SI9011710B - 13-alkil-23-imino in 13-halo-23-imino derivati makrolidnih spojin - Google Patents
13-alkil-23-imino in 13-halo-23-imino derivati makrolidnih spojin Download PDFInfo
- Publication number
- SI9011710B SI9011710B SI9011710A SI9011710A SI9011710B SI 9011710 B SI9011710 B SI 9011710B SI 9011710 A SI9011710 A SI 9011710A SI 9011710 A SI9011710 A SI 9011710A SI 9011710 B SI9011710 B SI 9011710B
- Authority
- SI
- Slovenia
- Prior art keywords
- alkyl
- hydrogen
- methyl
- isopropyl
- ethyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 9
- 241000238631 Hexapoda Species 0.000 claims abstract 4
- 241000244206 Nematoda Species 0.000 claims abstract 4
- 244000078703 ectoparasite Species 0.000 claims abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 16
- 239000001257 hydrogen Substances 0.000 claims 16
- 150000002431 hydrogen Chemical class 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000002252 acyl group Chemical group 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- -1 C 1 -C 4 alkoxy Chemical group 0.000 claims 2
- 230000000895 acaricidal effect Effects 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 claims 2
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 230000000749 insecticidal effect Effects 0.000 claims 2
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims 2
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 claims 2
- 125000002861 (C1-C4) alkanoyl group Chemical group 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 239000004593 Epoxy Substances 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Chemical group 0.000 claims 1
- 230000001984 ectoparasiticidal effect Effects 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 229910052740 iodine Chemical group 0.000 claims 1
- 239000011630 iodine Chemical group 0.000 claims 1
- 230000001069 nematicidal effect Effects 0.000 claims 1
- 239000005645 nematicide Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pest Control & Pesticides (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Agronomy & Crop Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/405,808 US5030650A (en) | 1989-09-11 | 1989-09-11 | 13-halo-23-imino derivatives of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
| US07/455,686 US5055486A (en) | 1989-12-22 | 1989-12-22 | 13-alkyl-23-imino derivative of LL-F28249 compounds and their use as endo- and ectoparasiticidal, insecticidal, acaricidal and nematocidal agents |
| YU171090A YU47592B (sh) | 1989-09-11 | 1990-09-10 | 13-alkil-23-imino i 13-halo-23-imino derivati makrolidnih jedinjenja |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9011710A SI9011710A (sl) | 1998-02-28 |
| SI9011710B true SI9011710B (sl) | 2000-12-31 |
Family
ID=27019245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9011710A SI9011710B (sl) | 1989-09-11 | 1990-09-10 | 13-alkil-23-imino in 13-halo-23-imino derivati makrolidnih spojin |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP0423445B1 (zh) |
| JP (1) | JP3026827B2 (zh) |
| KR (2) | KR0160972B1 (zh) |
| CN (2) | CN1032004C (zh) |
| AT (1) | ATE130006T1 (zh) |
| AU (1) | AU631454B2 (zh) |
| BG (1) | BG60271B1 (zh) |
| BR (1) | BR9004494A (zh) |
| DE (1) | DE69023454T2 (zh) |
| DK (1) | DK0423445T3 (zh) |
| ES (1) | ES2081880T3 (zh) |
| GR (1) | GR3018033T3 (zh) |
| HU (1) | HU217357B (zh) |
| IE (1) | IE71210B1 (zh) |
| IL (1) | IL109791A (zh) |
| PL (1) | PL164168B1 (zh) |
| PT (1) | PT95241B (zh) |
| RU (1) | RU2070885C1 (zh) |
| SI (1) | SI9011710B (zh) |
| UA (1) | UA41246C2 (zh) |
| YU (1) | YU47592B (zh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4988824A (en) * | 1989-09-11 | 1991-01-29 | Maulding Donald R | Process for the preparation of 23-(C1-C6 alkyloxime)-LL-F28249 compounds |
| US5229416A (en) * | 1992-04-29 | 1993-07-20 | Merck & Co., Inc. | Avermectin difluoro derivatives |
| DE19654079A1 (de) | 1996-12-23 | 1998-06-25 | Bayer Ag | Endo-ekto-parasitizide Mittel |
| DE102004053964A1 (de) | 2004-11-09 | 2006-05-11 | Bayer Healthcare Ag | Mittel gegen Demodikose |
| CN105085540B (zh) * | 2015-08-12 | 2017-07-07 | 内蒙古佳瑞米精细化工有限公司 | 一种制备高含量尼莫克汀的方法 |
| US20210137960A1 (en) | 2018-02-01 | 2021-05-13 | Yale University | Compositions and methods for inhibition of nuclear-penetrating antibodies |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0253378A3 (de) * | 1986-07-18 | 1988-03-23 | Ciba-Geigy Ag | 13Beta-Alkyl-derivate von S541-Antibiotika zur Bekämpfung von Parasiten an Nutztieren und Pflanzen |
| DE3750355T2 (de) * | 1986-09-12 | 1995-04-06 | American Cyanamid Co | 23-Oxo(keto) und 23-Imino-Derivate von LL-F28249-Verbindungen. |
| US4831016A (en) * | 1986-10-31 | 1989-05-16 | Merck & Co., Inc. | Reduced avermectin derivatives |
| US4886829A (en) * | 1987-03-06 | 1989-12-12 | American Cyanamid Company | 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds |
| US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
| US5830875A (en) * | 1989-10-30 | 1998-11-03 | Merck & Co., Inc. | 24-and 25-substituted avermectin and milbemycin derivatives |
-
1990
- 1990-08-03 AT AT90114920T patent/ATE130006T1/de not_active IP Right Cessation
- 1990-08-03 DE DE69023454T patent/DE69023454T2/de not_active Expired - Lifetime
- 1990-08-03 EP EP90114920A patent/EP0423445B1/en not_active Expired - Lifetime
- 1990-08-03 DK DK90114920.3T patent/DK0423445T3/da active
- 1990-08-03 ES ES90114920T patent/ES2081880T3/es not_active Expired - Lifetime
- 1990-08-06 IL IL10979190A patent/IL109791A/en not_active IP Right Cessation
- 1990-08-30 CN CN90107011A patent/CN1032004C/zh not_active Expired - Fee Related
- 1990-09-07 JP JP2235957A patent/JP3026827B2/ja not_active Expired - Lifetime
- 1990-09-07 PT PT95241A patent/PT95241B/pt not_active IP Right Cessation
- 1990-09-10 UA UA4831124A patent/UA41246C2/uk unknown
- 1990-09-10 YU YU171090A patent/YU47592B/sh unknown
- 1990-09-10 RU SU904831124A patent/RU2070885C1/ru not_active IP Right Cessation
- 1990-09-10 AU AU62357/90A patent/AU631454B2/en not_active Expired
- 1990-09-10 HU HU844/90A patent/HU217357B/hu not_active IP Right Cessation
- 1990-09-10 SI SI9011710A patent/SI9011710B/sl not_active IP Right Cessation
- 1990-09-10 PL PL90286823A patent/PL164168B1/pl unknown
- 1990-09-10 KR KR1019900014282A patent/KR0160972B1/ko not_active Expired - Fee Related
- 1990-09-10 BG BG092811A patent/BG60271B1/bg unknown
- 1990-09-10 IE IE327490A patent/IE71210B1/en not_active IP Right Cessation
- 1990-09-10 BR BR909004494A patent/BR9004494A/pt not_active IP Right Cessation
-
1994
- 1994-11-24 CN CN94118512A patent/CN1053556C/zh not_active Expired - Fee Related
-
1995
- 1995-11-09 GR GR940403514T patent/GR3018033T3/el unknown
-
1998
- 1998-06-23 KR KR1019980023560A patent/KR0168751B1/ko not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20050610 |