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SI8810781B - Patch with active substance for controlled application of the active substance on the skin - Google Patents

Patch with active substance for controlled application of the active substance on the skin Download PDF

Info

Publication number
SI8810781B
SI8810781B SI8810781A SI8810781A SI8810781B SI 8810781 B SI8810781 B SI 8810781B SI 8810781 A SI8810781 A SI 8810781A SI 8810781 A SI8810781 A SI 8810781A SI 8810781 B SI8810781 B SI 8810781B
Authority
SI
Slovenia
Prior art keywords
active substance
skin
reservoir
patch
active
Prior art date
Application number
SI8810781A
Other languages
Slovenian (sl)
Other versions
SI8810781A (en
Inventor
Hans Rainer Hoffmann
Karin Wolter
Guenther Simon
Peter Barth
Original Assignee
Lts Lohmann Therapie-Systeme Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie-Systeme Gmbh & Co. Kg filed Critical Lts Lohmann Therapie-Systeme Gmbh & Co. Kg
Publication of SI8810781A publication Critical patent/SI8810781A/en
Publication of SI8810781B publication Critical patent/SI8810781B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H37/00—Accessories for massage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A plaster containing active ingredients for controlled administration of active ingredients to the skin and possessing a rear side and a skin side, has a rear layer, an active ingredient reservoir containing one or more active ingredients arranged essentially perpendicular to the surface of the plaster in contact with the skin, and an adhesive device on the skin side and possibly a covering layer which is detached before application of the plaster. At least one active ingredient reservoir part (12) can be detached on to the skin while one or more active ingredient reservoir parts remain. For this purpose, the part (13) of the active ingredient reservoir remaining on the skin adheres more strongly to the skin than to the rear side (11).

Claims (1)

12 1. . e ο οοοβ ,e ο ·· ”β„ Ο Ο * 5 Γ ΟΟ « * β e r-r ο ^ Ο ο ° ·' Q Patentni zahtevki 5 10 Obliž z aktivno snovjo za kontroliran nanos aktivne snovi na kožo, obsegajoč nosilno stran in h koži obrnjeno stran, z nosilnim slojem, rezervoarjem aktivne snovi, ki je po vertikali predeljen na stično površino s kožo, pri čemer obsega eno ali več aktivnih snovi, slojem kontaktnega lepila na kožni strani in, po potrebi, prekrivni sloj, ki se ga odstrani pred uporabo obliža, pri katerem se z odstranitvijo dela rezervoarja aktivne snovi lahko zmanjša površino izpuščanja aktivne snovi obliža za vnaprej določeno količino, značilen po tem, da se da vsaj en del (12, 25, 43, 61, 81, 91, 101, 103) rezervoarja aktivne snovi odstraniti s kože, pri čemer pušča na koži dele (13, 24, 42, 63, 82, 92) rezervoarja z eno ali več aktivnimi snovmi, in da ima del rezervoarja aktivne snovi, ki ostane na koži, boljše sprijemanje s kožo kot nosilni sloj (11, 28, 45, 65, 88, 95, 108). 15 2. Sloj obliža z aktivno snovjo po snovi vecdefen. D ^oOELeU,12 1.. e ο οοοβ, e ο ·· ”β„ Ο Ο * 5 Γ ΟΟ «* β e rr ο ^ Ο ο ° · 'Q Patent Claims 5 10 Plaster with active substance for controlled application of the active substance to the skin, comprising a carrier side and skin-facing side, with a carrier layer, an active substance reservoir vertically distributed on the skin contact surface, comprising one or more active substances, a layer of contact adhesive on the skin side and, if necessary, a cover layer to be applied removed before use of the patch, in which by removing a part of the active substance reservoir, the discharge area of the active substance of the patch can be reduced by a predetermined amount, characterized in that at least one part (12, 25, 43, 61, 81, 91, 101 , 103) removing the active substance reservoir from the skin, leaving on the skin portions (13, 24, 42, 63, 82, 92) of the reservoir containing one or more active substances, and having a portion of the active substance reservoir remaining on the skin, better adhesion to the skin than the carrier layer (11, 28, 45, 65, 88, 95, 108). 15 2. The active substance patch layer after the substance vecdefen. D ^ oOELeU, , značilen po tem, daje rezervoar aktivne 3. Sloj obliža z aktivno snovjo po zahtevku 1, značilen po tem, daje rezervoar aktivne snovi tridelen. 20 25 4. 5. 6. Obliž z aktivno snovjo po enem od predhodnih zahtevkov, značilen po tem, da so površine izpuščanja delov rezervoarja aktivne snovi geometrijsko enake ali različne. Obliž z aktivno snovjo po enem od predhodnih zahtevkov, značilen po tem, da del (61, 81, 91, 101, 103) rezervoarja aktivne snovi popolnoma obkroža enega ali več drugih delov (63, 82, 92, 103, 105), gledano ploskovno ali površinsko. Obliž z aktivno snovjo po zahtevkih 4 in 5, značilen po tem, da del (61, 81, 91, 101, 103) rezervoarja aktivne snovi prstanasto obkroža enega ali več drugih delov (63, 82, 92, 103, 105) rezervoarja aktivne snovi. Obliž, z aktivno snovjo po enem ali več zahtevkih 1 do 5, značilen po tem, da razmerje velikosti površin izpuščanja enega dela rezervoarja aktivne snovi proti 7. 30 drugemu leži med približno 1:1 in 1:10. Obliž z aktivno snovjo po enem od predhodnih zahtevkov, značilen po tem, da se ista aktivna snov ali ista kombinacija aktivnih snovi nahaja v vseh delih rezervoarja aktivne snovi. Obliž z aktivno snovjo po enem od zahtevkov 1 in 7, značilen po tem, da je vsaj v enem od delov rezervoarja aktivne snovi različna aktivna snov/kombinacija aktivnih snovi v primerjavi z drugim delom rezervoarja aktivne snovi. Obliž z aktivno snovjo po enem od predhodnih zahtevkov, značilen po tem, da aktivna snov deluje bodisi lokalno ali sistemsko. Postopek nadzorovanega nanašanja ene ali več aktivnih snovi na kožo s pomočjo obliža po enem od predhodnih zahtevkov, značilen po tem, da na kožo pritiska obliž, ki po potrebi obsega nekaj aktivnih snovi in/ali isto aktivno snov v različnih ali enakih koncentracijah v različnih delih rezervoarja aktivne snovi, ki so medsebojno lahko ločeni, in da se v vsakem primeru enega ali več delov obliža odstrani z enim ali več deli rezervoarja aktivne snovi po preteku vnaprej določenega časa, pri čemer ostane preostanek obliža z vsaj enim delom rezervoarja aktivne snovi na koži, in da se po potrebi zadnjo fazo ponavlja po vnaprej določenem časovnem zaporedju. Uporaba obliža z aktivno snovjo po enem od predhodnih zahtevkov, za lokalno incharacterized in that the active substance reservoir is 3. The active substance patch layer according to claim 1, characterized in that the active substance reservoir is three-part. Active substance patch according to one of the preceding claims, characterized in that the discharge surfaces of the active substance reservoir parts are geometrically identical or different. Active substance patch according to one of the preceding claims, characterized in that the part (61, 81, 91, 101, 103) of the active substance reservoir completely surrounds one or more other parts (63, 82, 92, 103, 105), surface or surface. Active substance patch according to claims 4 and 5, characterized in that the active substance reservoir portion (61, 81, 91, 101, 103) surrounds one or more other portions (63, 82, 92, 103, 105) of the active substance reservoir dreams. The active substance patch according to one or more of claims 1 to 5, characterized in that the ratio of the size of the discharge surfaces of one part of the active substance reservoir to 7. 30 to the other lies between about 1: 1 and 1:10. Active substance patch according to one of the preceding claims, characterized in that the same active substance or the same combination of active substances is present in all parts of the active substance reservoir. Active substance patch according to one of Claims 1 and 7, characterized in that at least one part of the active substance reservoir contains a different active substance / combination of active substances compared to the other part of the active substance reservoir. Active substance patch according to one of the preceding claims, characterized in that the active substance acts either locally or systemically. Method for the controlled application of one or more active substances to the skin by means of a patch according to one of the preceding claims, characterized in that a patch is applied to the skin which optionally comprises several active substances and / or the same active substance in different or equal concentrations in different parts. the active substance reservoir, which can be separated from each other, and in any case one or more parts of the patch are removed with one or more parts of the active substance reservoir after a predetermined time, leaving the remaining patch with at least one part of the active substance reservoir on the skin. , and that, if necessary, the last phase is repeated in a predetermined time sequence. Use of an active substance patch according to one of the preceding claims, for topical and LTS LOHMANN Therapie-Systeme GmbH & Co. KGLTS LOHMANN Therapie-Systeme GmbH & Co. KG
SI8810781A 1987-04-28 1988-04-19 Patch with active substance for controlled application of the active substance on the skin SI8810781B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873714140 DE3714140A1 (en) 1987-04-28 1987-04-28 ACTIVE SUBSTANCE PLASTER FOR THE CONTROLLED ADMINISTRATION OF ACTIVE SUBSTANCES TO THE SKIN, ITS USE AND METHOD FOR THE CONTROLLED ADMINISTRATION OF ACTIVE SUBSTANCES TO THE SKIN

Publications (2)

Publication Number Publication Date
SI8810781A SI8810781A (en) 1996-12-31
SI8810781B true SI8810781B (en) 1999-04-30

Family

ID=6326433

Family Applications (1)

Application Number Title Priority Date Filing Date
SI8810781A SI8810781B (en) 1987-04-28 1988-04-19 Patch with active substance for controlled application of the active substance on the skin

Country Status (28)

Country Link
EP (1) EP0288734B1 (en)
JP (1) JP2683264B2 (en)
KR (1) KR910002250B1 (en)
AT (1) ATE69962T1 (en)
AU (1) AU627422B2 (en)
CA (1) CA1316062C (en)
CZ (1) CZ278969B6 (en)
DD (1) DD281349A5 (en)
DE (2) DE3714140A1 (en)
DK (1) DK166193C (en)
ES (1) ES2027720T3 (en)
FI (1) FI91599C (en)
GR (1) GR3003289T3 (en)
HR (1) HRP920828B1 (en)
HU (1) HU204203B (en)
IE (1) IE61005B1 (en)
IL (1) IL85859A (en)
MY (1) MY103355A (en)
NO (1) NO172278C (en)
NZ (1) NZ223894A (en)
PH (1) PH25091A (en)
PL (1) PL161617B1 (en)
PT (1) PT87345B (en)
SI (1) SI8810781B (en)
SK (1) SK288388A3 (en)
WO (1) WO1988008318A1 (en)
YU (1) YU47056B (en)
ZA (1) ZA881739B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0725669B2 (en) * 1988-12-23 1995-03-22 日東電工株式会社 Pharmaceutical formulation for transdermal administration
DE3844247A1 (en) * 1988-12-29 1990-07-12 Minnesota Mining & Mfg DEVICE, IN PARTICULAR PLASTER FOR TRANSDERMAL ADMINISTRATION OF A MEDICINAL PRODUCT
DE3901551A1 (en) * 1989-01-20 1990-07-26 Lohmann Therapie Syst Lts SUPERFICIAL THERAPEUTIC SYSTEM WITH AN ANTINEOPLASTIC ACTIVE SUBSTANCE, IN PARTICULAR 5-FLUORURACIL
DE4020144A1 (en) * 1990-06-25 1992-01-09 Lohmann Therapie Syst Lts Patches for topical or transdermal drug delivery - with adhesive layer contg. polyacrylate adhesive and film former
DE4110027C2 (en) * 1991-03-27 1996-08-29 Lohmann Therapie Syst Lts Process for packaging transdermal therapeutic patches
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
DE4405898A1 (en) * 1994-02-18 1995-08-24 Schering Ag Transdermal therapeutic systems containing sex steroids
FR2728463A1 (en) * 1994-12-21 1996-06-28 Lhd Lab Hygiene Dietetique TRANSDERMIC SYSTEM FOR SIMULTANEOUS DELIVERY OF SEVERAL ACTIVE PRINCIPLES
DE29514849U1 (en) * 1995-09-15 1995-11-16 Weyergans, Rudolf, 52355 Düren Cellulite patch
FR2749514B1 (en) * 1996-06-11 1998-08-07 Hoechst Marion Roussel TRANSDERMAL SYSTEMS CONTAINING 2 ACTIVE INGREDIENTS IN SEPARATE COMPARTMENTS, THEIR PREPARATION METHOD AND THEIR APPLICATION AS A MEDICAMENT
DE19820999A1 (en) * 1998-05-11 1999-11-18 Lohmann Therapie Syst Lts Layered medicinal adhesive plaster with high holding power and flexibility
DE19911262C2 (en) * 1999-03-13 2003-04-10 Scs Skin Care Systems Gmbh Device for dispensing cosmetic active ingredients
DE19923427A1 (en) 1999-05-21 2000-11-23 Lohmann Therapie Syst Lts Device for improved delivery of active agents to skin, useful e.g. for administering opiates, contains agent that increases local skin temperature or blood flow
DE10042412B4 (en) * 2000-08-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag Transceiver for bus subscriber of bus system of building system engineering, has two wires, where microcontroller is connected with receiver unit over connection on one hand, which is connected to two wires of bus system
GB2383282B (en) 2002-04-02 2004-06-16 Crane Electronics Torque sensing tool
DE102004009903A1 (en) 2004-02-26 2005-09-22 Grünenthal GmbH Patch with reduced skin irritation
EP2000119A1 (en) * 2007-06-08 2008-12-10 Royal College of Surgeons in Ireland Wound dressings
HU227970B1 (en) 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
JP5386205B2 (en) * 2009-03-19 2014-01-15 リンテック株式会社 Transdermal patch
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
IL260290B2 (en) 2015-12-30 2023-11-01 Corium Inc Systems and methods for long term transdermal administration
AU2017281789B2 (en) 2016-06-23 2023-04-13 Corium, LLC. Adhesive matrix with hydrophilic and hydrophobic domains and a therapeutic agent
DE102023107257B4 (en) * 2023-03-22 2025-02-20 Xeno Patch GmbH Flexible plaster

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297995A (en) * 1980-06-03 1981-11-03 Key Pharmaceuticals, Inc. Bandage containing attachment post
US4622031A (en) * 1983-08-18 1986-11-11 Drug Delivery Systems Inc. Indicator for electrophoretic transcutaneous drug delivery device

Also Published As

Publication number Publication date
CZ278969B6 (en) 1994-11-16
EP0288734A1 (en) 1988-11-02
DK166193B (en) 1993-03-22
MY103355A (en) 1993-06-30
PT87345A (en) 1989-05-12
KR890700375A (en) 1989-04-24
IE61005B1 (en) 1994-09-07
DK166193C (en) 1993-08-16
HRP920828A2 (en) 1994-04-30
DE3866582D1 (en) 1992-01-16
AU627422B2 (en) 1992-08-27
WO1988008318A1 (en) 1988-11-03
JP2683264B2 (en) 1997-11-26
NO884530D0 (en) 1988-10-11
YU78188A (en) 1989-12-31
PL161617B1 (en) 1993-07-30
SI8810781A (en) 1996-12-31
DK722888D0 (en) 1988-12-23
NZ223894A (en) 1990-11-27
ATE69962T1 (en) 1991-12-15
NO172278B (en) 1993-03-22
AU1489488A (en) 1988-12-02
ES2027720T3 (en) 1992-06-16
HU204203B (en) 1991-12-30
EP0288734B1 (en) 1991-12-04
DE3714140A1 (en) 1988-11-10
HUT53294A (en) 1990-10-28
FI91599C (en) 1994-07-25
CA1316062C (en) 1993-04-13
IE880834L (en) 1988-10-28
ZA881739B (en) 1988-08-31
NO172278C (en) 1993-06-30
PL272134A1 (en) 1989-05-16
DK722888A (en) 1988-12-23
HRP920828B1 (en) 1998-02-28
CZ288388A3 (en) 1994-04-13
YU47056B (en) 1994-12-28
IL85859A (en) 1992-11-15
KR910002250B1 (en) 1991-04-08
DE3714140C2 (en) 1989-03-09
IL85859A0 (en) 1988-09-30
SK278466B6 (en) 1997-06-04
JPH01503383A (en) 1989-11-16
PT87345B (en) 1995-03-01
FI91599B (en) 1994-04-15
FI886019A7 (en) 1988-12-28
NO884530L (en) 1988-11-03
GR3003289T3 (en) 1993-02-17
PH25091A (en) 1991-02-19
SK288388A3 (en) 1997-06-04
DD281349A5 (en) 1990-08-08

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