et les medicaments qui les contiennent |
-
1990
- 1990-09-27 SI SI9011830A patent/SI9011830B/sl unknown
- 1990-09-27 YU YU183090A patent/YU183090A/sh unknown
-
1991
- 1991-09-25 EP EP91116356A patent/EP0477912B1/en not_active Expired - Lifetime
- 1991-09-25 DE DE69132707T patent/DE69132707T2/de not_active Expired - Lifetime
- 1991-09-25 AT AT91116356T patent/ATE204880T1/de not_active IP Right Cessation
- 1991-09-27 JP JP3318721A patent/JP2795421B2/ja not_active Expired - Fee Related
-
1994
- 1994-05-18 US US08/245,810 patent/US5514654A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0477912A3 (en) | 1992-08-12 |
| US5514654A (en) | 1996-05-07 |
| YU183090A (sh) | 1992-12-21 |
| SI9011830A (en) | 1997-10-31 |
| DE69132707D1 (de) | 2001-10-04 |
| EP0477912A2 (en) | 1992-04-01 |
| JPH06220087A (ja) | 1994-08-09 |
| EP0477912B1 (en) | 2001-08-29 |
| DE69132707T2 (de) | 2002-06-20 |
| JP2795421B2 (ja) | 1998-09-10 |
| ATE204880T1 (de) | 2001-09-15 |
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Legal Events
| Date | Code | Title | Description |
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| IF | Valid on the event date |